Lyophilized Maqui (Aristotelia chilensis) Berry Induces Browning in the Subcutaneous White Adipose Tissue and Ameliorates the Insulin Resistance in High Fat Diet-Induced Obese Mice
Por:
Sandoval, V, Femenias, A, Martinez-Garza, U, Sanz-Lamora, H, Castagnini, JM, Quifer-Rada, P, Lamuela-Raventos, RM, Marrero, PF, Haro, D, Relat, J
Publicada:
1 sep 2019
Resumen:
Maqui (Aristotelia Chilensis) berry features a unique profile of anthocyanidins that includes high amounts of delphinidin-3-O-sambubioside-5-O-glucoside and delphinidin-3-O-sambubioside and has shown positive effects on fasting glucose and insulin levels in humans and murine models of type 2 diabetes and obesity. The molecular mechanisms underlying the impact of maqui on the onset and development of the obese phenotype and insulin resistance was investigated in high fat diet-induced obese mice supplemented with a lyophilized maqui berry. Maqui-dietary supplemented animals showed better insulin response and decreased weight gain but also a differential expression of genes involved in de novo lipogenesis, fatty acid oxidation, multilocular lipid droplet formation and thermogenesis in subcutaneous white adipose tissue (scWAT). These changes correlated with an increased expression of the carbohydrate response element binding protein b (Chrebpb), the sterol regulatory binding protein 1c (Srebp1c) and Cellular repressor of adenovirus early region 1A-stimulated genes 1 (Creg1) and an improvement in the fibroblast growth factor 21 (FGF21) signaling. Our evidence suggests that maqui dietary supplementation activates the induction of fuel storage and thermogenesis characteristic of a brown-like phenotype in scWAT and counteracts the unhealthy metabolic impact of an HFD. This induction constitutes a putative strategy to prevent/treat diet-induced obesity and its associated comorbidities.
Filiaciones:
Sandoval, V:
Univ Barcelona, Sch Pharm & Food Sci, Dept Nutr Food Sci & Gastron, Food Torribera Campus, E-08921 Santa Coloma De Gramenet, Spain
Univ Barcelona INSA UB, Inst Nutr & Food Safety, E-08921 Santa Coloma De Gramenet, Spain
Femenias, A:
Univ Lleida, UTPV XaRTA, Food Technol Dept, Appl Mycol Unit, E-25198 Lleida, Spain
Martinez-Garza, U:
Univ Barcelona, Sch Pharm & Food Sci, Dept Nutr Food Sci & Gastron, Food Torribera Campus, E-08921 Santa Coloma De Gramenet, Spain
Univ Barcelona INSA UB, Inst Nutr & Food Safety, E-08921 Santa Coloma De Gramenet, Spain
Sanz-Lamora, H:
Univ Barcelona, Sch Pharm & Food Sci, Dept Nutr Food Sci & Gastron, Food Torribera Campus, E-08921 Santa Coloma De Gramenet, Spain
Univ Barcelona INSA UB, Inst Nutr & Food Safety, E-08921 Santa Coloma De Gramenet, Spain
Castagnini, JM:
Univ Nacl Entre Rios, Fac Ciencias Alimentac, Tavella 1450, RA-3200 Concordia, Argentina
Quifer-Rada, P:
Hosp Santa Creu & Sant Pau, Biomed Res Inst St Pau, CIBER Diabet & Associated Metab Dis, Dept Endocrinol & Nutr, E-08041 Barcelona, Spain
Lamuela-Raventos, RM:
Univ Barcelona, Sch Pharm & Food Sci, Dept Nutr Food Sci & Gastron, Food Torribera Campus, E-08921 Santa Coloma De Gramenet, Spain
Univ Barcelona INSA UB, Inst Nutr & Food Safety, E-08921 Santa Coloma De Gramenet, Spain
Inst Salud Carlos III, CIBER Physiopathol Obes & Nutr CIBER OBN, E-28029 Madrid, Spain
Marrero, PF:
Univ Barcelona, Sch Pharm & Food Sci, Dept Nutr Food Sci & Gastron, Food Torribera Campus, E-08921 Santa Coloma De Gramenet, Spain
Inst Salud Carlos III, CIBER Physiopathol Obes & Nutr CIBER OBN, E-28029 Madrid, Spain
IBUB, E-08028 Barcelona, Spain
Haro, D:
Univ Barcelona, Sch Pharm & Food Sci, Dept Nutr Food Sci & Gastron, Food Torribera Campus, E-08921 Santa Coloma De Gramenet, Spain
Inst Salud Carlos III, CIBER Physiopathol Obes & Nutr CIBER OBN, E-28029 Madrid, Spain
IBUB, E-08028 Barcelona, Spain
Relat, J:
Univ Barcelona, Sch Pharm & Food Sci, Dept Nutr Food Sci & Gastron, Food Torribera Campus, E-08921 Santa Coloma De Gramenet, Spain
Univ Barcelona INSA UB, Inst Nutr & Food Safety, E-08921 Santa Coloma De Gramenet, Spain
Inst Salud Carlos III, CIBER Physiopathol Obes & Nutr CIBER OBN, E-28029 Madrid, Spain
Gold, Green Published
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