Genome-wide association analysis of dementia and its clinical endophenotypes reveal novel loci associated with Alzheimer's disease and three causality networks: The GR@ACE project
Por:
Moreno-Grau, S, de Rojas, I, Hernandez, I, Quintela, I, Montrreal, L, Alegret, M, Hernandez-Olasagarre, B, Madrid, L, Gonzalez-Perez, A, Maronas, O, Rosende-Roca, M, Mauleon, A, Vargas, L, Lafuente, A, Abdelnour, C, Rodriguez-Gomez, O, Gil, S, Santos-Santos, MA, Espinosa, A, Ortega, G, Sanabria, A, Perez-Cordon, A, Canabate, P, Moreno, M, Preckler, S, Ruiz, S, Aguilera, N, Pineda, JA, Macias, J, Alarcon-Martin, E, Sotolongo-Grau, O, Marquie, M, Monte-Rubio, G, Valero, S, Benaque, A, Clarimon, J, Bullido, MJ, Garcia-Ribas, G, Pastor, P, Sanchez-Juan, P, Alvarez, V, Pinol-Ripoll, G, Garcia-Alberca, JM, Royo, JL, Franco, E, Mir, P, Calero, M, Medina, M, Rabano, A, Avila, J, Antunez, C, Real, LM, Orellana, A, Carracedo, A, Saez, ME, Tarraga, L, Boada, M, Ruiz, A, Alarcon, E, Buendia, M, Corbaton, A, Diego, S, Gailhajenet, A, Gonzalez, PG, Guitart, M, Ibarria, M, Martin, E, Martinez, MT, Pancho, A, Peleja, E, Pineda, JA, Real, LM, Serrano-Rios, M, Adarmes-Gomez, AD, Alvarez, I, Amer-Ferrer, G, Antequera, M, Baquero, M, Bernal, M, Blesa, R, Buiza-Rueda, D, Bullido, MJ, Burguera, JA, Carrillo, F, Carrion-Claro, M, Casajeros, MJ, Cruz-Gamero, JM, de Pancorbo, MM, del Ser, T, Diez-Fairen, M, Fortea, J, Frank-Garcia, A, Madrona, SG, Gomez-Garre, P, Hevilla, S, Jesus, S, Espinosa, MAL, Lage, C, Legaz, A, Lleo, A, de Munain, AL, Lopez-Garcia, S, Macias, D, Manzanares, S, Marin, M, Marin-Munoz, J, Marin, T, Montes, AM, Martinez, B, Martinez, C, Martinez, V, Alvarez, PML, Iriarte, MM, Menendez-Gonzalez, M, Molinuevo, JL, Pastor, AB, Tur, JP, Perinan-Tocino, T, de Asua, DR, Rodrigo, S, Rodriguez-Rodriguez, E, Diaz, RSD, Sastre, E, Vicente, MP, Vivancos, L
Publicada:
1 oct 2019
Resumen:
Introduction: Large variability among Alzheimer's disease (AD) cases might impact genetic discoveries and complicate dissection of underlying biological pathways.
Methods: Genome Research at Fundacio ACE (GR@ACE) is a genome-wide study of dementia and its clinical endophenotypes, defined based on AD's clinical certainty and vascular burden. We assessed the impact of known AD loci across endophenotypes to generate loci categories. We incorporated gene coexpression data and conducted pathway analysis per category. Finally, to evaluate the effect of heterogeneity in genetic studies, GR@ACE series were meta-analyzed with additional genome-wide association study data sets.
Results: We classified known AD loci into three categories, which might reflect the disease clinical heterogeneity. Vascular processes were only detected as a causal mechanism in probable AD. The meta-analysis strategy revealed the ANKRD31-rs4704171 and NDUFAF6-rs10098778 and confirmed SCIMP-rs7225151 and CD33-rs3865444.
Discussion: The regulation of vasculature is a prominent causal component of probable AD. GR@ACE meta-analysis revealed novel AD genetic signals, strongly driven by the presence of clinical heterogeneity in the AD series. (C) 2019 The Authors. Published by Elsevier Inc. on behalf of the Alzheimer's Association.
Filiaciones:
Moreno-Grau, S:
Univ Int Catalunya, Res Ctr & Memory Clin Fundacio ACE, Inst Catala Neurociencies Aplicades, Barcelona, Spain
Natl Inst Hlth Carlos III, CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Natl Inst Hlth Carlos III, Minist Econ & Competitiveness, CIBERNED, Ctr Networked Biomed Res Neurodegenerat Dis, Madrid, Spain
de Rojas, I:
Univ Int Catalunya, Res Ctr & Memory Clin Fundacio ACE, Inst Catala Neurociencies Aplicades, Barcelona, Spain
Hernandez, I:
Univ Int Catalunya, Res Ctr & Memory Clin Fundacio ACE, Inst Catala Neurociencies Aplicades, Barcelona, Spain
Natl Inst Hlth Carlos III, CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Natl Inst Hlth Carlos III, Minist Econ & Competitiveness, CIBERNED, Ctr Networked Biomed Res Neurodegenerat Dis, Madrid, Spain
Quintela, I:
Univ Santiago de Compostela, Grp Med Xenom, Ctr Nacl Genotipado CEGEN, PRB3,ISCIII, Santiago De Compostela, Spain
Univ Malaga, Sch Med, Dept Surg Biochem & Mol Biol, Malaga, Spain
Montrreal, L:
Univ Int Catalunya, Res Ctr & Memory Clin Fundacio ACE, Inst Catala Neurociencies Aplicades, Barcelona, Spain
Alegret, M:
Univ Int Catalunya, Res Ctr & Memory Clin Fundacio ACE, Inst Catala Neurociencies Aplicades, Barcelona, Spain
Natl Inst Hlth Carlos III, CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Natl Inst Hlth Carlos III, Minist Econ & Competitiveness, CIBERNED, Ctr Networked Biomed Res Neurodegenerat Dis, Madrid, Spain
Hernandez-Olasagarre, B:
Univ Int Catalunya, Res Ctr & Memory Clin Fundacio ACE, Inst Catala Neurociencies Aplicades, Barcelona, Spain
Madrid, L:
Ctr Andaluz Estudios Bioinformat, CAEBI, Seville, Spain
Gonzalez-Perez, A:
Ctr Andaluz Estudios Bioinformat, CAEBI, Seville, Spain
Maronas, O:
Univ Santiago de Compostela, Grp Med Xenom, Ctr Nacl Genotipado CEGEN, PRB3,ISCIII, Santiago De Compostela, Spain
Rosende-Roca, M:
Univ Int Catalunya, Res Ctr & Memory Clin Fundacio ACE, Inst Catala Neurociencies Aplicades, Barcelona, Spain
Mauleon, A:
Univ Int Catalunya, Res Ctr & Memory Clin Fundacio ACE, Inst Catala Neurociencies Aplicades, Barcelona, Spain
Vargas, L:
Univ Int Catalunya, Res Ctr & Memory Clin Fundacio ACE, Inst Catala Neurociencies Aplicades, Barcelona, Spain
Lafuente, A:
Univ Int Catalunya, Res Ctr & Memory Clin Fundacio ACE, Inst Catala Neurociencies Aplicades, Barcelona, Spain
Abdelnour, C:
Univ Int Catalunya, Res Ctr & Memory Clin Fundacio ACE, Inst Catala Neurociencies Aplicades, Barcelona, Spain
Natl Inst Hlth Carlos III, CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Natl Inst Hlth Carlos III, Minist Econ & Competitiveness, CIBERNED, Ctr Networked Biomed Res Neurodegenerat Dis, Madrid, Spain
Rodriguez-Gomez, O:
Univ Int Catalunya, Res Ctr & Memory Clin Fundacio ACE, Inst Catala Neurociencies Aplicades, Barcelona, Spain
Natl Inst Hlth Carlos III, CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Natl Inst Hlth Carlos III, Minist Econ & Competitiveness, CIBERNED, Ctr Networked Biomed Res Neurodegenerat Dis, Madrid, Spain
Gil, S:
Univ Int Catalunya, Res Ctr & Memory Clin Fundacio ACE, Inst Catala Neurociencies Aplicades, Barcelona, Spain
Santos-Santos, MA:
Univ Int Catalunya, Res Ctr & Memory Clin Fundacio ACE, Inst Catala Neurociencies Aplicades, Barcelona, Spain
Espinosa, A:
Univ Int Catalunya, Res Ctr & Memory Clin Fundacio ACE, Inst Catala Neurociencies Aplicades, Barcelona, Spain
Natl Inst Hlth Carlos III, CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Natl Inst Hlth Carlos III, Minist Econ & Competitiveness, CIBERNED, Ctr Networked Biomed Res Neurodegenerat Dis, Madrid, Spain
Ortega, G:
Univ Int Catalunya, Res Ctr & Memory Clin Fundacio ACE, Inst Catala Neurociencies Aplicades, Barcelona, Spain
Natl Inst Hlth Carlos III, CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Natl Inst Hlth Carlos III, Minist Econ & Competitiveness, CIBERNED, Ctr Networked Biomed Res Neurodegenerat Dis, Madrid, Spain
Sanabria, A:
Univ Int Catalunya, Res Ctr & Memory Clin Fundacio ACE, Inst Catala Neurociencies Aplicades, Barcelona, Spain
Natl Inst Hlth Carlos III, CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Natl Inst Hlth Carlos III, Minist Econ & Competitiveness, CIBERNED, Ctr Networked Biomed Res Neurodegenerat Dis, Madrid, Spain
Perez-Cordon, A:
Univ Int Catalunya, Res Ctr & Memory Clin Fundacio ACE, Inst Catala Neurociencies Aplicades, Barcelona, Spain
Natl Inst Hlth Carlos III, CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Canabate, P:
Univ Int Catalunya, Res Ctr & Memory Clin Fundacio ACE, Inst Catala Neurociencies Aplicades, Barcelona, Spain
Natl Inst Hlth Carlos III, CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Natl Inst Hlth Carlos III, Minist Econ & Competitiveness, CIBERNED, Ctr Networked Biomed Res Neurodegenerat Dis, Madrid, Spain
Moreno, M:
Univ Int Catalunya, Res Ctr & Memory Clin Fundacio ACE, Inst Catala Neurociencies Aplicades, Barcelona, Spain
Preckler, S:
Univ Int Catalunya, Res Ctr & Memory Clin Fundacio ACE, Inst Catala Neurociencies Aplicades, Barcelona, Spain
Ruiz, S:
Univ Int Catalunya, Res Ctr & Memory Clin Fundacio ACE, Inst Catala Neurociencies Aplicades, Barcelona, Spain
Natl Inst Hlth Carlos III, CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Natl Inst Hlth Carlos III, Minist Econ & Competitiveness, CIBERNED, Ctr Networked Biomed Res Neurodegenerat Dis, Madrid, Spain
Aguilera, N:
Univ Int Catalunya, Res Ctr & Memory Clin Fundacio ACE, Inst Catala Neurociencies Aplicades, Barcelona, Spain
Pineda, JA:
Hosp Univ Valme, Unidad Clin Enfermedades Infecciosas & Microbiol, Seville, Spain
Macias, J:
Hosp Univ Valme, Unidad Clin Enfermedades Infecciosas & Microbiol, Seville, Spain
Alarcon-Martin, E:
Univ Int Catalunya, Res Ctr & Memory Clin Fundacio ACE, Inst Catala Neurociencies Aplicades, Barcelona, Spain
Univ Malaga, Sch Med, Dept Surg Biochem & Mol Biol, Malaga, Spain
Sotolongo-Grau, O:
Univ Int Catalunya, Res Ctr & Memory Clin Fundacio ACE, Inst Catala Neurociencies Aplicades, Barcelona, Spain
Marquie, M:
Univ Int Catalunya, Res Ctr & Memory Clin Fundacio ACE, Inst Catala Neurociencies Aplicades, Barcelona, Spain
Monte-Rubio, G:
Univ Int Catalunya, Res Ctr & Memory Clin Fundacio ACE, Inst Catala Neurociencies Aplicades, Barcelona, Spain
Valero, S:
Univ Int Catalunya, Res Ctr & Memory Clin Fundacio ACE, Inst Catala Neurociencies Aplicades, Barcelona, Spain
Natl Inst Hlth Carlos III, CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Natl Inst Hlth Carlos III, Minist Econ & Competitiveness, CIBERNED, Ctr Networked Biomed Res Neurodegenerat Dis, Madrid, Spain
Benaque, A:
Univ Int Catalunya, Res Ctr & Memory Clin Fundacio ACE, Inst Catala Neurociencies Aplicades, Barcelona, Spain
Clarimon, J:
Natl Inst Hlth Carlos III, CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Memory Unit, Neurol Dept, Barcelona, Spain
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, St Pau Biomed Res Inst, Barcelona, Spain
Bullido, MJ:
Natl Inst Hlth Carlos III, CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Univ Autonoma Madrid, CSIC, Ctr Biol Mol Severn Ochoa, Madrid, Spain
Inst Invest Sanitaria Hosp La Paz IdiPaz, Madrid, Spain
Garcia-Ribas, G:
Hosp Univ Ramon y Cajal, Madrid, Spain
Inst Salud Carlos III, Madrid, Spain
Pastor, P:
Fundacio Recerca Biomed & Social Mutua Terrassa, Terrassa, Spain
Univ Barcelona, Hosp Univ Mutua Terrassa, Dept Neurol, Sch Med,Memory Disorders Unit, Terrassa, Spain
Fundacio Recerca Biomed & Social Mutua Terrassa, Barcelona, Spain
Univ Barcelona, Sch Med, Hosp Mutua Terrassa, Memory Disorders Unit,Dept Neurol, Barcelona, Spain
Sanchez-Juan, P:
Natl Inst Hlth Carlos III, CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Univ Cantabria, Neurol Serv, Marques de Valdecilla Univ Hosp, Santander, Spain
IDIVAL, Santander, Spain
Alvarez, V:
Hosp Univ Cent Asturias, Lab Genet, Oviedo, Spain
Inst Invest Biosanit Principado Asturias ISPA, Oviedo, Spain
Pinol-Ripoll, G:
Natl Inst Hlth Carlos III, CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Hosp Univ Santa Maria Lleida, Inst Recerca Biomed Lleida IRBLLeida, Unitat Trastorns Cognitius, Lleida, Spain
Garcia-Alberca, JM:
Andalusian Inst Neurosci, Alzheimer Res Ctr, Malaga, Spain
Andalusian Inst Neurosci, Memory Clin, Malaga, Spain
Royo, JL:
Univ Malaga, Sch Med, Dept Surg Biochem & Mol Biol, Malaga, Spain
Franco, E:
Univ Seville, Hosp Univ Virgen del Rocio, CSIC,Inst Biomed Sevilla IBiS, Unidad Demencias,Serv Neurol & Neurofisiol, Seville, Spain
Mir, P:
Natl Inst Hlth Carlos III, CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Univ Seville, Hosp Univ Virgen del Rocio, CSIC,Inst Biomed Sevilla IBiS, Unidad Trastornos Movimiento,Serv Neurol & Neurof, Seville, Spain
Calero, M:
Natl Inst Hlth Carlos III, CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Queen Sofia Fdn Alzheimer Ctr, CIEN Fdn, Madrid, Spain
Inst Salud Carlos III, Madrid, Spain
Medina, M:
Natl Inst Hlth Carlos III, CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Inst Invest Sanitaria Hosp La Paz IdiPaz, Madrid, Spain
Queen Sofia Fdn Alzheimer Ctr, CIEN Fdn, Madrid, Spain
Rabano, A:
Natl Inst Hlth Carlos III, CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Queen Sofia Fdn Alzheimer Ctr, CIEN Fdn, Madrid, Spain
BT CIEN, Madrid, Spain
Avila, J:
Natl Inst Hlth Carlos III, CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
UAM, CSIC, CBMSO, Dept Mol Neuropathol, Madrid, Spain
Antunez, C:
Hosp Clin Univ Virgen de la Arrixaca, Unidad Demencias, Murcia, Spain
Real, LM:
Hosp Univ Valme, Unidad Clin Enfermedades Infecciosas & Microbiol, Seville, Spain
Univ Malaga, Sch Med, Dept Surg Biochem & Mol Biol, Malaga, Spain
Orellana, A:
Univ Int Catalunya, Res Ctr & Memory Clin Fundacio ACE, Inst Catala Neurociencies Aplicades, Barcelona, Spain
Carracedo, A:
Univ Santiago de Compostela, Grp Med Xenom, Ctr Nacl Genotipado CEGEN, PRB3,ISCIII, Santiago De Compostela, Spain
Fdn Publ Galega Med Xenom, CIBERER IDIS, Santiago De Compostela, Spain
Saez, ME:
Ctr Andaluz Estudios Bioinformat, CAEBI, Seville, Spain
Tarraga, L:
Univ Int Catalunya, Res Ctr & Memory Clin Fundacio ACE, Inst Catala Neurociencies Aplicades, Barcelona, Spain
Natl Inst Hlth Carlos III, CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Natl Inst Hlth Carlos III, Minist Econ & Competitiveness, CIBERNED, Ctr Networked Biomed Res Neurodegenerat Dis, Madrid, Spain
Boada, M:
Univ Int Catalunya, Res Ctr & Memory Clin Fundacio ACE, Inst Catala Neurociencies Aplicades, Barcelona, Spain
Natl Inst Hlth Carlos III, CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Natl Inst Hlth Carlos III, Minist Econ & Competitiveness, CIBERNED, Ctr Networked Biomed Res Neurodegenerat Dis, Madrid, Spain
Ruiz, A:
Univ Int Catalunya, Res Ctr & Memory Clin Fundacio ACE, Inst Catala Neurociencies Aplicades, Barcelona, Spain
Natl Inst Hlth Carlos III, CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Natl Inst Hlth Carlos III, Minist Econ & Competitiveness, CIBERNED, Ctr Networked Biomed Res Neurodegenerat Dis, Madrid, Spain
Alarcon, E:
Univ Int Catalunya, Res Ctr & Memory Clin Fundacio ACE, Inst Catala Neurociencies Aplicades, Barcelona, Spain
Univ Malaga, Sch Med, Dept Surg Biochem & Mol Biol, Malaga, Spain
Buendia, M:
Univ Int Catalunya, Res Ctr & Memory Clin Fundacio ACE, Inst Catala Neurociencies Aplicades, Barcelona, Spain
Corbaton, A:
Hosp Clin San Carlos, CIBERDEM, Ctr Invest Biomed Red Diabet & Enfermedades Metab, Madrid, Spain
Diego, S:
Univ Int Catalunya, Res Ctr & Memory Clin Fundacio ACE, Inst Catala Neurociencies Aplicades, Barcelona, Spain
Gailhajenet, A:
Univ Int Catalunya, Res Ctr & Memory Clin Fundacio ACE, Inst Catala Neurociencies Aplicades, Barcelona, Spain
Gonzalez, PG:
Univ Int Catalunya, Res Ctr & Memory Clin Fundacio ACE, Inst Catala Neurociencies Aplicades, Barcelona, Spain
Guitart, M:
Univ Int Catalunya, Res Ctr & Memory Clin Fundacio ACE, Inst Catala Neurociencies Aplicades, Barcelona, Spain
Ibarria, M:
Univ Int Catalunya, Res Ctr & Memory Clin Fundacio ACE, Inst Catala Neurociencies Aplicades, Barcelona, Spain
Martin, E:
Univ Int Catalunya, Res Ctr & Memory Clin Fundacio ACE, Inst Catala Neurociencies Aplicades, Barcelona, Spain
Univ Malaga, Sch Med, Dept Surg Biochem & Mol Biol, Malaga, Spain
Martinez, MT:
Hosp Clin San Carlos, CIBERDEM, Ctr Invest Biomed Red Diabet & Enfermedades Metab, Madrid, Spain
Pancho, A:
Univ Int Catalunya, Res Ctr & Memory Clin Fundacio ACE, Inst Catala Neurociencies Aplicades, Barcelona, Spain
Peleja, E:
Univ Int Catalunya, Res Ctr & Memory Clin Fundacio ACE, Inst Catala Neurociencies Aplicades, Barcelona, Spain
Pineda, JA:
Hosp Univ Valme, Unidad Clin Enfermedades Infecciosas & Microbiol, Seville, Spain
Real, LM:
Hosp Univ Valme, Unidad Clin Enfermedades Infecciosas & Microbiol, Seville, Spain
Univ Malaga, Sch Med, Dept Surg Biochem & Mol Biol, Malaga, Spain
Serrano-Rios, M:
Hosp Clin San Carlos, CIBERDEM, Ctr Invest Biomed Red Diabet & Enfermedades Metab, Madrid, Spain
Adarmes-Gomez, AD:
Natl Inst Hlth Carlos III, CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Univ Seville, Hosp Univ Virgen del Rocio, CSIC,Inst Biomed Sevilla IBiS, Unidad Trastornos Movimiento,Serv Neurol & Neurof, Seville, Spain
Alvarez, I:
Fundacio Recerca Biomed & Social Mutua Terrassa, Barcelona, Spain
Univ Barcelona, Sch Med, Hosp Mutua Terrassa, Memory Disorders Unit,Dept Neurol, Barcelona, Spain
Amer-Ferrer, G:
Hosp Univ Son Espases, Dept Neurol, Palma De Mallorca, Spain
Antequera, M:
Hosp Clin Univ Virgen de la Arrixaca, Unidad Demencias, Murcia, Spain
Baquero, M:
Hosp Univ & Politecn La Fe, Servei Neurol, Valencia, Spain
Bernal, M:
Univ Seville, Hosp Univ Virgen del Rocio, CSIC,Inst Biomed Sevilla IBiS, Unidad Demencias,Serv Neurol & Neurofisiol, Seville, Spain
Blesa, R:
Natl Inst Hlth Carlos III, CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Memory Unit, Neurol Dept, Barcelona, Spain
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, St Pau Biomed Res Inst, Barcelona, Spain
Buiza-Rueda, D:
Natl Inst Hlth Carlos III, CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Univ Seville, Hosp Univ Virgen del Rocio, CSIC,Inst Biomed Sevilla IBiS, Unidad Trastornos Movimiento,Serv Neurol & Neurof, Seville, Spain
Bullido, MJ:
Natl Inst Hlth Carlos III, CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Univ Autonoma Madrid, CSIC, Ctr Biol Mol Severn Ochoa, Madrid, Spain
Inst Invest Sanitaria Hosp La Paz IdiPaz, Madrid, Spain
Burguera, JA:
Hosp Univ & Politecn La Fe, Servei Neurol, Valencia, Spain
Carrillo, F:
Natl Inst Hlth Carlos III, CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Univ Seville, Hosp Univ Virgen del Rocio, CSIC,Inst Biomed Sevilla IBiS, Unidad Trastornos Movimiento,Serv Neurol & Neurof, Seville, Spain
Carrion-Claro, M:
Natl Inst Hlth Carlos III, CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Univ Seville, Hosp Univ Virgen del Rocio, CSIC,Inst Biomed Sevilla IBiS, Unidad Trastornos Movimiento,Serv Neurol & Neurof, Seville, Spain
Casajeros, MJ:
Hosp Univ Ramon y Cajal, Madrid, Spain
Cruz-Gamero, JM:
Univ Malaga, Sch Med, Dept Surg Biochem & Mol Biol, Malaga, Spain
de Pancorbo, MM:
BIOMICs, Pais Vasco, Spain
Univ Basque Country, UPV EHU, Ctr Invest Lascaray, Bilbao, Spain
del Ser, T:
Inst Invest Sanitaria Hosp La Paz IdiPaz, Madrid, Spain
Diez-Fairen, M:
Fundacio Recerca Biomed & Social Mutua Terrassa, Barcelona, Spain
Univ Barcelona, Sch Med, Hosp Mutua Terrassa, Memory Disorders Unit,Dept Neurol, Barcelona, Spain
Fortea, J:
Natl Inst Hlth Carlos III, CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Memory Unit, Neurol Dept, Barcelona, Spain
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, St Pau Biomed Res Inst, Barcelona, Spain
Frank-Garcia, A:
Natl Inst Hlth Carlos III, CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Inst Invest Sanitaria Hosp La Paz IdiPaz, Madrid, Spain
Hosp Univ La Paz UAM, Neurol Serv, Madrid, Spain
Madrona, SG:
Inst Salud Carlos III, Madrid, Spain
Gomez-Garre, P:
Natl Inst Hlth Carlos III, CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Univ Seville, Hosp Univ Virgen del Rocio, CSIC,Inst Biomed Sevilla IBiS, Unidad Trastornos Movimiento,Serv Neurol & Neurof, Seville, Spain
Hevilla, S:
Andalusian Inst Neurosci, Alzheimer Res Ctr, Malaga, Spain
Andalusian Inst Neurosci, Memory Clin, Malaga, Spain
Jesus, S:
Natl Inst Hlth Carlos III, CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Univ Seville, Hosp Univ Virgen del Rocio, CSIC,Inst Biomed Sevilla IBiS, Unidad Trastornos Movimiento,Serv Neurol & Neurof, Seville, Spain
Espinosa, MAL:
Natl Inst Hlth Carlos III, CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Univ Seville, Hosp Univ Virgen del Rocio, CSIC,Inst Biomed Sevilla IBiS, Unidad Trastornos Movimiento,Serv Neurol & Neurof, Seville, Spain
Lage, C:
Natl Inst Hlth Carlos III, CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Univ Cantabria, Neurol Serv, Marques de Valdecilla Univ Hosp, Santander, Spain
IDIVAL, Santander, Spain
Legaz, A:
Hosp Clin Univ Virgen de la Arrixaca, Unidad Demencias, Murcia, Spain
Lleo, A:
Natl Inst Hlth Carlos III, CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Memory Unit, Neurol Dept, Barcelona, Spain
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, St Pau Biomed Res Inst, Barcelona, Spain
de Munain, AL:
Hosp Donostia San Sebastian, Donostia San Sebastian, Gipuzkoa, Spain
Lopez-Garcia, S:
Natl Inst Hlth Carlos III, CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Univ Cantabria, Neurol Serv, Marques de Valdecilla Univ Hosp, Santander, Spain
IDIVAL, Santander, Spain
Macias, D:
Natl Inst Hlth Carlos III, CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Univ Seville, Hosp Univ Virgen del Rocio, CSIC,Inst Biomed Sevilla IBiS, Unidad Trastornos Movimiento,Serv Neurol & Neurof, Seville, Spain
Manzanares, S:
Hosp Clin Univ Virgen de la Arrixaca, Unidad Demencias, Murcia, Spain
Fdn Formac & Invest Sanitarias Reg Murcia, Murcia, Spain
Marin, M:
Univ Seville, Hosp Univ Virgen del Rocio, CSIC,Inst Biomed Sevilla IBiS, Unidad Demencias,Serv Neurol & Neurofisiol, Seville, Spain
Marin-Munoz, J:
Hosp Clin Univ Virgen de la Arrixaca, Unidad Demencias, Murcia, Spain
Marin, T:
Andalusian Inst Neurosci, Alzheimer Res Ctr, Malaga, Spain
Andalusian Inst Neurosci, Memory Clin, Malaga, Spain
Montes, AM:
Natl Inst Hlth Carlos III, CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Univ Autonoma Madrid, CSIC, Ctr Biol Mol Severn Ochoa, Madrid, Spain
Hosp Univ La Paz UAM, Neurol Serv, Madrid, Spain
Martinez, B:
Hosp Clin Univ Virgen de la Arrixaca, Unidad Demencias, Murcia, Spain
Martinez, C:
Inst Invest Biosanit Principado Asturias ISPA, Oviedo, Spain
Hosp Cabuenes Gijon, Serv Neurol, Gijon, Spain
Martinez, V:
Hosp Clin Univ Virgen de la Arrixaca, Unidad Demencias, Murcia, Spain
Alvarez, PML:
Fdn CITA Alzheimer, Ctr Invest & Terapias Avanzadas, Donostia San Sebastian, Gipuzkoa, Spain
Iriarte, MM:
Navarrabiomed, Pamplona, Spain
Menendez-Gonzalez, M:
Inst Invest Biosanit Principado Asturias ISPA, Oviedo, Spain
Hosp Univ Cent Asturias, Serv Neurol, Oviedo, Spain
Molinuevo, JL:
Fundacio Pasqual Maragall, Barcelona Brain Res Ctr, Barcelona, Spain
Pastor, AB:
Queen Sofia Fdn Alzheimer Ctr, CIEN Fdn, Madrid, Spain
Tur, JP:
Natl Inst Hlth Carlos III, CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Inst Biomed Valencia, CSIC, Unitat Genet Mol, Valencia, Spain
Inst Invest Sanitaria La Fe, Unidad Mixta Neurol Genet, Valencia, Spain
Perinan-Tocino, T:
Natl Inst Hlth Carlos III, CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Univ Seville, Hosp Univ Virgen del Rocio, CSIC,Inst Biomed Sevilla IBiS, Unidad Trastornos Movimiento,Serv Neurol & Neurof, Seville, Spain
de Asua, DR:
Hosp Univ La Princes, Madrid, Spain
Rodrigo, S:
Univ Seville, Hosp Univ Virgen del Rocio, CSIC,Inst Biomed Sevilla IBiS, Unidad Demencias,Serv Neurol & Neurofisiol, Seville, Spain
Rodriguez-Rodriguez, E:
Natl Inst Hlth Carlos III, CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Univ Cantabria, Neurol Serv, Marques de Valdecilla Univ Hosp, Santander, Spain
IDIVAL, Santander, Spain
Diaz, RSD:
Hosp Clin Barcelona, Barcelona, Spain
Sastre, E:
Natl Inst Hlth Carlos III, CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain
Univ Autonoma Madrid, CSIC, Ctr Biol Mol Severn Ochoa, Madrid, Spain
Vicente, MP:
Hosp Clin Univ Virgen de la Arrixaca, Unidad Demencias, Murcia, Spain
Vivancos, L:
Hosp Clin Univ Virgen de la Arrixaca, Unidad Demencias, Murcia, Spain
Green Published, Green Accepted, Hybrid Gold
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