Different pattern of CSF glial markers between dementia with Lewy bodies and Alzheimer's disease
Por:
Morenas-Rodriguez, E, Alcolea, D, Suarez-Calvet, M, Munoz-Llahuna, L, Vilaplana, E, Sala, I, Subirana, A, Querol-Vilaseca, M, Carmona-Iragui, M, Illan-Gala, I, Ribosa-Nogue, R, Blesa, R, Haass, C, Fortea, J, Lleo, A
Publicada:
24 may 2019
Resumen:
The role of innate immunity in dementia with Lewy bodies (DLB) has been little studied. We investigated the levels in cerebrospinal fluid (CSF) of glial proteinsYKL-40, soluble TREM2 (sTREM2) and progranulin in DLB and their relationship with Alzheimer's disease (AD) biomarkers. We included patients with DLB (n = 37), prodromal DLB (prodDLB, n= 23), AD dementia (n = 50), prodromal AD (prodAD, n= 53), and cognitively normal subjects (CN, n= 44).We measured levels ofYKL-40, sTREM2, progranulin, A beta(1-42), total tau (t-tau) and phosphorylated tau (p-tau) in CSF. We stratified the group DLB according to the ratio t-tau/A beta(1-42 ) (>= 0.52, indicative of AD pathology) and the A/T classification. YKL-40, sTREM2 and progranulin levels did not differ between DLB groups and CN.YKL-40 levels were higher in AD and prodAD compared to CN and to DLB and prodDLB. Patients with DLB with a CSF profile suggestive of AD copathology had higher levels of YKL-40, but not sTREM2 or PGRN, than those without. T+ DLB patients had also higherYKL-40 levels than T-. Of these glial markers, onlyYKL-40 correlated with t-tau and p-tau in DLB and in prodDLB. In contrast, in prodAD, sTREM2 and PGRN also correlated with t-tau and p-tau. In conclusion, sTREM2 and PGRN are not increased in the CSF of DLB patients. YKL-40 is only increased in DLB patients with an AD biomarker profile, suggesting that the increase is driven by AD-related neurodegeneration. These data suggest a differential glial activation between DLB and AD.
Filiaciones:
Morenas-Rodriguez, E:
Hosp Santa Creu & Sant Pau, Neurol Dept, Memory Unit, Barcelona, Spain
Univ Autonoma Barcelona, Inst Invest Biomed St Pau, Barcelona, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Neurodegenerat, CIBERNED, Barcelona, Spain
Alcolea, D:
Hosp Santa Creu & Sant Pau, Neurol Dept, Memory Unit, Barcelona, Spain
Univ Autonoma Barcelona, Inst Invest Biomed St Pau, Barcelona, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Neurodegenerat, CIBERNED, Barcelona, Spain
Suarez-Calvet, M:
Ludwig Maximilians Univ Munchen, Chair Metab Biochem, Biomed Ctr BMC, Fac Med, Munich, Germany
German Ctr Neurodegenerat Dis DZNE Munich, Munich, Germany
Munoz-Llahuna, L:
Hosp Santa Creu & Sant Pau, Neurol Dept, Memory Unit, Barcelona, Spain
Univ Autonoma Barcelona, Inst Invest Biomed St Pau, Barcelona, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Neurodegenerat, CIBERNED, Barcelona, Spain
Vilaplana, E:
Hosp Santa Creu & Sant Pau, Neurol Dept, Memory Unit, Barcelona, Spain
Univ Autonoma Barcelona, Inst Invest Biomed St Pau, Barcelona, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Neurodegenerat, CIBERNED, Barcelona, Spain
Sala, I:
Hosp Santa Creu & Sant Pau, Neurol Dept, Memory Unit, Barcelona, Spain
Univ Autonoma Barcelona, Inst Invest Biomed St Pau, Barcelona, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Neurodegenerat, CIBERNED, Barcelona, Spain
Subirana, A:
Hosp Santa Creu & Sant Pau, Neurol Dept, Memory Unit, Barcelona, Spain
Univ Autonoma Barcelona, Inst Invest Biomed St Pau, Barcelona, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Neurodegenerat, CIBERNED, Barcelona, Spain
Querol-Vilaseca, M:
Hosp Santa Creu & Sant Pau, Neurol Dept, Memory Unit, Barcelona, Spain
Univ Autonoma Barcelona, Inst Invest Biomed St Pau, Barcelona, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Neurodegenerat, CIBERNED, Barcelona, Spain
Carmona-Iragui, M:
Hosp Santa Creu & Sant Pau, Neurol Dept, Memory Unit, Barcelona, Spain
Univ Autonoma Barcelona, Inst Invest Biomed St Pau, Barcelona, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Neurodegenerat, CIBERNED, Barcelona, Spain
Illan-Gala, I:
Hosp Santa Creu & Sant Pau, Neurol Dept, Memory Unit, Barcelona, Spain
Univ Autonoma Barcelona, Inst Invest Biomed St Pau, Barcelona, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Neurodegenerat, CIBERNED, Barcelona, Spain
Ribosa-Nogue, R:
Hosp Santa Creu & Sant Pau, Neurol Dept, Memory Unit, Barcelona, Spain
Univ Autonoma Barcelona, Inst Invest Biomed St Pau, Barcelona, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Neurodegenerat, CIBERNED, Barcelona, Spain
Blesa, R:
Hosp Santa Creu & Sant Pau, Neurol Dept, Memory Unit, Barcelona, Spain
Univ Autonoma Barcelona, Inst Invest Biomed St Pau, Barcelona, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Neurodegenerat, CIBERNED, Barcelona, Spain
Haass, C:
Ludwig Maximilians Univ Munchen, Chair Metab Biochem, Biomed Ctr BMC, Fac Med, Munich, Germany
German Ctr Neurodegenerat Dis DZNE Munich, Munich, Germany
Munich Cluster Syst Neurol SyNergy, Munich, Germany
Fortea, J:
Hosp Santa Creu & Sant Pau, Neurol Dept, Memory Unit, Barcelona, Spain
Univ Autonoma Barcelona, Inst Invest Biomed St Pau, Barcelona, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Neurodegenerat, CIBERNED, Barcelona, Spain
Lleo, A:
Hosp Santa Creu & Sant Pau, Neurol Dept, Memory Unit, Barcelona, Spain
Univ Autonoma Barcelona, Inst Invest Biomed St Pau, Barcelona, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Neurodegenerat, CIBERNED, Barcelona, Spain
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