Genetic variation across RNA metabolism and cell death gene networks is implicated in the semantic variant of primary progressive aphasia
Por:
Bonham, LW, Steele, NZR, Karch, CM, Broce, I, Geier, EG, Wen, NL, Momeni, P, Hardy, J, Miller, ZA, Gorno-Tempini, ML, Hess, CP, Lewis, P, Miller, BL, Seeley, WW, Manzoni, C, Desikan, RS, Baranzini, SE, Ferraris, R, Yokoyama, JS, Hernandez, DG, Nalls, MA, Rohrer, JD, Ramasamy, A, Kwok, JBJ, Dobson-Stone, C, Schofield, PR, Halliday, GM, Hodges, JR, Piguet, O, Bartley, L, Thompson, E, Haan, E, Hernandez, I, Ruiz, A, Boada, M, Borroni, B, Padovani, A, Cruchaga, C, Cairns, NJ, Benussi, L, Binetti, G, Ghidoni, R, Forloni, G, Albani, D, Galimberti, D, Fenoglio, C, Serpente, M, Scarpini, E, Clarimon, J, Lleo, A, Blesa, R, Waldo, ML, Nilsson, K, Nilsson, C, Mackenzie, IRA, Hsiung, GYR, Mann, DMA, Grafman, J, Morris, CM, Attems, J, Griffiths, TD, McKeith, IG, Thomas, AJ, Pietrini, P, Huey, ED, Wassermann, EM, Baborie, A, Jaros, E, Tierney, MC, Pastor, P, Razquin, C, Ortega-Cubero, S, Alonso, E, Perneczky, R, Diehl-Schmid, J, Alexopoulos, P, Kurz, A, Rainero, I, Rubino, E, Pinessi, L, Rogaeva, E, St George-Hyslop, P, Rossi, G, Tagliavini, F, Giaccone, G, Rowe, JB, Schlachetzki, JCM, Uphill, J, Collinge, J, Mead, S, Danek, A, Van Deerlin, VM, Grossman, M, Trojanowski, JQ, van der Zee, J, Cruts, M, Van Broeckhoven, C, Cappa, SF, Leber, I, Hannequin, D, Golfier, V, Vercelletto, M, Brice, A, Nacmias, B, Sorbin, S, Bagnoli, S, Piaceri, I, Nielsen, JE, Hjermind, LE, Riemenschneider, M, Mayhaus, M, Ibach, B, Gasparoni, G, Pichler, S, Gu, W, Rossor, MN, Fox, NC, Warren, JD, Spillantini, MG, Morriss, HR, Rizzu, P, Heutink, P, Snowden, JS, Rollinson, S, Richardson, A, Gerhard, A, Bruni, AC, Maletta, R, Frangipane, F, Cupidi, C, Bernardi, L, Anfossi, M, Gallo, M, Conidi, ME, Smirne, N, Rademakers, R, Baker, M, Dickson, DW, Graff-Radford, NR, Petersen, RC, Knopman, D, Josephs, KA, Boeve, BF, Parisi, JE, Karydas, AM, Rosen, H, van Swieten, JC, Dopper, EGP, Seelaar, H, Pijnenburg, YAL, Scheltens, P, Logroscino, G, Capozzo, R, Novelli, V, Puca, AA, Franceschi, M, Postiglione, A, Milan, G, Sorrentino, P, Kristiansen, M, Chian, HH, Graff, C, Pasquier, F, Rollin, A, Deramecourt, V, Lebouvier, T, Kapogiannis, D, Ferrucci, L, Pickering-Brown, S, Singleton, AB
Publicada:
26 jul 2019
Resumen:
The semantic variant of primary progressive aphasia (svPPA) is a clinical syndrome characterized by neurodegeneration and progressive loss of semantic knowledge. Unlike many other forms of frontotemporal lobar degeneration (FTLD), svPPA has a highly consistent underlying pathology composed of TDP-43 (a regulator of RNA and DNA transcription metabolism). Previous genetic studies of svPPA are limited by small sample sizes and a paucity of common risk variants. Despite this, svPPA's relatively homogenous clinicopathologic phenotype makes it an ideal investigative model to examine genetic processes that may drive neurodegenerative disease. In this study, we used GWAS metadata, tissue samples from pathologically confirmed frontotemporal lobar degeneration, and in silico techniques to identify and characterize protein interaction networks associated with svPPA risk. We identified 64 svPPA risk genes that interact at the protein level. The protein pathways represented in this svPPA gene network are critical regulators of RNA metabolism and cell death, such as SMAD proteins and NOTCH1. Many of the genes in this network are involved in TDP-43 metabolism. Contrary to the conventional notion that svPPA is a clinical syndrome with few genetic risk factors, our analyses show that svPPA risk is complex and polygenic in nature. Risk for svPPA is likely driven by multiple common variants in genes interacting with TDP-43, along with cell death, x' working in combination to promote neurodegeneration.
Filiaciones:
Bonham, LW:
Univ Calif San Francisco, Memory & Aging Ctr, Dept Neurol, San Francisco, CA 94143 USA
Univ Calif San Francisco, Dept Radiol & Biomed Imaging, Neuroradiol Sect, San Francisco, CA USA
Steele, NZR:
Univ Calif San Francisco, Memory & Aging Ctr, Dept Neurol, San Francisco, CA 94143 USA
Karch, CM:
Washington Univ, Dept Psychiat, St Louis, MO USA
Broce, I:
Univ Calif San Francisco, Dept Radiol & Biomed Imaging, Neuroradiol Sect, San Francisco, CA USA
Geier, EG:
Univ Calif San Francisco, Memory & Aging Ctr, Dept Neurol, San Francisco, CA 94143 USA
Wen, NL:
Washington Univ, Dept Psychiat, St Louis, MO USA
Momeni, P:
Texas Tech Univ, Hlth Sci Ctr, Lab Neurogenet, Lubbock, TX 79430 USA
Hardy, J:
UCL Inst Neurol, Dept Mol Neurosci, London, England
Miller, ZA:
Univ Calif San Francisco, Memory & Aging Ctr, Dept Neurol, San Francisco, CA 94143 USA
Gorno-Tempini, ML:
Univ Calif San Francisco, Memory & Aging Ctr, Dept Neurol, San Francisco, CA 94143 USA
Hess, CP:
Univ Calif San Francisco, Dept Radiol & Biomed Imaging, Neuroradiol Sect, San Francisco, CA USA
Lewis, P:
UCL Inst Neurol, Dept Mol Neurosci, London, England
Univ Reading, Sch Pharm, Reading, Berks, England
Miller, BL:
Univ Calif San Francisco, Memory & Aging Ctr, Dept Neurol, San Francisco, CA 94143 USA
Seeley, WW:
Univ Calif San Francisco, Memory & Aging Ctr, Dept Neurol, San Francisco, CA 94143 USA
Manzoni, C:
UCL Inst Neurol, Dept Mol Neurosci, London, England
Univ Reading, Sch Pharm, Reading, Berks, England
Desikan, RS:
Univ Calif San Francisco, Dept Radiol & Biomed Imaging, Neuroradiol Sect, San Francisco, CA USA
Baranzini, SE:
Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA
Ferraris, R:
NIA, Lab Neurogenet, NIH, Bethesda, MD 20892 USA
Yokoyama, JS:
Univ Calif San Francisco, Memory & Aging Ctr, Dept Neurol, San Francisco, CA 94143 USA
Hernandez, DG:
NIA, Lab Neurogenet, NIH, Bethesda, MD 20892 USA
UCL Inst Neurol, Dept Mol Neurosci, Reta Lila Weston Res Labs, London, England
Nalls, MA:
NIA, Lab Neurogenet, NIH, Bethesda, MD 20892 USA
Rohrer, JD:
UCL Inst Neurol, Dept Mol Neurosci, Reta Lila Weston Res Labs, London, England
UCL Inst Neurol, Dementia Res Ctr, Dept Neurodegenerat Dis, London, England
Ramasamy, A:
UCL Inst Neurol, Dept Mol Neurosci, Reta Lila Weston Res Labs, London, England
Kings Coll London, Guys Hosp, Dept Med & Mol Genet, Tower Wing, London, England
Univ Oxford, Jenner Inst, Oxford, England
Kwok, JBJ:
Neurosci Res Australia, Sydney, NSW, Australia
Univ New South Wales, Sch Med Sci, Sydney, NSW, Australia
Dobson-Stone, C:
Neurosci Res Australia, Sydney, NSW, Australia
Univ New South Wales, Sch Med Sci, Sydney, NSW, Australia
Schofield, PR:
Neurosci Res Australia, Sydney, NSW, Australia
Univ New South Wales, Sch Med Sci, Sydney, NSW, Australia
Halliday, GM:
Neurosci Res Australia, Sydney, NSW, Australia
Univ New South Wales, Sch Med Sci, Sydney, NSW, Australia
Hodges, JR:
Neurosci Res Australia, Sydney, NSW, Australia
Univ New South Wales, Sch Med Sci, Sydney, NSW, Australia
Piguet, O:
Neurosci Res Australia, Sydney, NSW, Australia
Univ New South Wales, Sch Med Sci, Sydney, NSW, Australia
Bartley, L:
Neurosci Res Australia, Sydney, NSW, Australia
Univ New South Wales, Sch Med Sci, Sydney, NSW, Australia
Thompson, E:
Womens & Childrens Hosp, SA Pathol, South Australian Clin Genet Serv, North Adelaide, SA, Australia
Univ Adelaide, Dept Paediat, Adelaide, SA, Australia
Haan, E:
Womens & Childrens Hosp, SA Pathol, South Australian Clin Genet Serv, North Adelaide, SA, Australia
Univ Adelaide, Dept Paediat, Adelaide, SA, Australia
Hernandez, I:
Fdn ACE, Inst Catala Neurociencies Aplicades, Res Ctr & Memory Clin, Barcelona, Spain
Ruiz, A:
Fdn ACE, Inst Catala Neurociencies Aplicades, Res Ctr & Memory Clin, Barcelona, Spain
Boada, M:
Fdn ACE, Inst Catala Neurociencies Aplicades, Res Ctr & Memory Clin, Barcelona, Spain
Borroni, B:
Univ Brescia, Neurol Clin, Brescia, Italy
Padovani, A:
Univ Brescia, Neurol Clin, Brescia, Italy
Cruchaga, C:
Washington Univ, Dept Psychiat, St Louis, MO USA
Washington Univ, Sch Med, Hope Ctr, St Louis, MO USA
Cairns, NJ:
Washington Univ, Sch Med, Hope Ctr, St Louis, MO USA
Washington Univ, Dept Pathol & Immunol, St Louis, MO 63110 USA
Benussi, L:
IRCCS Ist Ctr San Giovanni di Dio Fatebenefratell, Mol Markers Lab, Brescia, Italy
Binetti, G:
IRCCS Ist Ctr San Giovanni di Dio Fatebenefratell, MAC Memory Clin, Brescia, Italy
Ghidoni, R:
IRCCS Ist Ctr San Giovanni di Dio Fatebenefratell, Mol Markers Lab, Brescia, Italy
Forloni, G:
IRCCS Ist Ric Farmacol Mario Negri, Biol Neurodegenerat Disorders, Milan, Italy
Albani, D:
IRCCS Ist Ric Farmacol Mario Negri, Biol Neurodegenerat Disorders, Milan, Italy
Galimberti, D:
Univ Milan, Milan, Italy
IRCCS Osped Maggiore Policlin, Fdn Ca Granda, Milan, Italy
Fenoglio, C:
Univ Milan, Milan, Italy
IRCCS Osped Maggiore Policlin, Fdn Ca Granda, Milan, Italy
Serpente, M:
Univ Milan, Milan, Italy
IRCCS Osped Maggiore Policlin, Fdn Ca Granda, Milan, Italy
Scarpini, E:
Univ Milan, Milan, Italy
IRCCS Osped Maggiore Policlin, Fdn Ca Granda, Milan, Italy
Clarimon, J:
Univ Autonoma Barcelona, Neurol Dept, Memory Unit, Barcelona, Spain
Univ Autonoma Barcelona, St Pau Biomed Res Inst, Barcelona, Spain
Ctr Networker Biomed Res Neurodegenerat Dis CIBER, Madrid, Spain
Lleo, A:
Univ Autonoma Barcelona, Neurol Dept, Memory Unit, Barcelona, Spain
Univ Autonoma Barcelona, St Pau Biomed Res Inst, Barcelona, Spain
Ctr Networker Biomed Res Neurodegenerat Dis CIBER, Madrid, Spain
Blesa, R:
Univ Autonoma Barcelona, Neurol Dept, Memory Unit, Barcelona, Spain
Univ Autonoma Barcelona, St Pau Biomed Res Inst, Barcelona, Spain
Ctr Networker Biomed Res Neurodegenerat Dis CIBER, Madrid, Spain
Waldo, ML:
Lund Univ, Dept Clin Sci, Unit Geriatr Psychiat, Lund, Sweden
Nilsson, K:
Lund Univ, Dept Clin Sci, Unit Geriatr Psychiat, Lund, Sweden
Nilsson, C:
Lund Univ, Dept Clin Sci, Clin Memory Res Unit, Lund, Sweden
Mackenzie, IRA:
Univ British Columbia, Dept Pathol & Lab Med, Vancouver, BC, Canada
Hsiung, GYR:
Univ British Columbia, Div Neurol, Vancouver, BC, Canada
Mann, DMA:
Univ Manchester, Salford Royal Hosp, Inst Brain Behav & Mental Hlth, Salford, Lancs, England
Grafman, J:
Rehabil Inst Chicago, Dept Phys Med & Rehabil, Chicago, IL 60611 USA
Rehabil Inst Chicago, Dept Psychiat, Chicago, IL 60611 USA
Rehabil Inst Chicago, Dept Cognit Neurol, Chicago, IL 60611 USA
Rehabil Inst Chicago, Alzheimers Dis Ctr, Chicago, IL 60611 USA
Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA
Northwestern Univ, Weinberg Coll Arts & Sci, Dept Psychol, Chicago, IL 60611 USA
Morris, CM:
Newcastle Univ, Inst Ageing, Newcastle Brain Tissue Resource, Newcastle Upon Tyne, Tyne & Wear, England
Newcastle Univ, Inst Neurosci, Campus Ageing & Vital, Newcastle Upon Tyne, Tyne & Wear, England
Newcastle Univ, Inst ForAgeing, Campus Ageing & Vital, Newcastle Upon Tyne, Tyne & Wear, England
Newcastle Univ, Med Sch, Inst Neurosci, Newcastle Upon Tyne, Tyne & Wear, England
Attems, J:
Newcastle Univ, Inst Neurosci, Campus Ageing & Vital, Newcastle Upon Tyne, Tyne & Wear, England
Newcastle Univ, Inst ForAgeing, Campus Ageing & Vital, Newcastle Upon Tyne, Tyne & Wear, England
Griffiths, TD:
Newcastle Univ, Med Sch, Inst Neurosci, Newcastle Upon Tyne, Tyne & Wear, England
McKeith, IG:
Newcastle Univ, Inst Neurosci, Campus Ageing & Vital, Newcastle Upon Tyne, Tyne & Wear, England
Newcastle Univ, Inst ForAgeing, Campus Ageing & Vital, Newcastle Upon Tyne, Tyne & Wear, England
Thomas, AJ:
Newcastle Univ, Inst Neurosci, Campus Ageing & Vital, Newcastle Upon Tyne, Tyne & Wear, England
Newcastle Univ, Inst ForAgeing, Campus Ageing & Vital, Newcastle Upon Tyne, Tyne & Wear, England
Pietrini, P:
IMT Sch Adv Studies, Lucca, Italy
Huey, ED:
Columbia Univ, Taub Inst, Dept Psychiat, New York, NY USA
Columbia Univ, Taub Inst, Dept Neurol, New York, NY USA
Wassermann, EM:
NINDS, Behav Neurol Unit, NIH, Bldg 36,Rm 4D04, Bethesda, MD 20892 USA
Baborie, A:
Univ Alberta, Dept Lab Med & Pathol, Edmonton, AB, Canada
Jaros, E:
Newcastle Univ, Inst Neurosci, Campus Ageing & Vital, Newcastle Upon Tyne, Tyne & Wear, England
Newcastle Univ, Inst ForAgeing, Campus Ageing & Vital, Newcastle Upon Tyne, Tyne & Wear, England
Tierney, MC:
NINDS, Behav Neurol Unit, NIH, Bldg 36,Rm 4D04, Bethesda, MD 20892 USA
Pastor, P:
Ctr Networker Biomed Res Neurodegenerat Dis CIBER, Madrid, Spain
Razquin, C:
Univ Navarra, Ctr Appl Med Res, Neurogenet Lab, Div Neurosci, Pamplona, Spain
Ortega-Cubero, S:
Ctr Networker Biomed Res Neurodegenerat Dis CIBER, Madrid, Spain
Univ Navarra, Ctr Appl Med Res, Neurogenet Lab, Div Neurosci, Pamplona, Spain
Alonso, E:
Univ Navarra, Ctr Appl Med Res, Neurogenet Lab, Div Neurosci, Pamplona, Spain
Univ Navarra, Sch Med, Clin Univ Navarra, Dept Neurol, Pamplona, Spain
Perneczky, R:
Imperial Coll Sci Technol & Med, Fac Med, Sch Publ Hlth, Neuroepidemiol & Ageing Res Unit, London, England
West London Mental Hlth Trust, West London Cognit Disorders Treatment & Res Unit, London, England
Tech Univ Munich, Dept Psychiat & Psychotherapy, Munich, Germany
Diehl-Schmid, J:
Tech Univ Munich, Dept Psychiat & Psychotherapy, Munich, Germany
Alexopoulos, P:
Tech Univ Munich, Dept Psychiat & Psychotherapy, Munich, Germany
Kurz, A:
Tech Univ Munich, Dept Psychiat & Psychotherapy, Munich, Germany
Rainero, I:
Univ Torino, Dept Neurosci, Neurol 1, Turin, Italy
AO Citta Salute & Sci Torino, Turin, Italy
Rubino, E:
Univ Torino, Dept Neurosci, Neurol 1, Turin, Italy
AO Citta Salute & Sci Torino, Turin, Italy
Pinessi, L:
Univ Torino, Dept Neurosci, Neurol 1, Turin, Italy
AO Citta Salute & Sci Torino, Turin, Italy
Rogaeva, E:
Univ Toronto, Tanz Ctr Res Neurodegenerat Dis, Toronto, ON, Canada
St George-Hyslop, P:
Univ Toronto, Tanz Ctr Res Neurodegenerat Dis, Toronto, ON, Canada
Univ Cambridge, Cambridge Inst Med Res, Cambridge, England
Univ Cambridge, Dept Clin Neurosci, Cambridge, England
Rossi, G:
Fdn IRCCS Ist Neurol Carlo Besta, Div Neurol & Neuropathol, Milan, Italy
Tagliavini, F:
Fdn IRCCS Ist Neurol Carlo Besta, Div Neurol & Neuropathol, Milan, Italy
Giaccone, G:
Fdn IRCCS Ist Neurol Carlo Besta, Div Neurol & Neuropathol, Milan, Italy
Rowe, JB:
Univ Cambridge, John Van Geest Brain Repair Ctr, Dept Neurosci John, Forvie Site, Cambridge, England
MRC, Cognit & Brain Sci Unit, Cambridge, England
Behav & Clin Neurosci Inst, Cambridge, England
Schlachetzki, JCM:
Univ Calif San Diego, Dept Cellular & Mol Med, La Jolla, CA 92093 USA
Uphill, J:
UCL Inst Neurol, Dept Neurodegenerat Dis, MRC Prion Unit, Queen Sq House,Queen Sq, London, England
Collinge, J:
UCL Inst Neurol, Dept Neurodegenerat Dis, MRC Prion Unit, Queen Sq House,Queen Sq, London, England
Mead, S:
UCL Inst Neurol, Dept Neurodegenerat Dis, MRC Prion Unit, Queen Sq House,Queen Sq, London, England
Danek, A:
Ludwig Maximilians Univ Munchen, Neurol Klin & Poliklin, Munich, Germany
Van Deerlin, VM:
Univ Penn, Perelman Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA
Grossman, M:
Univ Penn, Perelman Sch Med, Dept Neurol, Philadelphia, PA 19104 USA
Univ Penn, Penn Frontotemporal Degenerat Ctr, Perelman Sch Med, Philadelphia, PA 19104 USA
Trojanowski, JQ:
VIB, Dept Mol Genet, Neurodegenerat Brain Dis Grp, Antwerp, Belgium
Univ Antwerp, Inst Born Bunge, Lab Neurogenet, Antwerp, Belgium
van der Zee, J:
VIB, Dept Mol Genet, Neurodegenerat Brain Dis Grp, Antwerp, Belgium
Univ Antwerp, Inst Born Bunge, Lab Neurogenet, Antwerp, Belgium
Cruts, M:
VIB, Dept Mol Genet, Neurodegenerat Brain Dis Grp, Antwerp, Belgium
Univ Antwerp, Inst Born Bunge, Lab Neurogenet, Antwerp, Belgium
Van Broeckhoven, C:
VIB, Dept Mol Genet, Neurodegenerat Brain Dis Grp, Antwerp, Belgium
Univ Antwerp, Inst Born Bunge, Lab Neurogenet, Antwerp, Belgium
Cappa, SF:
Univ Vita Salute San Raffaele, Dept Clin Neurosci, Neurorehabil Unit, Milan, Italy
Ist Sci San Raffaele, Milan, Italy
Leber, I:
CRICM, Paris, France
UPMC Univ Paris 06, UMR 5975, Paris, France
Univ Paris 06, Univ Paris 06, UMR 5975, Paris, France
Hop La Pitie Salpetriere, AP HP, Dept Neurol Ctr References Demences Rares, Paris, France
CNRS, UMR 7225, F-75013 Paris, France
Hannequin, D:
Rouen Univ Hosp, CNR MAJ, Inserm U1079, Serv Neurol, Rouen, France
Golfier, V:
CH St Brieuc, Serv Neurol, Rouen, France
Vercelletto, M:
CHU Nantes, Serv Neurol, Nantes, France
Brice, A:
CRICM, Paris, France
UPMC Univ Paris 06, UMR 5975, Paris, France
Univ Paris 06, Univ Paris 06, UMR 5975, Paris, France
Hop La Pitie Salpetriere, AP HP, Dept Neurol Ctr References Demences Rares, Paris, France
CNRS, UMR 7225, F-75013 Paris, France
Nacmias, B:
Univ Florence, Dept Neurosci Psychol Drug Res & Child Hlth NEURO, Florence, Italy
Sorbin, S:
Univ Florence, Dept Neurosci Psychol Drug Res & Child Hlth NEURO, Florence, Italy
Bagnoli, S:
Univ Florence, Dept Neurosci Psychol Drug Res & Child Hlth NEURO, Florence, Italy
Piaceri, I:
Univ Florence, Dept Neurosci Psychol Drug Res & Child Hlth NEURO, Florence, Italy
Nielsen, JE:
Copenhagen Univ Hosp, Rigshosp, Danish Dementia Res Ctr, Neurogenet Clin,Dept Neurol, Copenhagen, Denmark
Univ Copenhagen, Panum Inst, Dept Cellular & Mol Med, Sect Neurogenet, Copenhagen, Denmark
Hjermind, LE:
Copenhagen Univ Hosp, Rigshosp, Danish Dementia Res Ctr, Neurogenet Clin,Dept Neurol, Copenhagen, Denmark
Univ Copenhagen, Panum Inst, Dept Cellular & Mol Med, Sect Neurogenet, Copenhagen, Denmark
Riemenschneider, M:
Saarland Univ Hosp, Dept Psychiat & Psychotherapy, Homburg, Saar, Germany
Saarland Univ, Lab Neurogenet, Homburg, Saar, Germany
Mayhaus, M:
Saarland Univ, Lab Neurogenet, Homburg, Saar, Germany
Ibach, B:
Univ Regensburg, Dept Psychiat Psychotherapy & Psychosomat, Regensburg, Germany
Gasparoni, G:
Saarland Univ, Lab Neurogenet, Homburg, Saar, Germany
Pichler, S:
Saarland Univ, Lab Neurogenet, Homburg, Saar, Germany
Gu, W:
Saarland Univ, Lab Neurogenet, Homburg, Saar, Germany
Univ Luxembourg, LCSB, Esch Sur Alzette, Luxembourg
Rossor, MN:
UCL Inst Neurol, Dementia Res Ctr, Dept Neurodegenerat Dis, London, England
Fox, NC:
UCL Inst Neurol, Dementia Res Ctr, Dept Neurodegenerat Dis, London, England
Warren, JD:
UCL Inst Neurol, Dementia Res Ctr, Dept Neurodegenerat Dis, London, England
Spillantini, MG:
Univ Cambridge, John Van Geest Brain Repair Ctr, Dept Neurosci John, Forvie Site, Cambridge, England
Morriss, HR:
UCL Inst Neurol, Dept Mol Neurosci, London, England
Rizzu, P:
German Ctr Neurodegenerat Dis, Tubingen Site, Tubingen, Germany
Heutink, P:
German Ctr Neurodegenerat Dis, Tubingen Site, Tubingen, Germany
Snowden, JS:
Univ Manchester, Salford Royal Hosp, Inst Brain Behav & Mental Hlth, Salford, Lancs, England
Rollinson, S:
Univ Manchester, Salford Royal Hosp, Inst Brain Behav & Mental Hlth, Salford, Lancs, England
Richardson, A:
Univ Manchester, Fac Med & Human Sci, Salford Royal Fdn Trust, Manchester, Lancs, England
Gerhard, A:
Univ Manchester, Salford Royal Hosp, Inst Brain Behav & Mental Hlth, Salford, Lancs, England
Bruni, AC:
ASPCZ, Reg Neurogenet Ctr, Lamezia Terme, Italy
Maletta, R:
ASPCZ, Reg Neurogenet Ctr, Lamezia Terme, Italy
Frangipane, F:
ASPCZ, Reg Neurogenet Ctr, Lamezia Terme, Italy
Cupidi, C:
ASPCZ, Reg Neurogenet Ctr, Lamezia Terme, Italy
Bernardi, L:
ASPCZ, Reg Neurogenet Ctr, Lamezia Terme, Italy
Anfossi, M:
ASPCZ, Reg Neurogenet Ctr, Lamezia Terme, Italy
Gallo, M:
ASPCZ, Reg Neurogenet Ctr, Lamezia Terme, Italy
Conidi, ME:
ASPCZ, Reg Neurogenet Ctr, Lamezia Terme, Italy
Smirne, N:
ASPCZ, Reg Neurogenet Ctr, Lamezia Terme, Italy
Rademakers, R:
Mayo Clin Jacksonville, Dept Neurosci, 4500 San Pablo Rd, Jacksonville, FL 32224 USA
Baker, M:
Mayo Clin Jacksonville, Dept Neurosci, 4500 San Pablo Rd, Jacksonville, FL 32224 USA
Dickson, DW:
Mayo Clin Jacksonville, Dept Neurosci, 4500 San Pablo Rd, Jacksonville, FL 32224 USA
Graff-Radford, NR:
Mayo Clin Jacksonville, Dept Neurosci, 4500 San Pablo Rd, Jacksonville, FL 32224 USA
Petersen, RC:
Mayo Clin Rochester, Dept Neurol, Rochester, MN USA
Knopman, D:
Mayo Clin Rochester, Dept Neurol, Rochester, MN USA
Josephs, KA:
Mayo Clin Rochester, Dept Neurol, Rochester, MN USA
Boeve, BF:
Mayo Clin Rochester, Dept Neurol, Rochester, MN USA
Parisi, JE:
Mayo Clin Rochester, Dept Pathol, Rochester, MN USA
Karydas, AM:
Univ Calif San Francisco, Memory & Aging Ctr, Dept Neurol, San Francisco, CA 94143 USA
Rosen, H:
Univ Calif San Francisco, Memory & Aging Ctr, Dept Neurol, San Francisco, CA 94143 USA
van Swieten, JC:
Erasmus MC, Dept Neurol, Rotterdam, Netherlands
Vrije Univ Amsterdam, Med Ctr, Dept Med Genet, Amsterdam, Netherlands
Dopper, EGP:
Erasmus MC, Dept Neurol, Rotterdam, Netherlands
Vrije Univ Amsterdam, Med Ctr, Dept Med Genet, Amsterdam, Netherlands
Seelaar, H:
Erasmus MC, Dept Neurol, Rotterdam, Netherlands
Vrije Univ Amsterdam, Med Ctr, Dept Med Genet, Amsterdam, Netherlands
Pijnenburg, YAL:
Vrije Univ Amsterdam, Med Ctr, Alzheimer Ctr, Amsterdam, Netherlands
Vrije Univ Amsterdam, Med Ctr, Dept Neurol, Amsterdam, Netherlands
Scheltens, P:
Vrije Univ Amsterdam, Med Ctr, Alzheimer Ctr, Amsterdam, Netherlands
Vrije Univ Amsterdam, Med Ctr, Dept Neurol, Amsterdam, Netherlands
Logroscino, G:
Aldo Moro Univ Bari, Dept Basic Med Sci Neurosci & Sense Organs, Bari, Italy
Capozzo, R:
Aldo Moro Univ Bari, Dept Basic Med Sci Neurosci & Sense Organs, Bari, Italy
Novelli, V:
Fdn Policlin Univ A Gemelli, Med Genet Unit, Rome, Italy
Puca, AA:
IRCCS Multimed, Cardiovasc Res Unit, Milan, Italy
Univ Salerno, Dept Med & Surg, Baronissi, SA, Italy
Franceschi, M:
IRCCS Multimed, Neurol Dept, Milan, Italy
Postiglione, A:
Univ Naples Federico II, Dept Clin Med & Surg, Naples, Italy
Milan, G:
Geriatr Ctr Frullone ASL Napoli 1 Ctr, Naples, Italy
Sorrentino, P:
Geriatr Ctr Frullone ASL Napoli 1 Ctr, Naples, Italy
Kristiansen, M:
UCL, ICH, UCL Genom, London, England
Chian, HH:
Karolinska Inst, Alzheimer Res Ctr, Dept NVS, Stockholm, Sweden
Karolinska Univ Hosp, Dept Geriatr Med, Genet Unit, Stockholm, Sweden
Graff, C:
Karolinska Inst, Alzheimer Res Ctr, Dept NVS, Stockholm, Sweden
Karolinska Univ Hosp, Dept Geriatr Med, Genet Unit, Stockholm, Sweden
Pasquier, F:
Univ Sci & Technol Lille, DISTALZ, CHU, Inserm 1171, F-59000 Lille, France
Rollin, A:
Univ Sci & Technol Lille, DISTALZ, CHU, Inserm 1171, F-59000 Lille, France
Deramecourt, V:
Univ Sci & Technol Lille, DISTALZ, CHU, Inserm 1171, F-59000 Lille, France
Lebouvier, T:
Univ Sci & Technol Lille, DISTALZ, CHU, Inserm 1171, F-59000 Lille, France
Kapogiannis, D:
NIA, NIH, Baltimore, MD 21224 USA
Ferrucci, L:
NIA, Clin Res Branch, Baltimore, MD 21224 USA
Pickering-Brown, S:
Univ Manchester, Salford Royal Hosp, Inst Brain Behav & Mental Hlth, Salford, Lancs, England
Singleton, AB:
NIA, Lab Neurogenet, NIH, Bethesda, MD 20892 USA
Gold, Green Published, Green Accepted
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