Rapid decrease in titer and breadth of neutralizing anti-HCV antibodies in HIV/HCV-coinfected patients who achieved SVR
Por:
Vigon, L, Vazquez-Moron, S, Berenguer, J, Gonzalez-Garcia, J, Jimenez-Sousa, MA, Guardiola, JM, Crespo, M, de Los Santos, I, Von Wichmann, MA, Carrero, A, Yelamos, MB, Gomez, J, Resino, S, Martinez, I, Miralles, P, Lopez, JC, Parras, F, Padilla, B, Aldamiz-Echevarria, T, Tejerina, F, Diez, C, Perez-Latorre, L, Fanciulli, C, Gutierrez, I, Ramirez, M, Carretero, S, Bellon, JM, Bermejo, J, Hontanon, V, Arribas, JR, Montes, ML, Bernardino, I, Pascual, JF, Zamora, F, Pena, JM, Arnalich, F, Diaz, M, Domingo, P, Sanz, J, Bustinduy, MJ, Iribarren, JA, Rodriguez-Arrondo, F, Van den Eynde, E, Perez, M, Ribera, E, Casado, JL, Dronda, F, Morenoll, A, Perez-Elias, MJ, Sanfrutos, MA, Moreno, S, Quereda, C, Arranz, A, Casas, E, de Miguel, J, Schroeder, S, Vergas, J, Tellez, MJ, Vinuesa, D, Munoz, L, Hernandez-Quero, J, Ferrer, A, Galindo, MJ, Ortiz, L, Ortega, E, Montero, M, Blanes, M, Cuellar, S, Lacruz, J, Salavert, M, Lopez-Aldeguer, J, Perez, G, Gaspar, G, Yllescasl, M, Crespo, P, Aznar, E, Esteban, H
Publicada:
21 ago 2019
Resumen:
The main targets for neutralizing anti-hepatitis C virus (HCV) antibodies (HCV-nAbs) are the E1 and E2 envelope glycoproteins. We have studied the characteristics of HCV-nAbs through a retrospective study involving 29 HIV/HCV-coinfected patients who achieved sustained virological response (SVR) with peg-IFN alpha + ribavirin anti-HCV therapy. Plasma samples at baseline and week 24 after SVR were used to perform neutralization assays against five JFH1-based HCV recombinant viruses coding for E1 and E2 from genotypes 1a (H77), 1b (J4), 2a (JFH1), 3a (552) and 4a (ED43). At baseline, the majority of plasma samples neutralized 1a, 1b, 2a, and 4a, but not 3a, genotypes. Twenty-four weeks following SVR, most neutralizing titers declined substantially. Furthermore, titers against 3a and 2a were not detected in many patients. Plasma samples with high HCV-nAb titers neutralized all genotypes, and the highest titers at the starting point correlated with the highest titers at week 24 after SVR. In conclusion, high titers of broad-spectrum HCV-nAbs were detected in HIV/HCV-coinfected individuals, however, those titers declined soon after SVR.
Filiaciones:
Vigon, L:
Inst Salud Carlos III, Ctr Nacl Microbiol, Unidad Infecc Viral & Inmunidad, Madrid, Spain
Vazquez-Moron, S:
Inst Salud Carlos III, Ctr Nacl Microbiol, Unidad Infecc Viral & Inmunidad, Madrid, Spain
Berenguer, J:
Hosp Gen Univ Gregorio Maranon, Unidad Enfermedades Infecciosas VIH, Madrid, Spain
Inst Invest Sanitaria Gregorio Maranon, Madrid, Spain
Gonzalez-Garcia, J:
Hosp Univ La Paz, Serv Med Interna, Unidad VIH, Madrid, Spain
Jimenez-Sousa, MA:
Inst Salud Carlos III, Ctr Nacl Microbiol, Unidad Infecc Viral & Inmunidad, Madrid, Spain
Guardiola, JM:
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Crespo, M:
Hosp Alvaro Cunqueiro, Vigo, Spain
de Los Santos, I:
Hosp Univ La Princesa, Madrid, Spain
Von Wichmann, MA:
Hosp Univ Donostia, San Sebastian, Gipuzkoa, Spain
Carrero, A:
Hosp Gen Univ Gregorio Maranon, Unidad Enfermedades Infecciosas VIH, Madrid, Spain
Inst Invest Sanitaria Gregorio Maranon, Madrid, Spain
Yelamos, MB:
Univ Complutense, Fac Ciencias Quim, Dept Bioquim & Biol Mol, Madrid, Spain
Gomez, J:
Univ Complutense, Fac Ciencias Quim, Dept Bioquim & Biol Mol, Madrid, Spain
Resino, S:
Inst Salud Carlos III, Ctr Nacl Microbiol, Unidad Infecc Viral & Inmunidad, Madrid, Spain
Martinez, I:
Inst Salud Carlos III, Ctr Nacl Microbiol, Unidad Infecc Viral & Inmunidad, Madrid, Spain
Miralles, P:
Inst Invest Sanitaria Gregorio Maranon, Madrid, Spain
Lopez, JC:
Inst Invest Sanitaria Gregorio Maranon, Madrid, Spain
Parras, F:
Inst Invest Sanitaria Gregorio Maranon, Madrid, Spain
Padilla, B:
Inst Invest Sanitaria Gregorio Maranon, Madrid, Spain
Aldamiz-Echevarria, T:
Inst Invest Sanitaria Gregorio Maranon, Madrid, Spain
Tejerina, F:
Inst Invest Sanitaria Gregorio Maranon, Madrid, Spain
Diez, C:
Inst Invest Sanitaria Gregorio Maranon, Madrid, Spain
Perez-Latorre, L:
Inst Invest Sanitaria Gregorio Maranon, Madrid, Spain
Fanciulli, C:
Inst Invest Sanitaria Gregorio Maranon, Madrid, Spain
Gutierrez, I:
Inst Invest Sanitaria Gregorio Maranon, Madrid, Spain
Ramirez, M:
Inst Invest Sanitaria Gregorio Maranon, Madrid, Spain
Carretero, S:
Inst Invest Sanitaria Gregorio Maranon, Madrid, Spain
Bellon, JM:
Inst Invest Sanitaria Gregorio Maranon, Madrid, Spain
Bermejo, J:
Inst Invest Sanitaria Gregorio Maranon, Madrid, Spain
Hontanon, V:
Hosp Univ La Paz, Serv Med Interna, Unidad VIH, Madrid, Spain
Arribas, JR:
Hosp Univ La Paz, Serv Med Interna, Unidad VIH, Madrid, Spain
Montes, ML:
Hosp Univ La Paz, Serv Med Interna, Unidad VIH, Madrid, Spain
Bernardino, I:
Hosp Univ La Paz, Serv Med Interna, Unidad VIH, Madrid, Spain
Pascual, JF:
Hosp Univ La Paz, Serv Med Interna, Unidad VIH, Madrid, Spain
Zamora, F:
Hosp Univ La Paz, Serv Med Interna, Unidad VIH, Madrid, Spain
Pena, JM:
Hosp Univ La Paz, Serv Med Interna, Unidad VIH, Madrid, Spain
Arnalich, F:
Hosp Univ La Paz, Serv Med Interna, Unidad VIH, Madrid, Spain
Diaz, M:
Hosp Univ La Paz, Serv Med Interna, Unidad VIH, Madrid, Spain
Domingo, P:
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Sanz, J:
Hosp Univ La Princesa, Madrid, Spain
Hosp Univ Principe Asturias, Alcala De Henares, Spain
Bustinduy, MJ:
Hosp Univ Donostia, San Sebastian, Gipuzkoa, Spain
Iribarren, JA:
Hosp Univ Donostia, San Sebastian, Gipuzkoa, Spain
Rodriguez-Arrondo, F:
Hosp Univ Donostia, San Sebastian, Gipuzkoa, Spain
Van den Eynde, E:
Hosp Univ Vall dHebron, Barcelona, Spain
Perez, M:
Hosp Univ Vall dHebron, Barcelona, Spain
Ribera, E:
Hosp Univ Vall dHebron, Barcelona, Spain
Casado, JL:
Hosp Univ Ramon & Cajal, Madrid, Spain
Dronda, F:
Hosp Univ Ramon & Cajal, Madrid, Spain
Morenoll, A:
Hosp Univ Ramon & Cajal, Madrid, Spain
Perez-Elias, MJ:
Hosp Univ Ramon & Cajal, Madrid, Spain
Sanfrutos, MA:
Hosp Univ Ramon & Cajal, Madrid, Spain
Moreno, S:
Hosp Univ Ramon & Cajal, Madrid, Spain
Quereda, C:
Hosp Univ Ramon & Cajal, Madrid, Spain
Arranz, A:
Hosp Univ Principe Asturias, Alcala De Henares, Spain
Casas, E:
Hosp Univ Principe Asturias, Alcala De Henares, Spain
de Miguel, J:
Hosp Univ Principe Asturias, Alcala De Henares, Spain
Schroeder, S:
Hosp Univ Principe Asturias, Alcala De Henares, Spain
Vergas, J:
Hosp Clin San Carlos, Madrid, Spain
Tellez, MJ:
Hosp Clin San Carlos, Madrid, Spain
Vinuesa, D:
Hosp Univ San Cecilio, Granada, Spain
Munoz, L:
Hosp Univ San Cecilio, Granada, Spain
Hernandez-Quero, J:
Hosp Univ San Cecilio, Granada, Spain
Ferrer, A:
Hosp Clin Univ, Valencia, Spain
Galindo, MJ:
Hosp Clin Univ, Valencia, Spain
Ortiz, L:
Hosp Gen Univ, Valencia, Spain
Ortega, E:
Hosp Gen Univ, Valencia, Spain
Montero, M:
Hosp Univ La Fe, Valencia, Spain
Blanes, M:
Hosp Univ La Fe, Valencia, Spain
Cuellar, S:
Hosp Univ La Fe, Valencia, Spain
Lacruz, J:
Hosp Univ La Fe, Valencia, Spain
Salavert, M:
Hosp Univ La Fe, Valencia, Spain
Lopez-Aldeguer, J:
Hosp Univ La Fe, Valencia, Spain
Perez, G:
Hosp Univ Getafe, Getafe, Spain
Gaspar, G:
Hosp Univ Getafe, Getafe, Spain
Yllescasl, M:
Fdn SEIMC GESIDA, Madrid, Spain
Crespo, P:
Fdn SEIMC GESIDA, Madrid, Spain
Aznar, E:
Fdn SEIMC GESIDA, Madrid, Spain
Esteban, H:
Fdn SEIMC GESIDA, Madrid, Spain
Gold, Green Published
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