Non-motor symptoms burden, mood, and gait problems are the most significant factors contributing to a poor quality of life in non-demented Parkinson's disease patients: Results from the COPPADIS Study Cohort
Por:
Garcia, DS, Fonticoba, TD, Castro, ES, Borrue, C, Mata, M, Vila, BS, Foraster, AC, Sauco, MA, Perez, ABR, Vela, L, Macias, Y, Escalante, S, Esteve, P, Villarroya, SR, Cubo, E, Casas, E, Arnaiz, S, Padilla, FC, Morlans, MP, Mir, P, Martinez-Martin, P, Adarmes, AD, Almeria, M, Losada, GA, Canovas, AA, Alonso-Frech, F, Arribas, S, Vidondo, AA, Aguilar, M, Avila, MA, Lambrich, NB, Bejr-Kasem, H, Estrada, MB, Boti, M, Gonzalez, CC, Lopez, IC, Caballol, N, Lorenzo, AC, Carrillo, F, Catalan, MJ, Clavero, P, Fernandez, AC, Cuevas, AC, de Fabregues-Boixar, O, Diez-Fairen, M, Erro, E, Peyret, EE, Guinan, NF, Gamez, P, Gallego, M, Caldentey, JG, Campos, CG, Moreno, JMG, Gaston, I, Garre, MPG, Aloy, JG, Gonzalez-Aramburu, I, Ardura, JG, Garcia, BG, Palmas, MJG, Toledo, GRG, Diaz, AG, Sola, MG, Guardia, G, Hernandez-Vara, J, Barba, AH, Infante, J, Jesus, S, Kulisevsky, J, Kurtis, M, Labandeira, C, Labrador, MA, Lacruz, F, Castro, ML, Legarda, I, Ariztegui, NL, Diaz, LML, Manzanares, LL, Seoane, BL, Andres, GM, Marti, MJ, Martinez-Castrillo, JC, McAfee, D, Meitin, MT, Gonzalez, MM, del Barrio, CM, Santiago, JM, Casado, MIM, Dieguez, AM, Nogueira, V, Amado, AN, Ponte, SN, Ordas, C, Pagonabarraga, J, Parees, I, Pascual-Sedano, B, Pastor, P, Fuertes, AP, Noguera, RP, Planellas, L, Fuster, JP, Prats, MA, Jurczynska, CP, Puente, V, Rafales, NR, Mendez, LR, Roldan, F, De Arcos, MR, Martinez, JR, Alonso, PS, Sanchez-Carpintero, M, Diez, GS, Rodriguez, AS, Santacruz, P, Rodriguez, JCS, Seijo, M, Serarols, A, Pena, M, Tartari, JP, Vargas, L, Gomez, RV, Villanueva, C, Vives, B, Villar, MD
Publicada:
1 sep 2019
Resumen:
Objective: To identify factors related to a poor health-related and global quality of life (QoL) in a cohort of nondemented Parkinson's disease (PD) patients and compare to a control group.
Methods: The data correspond to the baseline evaluation of the COPPADIS-2015 Study, an observational, 5-year follow-up, multicenter, evaluation study. Three instruments were used to assess QoL: (1) the 39-item Parkinson's disease Questionnaire (PDQ-39), (2) a subjective rating of global QoL (PQ-10), and (3) the EUROHIS-QOL 8-item index (EUROHIS-QOL8). Multiple linear regression methods were used to evaluate the direct impact of different variables on these QoL measures.
Results: QoL was worse in PD patients (n = 692; 62.6 +/- 8.9 years old, 60.3% males) than controls (n = 206; 61 +/- 8.3 years old, 49.5% males): PDQ-39, 17.1 +/- 13.5 vs 4.4 +/- 6.3 (p < 0.0001); PQ-10, 7.3 +/- 1.6 vs 8.1 +/- 1.2 (p < 0.0001); EUROHIS-Q0L8, 3.8 +/- 0.6 vs 4.2 +/- 0.5 (p < 0.0001). A high correlation was observed between PDQ-39 and Non-Motor Symptoms Scale (NMSS) (r = 0.72; p < 0.0001), and PDQ-39 and Beck Depression Inventory-II (BDI-II) (r = 0.65; p < 0.0001). For health-related QoL (PDQ-39), non-motor symptoms burden (NMSS), mood (BDI-II), and gait problems (Freezing Of Gait Questionnaire [FOGQ]) provided the highest contribution to the model (beta = 0.32, 0.28, and 0.27, respectively; p < 0.0001); whereas mood and gait pro- blems contributed the most to global QoL (PQ-10, beta = -0.46 and -0.21, respectively; EUROHIS-QOL8, beta = - 0.44 and - 0.23, respectively).
Conclusions: QoL is worse in PD patients than in controls. Mood, non-motor symptoms burden, and gait problems seem to be the most relevant factors affecting health-related and global perceived QoL in non-demented PD patients.
Filiaciones:
Garcia, DS:
CHUAC, La Coruna, Spain
CHUF, Hosp Arquitecto Marcide & Hosp Naval, Ferrol, A Coruna, Spain
Fonticoba, TD:
CHUF, Hosp Arquitecto Marcide & Hosp Naval, Ferrol, A Coruna, Spain
Castro, ES:
CHUF, Hosp Arquitecto Marcide & Hosp Naval, Ferrol, A Coruna, Spain
Borrue, C:
Hosp Infanta Sofia, Madrid, Spain
Mata, M:
Hosp Infanta Sofia, Madrid, Spain
Vila, BS:
IAS, Inst Catala Salud, Girona, Spain
Foraster, AC:
IAS, Inst Catala Salud, Girona, Spain
Sauco, MA:
Hosp Gen Univ Elche, Elche, Spain
Perez, ABR:
Hosp Gen Univ Elche, Elche, Spain
Vela, L:
Fdn Hosp Alcorcon, Madrid, Spain
Hosp HM Puerta Sur, CINAC Ctr Integral Neurociencias AC, Madrid, Spain
Macias, Y:
Fdn Hosp Alcorcon, Madrid, Spain
Escalante, S:
HTVC, Tarragona, Spain
Esteve, P:
HTVC, Tarragona, Spain
Villarroya, SR:
HTVC, Tarragona, Spain
Cubo, E:
Complejo Asistencial Univ Burgos, Burgos, Spain
Casas, E:
Complejo Asistencial Univ Burgos, Burgos, Spain
Arnaiz, S:
Complejo Asistencial Univ Burgos, Burgos, Spain
Padilla, FC:
Hosp Univ Conarias, San Cristobal De La Lagu, Santa Cruz De T, Spain
Morlans, MP:
Hosp Univ Conarias, San Cristobal De La Lagu, Santa Cruz De T, Spain
Mir, P:
Univ Seville, Unidad Trommos Movimiento, Serv Neurol Neumfisiol ClM, Seville, Spain
Martinez-Martin, P:
Inst Salad Carlos III, Ctr Nacl Epidemiol, Madrid, Spain
Inst Salad Carlos III, CIBERNED, Madrid, Spain
Bejr-Kasem, H:
Institut d’Investigació Biomèdica Sant Pau (IIB SANT PAU), Sant Quintí 77-79, 08041 Barcelona, Spain
Boti, M:
Institut d’Investigació Biomèdica Sant Pau (IIB SANT PAU), Sant Quintí 77-79, 08041 Barcelona, Spain
Kulisevsky, J:
Institut d’Investigació Biomèdica Sant Pau (IIB SANT PAU), Sant Quintí 77-79, 08041 Barcelona, Spain
Pagonabarraga, J:
Institut d’Investigació Biomèdica Sant Pau (IIB SANT PAU), Sant Quintí 77-79, 08041 Barcelona, Spain
Pascual-Sedano, B:
Institut d’Investigació Biomèdica Sant Pau (IIB SANT PAU), Sant Quintí 77-79, 08041 Barcelona, Spain
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