Moving beyond neurons: the role of cell type-specific gene regulation in Parkinson's disease heritability
Por:
Reynolds, RH, Botia, J, Nalls, MA, Hardy, J, Taliun, SAG, Ryten, M, Noyce, AJ, Nicolas, A, Cookson, MR, Bandres-Ciga, S, Gibbs, JR, Hernandez, DG, Singleton, AB, Reed, X, Leonard, H, Blauwendraat, C, Faghri, F, Bras, J, Guerreiro, R, Tucci, A, Kia, DA, Houlden, H, Plun-Favreau, H, Mok, KY, Wood, NW, Lovering, R, R'Bibo, L, Rizig, M, Chelban, V, Trabzuni, D, Tan, M, Morris, HR, Middlehurst, B, Quinn, J, Billingsley, K, Holmans, P, Kinghorn, KJ, Lewis, P, Escott-Price, V, Williams, N, Foltynie, T, Brice, A, Danjou, F, Lesage, S, Corvol, JC, Martinez, M, Giri, A, Schulte, C, Brockmann, K, Simon-Sanchez, J, Heutink, P, Gasser, T, Rizzu, P, Sharma, M, Shulman, JM, Robak, L, Lubbe, S, Mencacci, NE, Finkbeiner, S, Lungu, C, Scholz, SW, Gan-Or, Z, Rouleau, GA, Krohan, L, van Hilten, JJ, Marinus, J, Adarmes-Gomez, AD, Bernal-Bernal, I, Bonilla-Toribio, M, Buiza-Rueda, D, Carrillo, F, Carrion-Claro, M, Mir, P, Gomez-Garre, P, Jesus, S, Labrador-Espinosa, MA, Macias, D, Vargas-Gonzalez, L, Mendez-del-Barrio, C, Perinan-Tocino, T, Tejera-Parrado, C, Diez-Fairen, M, Aguilar, M, Alvarez, I, Boungiorno, MT, Carcel, M, Pastor, P, Tartari, JP, Alvarez, V, Gonzalez, MM, Blazquez, M, Garcia, C, Suarez-Sanmartin, E, Barrero, FJ, Rezola, EM, Yarza, JAB, Pagola, AG, Arregui, ALD, Ruiz-Martinez, J, Cerdan, D, Duarte, J, Clarimon, J, Dols-Icardo, O, Infante, J, Marin, J, Kulisevsky, J, Pagonabarraga, J, Gonzalez-Aramburu, I, Rodriguez, AS, Sierra, M, Duran, R, Ruz, C, Vives, F, Escamilla-Sevilla, F, Minguez, A, Camara, A, Compta, Y, Ezquerra, M, Marti, MJ, Fernandez, M, Munoz, E, Fernandez-Santiago, R, Tolosa, E, Valldeoriola, F, Garcia-Ruiz, P, Heredia, MJG, Errazquin, FP, Hoenicka, J, Jimenez-Escrig, A, Martinez-Castrillo, JC, Lopez-Sendon, JL, Torres, IM, Tabernero, C, Vela, L, Zimprich, A, Pihlstrom, L, Koks, S, Taba, P, Majamaa, K, Siitonen, A, Okubadejo, NU, Ojo, OO, Pitcher, T, Anderson, T, Bentley, S, Fowdar, J, Mellick, G, Dalrymple-Alford, J, Henders, AK, Kassam, I, Montgomery, G, Sidorenko, J, Zhang, FT, Xue, AL, Vallerga, CL, Wallace, L, Wray, NR, Yang, J, Visscher, PM, Gratten, J, Silburn, PA, Halliday, G, Hickie, I, Kwok, J, Lewis, S, Kennedy, M, Pearson, J
Publicada:
17 abr 2019
Resumen:
Parkinson's disease (PD), with its characteristic loss of nigrostriatal dopaminergic neurons and deposition of a-synuclein in neurons, is often considered a neuronal disorder. However, in recent years substantial evidence has emerged to implicate glial cell types, such as astrocytes and microglia. In this study, we used stratified LD score regression and expression-weighted cell-type enrichment together with several brain-related and cell-type-specific genomic annotations to connect human genomic PD findings to specific brain cell types. We found that PD heritability attributable to common variation does not enrich in global and regional brain annotations or brain-related cell-type-specific annotations. Likewise, we found no enrichment of PD susceptibility genes in brain-related cell types. In contrast, we demonstrated a significant enrichment of PD heritability in a curated lysosomal gene set highly expressed in astrocytic, microglial, and oligodendrocyte subtypes, and in LoF-intolerant genes, which were found highly expressed in almost all tested cellular subtypes. Our results suggest that PD risk loci do not lie in specific cell types or individual brain regions, but rather in global cellular processes detectable across several cell types.
Filiaciones:
Reynolds, RH:
UCL, Dept Neurodegenerat Dis, Inst Neurol, London, England
Botia, J:
UCL, Dept Neurodegenerat Dis, Inst Neurol, London, England
Univ Murcia, Dept Ingn Informat & Comunicac, Murcia, Spain
Nalls, MA:
NIH, Lab Neurogenet, US Natl Inst Hlth, Bldg 10, Bethesda, MD 20892 USA
Data Tecn Int, Glen Echo, MD USA
Hardy, J:
UCL, Dept Neurodegenerat Dis, Inst Neurol, London, England
UCL, UK Dementia Res Inst, London, England
Taliun, SAG:
Univ Michigan, Ctr Stat Genet, Ann Arbor, MI 48109 USA
Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA
Ryten, M:
UCL, Dept Neurodegenerat Dis, Inst Neurol, London, England
Noyce, AJ:
UCL, Dept Neurodegenerat Dis, Inst Neurol, London, England
QMUL, Wolfson Inst Prevent Med, Prevent Neurol Unit, London, England
Nicolas, A:
NIH, Lab Neurogenet, US Natl Inst Hlth, Bldg 10, Bethesda, MD 20892 USA
Cookson, MR:
NIH, Lab Neurogenet, US Natl Inst Hlth, Bldg 10, Bethesda, MD 20892 USA
Bandres-Ciga, S:
NIH, Lab Neurogenet, US Natl Inst Hlth, Bldg 10, Bethesda, MD 20892 USA
Gibbs, JR:
NIH, Lab Neurogenet, US Natl Inst Hlth, Bldg 10, Bethesda, MD 20892 USA
Hernandez, DG:
NIH, Lab Neurogenet, US Natl Inst Hlth, Bldg 10, Bethesda, MD 20892 USA
Singleton, AB:
NIH, Lab Neurogenet, US Natl Inst Hlth, Bldg 10, Bethesda, MD 20892 USA
Reed, X:
NIH, Lab Neurogenet, US Natl Inst Hlth, Bldg 10, Bethesda, MD 20892 USA
Leonard, H:
NIH, Lab Neurogenet, US Natl Inst Hlth, Bldg 10, Bethesda, MD 20892 USA
Blauwendraat, C:
NIH, Lab Neurogenet, US Natl Inst Hlth, Bldg 10, Bethesda, MD 20892 USA
NINDS, Bldg 36,Rm 4D04, Bethesda, MD 20892 USA
Faghri, F:
NIH, Lab Neurogenet, US Natl Inst Hlth, Bldg 10, Bethesda, MD 20892 USA
Univ Illinois, Dept Comp Sci, Urbana, IL USA
Bras, J:
UCL, UK Dementia Res Inst, London, England
UCL, Dept Mol Neurosci, London, England
Guerreiro, R:
UCL, UK Dementia Res Inst, London, England
UCL, Dept Mol Neurosci, London, England
Tucci, A:
UCL, Dept Mol Neurosci, London, England
Kia, DA:
UCL, Dept Mol Neurosci, London, England
Houlden, H:
UCL, Dept Mol Neurosci, London, England
Plun-Favreau, H:
UCL, Dept Mol Neurosci, London, England
Mok, KY:
UCL, Dept Mol Neurosci, London, England
Wood, NW:
UCL, Dept Mol Neurosci, London, England
Lovering, R:
UCL, Dept Mol Neurosci, London, England
R'Bibo, L:
UCL, Dept Mol Neurosci, London, England
Rizig, M:
UCL, Dept Mol Neurosci, London, England
Chelban, V:
UCL, Dept Mol Neurosci, London, England
Trabzuni, D:
UCL, Dept Mol Neurosci, London, England
King Faisal Specialist Hosp & Res Ctr, Dept Genet, Riyadh 1121, Saudi Arabia
Tan, M:
UCL, Dept Clin Neurosci, London, England
Morris, HR:
UCL, Dept Clin Neurosci, London, England
Middlehurst, B:
Univ Liverpool, Inst Translat Med, Liverpool, Merseyside, England
Quinn, J:
Univ Liverpool, Inst Translat Med, Liverpool, Merseyside, England
Billingsley, K:
Univ Liverpool, Inst Translat Med, Liverpool, Merseyside, England
Holmans, P:
MRC Ctr Neuropsychiat Genet & Genom, Inst Psychol Med & Clin Neurosci, Biostat & Bioinformat Unit, Cardiff, S Glam, Wales
Kinghorn, KJ:
UCL, Inst Hlth Ageing, London, England
Lewis, P:
Univ Reading, Reading, Berks, England
Escott-Price, V:
Cardiff Univ, Sch Med, MRC Ctr Neuropsychiat Genet & Genom, Cardiff, S Glam, Wales
Williams, N:
Cardiff Univ, Sch Med, MRC Ctr Neuropsychiat Genet & Genom, Cardiff, S Glam, Wales
Foltynie, T:
UCL Inst Neurol, London, England
Brice, A:
UPMC Univ Paris 06, Sorbonne Univ, AP HP,ICM,Inserm U 1127,CNRS,UMR 7225, Pitie Salpetriere Hosp,Inst Cerveau & Moelle Epin, Paris, France
Danjou, F:
UPMC Univ Paris 06, Sorbonne Univ, AP HP,ICM,Inserm U 1127,CNRS,UMR 7225, Pitie Salpetriere Hosp,Inst Cerveau & Moelle Epin, Paris, France
Lesage, S:
UPMC Univ Paris 06, Sorbonne Univ, AP HP,ICM,Inserm U 1127,CNRS,UMR 7225, Pitie Salpetriere Hosp,Inst Cerveau & Moelle Epin, Paris, France
Corvol, JC:
UPMC Univ Paris 06, Sorbonne Univ, AP HP,ICM,Inserm U 1127,CNRS,UMR 7225, Pitie Salpetriere Hosp,Inst Cerveau & Moelle Epin, Paris, France
Martinez, M:
UPMC Univ Paris 06, Sorbonne Univ, AP HP,ICM,Inserm U 1127,CNRS,UMR 7225, Pitie Salpetriere Hosp,Inst Cerveau & Moelle Epin, Paris, France
Paul Sabatier Univ, Toulouse, France
Giri, A:
Univ Tubingen, Hertie Inst Clin Brain Res, Dept Neurodegenerat Dis, Tubingen, Germany
German Ctr Neurodegenerat Dis, DZNE, Tubingen, Germany
Schulte, C:
Univ Tubingen, Hertie Inst Clin Brain Res, Dept Neurodegenerat Dis, Tubingen, Germany
German Ctr Neurodegenerat Dis, DZNE, Tubingen, Germany
Brockmann, K:
Univ Tubingen, Hertie Inst Clin Brain Res, Dept Neurodegenerat Dis, Tubingen, Germany
German Ctr Neurodegenerat Dis, DZNE, Tubingen, Germany
Simon-Sanchez, J:
Univ Tubingen, Hertie Inst Clin Brain Res, Dept Neurodegenerat Dis, Tubingen, Germany
German Ctr Neurodegenerat Dis, DZNE, Tubingen, Germany
Heutink, P:
Univ Tubingen, Hertie Inst Clin Brain Res, Dept Neurodegenerat Dis, Tubingen, Germany
German Ctr Neurodegenerat Dis, DZNE, Tubingen, Germany
Gasser, T:
Univ Tubingen, Hertie Inst Clin Brain Res, Dept Neurodegenerat Dis, Tubingen, Germany
German Ctr Neurodegenerat Dis, DZNE, Tubingen, Germany
Rizzu, P:
German Ctr Neurodegenerat Dis, DZNE, Tubingen, Germany
Sharma, M:
Univ Tubingen, Inst Clin Epidemiol & Appl Biometry, Ctr Genet Epidemiol, Tubingen, Germany
Shulman, JM:
Baylor Coll Med, Dept Neurol, Houston, TX 77030 USA
Baylor Coll Med, Dept Neurosci, Houston, TX 77030 USA
Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA
Texas Childrens Hosp, Jan & Dan Duncan Neurol Res Inst, Houston, TX 77030 USA
Robak, L:
Baylor Coll Med, Dept Neurol, Houston, TX 77030 USA
Baylor Coll Med, Dept Neurosci, Houston, TX 77030 USA
Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA
Lubbe, S:
Northwestern Univ, Ken & Ruth Davee Dept Neurol, Feinberg Sch Med, Chicago, IL 60611 USA
Mencacci, NE:
Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA
Finkbeiner, S:
Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA
Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94143 USA
Taube Koret Ctr Neurodegenerat Dis Res, Gladstone Inst Neurol Dis, San Francisco, CA USA
Lungu, C:
NINDS, NIH, Div Clin Res, Bldg 36,Rm 4D04, Bethesda, MD 20892 USA
Scholz, SW:
NINDS, Neurodegenerat Dis Res Unit, Bldg 36,Rm 4D04, Bethesda, MD 20892 USA
Gan-Or, Z:
McGill Univ, Dept Human Genet, Montreal Neurol Inst & Hosp, Dept Neurol, Montreal, PQ H3A 0G4, Canada
McGill Univ, Dept Human Genet, Montreal Neurol Inst & Hosp, Dept Neurosurg, Montreal, PQ H3A 0G4, Canada
Rouleau, GA:
McGill Univ, Dept Human Genet, Montreal Neurol Inst & Hosp, Dept Neurol, Montreal, PQ H3A 0G4, Canada
McGill Univ, Dept Human Genet, Montreal Neurol Inst & Hosp, Dept Neurosurg, Montreal, PQ H3A 0G4, Canada
Krohan, L:
McGill Univ, Dept Human Genet, Montreal, PQ H3A 0G4, Canada
van Hilten, JJ:
Leiden Univ, Dept Neurol, Med Ctr, Leiden, Netherlands
Marinus, J:
Leiden Univ, Dept Neurol, Med Ctr, Leiden, Netherlands
Adarmes-Gomez, AD:
Univ Seville, CSIC, Hosp Univ Virgen Rocio, Inst Biomed Sevilla IBiS, Seville, Spain
Bernal-Bernal, I:
Univ Seville, CSIC, Hosp Univ Virgen Rocio, Inst Biomed Sevilla IBiS, Seville, Spain
Bonilla-Toribio, M:
Univ Seville, CSIC, Hosp Univ Virgen Rocio, Inst Biomed Sevilla IBiS, Seville, Spain
Buiza-Rueda, D:
Univ Seville, CSIC, Hosp Univ Virgen Rocio, Inst Biomed Sevilla IBiS, Seville, Spain
Carrillo, F:
Univ Seville, CSIC, Hosp Univ Virgen Rocio, Inst Biomed Sevilla IBiS, Seville, Spain
Carrion-Claro, M:
Univ Seville, CSIC, Hosp Univ Virgen Rocio, Inst Biomed Sevilla IBiS, Seville, Spain
Mir, P:
Univ Seville, CSIC, Hosp Univ Virgen Rocio, Inst Biomed Sevilla IBiS, Seville, Spain
Gomez-Garre, P:
Univ Seville, CSIC, Hosp Univ Virgen Rocio, Inst Biomed Sevilla IBiS, Seville, Spain
Jesus, S:
Univ Seville, CSIC, Hosp Univ Virgen Rocio, Inst Biomed Sevilla IBiS, Seville, Spain
Labrador-Espinosa, MA:
Univ Seville, CSIC, Hosp Univ Virgen Rocio, Inst Biomed Sevilla IBiS, Seville, Spain
Macias, D:
Univ Seville, CSIC, Hosp Univ Virgen Rocio, Inst Biomed Sevilla IBiS, Seville, Spain
Vargas-Gonzalez, L:
Univ Seville, CSIC, Hosp Univ Virgen Rocio, Inst Biomed Sevilla IBiS, Seville, Spain
Mendez-del-Barrio, C:
Univ Seville, CSIC, Hosp Univ Virgen Rocio, Inst Biomed Sevilla IBiS, Seville, Spain
Perinan-Tocino, T:
Univ Seville, CSIC, Hosp Univ Virgen Rocio, Inst Biomed Sevilla IBiS, Seville, Spain
Tejera-Parrado, C:
Univ Seville, CSIC, Hosp Univ Virgen Rocio, Inst Biomed Sevilla IBiS, Seville, Spain
Diez-Fairen, M:
Univ Hosp Mutua Terrassa, Dept Neurol, Fundacio Docencia & Recerca Mutua Terrassa, Barcelona, Spain
Univ Hosp Mutua Terrassa, Dept Neurol, Movement Disorders Unit, Barcelona, Spain
Aguilar, M:
Univ Hosp Mutua Terrassa, Dept Neurol, Fundacio Docencia & Recerca Mutua Terrassa, Barcelona, Spain
Univ Hosp Mutua Terrassa, Dept Neurol, Movement Disorders Unit, Barcelona, Spain
Alvarez, I:
Univ Hosp Mutua Terrassa, Dept Neurol, Fundacio Docencia & Recerca Mutua Terrassa, Barcelona, Spain
Univ Hosp Mutua Terrassa, Dept Neurol, Movement Disorders Unit, Barcelona, Spain
Boungiorno, MT:
Univ Hosp Mutua Terrassa, Dept Neurol, Fundacio Docencia & Recerca Mutua Terrassa, Barcelona, Spain
Univ Hosp Mutua Terrassa, Dept Neurol, Movement Disorders Unit, Barcelona, Spain
Carcel, M:
Univ Hosp Mutua Terrassa, Dept Neurol, Fundacio Docencia & Recerca Mutua Terrassa, Barcelona, Spain
Univ Hosp Mutua Terrassa, Dept Neurol, Movement Disorders Unit, Barcelona, Spain
Pastor, P:
Univ Hosp Mutua Terrassa, Dept Neurol, Fundacio Docencia & Recerca Mutua Terrassa, Barcelona, Spain
Univ Hosp Mutua Terrassa, Dept Neurol, Movement Disorders Unit, Barcelona, Spain
Tartari, JP:
Univ Hosp Mutua Terrassa, Dept Neurol, Fundacio Docencia & Recerca Mutua Terrassa, Barcelona, Spain
Univ Hosp Mutua Terrassa, Dept Neurol, Movement Disorders Unit, Barcelona, Spain
Alvarez, V:
Hosp Univ Cent Asturias, Oviedo, Spain
Gonzalez, MM:
Hosp Univ Cent Asturias, Oviedo, Spain
Blazquez, M:
Hosp Univ Cent Asturias, Oviedo, Spain
Garcia, C:
Hosp Univ Cent Asturias, Oviedo, Spain
Suarez-Sanmartin, E:
Hosp Univ Cent Asturias, Oviedo, Spain
Barrero, FJ:
Hosp Univ Parque Tecnol Salud, Granada, Spain
Rezola, EM:
Inst Invest Sanitaria Biodonostia, San Sebastian, Spain
Yarza, JAB:
Inst Invest Sanitaria Biodonostia, San Sebastian, Spain
Pagola, AG:
Inst Invest Sanitaria Biodonostia, San Sebastian, Spain
Arregui, ALD:
Inst Invest Sanitaria Biodonostia, San Sebastian, Spain
Ruiz-Martinez, J:
Inst Invest Sanitaria Biodonostia, San Sebastian, Spain
Cerdan, D:
Hosp Gen Segovia, Segovia, Spain
Duarte, J:
Hosp Gen Segovia, Segovia, Spain
Clarimon, J:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, IIB St Pau, Memory Unit,Dept Neurol, Barcelona, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Dols-Icardo, O:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, IIB St Pau, Memory Unit,Dept Neurol, Barcelona, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Infante, J:
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Hosp Univ Marques Valdecilla, IDIVAL, Santander, Spain
Univ Cantabria, Santander, Spain
Marin, J:
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, IIB St Pau, Movement Disorders Unit,Dept Neurol, Barcelona, Spain
Kulisevsky, J:
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, IIB St Pau, Movement Disorders Unit,Dept Neurol, Barcelona, Spain
Pagonabarraga, J:
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, IIB St Pau, Movement Disorders Unit,Dept Neurol, Barcelona, Spain
Gonzalez-Aramburu, I:
Hosp Univ Marques Valdecilla, IDIVAL, Santander, Spain
Rodriguez, AS:
Hosp Univ Marques Valdecilla, IDIVAL, Santander, Spain
Sierra, M:
Hosp Univ Marques Valdecilla, IDIVAL, Santander, Spain
Duran, R:
Univ Granada, Ctr Invest Biomed, Granada, Spain
Ruz, C:
Univ Granada, Ctr Invest Biomed, Granada, Spain
Vives, F:
Univ Granada, Ctr Invest Biomed, Granada, Spain
Escamilla-Sevilla, F:
Hosp Univ Virgen Nieves, Inst Invest Biosanitaria Granada, Granada, Spain
Minguez, A:
Hosp Univ Virgen Nieves, Inst Invest Biosanitaria Granada, Granada, Spain
Camara, A:
Hosp Clin Barcelona, Barcelona, Spain
Compta, Y:
Hosp Clin Barcelona, Barcelona, Spain
Ezquerra, M:
Hosp Clin Barcelona, Barcelona, Spain
Marti, MJ:
Hosp Clin Barcelona, Barcelona, Spain
Fernandez, M:
Hosp Clin Barcelona, Barcelona, Spain
Munoz, E:
Hosp Clin Barcelona, Barcelona, Spain
Fernandez-Santiago, R:
Hosp Clin Barcelona, Barcelona, Spain
Tolosa, E:
Hosp Clin Barcelona, Barcelona, Spain
Valldeoriola, F:
Hosp Clin Barcelona, Barcelona, Spain
Garcia-Ruiz, P:
Inst Invest Sanitaria Fdn Jimenez Diaz, Madrid, Spain
Heredia, MJG:
Hosp Univ Virgen Victoria, Malaga, Spain
Errazquin, FP:
Hosp Univ Virgen Victoria, Malaga, Spain
Hoenicka, J:
Inst Recerca St Joan Deu, Barcelona, Spain
Jimenez-Escrig, A:
Hosp Univ Ramon & Cajal, Madrid, Spain
Martinez-Castrillo, JC:
Hosp Univ Ramon & Cajal, Madrid, Spain
Lopez-Sendon, JL:
Hosp Univ Ramon & Cajal, Madrid, Spain
Torres, IM:
Hosp Univ & Politecn La Fe, Inst Invest Sanitaria La Fe, Dept Neurol, Valencia, Spain
Tabernero, C:
Hosp Gen Segovia, Segovia, Spain
Vela, L:
Hosp Univ Fdn Alcorcon, Dept Neurol, Madrid, Spain
Zimprich, A:
Med Univ Vienna, Dept Neurol, Vienna, Austria
Pihlstrom, L:
Oslo Univ Hosp, Dept Neurol, Oslo, Norway
Koks, S:
Univ Tartu, Dept Pathophysiol, Tartu, Estonia
Estonian Univ Life Sci, Dept Reprod Biol, Tartu, Estonia
Perron Inst Neurol & Translat Sci, Perth, WA, Australia
Taba, P:
Univ Tartu, Dept Neurol, Tartu, Estonia
Univ Tartu, Dept Neurosurg, Tartu, Estonia
Majamaa, K:
Univ Oulu, Dept Neurol, Inst Clin Med, Oulu, Finland
Oulu Univ Hosp, Dept Neurol, Oulu, Finland
Oulu Univ Hosp, Med Res Ctr, Oulu, Finland
Siitonen, A:
Univ Oulu, Dept Neurol, Inst Clin Med, Oulu, Finland
Oulu Univ Hosp, Dept Neurol, Oulu, Finland
Oulu Univ Hosp, Med Res Ctr, Oulu, Finland
Okubadejo, NU:
Univ Lagos, Lagos, Lagos State, Nigeria
Ojo, OO:
Univ Lagos, Lagos, Lagos State, Nigeria
Pitcher, T:
New Zealand Brain Res Inst, Christchurch, New Zealand
Univ Otago, Dept Med, Christchurch, New Zealand
Anderson, T:
New Zealand Brain Res Inst, Christchurch, New Zealand
Univ Otago, Dept Med, Christchurch, New Zealand
Bentley, S:
Griffith Univ, Griffith Inst Drug Discovery, Brisbane, Qld, Australia
Fowdar, J:
Griffith Univ, Griffith Inst Drug Discovery, Brisbane, Qld, Australia
Mellick, G:
Griffith Univ, Griffith Inst Drug Discovery, Brisbane, Qld, Australia
Dalrymple-Alford, J:
Univ Canterbury, New Zealand Brain Res Inst, Dept Psychol, Christchurch, New Zealand
Henders, AK:
Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia
Kassam, I:
Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia
Montgomery, G:
Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia
Sidorenko, J:
Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia
Zhang, FT:
Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia
Xue, AL:
Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia
Vallerga, CL:
Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia
Wallace, L:
Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia
Wray, NR:
Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia
Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia
Yang, J:
Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia
Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia
Visscher, PM:
Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia
Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia
Gratten, J:
Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia
Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia
Silburn, PA:
Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia
Halliday, G:
Univ Sydney, Sydney Med Sch, Brain & Mind Ctr, Sydney, NSW, Australia
Hickie, I:
Univ Sydney, Sydney Med Sch, Brain & Mind Ctr, Sydney, NSW, Australia
Kwok, J:
Univ Sydney, Sydney Med Sch, Brain & Mind Ctr, Sydney, NSW, Australia
Lewis, S:
Univ Sydney, Sydney Med Sch, Brain & Mind Ctr, Sydney, NSW, Australia
Kennedy, M:
Univ Otago, Dept Pathol, Christchurch, New Zealand
Pearson, J:
Univ Otago, Dept Pathol, Christchurch, New Zealand
Gold, Green Published
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