LAUDES Study: impact of digital ulcers on hand functional limitation, work productivity and daily activities, in systemic sclerosis patients
Por:
Castellvi, I, Eguiluz, S, Escudero-Contreras, A, Rios, JJ, Calvo-Alen, J, Callejas-Rubio, JL, De la Puente, C, Simeon, CP, Narvaez, FJ, Espinosa, G, Carreira, PE, Rubio-Rivas, M, Alegre, JJ, Roman-Ivorra, JA, Fonollosa, V, de la Iglesia, BA, Ajo, JB, Perdomo, DB, Catalan, EB, Otano, JB, Rodriguez, JSB, Freire, MC, Alutiz, C, Montes, IC, Lecumberri, MC, Monsalvo, RD, Alvarez, ED, Dubuc, CAE, Arberas, MVE, Mateo, PF, Dapena, FDF, Gonzalez, MF, Aparicio, AG, Hernandez, FJG, de Salazar, JG, Nieto, JAG, Gil, JG, Guillen-Del-Castillo, A, Hidalgo, JI, Mas, TJ, Pineiro, MCL, Longo, FJL, Nunez, LML, Ballve, AM, Fernandez-Cid, CM, Miguelez, R, Rodriguez, MAM, Morales, JM, Morla, RM, Bruno, SO, Marques, AO, Laraundogoitia, EO, Ortego, N, Santamaria, VO, Conesa, MPP, Sandoval, TP, Simon, AP, Lozano, BR, Cid, AR, Comet, LS, Osorio, JS, Lopez, AS, Soler, GS, Guevara, MS, Parra, JAT, Ramos, CT, Beltran, JT, Montanez, JMU, Rabaneda, EV
Publicada:
1 nov 2019
Resumen:
The objective of this study was to evaluate the impact of digital ulcers (DUs) in daily life of systemic sclerosis (SSc) Spanish patients. We developed a multicenter observational study to compare functional disability in SSc patients with active DUs vs. those without DUs. An additional correlation between perception of patients and physicians on disability due to DUs was performed. A total of 199 patients were enrolled, 70 (35%) with DUs. Patients with DUs were younger (48 vs. 58 years; p < 0.001) and had more frequently the diffuse subtype of SSc (45 vs. 24%; p = 0.004) than patients without DUs. Patients with DUs showed significantly higher scores in the Cochin Hand Function Scale overall (p < 0.002) and for each of its five dimensions. They also showed higher scores in the Systemic Sclerosis Health Assessment Questionnaire items related to hand function such as, dress and self-care (p < 0.013), eat (p < 0.013) and grip (p < 0.03), and higher Visual Analogic Scale scores for pain (p < 0.013), trouble related with Raynaud's Phenomenon (p < 0.001) and sense of severity (p < 0.004). Impact on daily activities was significantly higher in patients with DUs (p = 0.002), with a non-significant trend to experience higher impact on work productivity (p = 0.07). A high correlation was found between DUs patients and physicians opinion on the impact of DUs (daily life: Pearson R = 0.86; work productivity: Pearson R = 0.87). Study findings show an impaired hand function and increased disability for daily life activities and work productivity in SSc patients with DUs compared with patients without DUs in Spanish population.
Filiaciones:
Castellvi, I:
Hosp Santa Creu & Sant Pau, Unitat Reumatol, Carrer St Quinti 89, Barcelona 08026, Spain
Eguiluz, S:
Hosp Univ Cruces, Serv Med Interna, Baracaldo, Spain
Escudero-Contreras, A:
Hosp Univ Reina Sofia, Unidad Gest Clin Reumatol, Cordoba, Spain
Calvo-Alen, J:
Hosp Univ Araba, Serv Reumatol, Vitoria, Spain
Callejas-Rubio, JL:
Hosp Univ San Cecilio, Unidad Enfermedades Autoinmunes Sistem, Granada, Spain
De la Puente, C:
Hosp Univ Ramon Cajal, Serv Reumatol, Madrid, Spain
Simeon, CP:
Hosp Univ Vall Hebron, Unitat Malalties Autoimmunes Sistem, Serv Med Interna, Barcelona, Spain
Narvaez, FJ:
Hosp Univ Bellvitge, Serv Reumatol, Barcelona, Spain
Espinosa, G:
Hosp Clin Barcelona, Serv Med Interna, Barcelona, Spain
Carreira, PE:
Hosp Univ 12 Octubre, Serv Reumatol, Madrid, Spain
Rubio-Rivas, M:
Hosp Univ Bellvitge, Serv Med Interna, Unitat Malalties Autoimmunes, Barcelona, Spain
Alegre, JJ:
Hosp Univ Dr Peset, Serv Reumatol, Valencia, Spain
Roman-Ivorra, JA:
Univ Catolica Valencia, Serv Reumatol, Hosp Univ & Politecn Fe, Valencia, Spain
Hosp Univ La Paz, Serv Med Interna, Madrid, Spain.
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