Associations of autozygosity with a broad range of human phenotypes


Por: Clark, DW, Okada, Y, Moore, KHS, Mason, D, Pirastu, N, Gandin, I, Mattsson, H, Barnes, CLK, Lin, K, Zhao, JH, Deelen, P, Rohde, R, Schurmann, C, Guo, XQ, Giulianini, F, Zhang, WH, Medina-Gomez, C, Karlsson, R, Bao, Y, Bartz, TM, Baumbach, C, Biino, G, Bixley, MJ, Brumat, M, Chai, JF, Corre, T, Cousminer, DL, Dekker, AM, Eccles, DA, Van Eijk, KR, Fuchsberger, C, Gao, H, Germain, M, Gordon, SD, de Haan, HG, Harris, SE, Hofer, E, Huerta-Chagoya, A, Igartua, C, Jansen, IE, Jia, YC, Kacprowski, T, Karlsson, T, Kleber, ME, Li, SA, Li-Gao, R, Mahajan, A, Matsuda, K, Meidtner, K, Meng, W, Montasser, ME, van der Most, PJ, Munz, M, Nutile, T, Palviainen, T, Prasad, G, Prasad, RB, Priyanka, TDS, Rizzi, F, Salvi, E, Sapkota, BR, Shriner, D, Skotte, L, Smart, MC, Smith, AV, van der Spek, A, Spracklen, CN, Strawbridge, RJ, Tajuddin, SM, Trompet, S, Turman, C, Verweij, N, Viberti, C, Wang, L, Warren, HR, Wootton, RE, Yanek, LR, Yao, J, Yousri, NA, Zhao, W, Adeyemo, AA, Afaq, S, Aguilar-Salinas, CA, Akiyama, M, Albert, ML, Allison, MA, Alver, M, Aung, T, Azizi, F, Bentley, AR, Boeing, H, Boerwinkle, E, Borja, JB, de Borst, GJ, Bottinger, EP, Broer, L, Campbell, H, Chanock, S, Chee, ML, Chen, G, Chen, YDI, Chen, ZM, Chiu, YF, Cocca, M, Collins, FS, Concas, MP, Corley, J, Cugliari, G, Van Dam, RM, Damulina, A, Daneshpour, MS, Day, FR, Delgado, GE, Dhana, K, Doney, ASF, Dorr, M, Doumatey, AP, Dzimiri, N, Ebenesersdottir, SS, Elliott, J, Elliott, P, Ewert, R, Felix, JF, Fischer, K, Freedman, BI, Girotto, G, Goel, A, Gogele, M, Goodarzi, MO, Graff, M, Granot-Hershkovitz, E, Grodstein, F, Guarrera, S, Gudbjartsson, DF, Guity, K, Gunnarsson, B, Guo, Y, Hagenaars, SP, Haiman, CA, Halevy, A, Harris, TB, Hedayati, M, van Heel, DA, Hirata, M, Hofer, I, Hsiung, CA, Huang, JY, Hung, YJ, Ikram, MA, Jagadeesan, A, Jousilahti, P, Kamatani, Y, Kanai, M, Kerrison, ND, Kessler, T, Khaw, KT, Khor, CC, de Kleijn, DPV, Koh, WP, Kolcic, I, Kraft, P, Kramer, BK, Kutalik, Z, Kuusisto, J, Langenberg, C, Launer, LJ, Lawlor, DA, Lee, IT, Lee, WJ, Lerch, MM, Li, LM, Liu, JJ, Loh, M, London, SJ, Loomis, S, Lu, YC, Luan, J, Magi, R, Manichaikul, AW, Manunta, P, Masson, G, Matoba, N, Mei, XW, Meisinger, C, Meitinger, T, Mezzavilla, M, Milani, L, Millwood, IY, Momozawa, Y, Moore, A, Morange, PE, Moreno-Macias, H, Mori, TA, Morrison, AC, Muka, T, Murakami, Y, Murray, AD, de Mutsert, R, Mychaleckyj, JC, Nalls, MA, Nauck, M, Neville, MJ, Nolte, IM, Ong, KK, Orozco, L, Padmanabhan, S, Palsson, G, Pankow, JS, Pattaro, C, Pattie, A, Polasek, O, Poulter, N, Pramstaller, PP, Quintana-Murci, L, Raikkonen, K, Ralhan, S, Rao, DC, van Rheenen, W, Rich, SS, Ridker, PM, Rietveld, CA, Robino, A, van Rooij, FJA, Ruggiero, D, Saba, Y, Sabanayagam, C, Sabater-Lleal, M, Sala, CF, Salomaa, V, Sandow, K, Schmidt, H, Scott, LJ, Scott, WR, Sedaghati-Khayat, B, Sennblad, B, van Setten, J, Sever, PJ, Sheu, WHH, Shi, Y, Shrestha, S, Shukla, SR, Sigurdsson, JK, Sikka, TT, Singh, JR, Smith, BH, Stancakova, A, Stanton, A, Starr, JM, Stefansdottir, L, Straker, L, Sulem, P, Sveinbjornsson, G, Swertz, MA, Taylor, AM, Taylor, KD, Terzikhan, N, Tham, YC, Thorleifsson, G, Thorsteinsdottir, U, Tillander, A, Tracy, RP, Tusie-Luna, T, Tzoulaki, I, Vaccargiu, S, Vangipurapu, J, Veldink, JH, Vitart, V, Volker, U, Vuoksimaa, E, Wakil, SM, Waldenberger, M, Wander, GS, Wang, YX, Wareham, NJ, Wild, S, Yajnik, CS, Yuan, JM, Zeng, LY, Zhang, L, Zhou, J, Amin, N, Asselbergs, FW, Bakker, SJL, Becker, DM, Lehne, B, Bennett, DA, den Berg, LH, Berndt, SI, Bharadwaj, D, Bielak, LF, Bochud, M, Boehnke, M, Bouchard, C, Bradfield, JP, Brody, JA, Campbell, A, Carmi, S, Caulfield, MJ, Cesarini, D, Chambers, JC, Chandak, GR, Cheng, CY, Ciullo, M, Cornelis, M, Cusi, D, Smith, GD, Deary, IJ, Dorajoo, R, van Duijn, CM, Ellinghaus, D, Erdmann, J, Eriksson, JG, Evangelou, E, Evans, MK, Faul, JD, Feenstra, B, Feitosa, M, Foisy, S, Franke, A, Friedlander, Y, Gasparini, P, Gieger, C, Gonzalez, C, Goyette, P, Grant, SFA, Griffiths, LR, Groop, L, Gudnason, V, Gyllensten, U, Hakonarson, H, Hamsten, A, van der Harst, P, Heng, CK, Hicks, AA, Hochner, H, Huikuri, H, Hunt, SC, Jaddoe, VWV, De Jager, PL, Johannesson, M, Johansson, A, Jonas, JB, Jukema, JW, Junttila, J, Kaprio, J, Kardia, SLR, Karpe, F, Kumari, M, Laakso, M, van der Laan, SW, Lahti, J, Laudes, M, Lea, RA, Lieb, W, Lumley, T, Martin, NG, Marz, W, Matullo, G, McCarthy, MI, Medland, SE, Merriman, TR, Metspalu, A, Meyer, BF, Mohlke, KL, Montgomery, GW, Mook-Kanamori, D, Munroe, PB, North, KE, Nyholt, DR, O'connell, JR, Ober, C, Oldehinkel, AJ, Palmas, W, Palmer, C, Pasterkamp, GG, Patin, E, Pennell, CE, Perusse, L, Peyser, PA, Pirastu, M, Polderman, TJC, Porteous, DJ, Posthuma, D, Psaty, BM, Rioux, JD, Rivadeneira, F, Rotimi, C, Rotter, JI, Rudan, I, Den Ruijter, HM, Sanghera, DK, Sattar, N, Schmidt, R, Schulze, MB, Schunkert, H, Scott, RA, Shuldiner, AR, Sim, X, Small, N, Smith, JA, Sotoodehnia, N, Tai, ES, Teumer, A, Timpson, NJ, Toniolo, D, Tregouet, DA, Tuomi, T, Vollenweider, P, Wang, CA, Weir, DR, Whitfield, JB, Wijmenga, C, Wong, TY, Wright, J, Yang, J, Yu, L, Zemel, BS, Zonderman, AB, Perola, M, Magnusson, PKE, Uitterlinden, AG, Kooner, JS, Chasman, DI, Loos, RJF, Franceschini, N, Franke, L, Haley, CS, Hayward, C, Walters, RG, Perry, JRB, Esko, T, Helgason, A, Stefansson, K, Joshi, PK, Kubo, M, Wilson, JF

Publicada: 31 oct 2019
Resumen:
In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because reproduction between close relatives is both rare and frequently associated with confounding social factors. Here, using genomic inbreeding coefficients (F-ROH) for >1.4 million individuals, we show that F-ROH is significantly associated (p < 0.0005) with apparently deleterious changes in 32 out of 100 traits analysed. These changes are associated with runs of homozygosity (ROH), but not with common variant homozygosity, suggesting that genetic variants associated with inbreeding depression are predominantly rare. The effect on fertility is striking: F-ROH equivalent to the offspring of first cousins is associated with a 55% decrease [95% CI 44-66%] in the odds of having children. Finally, the effects of F-ROH are confirmed within full-sibling pairs, where the variation in F-ROH is independent of all environmental confounding.

Filiaciones:
Clark, DW:
 Univ Edinburgh, Usher Inst, Ctr Global Hlth Res, Edinburgh EH8 9AG, Midlothian, Scotland

Okada, Y:
 Osaka Univ, Dept Stat Genet, Grad Sch Med, Suita, Osaka 5650871, Japan

 RIKEN, Lab Stat Anal, Ctr Integrat Med Sci, Yokohama, Kanagawa 2300045, Japan

 Osaka Univ, Immunol Frontier Res Ctr WPI IFReC, Lab Stat Immunol, Suita, Osaka 5650871, Japan

Moore, KHS:
 Amgen Inc, DeCODE Genet, IS-101 Reykjavik, Iceland

Mason, D:
 Bradford Teaching Hosp NHS Trust, Bradford Inst Hlth Res, Bradford BD9 6RJ, W Yorkshire, England

Pirastu, N:
 Univ Edinburgh, Usher Inst, Ctr Global Hlth Res, Edinburgh EH8 9AG, Midlothian, Scotland

Gandin, I:
 Area Sci Pk, Res Unit, I-34149 Trieste, Italy

 Univ Trieste, Dept Med Surg & Hlth Sci, Trieste, Italy

Mattsson, H:
 Natl Inst Hlth & Welf, Unit Publ Hlth Solut, Helsinki, Finland

 Univ Helsinki, Inst Mol Med Finland, Helsinki, Finland

Barnes, CLK:
 Univ Edinburgh, Usher Inst, Ctr Global Hlth Res, Edinburgh EH8 9AG, Midlothian, Scotland

Lin, K:
 Univ Oxford, Nuffield Dept Populat Hlth, Oxford OX3 7LF, England

Zhao, JH:
 Univ Cambridge, Sch Clin Med, MRC Epidemiol Unit, Cambridge CB2 0QQ, England

 Univ Cambridge, Dept Publ Hlth & Primary Care, Cardiovasc Epidemiol Unit, Cambridge CB1 8RN, England

Deelen, P:
 Univ Groningen, Univ Med Ctr Groningen, Dept Genet, NL-9700 RB Groningen, Netherlands

Rohde, R:
 Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27514 USA

Schurmann, C:
 Ichan Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA

Guo, XQ:
 Harbor UCLA Med Ctr, Inst Translat Genom & Populat Sci, LABioMed, Div Genom Outcomes,Dept Pediat, Torrance, CA 90502 USA

Giulianini, F:
 Brigham & Womens Hosp, Div Prevent Med, Boston, MA 02215 USA

Zhang, WH:
 Imperial Coll London, Dept Epidemiol & Biostat, London W2 1PG, England

 Ealing Gen Hosp, Dept Cardiol, Middlesex UB1 3HW, England

Medina-Gomez, C:
 Erasmus MC, Dept Internal Med, NL-3015 CN Rotterdam, Netherlands

 Erasmus MC, Dept Epidemiol, NL-3015 CN Rotterdam, Netherlands

 Erasmus MC, Generat R Study Grp, NL-3015 CN Rotterdam, Netherlands

Karlsson, R:
 Karolinska Inst, Dept Med Epidemiol & Biostat, S-17177 Stockholm, Sweden

Bao, Y:
 Univ Essex, Inst Social & Econ Res, Colchester CO4 3SQ, Essex, England

Bartz, TM:
 Univ Washington, Dept Biostat & Med, Cardiovasc Hlth Res Unit, Seattle, WA 98101 USA

Baumbach, C:
 German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Epidemiol, Res Unit Mol Epidemiol, D-85764 Neuherberg, Germany

Biino, G:
 Natl Res Council Italy, Inst Mol Genet, I-27100 Pavia, Italy

Bixley, MJ:
 Univ Otago, Dept Biochem, Dunedin 9054, New Zealand

Brumat, M:
 Univ Trieste, Dept Med Surg & Hlth Sci, Trieste, Italy

Chai, JF:
 Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore 117549, Singapore

Corre, T:
 Univ Lausanne, Dept Computat Biol, CH-1011 Lausanne, Switzerland

 Univ Lausanne, Ctr Primary Care & Publ Hlth Unisante, Lausanne, Switzerland

 Swiss Inst Bioinformat, CH-1015 Lausanne, Switzerland

Cousminer, DL:
 Childrens Hosp Philadelphia, Div Human Genet, Philadelphia, PA 19104 USA

 Univ Penn, Perelman Sch Med, Dept Genet, Philadelphia, PA 19104 USA

Dekker, AM:
 Univ Utrecht, Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Dept Neurol, NL-3584 CX Utrecht, Netherlands

Eccles, DA:
 Queensland Univ Technol, Inst Hlth & Biomed Innovat, Sch Biomed Sci, Genom Res Ctr, Brisbane, Qld 4059, Australia

 Malaghan Inst Med Res, Wellington 6242, New Zealand

Van Eijk, KR:
 Univ Utrecht, Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Dept Neurol, NL-3584 CX Utrecht, Netherlands

Fuchsberger, C:
 Univ Lubeck, Affiliated Inst, Inst Biomed, Eurac Res, I-39100 Bolzano, Italy

Gao, H:
 Imperial Coll London, Dept Epidemiol & Biostat, London W2 1PG, England

 Imperial Coll London, MRC PHE Ctr Environm & Hlth, London W2 1PG, England

Germain, M:
 Sorbonne Univ, INSERM, UMR S 1166, F-75013 Paris, France

 ICAN Inst Cardiometab & Nutr, F-75013 Paris, France

Gordon, SD:
 QIMR Berghofer Inst Med Res, Brisbane, Qld, Australia

de Haan, HG:
 Leiden Univ, Dept Clin Epidemiol, Med Ctr, NL-2333 ZA Leiden, Netherlands

Harris, SE:
 Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh EH8 9JZ, Midlothian, Scotland

 Univ Edinburgh, Inst Genet & Mol Med, Ctr Genom & Expt Med, Edinburgh EH4 2XU, Midlothian, Scotland

Hofer, E:
 Med Univ Graz, Clin Div Neurogeriatr, Dept Neurol, A-8036 Graz, Austria

 Med Univ Graz, Inst Med Informat Stat & Documentat, A-8036 Graz, Austria

Huerta-Chagoya, A:
 CONACyT, Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Mexico City 03940, DF, Mexico

Igartua, C:
 Univ Chicago, Dept Human Genet, Chicago, IL 60637 USA

Jansen, IE:
 Vrije Univ Amsterdam, Ctr Neurogenom & Cognit Res, Dept Complex Trait Genet, NL-1081 HV Amsterdam, Netherlands

 Vrije Univ Amsterdam Med Ctr, Alzheimer Ctr, Dept Neurol, Amsterdam Neurosci, NL-1081 HV Amsterdam, Netherlands

Jia, YC:
 Harbor UCLA Med Ctr, Inst Translat Genom & Populat Sci, LABioMed, Div Genom Outcomes,Dept Pediat, Torrance, CA 90502 USA

Kacprowski, T:
 Univ Med Greifswald, Interfaculty Inst Genet & Funct Genom, D-17475 Greifswald, Germany

 Tech Univ Munich, TUM Sch Life Sci Weihenstephan, Chair Expt Bioinformat, D-85354 Freising Weihenstephan, Germany

Karlsson, T:
 Uppsala Univ, Sci Life Lab, Dept Immunol Genet & Pathol, S-75108 Uppsala, Sweden

Kleber, ME:
 Heidelberg Univ, Med Fac Mannheim, Dept Med 5, Nephrol,Hypertensiol,Rheumatol,Endocrinol,Diabeto, D-68167 Mannheim, Germany

Li, SA:
 Leidos Biomed Res Inc, Frederick Natl Lab Canc Res, Canc Genom Res Lab, Frederick, MD USA

Li-Gao, R:
 Leiden Univ, Dept Clin Epidemiol, Med Ctr, NL-2333 ZA Leiden, Netherlands

Mahajan, A:
 Univ Oxford, Wellcome Ctr Human Genet, Oxford OX3 7BN, England

Matsuda, K:
 Univ Tokyo, Grad Sch Frontier Sci, Dept Computat Biol & Med Sci, Tokyo 1088639, Japan

Meidtner, K:
 German Inst Human Nutr Potsdam Rehbrucke, Dept Mol Epidemiol, Nuthetal, Germany

 German Ctr Diabet Res DZD, Munich, Germany

Meng, W:
 Univ Dundee, Ninewells Hosp, Med Res Inst, Dundee, Scotland

 Univ Dundee, Sch Med, Dundee, Scotland

Montasser, ME:
 Univ Maryland, Sch Med, Dept Med, Div Endocrinol Diabet & Nutr, Baltimore, MD 21201 USA

 Univ Maryland, Sch Med, Dept Med, Program Personalized & Genom Med, Baltimore, MD 21201 USA

van der Most, PJ:
 Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, NL-9700 RB Groningen, Netherlands

Munz, M:
 Univ Lubeck, Inst Cardiogenet, D-23562 Lubeck, Germany

 DZHK German Res Ctr Cardiovasc Res, Partner Site Hamburg Lubeck Kiel, D-23562 Lubeck, Germany

 Univ Heart Ctr Luebeck, D-23562 Lubeck, Germany

 Charite Univ Med Berlin, Berlin, Germany

 Free Univ Berlin, Berlin, Germany

 Humboldt Univ, Berlin, Germany

 Berlin Inst Hlth, Berlin, Germany

 Inst Dent & Craniofacial Sci, Dept Periodontol & Synopt Dent, Berlin, Germany

Nutile, T:
 CNR, Inst Genet & Biophys A Buzzati Traverso, I-80131 Naples, Italy

Palviainen, T:
 Univ Helsinki, Finnish Inst Mol Med, Helsinki, Finland

Prasad, G:
 CSIR Inst Genom & Integrat Biol, Genom & Mol Med Unit, New Delhi 110020, India

Prasad, RB:
 Lund Univ, Skane Univ Hosp, Diabet Ctr, Dept Clin Sci Diabet & Endocrinol, S-20502 Malmo, Sweden

Priyanka, TDS:
 CSIR Ctr Cellular & Mol Biol, Genom Res Complex Dis GRC Grp, Hyderabad 500007, Telangana, India

Rizzi, F:
 EPhood SRL, EPhood Sci Unit, I-20091 Milan, Italy

 Univ Milan, Dept Hlth Sci, I-20139 Milan, Italy

Salvi, E:
 Univ Milan, Dept Hlth Sci, I-20139 Milan, Italy

 IRCCS Fdn Carlo Besta Neurol Inst, Neuroalgol Unit, I-20133 Milan, Italy

Sapkota, BR:
 Univ Oklahoma, Hlth Sci Ctr, Coll Med, Dept Pediat, Oklahoma City, OK 73104 USA

Shriner, D:
 NHGRI, Ctr Res Genom & Global Hlth, NIH, Bethesda, MD 20892 USA

Skotte, L:
 Statens Serum Inst, Dept Epidemiol Res, DK-2300 Copenhagen, Denmark

Smart, MC:
 Univ Essex, Inst Social & Econ Res, Colchester CO4 3SQ, Essex, England

Smith, AV:
 Iceland Heart Assoc, IS-201 Kopavogur, Iceland

 Univ Iceland, Sch Hlth Sci, Fac Med, IS-101 Reykjavik, Iceland

van der Spek, A:
 Erasmus MC, Dept Epidemiol, NL-3015 CN Rotterdam, Netherlands

Spracklen, CN:
 Univ N Carolina, Dept Genet, Chapel Hill, NC 27599 USA

Strawbridge, RJ:
 Univ Glasgow, Inst Hlth & Wellbeing, Glasgow G12 8RZ, Lanark, Scotland

 Karolinska Inst, Ctr Mol Med, Dept Med Solna, Cardiovasc Med Unit, S-17176 Stockholm, Sweden

Tajuddin, SM:
 NIA, Lab Epidemiol & Populat Sci, NIH, Baltimore, MD 21224 USA

Trompet, S:
 Leiden Univ, Med Ctr, Dept Cardiol, NL-2300 RC Leiden, Netherlands

 Leiden Univ, Med Ctr, Dept Internal Med, Sect Gerontol & Geriatr, NL-2300 RC Leiden, Netherlands

Turman, C:
 Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

 Harvard TH Chan Sch Publ Hlth, Program Genet Epidemiol & Stat Genet, Boston, MA 02115 USA

Verweij, N:
 Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, NL-9713 GZ Groningen, Netherlands

Viberti, C:
 Univ Turin, IIGM, I-10126 Turin, Italy

 Univ Turin, Dept Med Sci, I-10126 Turin, Italy

Wang, L:
 Washington Univ, Sch Med, Dept Genet, Div Stat Genom, St Louis, MO 63110 USA

Warren, HR:
 Queen Mary Univ London, Barts & London Sch Med & Dent, NIHR Barts Cardiovasc Biomed Res Ctr, London EC1M 6BQ, England

 Queen Mary Univ London, William Harvey Res Inst, Barts & London Sch Med & Dent, Dept Clin Pharmacol, London EC1M 6BQ, England

Wootton, RE:
 Univ Bristol, MRC Integrat Epidemiol Unit, Bristol BS8 2BN, Avon, England

 Univ Bristol, Sch Psychol Sci, Bristol BS8 1TU, Avon, England

Yanek, LR:
 Johns Hopkins Univ, Sch Med, GeneSTAR Res Program, Dept Med, Baltimore, MD 21287 USA

Yao, J:
 Harbor UCLA Med Ctr, Inst Translat Genom & Populat Sci, LABioMed, Div Genom Outcomes,Dept Pediat, Torrance, CA 90502 USA

Yousri, NA:
 Weill Cornell Med Qatar, Dept Genet Med, Doha, Qatar

 Alexandria Univ, Comp & Syst Engn, Alexandria, Egypt

Zhao, W:
 Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA

Adeyemo, AA:
 NHGRI, Ctr Res Genom & Global Hlth, NIH, Bethesda, MD 20892 USA

Afaq, S:
 Imperial Coll London, Dept Epidemiol & Biostat, London W2 1PG, England

Aguilar-Salinas, CA:
 Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Endocrinol & Metab, Mexico City 14080, DF, Mexico

 Escuela Med & Ciencias Salud, Tecnol Monterrey, Unidad Invest Enfermades Metabol, Monterrey 64710, NL, Mexico

Akiyama, M:
 RIKEN, Lab Stat Anal, Ctr Integrat Med Sci, Yokohama, Kanagawa 2300045, Japan

 Kyushu Univ, Grad Sch Med Sci, Dept Ophthalmol, Fukuoka, Fukuoka 8128582, Japan

Albert, ML:
 Inst Pasteur, Immunobiol Dendrit Cells, F-75015 Paris, France

 INSERM, U1223, F-75015 Paris, France

 Inst Pasteur, Ctr Translat Res, F-75015 Paris, France

 Genentech Inc, Dept Canc Immunol, San Francisco, CA 94080 USA

Allison, MA:
 UC San Diego Sch Med, Dept Family Med & Publ Hlth, Div Prevent Med, La Jolla, CA 92093 USA

Alver, M:
 Univ Tartu, Estonian Genome Ctr, EE-51010 Tartu, Estonia

Aung, T:
 Singapore Natl Eye Ctr, Singapore Eye Res Inst, Singapore 169856, Singapore

 Duke NUS Med Sch, Ophthalmol & Visual Sci Acad Clin Program Eye ACP, Singapore 169857, Singapore

 Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Ophthalmol, Singapore 119228, Singapore

Azizi, F:
 Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Endocrine Res Ctr, Tehran 1983963113, Iran

Bentley, AR:
 NHGRI, Ctr Res Genom & Global Hlth, NIH, Bethesda, MD 20892 USA

Boeing, H:
 German Inst Human Nutr Potsdam Rehbrucke, Dept Epidemiol, Nuthetal, Germany

Boerwinkle, E:
 Univ Texas Houston, UTHlth Sch Publ Hlth, Hlth Sci Ctr Houston, Houston, TX 77030 USA

Borja, JB:
 Univ San Carlos, USC Off Populat Studies Fdn Inc, Dept Nutr & Dietet, Cebu 6000, Cebu, Philippines

de Borst, GJ:
 Univ Utrecht, Univ Med Ctr Utrecht, Div Surg Specialties, Dept Vasc Surg, NL-3584 CX Utrecht, Netherlands

Bottinger, EP:
 Ichan Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA

 Univ Potsdam, Hasso Plattner Inst, Digital Hlth Ctr, D-14482 Potsdam, Germany

Broer, L:
 Erasmus MC, Dept Internal Med, NL-3015 CN Rotterdam, Netherlands

Campbell, H:
 Univ Edinburgh, Usher Inst, Ctr Global Hlth Res, Edinburgh EH8 9AG, Midlothian, Scotland

Chanock, S:
 NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA

Chee, ML:
 Singapore Natl Eye Ctr, Singapore Eye Res Inst, Singapore 169856, Singapore

Chen, G:
 NHGRI, Ctr Res Genom & Global Hlth, NIH, Bethesda, MD 20892 USA

Chen, YDI:
 Harbor UCLA Med Ctr, Inst Translat Genom & Populat Sci, LABioMed, Div Genom Outcomes,Dept Pediat, Torrance, CA 90502 USA

Chen, ZM:
 Univ Oxford, Nuffield Dept Populat Hlth, Oxford OX3 7LF, England

Chiu, YF:
 Natl Hlth Res Inst, Inst Populat Hlth Sci, Miaoli, Taiwan

Cocca, M:
 IRCCS Burlo Garofolo, Inst Maternal & Child Hlth, I-34137 Trieste, Italy

Collins, FS:
 NHGRI, NIH, Bethesda, MD 20892 USA

Concas, MP:
 IRCCS Burlo Garofolo, Inst Maternal & Child Hlth, I-34137 Trieste, Italy

Corley, J:
 Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh EH8 9JZ, Midlothian, Scotland

 Univ Edinburgh, Dept Psychol, 7 George Sq, Edinburgh EH8 9JZ, Midlothian, Scotland

Cugliari, G:
 Univ Turin, IIGM, I-10126 Turin, Italy

 Univ Turin, Dept Med Sci, I-10126 Turin, Italy

Van Dam, RM:
 Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore 117549, Singapore

 Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Med, Singapore 119228, Singapore

 Harvard T H Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA

Damulina, A:
 Med Univ Graz, Clin Div Neurogeriatr, Dept Neurol, A-8036 Graz, Austria

Daneshpour, MS:
 Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Cellular & Mol Endocrine Res Ctr, Tehran 1983963113, Iran

Day, FR:
 Univ Cambridge, Sch Clin Med, MRC Epidemiol Unit, Cambridge CB2 0QQ, England

Delgado, GE:
 Heidelberg Univ, Med Fac Mannheim, Dept Med 5, Nephrol,Hypertensiol,Rheumatol,Endocrinol,Diabeto, D-68167 Mannheim, Germany

Dhana, K:
 Erasmus MC, Dept Epidemiol, NL-3015 CN Rotterdam, Netherlands

 Harvard T H Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA

 Rush Univ, Med Ctr, Dept Internal Med, Chicago, IL 60612 USA

Doney, ASF:
 Univ Dundee, MEMO Res Mol & Clin Med, Dundee DD1 9SY, Scotland

Dorr, M:
 Univ Med Greifswald, Dept Internal Med B, D-17475 Greifswald, Germany

 DZHK German Ctr Cardiovasc Res, Partner Site Greifswald, D-17475 Greifswald, Germany

Doumatey, AP:
 NHGRI, Ctr Res Genom & Global Hlth, NIH, Bethesda, MD 20892 USA

Dzimiri, N:
 King Faisal Specialist Hosp & Res Ctr, Dept Genet, Riyadh 12713, Saudi Arabia

Ebenesersdottir, SS:
 Amgen Inc, DeCODE Genet, IS-101 Reykjavik, Iceland

 Univ Iceland, Dept Anthropol, IS-101 Reykjavik, Iceland

Elliott, J:
 Imperial Coll London, Dept Epidemiol & Biostat, London W2 1PG, England

Elliott, P:
 Imperial Coll London, Dept Epidemiol & Biostat, London W2 1PG, England

 Imperial Coll London, MRC PHE Ctr Environm & Hlth, London W2 1PG, England

 Imperial Coll Healthcare NHS Trust, Imperial Biomed Res Ctr, Natl Inst Hlth Res, London, England

 Imperial Coll London, London, England

 Imperial Coll London, UK DRI, London, England

 Hlth Data Res UK London, London, England

Ewert, R:
 Univ Med Greifswald, Dept Internal Med B, D-17475 Greifswald, Germany

Felix, JF:
 Erasmus MC, Dept Epidemiol, NL-3015 CN Rotterdam, Netherlands

 Erasmus MC, Generat R Study Grp, NL-3015 CN Rotterdam, Netherlands

 Erasmus MC, Dept Pediat, NL-3015 CN Rotterdam, Netherlands

Fischer, K:
 Univ Tartu, Estonian Genome Ctr, EE-51010 Tartu, Estonia

Freedman, BI:
 Wake Forest Sch Med, Dept Internal Med, Sect Nephrol, Winston Salem, NC 27101 USA

Girotto, G:
 Univ Trieste, Dept Med Surg & Hlth Sci, Trieste, Italy

 IRCCS Burlo Garofolo, Inst Maternal & Child Hlth, Med Genet, Trieste, Italy

Goel, A:
 Univ Oxford, Wellcome Ctr Human Genet, Oxford OX3 7BN, England

 Univ Oxford, Radcliffe Dept Med, Div Cardiovasc Med, Oxford OX3 9DU, England

Gogele, M:
 Univ Lubeck, Affiliated Inst, Inst Biomed, Eurac Res, I-39100 Bolzano, Italy

Goodarzi, MO:
 Cedars Sinai Med Ctr, Dept Med, Div Endocrinol Diabet & Metab, Los Angeles, CA 90048 USA

Graff, M:
 Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27514 USA

Granot-Hershkovitz, E:
 Hebrew Univ Jerusalem, Hadassah Med Ctr, Braun Sch Publ Hlth, Jerusalem, Israel

Grodstein, F:
 Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

Guarrera, S:
 Univ Turin, IIGM, I-10126 Turin, Italy

 Univ Turin, Dept Med Sci, I-10126 Turin, Italy

Gudbjartsson, DF:
 Amgen Inc, DeCODE Genet, IS-101 Reykjavik, Iceland

 Univ Iceland, Sch Engn & Nat Sci, IS-101 Reykjavik, Iceland

Guity, K:
 Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Cellular & Mol Endocrine Res Ctr, Tehran 1983963113, Iran

Gunnarsson, B:
 Amgen Inc, DeCODE Genet, IS-101 Reykjavik, Iceland

Guo, Y:
 Chinese Acad Med Sci, Beijing 100730, Peoples R China

Hagenaars, SP:
 Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh EH8 9JZ, Midlothian, Scotland

 Univ Edinburgh, Dept Psychol, 7 George Sq, Edinburgh EH8 9JZ, Midlothian, Scotland

 Kings Coll London, Inst Psychiat Psychol & Neurosci, Social Genet & Dev Psychiat Ctr, London SE5 8AF, England

Haiman, CA:
 Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90089 USA

Halevy, A:
 Hebrew Univ Jerusalem, Hadassah Med Ctr, Braun Sch Publ Hlth, Jerusalem, Israel

Harris, TB:
 NIA, Lab Epidemiol & Populat Sci, NIH, Baltimore, MD 21224 USA

Hedayati, M:
 Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Cellular & Mol Endocrine Res Ctr, Tehran 1983963113, Iran

van Heel, DA:
 Queen Mary Univ London, Blizard Inst, London E1 2AT, England

Hirata, M:
 Univ Tokyo, Inst Med Sci, Lab Genome Technol, Tokyo 1088639, Japan

Hofer, I:
 Univ Utrecht, Univ Med Ctr Utrecht, Div Labs & Pharm, Lab Clin Chem & Hematol, NL-3584 CX Utrecht, Netherlands

Hsiung, CA:
 Natl Hlth Res Inst, Inst Populat Hlth Sci, Miaoli, Taiwan

Huang, JY:
 Shanghai Jiao Tong Univ, Sch Med, Rui Jin Hosp, State Key Lab Med Genom,Shanghai Inst Hematol, Shanghai 200025, Peoples R China

Hung, YJ:
 Triserv Gen Hosp, Div Endocrine & Metab, Songshan Branch, Taipei, Taiwan

 Natl Def Med Ctr, Sch Med, Taipei, Taiwan

Ikram, MA:
 Erasmus MC, Dept Epidemiol, NL-3015 CN Rotterdam, Netherlands

Jagadeesan, A:
 Amgen Inc, DeCODE Genet, IS-101 Reykjavik, Iceland

 Univ Iceland, Dept Anthropol, IS-101 Reykjavik, Iceland

Jousilahti, P:
 Natl Inst Hlth & Welf, Unit Publ Hlth Promot, Helsinki, Finland

Kamatani, Y:
 RIKEN, Lab Stat Anal, Ctr Integrat Med Sci, Yokohama, Kanagawa 2300045, Japan

 Kyoto Univ, Ctr Genom Med, Grad Sch Med, Kyoto 6068507, Japan

Kanai, M:
 Osaka Univ, Dept Stat Genet, Grad Sch Med, Suita, Osaka 5650871, Japan

 RIKEN, Lab Stat Anal, Ctr Integrat Med Sci, Yokohama, Kanagawa 2300045, Japan

 Harvard Med Sch, Dept Biomed Informat, Boston, MA 02115 USA

 Tech Univ Munich, Klin Herz & Kreislauferkrankungen, Deutsch Herzzentrum Munchen, D-80636 Munich, Germany

Kerrison, ND:
 Univ Cambridge, Sch Clin Med, MRC Epidemiol Unit, Cambridge CB2 0QQ, England

Khaw, KT:
 Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge CB2 0SR, England

Khor, CC:
 Singapore Natl Eye Ctr, Singapore Eye Res Inst, Singapore 169856, Singapore

 Agcy Sci Technol & Res, Genome Inst Singapore, Human Genet, Singapore 138672, Singapore

de Kleijn, DPV:
 Univ Utrecht, Univ Med Ctr Utrecht, Div Surg Specialties, Dept Vasc Surg, NL-3584 CX Utrecht, Netherlands

Koh, WP:
 Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore 117549, Singapore

 Duke NUS Med Sch, Hlth Serv & Syst Res, Singapore 169857, Singapore

Kolcic, I:
 Univ Split, Ctr Global Hlth, Fac Med, Split, Croatia

Kraft, P:
 Harvard T H Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA

Kramer, BK:
 Heidelberg Univ, Med Fac Mannheim, Dept Med 5, Nephrol,Hypertensiol,Rheumatol,Endocrinol,Diabeto, D-68167 Mannheim, Germany

Kutalik, Z:
 Univ Lausanne, Ctr Primary Care & Publ Hlth Unisante, Lausanne, Switzerland

 Swiss Inst Bioinformat, CH-1015 Lausanne, Switzerland

Kuusisto, J:
 Univ Eastern Finland, Inst Clin Med, Internal Med, Kuopio, Finland

 Kuopio Univ Hosp, Kuopio, Finland

Langenberg, C:
 Univ Cambridge, Sch Clin Med, MRC Epidemiol Unit, Cambridge CB2 0QQ, England

Launer, LJ:
 NIA, Lab Epidemiol & Populat Sci, NIH, Baltimore, MD 21224 USA

Lawlor, DA:
 Univ Bristol, MRC Integrat Epidemiol Unit, Bristol BS8 2BN, Avon, England

 Bristol NIHR Biomed Res Ctr, Bristol BS8 2BN, Avon, England

 Univ Bristol Sch Med, Populat Hlth Sci, Bristol BS8 2BY, Avon, England

Lee, IT:
 Taichung Vet Gen Hosp, Dept Internal Med, Div Endocrinol & Metab, Taichung, Taiwan

 Natl Yang Ming Univ, Sch Med, Taipei 112, Taiwan

 Chung Shan Med Univ, Sch Med, Taichung 402, Taiwan

Lee, WJ:
 Taichung Vet Gen Hosp, Dept Med Res, Taichung, Taiwan

Lerch, MM:
 Univ Med Greifswald, Dept Internal Med A, D-17475 Greifswald, Germany

Li, LM:
 Peking Univ, Hlth Sci Ctr, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China

Liu, JJ:
 Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Med, Singapore 119228, Singapore

 Agcy Sci Technol & Res, Genome Inst Singapore, Human Genet, Singapore 138672, Singapore

Loh, M:
 Imperial Coll London, Dept Epidemiol & Biostat, London W2 1PG, England

 ASTAR, Translat Lab Genet Med, Singapore 138648, Singapore

 Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Biochem, Singapore 117596, Singapore

London, SJ:
 NIEHS, Dept Hlth & Human Serv, NIH, Durham, NC 27709 USA

Loomis, S:
 Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USA

Lu, YC:
 Ichan Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA

Luan, J:
 Univ Cambridge, Sch Clin Med, MRC Epidemiol Unit, Cambridge CB2 0QQ, England

Magi, R:
 Univ Tartu, Estonian Genome Ctr, EE-51010 Tartu, Estonia

Manichaikul, AW:
 Univ Virginia, Sch Med, Ctr Publ Hlth Genom, Charlottesville, VA 22908 USA

Manunta, P:
 Univ Vita Salute San Raffaele, IRCCS San Raffaele Sci Inst, Genom Renal Dis & Hypertens Unit, I-20132 Milan, Italy

Masson, G:
 Amgen Inc, DeCODE Genet, IS-101 Reykjavik, Iceland

Matoba, N:
 RIKEN, Lab Stat Anal, Ctr Integrat Med Sci, Yokohama, Kanagawa 2300045, Japan

Mei, XW:
 Univ Oxford, Nuffield Dept Populat Hlth, Oxford OX3 7LF, England

Meisinger, C:
 Helmholtz Zentrum Munchen, Independent Res Grp Clin Epidemiol, D-85764 Neuherberg, Germany

Meitinger, T:
 Helmholtz Zentrum Muenchen, Inst Human Genet, D-85764 Neuherberg, Germany

 Tech Univ Munich, Inst Human Genet, D-81675 Munich, Germany

 DZHK German Ctr Cardiovasc Res, Partner Site Munich Heart Alliance, D-80802 Munich, Germany

Mezzavilla, M:
 IRCCS Burlo Garofolo, Inst Maternal & Child Hlth, Med Genet, Trieste, Italy

Milani, L:
 Univ Tartu, Inst Genom, Estonian Genome Ctr, EE-51010 Tartu, Estonia

Millwood, IY:
 Univ Oxford, Nuffield Dept Populat Hlth, Oxford OX3 7LF, England

Momozawa, Y:
 RIKEN, Lab Genotyping Dev, Ctr Integrat Med Sci, Yokohama, Kanagawa 2300045, Japan

Moore, A:
 NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA

Morange, PE:
 La Timone Hosp, Lab Haematol, Marseille, France

 Aix Marseille Univ, Ctr Cardiovasc & Nutr Res C2VN, INSERM, UMR S 1263, Marseille, France

Moreno-Macias, H:
 Univ Autonoma Metropolitana, Dept Econ, Mexico City 09340, DF, Mexico

Mori, TA:
 Univ Western Australia, Med Sch, Perth, WA 6009, Australia

Morrison, AC:
 Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Dept Epidemiol Human Genet & Environm Sci, Houston, TX 77030 USA

Muka, T:
 Erasmus MC, Dept Epidemiol, NL-3015 CN Rotterdam, Netherlands

 Univ Bern, ISPM, Bern, Switzerland

Murakami, Y:
 Univ Tokyo, Inst Med Sci, Div Mol Pathol, Tokyo 1088639, Japan

Murray, AD:
 Univ Aberdeen, Inst Med Sci, Aberdeen Biomed Imaging Ctr, Aberdeen AB25 2ZD, Scotland

de Mutsert, R:
 Leiden Univ, Dept Clin Epidemiol, Med Ctr, NL-2333 ZA Leiden, Netherlands

Mychaleckyj, JC:
 Univ Virginia, Sch Med, Ctr Publ Hlth Genom, Charlottesville, VA 22908 USA

Nalls, MA:
 Lab Neurogenet, Bethesda, MD 20892 USA

 Data Tecn Int LLC, Glen Echo, MD 20812 USA

Nauck, M:
 DZHK German Ctr Cardiovasc Res, Partner Site Greifswald, D-17475 Greifswald, Germany

 Univ Med Greifswald, Inst Clin Chem & Lab Med, D-17475 Greifswald, Germany

Neville, MJ:
 Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford OX3 7LJ, England

 Oxford Univ Hosp Trust, Oxford NIHR Biomed Res Ctr, Oxford, England

Nolte, IM:
 Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, NL-9700 RB Groningen, Netherlands

Ong, KK:
 Univ Cambridge, Sch Clin Med, MRC Epidemiol Unit, Cambridge CB2 0QQ, England

 Univ Cambridge, Dept Paediat, Sch Clin Med, Cambridge CB2 0QQ, England

Orozco, L:
 Inst Nacl Med Genom, Mexico City 14610, DF, Mexico

Padmanabhan, S:
 Univ Glasgow, Inst Cardiovasc & Med Sci, Glasgow G12 8TA, Lanark, Scotland

Palsson, G:
 Amgen Inc, DeCODE Genet, IS-101 Reykjavik, Iceland

Pankow, JS:
 Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN 55454 USA

Pattaro, C:
 Univ Lubeck, Affiliated Inst, Inst Biomed, Eurac Res, I-39100 Bolzano, Italy

Pattie, A:
 Univ Edinburgh, Dept Psychol, 7 George Sq, Edinburgh EH8 9JZ, Midlothian, Scotland

Polasek, O:
 Univ Split, Ctr Global Hlth, Fac Med, Split, Croatia

 Gen Info Ltd, Zagreb 10000, Croatia

Poulter, N:
 Imperial Coll London, Int Ctr Circulatory Hlth, London W2 1PG, England

 Imperial Coll London, Imperial Clin Trials Unit, London W12 7TA, England

Pramstaller, PP:
 Univ Lubeck, Affiliated Inst, Inst Biomed, Eurac Res, I-39100 Bolzano, Italy

Quintana-Murci, L:
 Inst Pasteur, Human Evolutionary Genet Unit, F-75015 Paris, France

 CNRS, UMR2000, F-75015 Paris, France

 Inst Pasteur, Ctr Bioinformat Biostat & Integrat Biol, F-75015 Paris, France

Raikkonen, K:
 Univ Helsinki, Fac Med, Dept Psychol & Logoped, Helsinki 00014, Finland

Ralhan, S:
 Hero Heart Inst, Ludhiana, Punjab, India

 Dyanand Med Coll & Hosp, Ludhiana, Punjab, India

Rao, DC:
 Washington Univ, Sch Med, Div Biostat, St Louis, MO 63110 USA

van Rheenen, W:
 Univ Utrecht, Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Dept Neurol, NL-3584 CX Utrecht, Netherlands

Rich, SS:
 Univ Virginia, Sch Med, Ctr Publ Hlth Genom, Charlottesville, VA 22908 USA

Ridker, PM:
 Brigham & Womens Hosp, Div Prevent Med, Boston, MA 02215 USA

 Harvard Med Sch, Boston, MA 02115 USA

Rietveld, CA:
 Erasmus Univ, Erasmus Sch Econ, Dept Appl Econ, NL-3062 PA Rotterdam, Netherlands

 Erasmus Univ, Inst Behav & Biol, NL-3062 PA Rotterdam, Netherlands

Robino, A:
 IRCCS Burlo Garofolo, Inst Maternal & Child Hlth, I-34137 Trieste, Italy

van Rooij, FJA:
 Erasmus MC, Dept Epidemiol, NL-3015 CN Rotterdam, Netherlands

Ruggiero, D:
 CNR, Inst Genet & Biophys A Buzzati Traverso, I-80131 Naples, Italy

 IRCCS Neuromed, I-86077 Pozzilli, IS, Italy

Saba, Y:
 Med Univ Graz, Gottfried Schatz Res Ctr Cell Signaling Metab & A, Div Mol Biol & Biochem, A-8010 Graz, Austria

Sabanayagam, C:
 Singapore Natl Eye Ctr, Singapore Eye Res Inst, Singapore 169856, Singapore

 Duke NUS Med Sch, Ophthalmol & Visual Sci Acad Clin Program Eye ACP, Singapore 169857, Singapore

 Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Ophthalmol, Singapore 119228, Singapore

Sabater-Lleal, M:
 Karolinska Inst, Ctr Mol Med, Dept Med Solna, Cardiovasc Med Unit, S-17176 Stockholm, Sweden

 IIB St Pau, Inst Recerca Hosp Santa Creu & St Pau, Unit Genom Complex Dis, Barcelona, Spain

Sala, CF:
 San Raffaele Res Inst, Milan, Italy

Salomaa, V:
 Natl Inst Hlth & Welf, Dept Publ Hlth Solut, FI-00271 Helsinki, Finland

Sandow, K:
 Harbor UCLA Med Ctr, Inst Translat Genom & Populat Sci, LABioMed, Div Genom Outcomes,Dept Pediat, Torrance, CA 90502 USA

Schmidt, H:
 Med Univ Graz, Gottfried Schatz Res Ctr Cell Signaling Metab & A, Div Mol Biol & Biochem, A-8010 Graz, Austria

Scott, LJ:
 Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA

 Univ Michigan, Ctr Stat Genet, Ann Arbor, MI 48109 USA

Scott, WR:
 Imperial Coll London, Dept Epidemiol & Biostat, London W2 1PG, England

Sedaghati-Khayat, B:
 Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Cellular & Mol Endocrine Res Ctr, Tehran 1983963113, Iran

Sennblad, B:
 Karolinska Inst, Ctr Mol Med, Dept Med Solna, Cardiovasc Med Unit, S-17176 Stockholm, Sweden

 Uppsala Univ, Sci Life Lab, Natl Bioinformat Infrastruct Sweden, Dept Cell & Mol Biol, SE-75237 Uppsala, Sweden

van Setten, J:
 Univ Utrecht, Univ Med Ctr Utrecht, Div Heart & Lungs, Dept Cardiol, NL-3485 CX Utrecht, Netherlands

Sever, PJ:
 Imperial Coll London, Int Ctr Circulatory Hlth, London W2 1PG, England

Sheu, WHH:
 Natl Def Med Ctr, Sch Med, Taipei, Taiwan

 Taichung Vet Gen Hosp, Dept Internal Med, Div Endocrinol & Metab, Taichung, Taiwan

 Natl Yang Ming Univ, Sch Med, Taipei, Taiwan

 Natl Chung Hsing Univ, Inst Med Technol, Taichung, Taiwan

Shi, Y:
 Singapore Natl Eye Ctr, Singapore Eye Res Inst, Singapore 169856, Singapore

Shrestha, S:
 CSIR Ctr Cellular & Mol Biol, Genom Res Complex Dis GRC Grp, Hyderabad 500007, Telangana, India

 Dayananda Sagar Univ, Sch Basic & Appl Sci, Bangalore 560078, Karnataka, India

Shukla, SR:
 KEM Hosp & Res Ctr, Diabet Unit, Pune 411101, Maharashtra, India

 Symbiosis Int Univ, Symbiosis Stat Inst, Pune 411007, Maharashtra, India

Sigurdsson, JK:
 Amgen Inc, DeCODE Genet, IS-101 Reykjavik, Iceland

Sikka, TT:
 Univ Tartu, Estonian Genome Ctr, EE-51010 Tartu, Estonia

Singh, JR:
 Panjab Univ, Chandigarh, India

Smith, BH:
 Univ Dundee, Ninewells Hosp & Med Sch, Div Populat Hlth Sci, Dundee DD1 9SY, Scotland

Stancakova, A:
 Univ Eastern Finland, Inst Clin Med, Internal Med, Kuopio, Finland

Stanton, A:
 Royal Coll Surgeons Ireland, Beaumont Hosp, RCSI Educ Res Ctr, RCSI Mol & Cellular Therapeut MCT, Dublin 9, Ireland

Starr, JM:
 Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh EH8 9JZ, Midlothian, Scotland

 Univ Edinburgh, Alzheimer Scotland Dementia Res Ctr, Edinburgh EH8 9JZ, Midlothian, Scotland

Stefansdottir, L:
 Amgen Inc, DeCODE Genet, IS-101 Reykjavik, Iceland

Straker, L:
 Curtin Univ, Sch Physiotherapy & Exercise Sci, Fac Hlth Sci, Perth, WA 6102, Australia

Sulem, P:
 Amgen Inc, DeCODE Genet, IS-101 Reykjavik, Iceland

Sveinbjornsson, G:
 Amgen Inc, DeCODE Genet, IS-101 Reykjavik, Iceland

Swertz, MA:
 Univ Groningen, Univ Med Ctr Groningen, Dept Genet, NL-9700 RB Groningen, Netherlands

Taylor, AM:
 Univ Edinburgh, Dept Psychol, 7 George Sq, Edinburgh EH8 9JZ, Midlothian, Scotland

Taylor, KD:
 Harbor UCLA Med Ctr, Inst Translat Genom & Populat Sci, LABioMed, Div Genom Outcomes,Dept Pediat, Torrance, CA 90502 USA

Terzikhan, N:
 Erasmus MC, Dept Epidemiol, NL-3015 CN Rotterdam, Netherlands

 Ghent Univ Hosp, Dept Resp Med, B-9000 Ghent, Belgium

Tham, YC:
 Singapore Natl Eye Ctr, Singapore Eye Res Inst, Singapore 169856, Singapore

 Duke NUS Med Sch, Ophthalmol & Visual Sci Acad Clin Program Eye ACP, Singapore 169857, Singapore

Thorleifsson, G:
 Amgen Inc, DeCODE Genet, IS-101 Reykjavik, Iceland

Thorsteinsdottir, U:
 Amgen Inc, DeCODE Genet, IS-101 Reykjavik, Iceland

 Univ Iceland, Sch Hlth Sci, Fac Med, IS-101 Reykjavik, Iceland

Tillander, A:
 Karolinska Inst, Dept Med Epidemiol & Biostat, S-17177 Stockholm, Sweden

Tracy, RP:
 Univ Vermont, Dept Pathol, Colchester, VT 05446 USA

Tusie-Luna, T:
 Univ Nacl Autonoma Mexico, Dept Med Genom & Toxicol Ambiental, Inst Invest Biomed, Mexico City 04510, DF, Mexico

 Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Unidad Biol Mol & Med Genom, Mexico City 14080, DF, Mexico

Tzoulaki, I:
 Imperial Coll London, Dept Epidemiol & Biostat, London W2 1PG, England

 Imperial Coll London, MRC PHE Ctr Environm & Hlth, London W2 1PG, England

 Univ Ioannina, Dept Hyg & Epidemiol, Med Sch, Ioannina 45110, Greece

Vaccargiu, S:
 Natl Res Council Italy, Inst Genet & Biomed Res Support Unity, Rome, Italy

Vangipurapu, J:
 Univ Eastern Finland, Inst Clin Med, Internal Med, Kuopio, Finland

Veldink, JH:
 Univ Utrecht, Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Dept Neurol, NL-3584 CX Utrecht, Netherlands

Vitart, V:
 Univ Edinburgh, Inst Genet & Mol Med, MRC Human Genet Unit, Edinburgh EH4 2XU, Midlothian, Scotland

Volker, U:
 Univ Med Greifswald, Interfaculty Inst Genet & Funct Genom, D-17475 Greifswald, Germany

 DZHK German Ctr Cardiovasc Res, Partner Site Greifswald, D-17475 Greifswald, Germany

Vuoksimaa, E:
 Univ Helsinki, Inst Mol Med Finland FIMM, FI-00014 Helsinki, Finland

Wakil, SM:
 King Faisal Specialist Hosp & Res Ctr, Dept Genet, Riyadh 12713, Saudi Arabia

Waldenberger, M:
 German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Epidemiol, Res Unit Mol Epidemiol, D-85764 Neuherberg, Germany

Wander, GS:
 Dayanand Med Coll & Hosp, Hero DMC Heart Inst, Dept Cardiol, Ludhiana 141001, Punjab, India

Wang, YX:
 Capital Med Univ, Beijing Ophthalmol & Visual Sci Key Lab, Beijing Inst Ophthalmol, Beijing Tongren Eye Ctr,Beijing Tongren Hosp, Beijing 100005, Peoples R China

Wareham, NJ:
 Univ Cambridge, Sch Clin Med, MRC Epidemiol Unit, Cambridge CB2 0QQ, England

Wild, S:
 Univ Edinburgh, Usher Inst Populat Hlth & Informat, Ctr Populat Hlth Sci, Edinburgh EH8 9AG, Midlothian, Scotland

Yajnik, CS:
 KEM Hosp Res Ctr, Diabet Unit, Pune 411011, Maharashtra, India

Yuan, JM:
 Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15260 USA

Zhang, L:
 Singapore Natl Eye Ctr, Singapore Eye Res Inst, Singapore 169856, Singapore

Zhou, J:
 NHGRI, Ctr Res Genom & Global Hlth, NIH, Bethesda, MD 20892 USA

Amin, N:
 Erasmus MC, Dept Epidemiol, NL-3015 CN Rotterdam, Netherlands

Asselbergs, FW:
 Univ Utrecht, Univ Med Ctr Utrecht, Div Heart & Lungs, Dept Cardiol, NL-3584 CX Utrecht, Netherlands

 UCL, Fac Populat Hlth Sci, Inst Cardiovasc Sci, London WC1E 6DD, England

 Netherlands Heart Inst, Durrer Ctr Cardiovasc Res, Utrecht, Netherlands

 UCL, Farr Inst Hlth Informat Res, London, England

 UCL, Inst Hlth Informat, London, England

Bakker, SJL:
 Univ Groningen, Univ Med Ctr Groningen, Dept Internal Med, NL-9713 GZ Groningen, Netherlands

Becker, DM:
 Johns Hopkins Univ, Sch Med, GeneSTAR Res Program, Dept Med, Baltimore, MD 21287 USA

Lehne, B:
 Imperial Coll London, Dept Epidemiol & Biostat, London W2 1PG, England

Bennett, DA:
 Rush Univ, Med Ctr, Rush Alzheimers Dis Ctr, Chicago, IL 60612 USA

 Rush Univ, Med Ctr, Dept Neurol Sci, Chicago, IL 60612 USA

den Berg, LH:
 Univ Utrecht, Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Dept Neurol, NL-3584 CX Utrecht, Netherlands

Berndt, SI:
 NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA

Bharadwaj, D:
 Jawaharlal Nehru Univ, Sch Biotechnol, Syst Genom Lab, New Delhi 110067, India

Bielak, LF:
 Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA

Bochud, M:
 Univ Lausanne, Ctr Primary Care & Publ Hlth Unisante, Lausanne, Switzerland

Boehnke, M:
 Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA

 Univ Michigan, Ctr Stat Genet, Ann Arbor, MI 48109 USA

Bouchard, C:
 Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA

Bradfield, JP:
 Childrens Hosp Philadelphia, Div Human Genet, Ctr Appl Genom, Philadelphia, PA 19104 USA

 Quantinuum Res LLC, San Diego, CA 92101 USA

Brody, JA:
 Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA 98101 USA

Campbell, A:
 Univ Edinburgh, Inst Genet & Mol Med, Ctr Genom & Expt Med, Edinburgh EH4 2XU, Midlothian, Scotland

Carmi, S:
 Hebrew Univ Jerusalem, Hadassah Med Ctr, Braun Sch Publ Hlth, Jerusalem, Israel

Caulfield, MJ:
 Queen Mary Univ London, Barts & London Sch Med & Dent, NIHR Barts Cardiovasc Biomed Res Ctr, London EC1M 6BQ, England

 Queen Mary Univ London, William Harvey Res Inst, Barts & London Sch Med & Dent, Dept Clin Pharmacol, London EC1M 6BQ, England

Cesarini, D:
 NYU, Dept Econ, Ctr Expt Social Sci, New York, NY 10003 USA

 Res Inst Ind Econ IFN, S-10215 Stockholm, Sweden

Chambers, JC:
 Imperial Coll London, Dept Epidemiol & Biostat, London W2 1PG, England

 Ealing Gen Hosp, Dept Cardiol, Middlesex UB1 3HW, England

 Imperial Coll London, MRC PHE Ctr Environm & Hlth, London W2 1PG, England

 Nanyang Technol Univ, Lee Kong Chian Sch Med, Singapore 308232, Singapore

 Imperial Coll Healthcare NHS Trust, London W12 0HS, England

Chandak, GR:
 CSIR Ctr Cellular & Mol Biol, Genom Res Complex Dis GRC Grp, Hyderabad 500007, Telangana, India

Cheng, CY:
 Singapore Natl Eye Ctr, Singapore Eye Res Inst, Singapore 169856, Singapore

 Duke NUS Med Sch, Ophthalmol & Visual Sci Acad Clin Program Eye ACP, Singapore 169857, Singapore

 Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Ophthalmol, Singapore 119228, Singapore

Ciullo, M:
 CNR, Inst Genet & Biophys A Buzzati Traverso, I-80131 Naples, Italy

 IRCCS Neuromed, I-86077 Pozzilli, IS, Italy

Cornelis, M:
 Northwestern Univ, Dept Prevent Med, Feinberg Sch Med, Chicago, IL 60611 USA

Cusi, D:
 Univ Milan, Dept Hlth Sci, I-20139 Milan, Italy

 Natl Res Council Italy CNR, Inst Biomed Technol Milano, I-20090 Milan, Italy

 Bio4Dreams Business Nursery Life Sci, Bio4Dreams SRL, Bio4Dreams Sci Unit, I-20121 Milan, Italy

Smith, GD:
 Univ Bristol, MRC Integrat Epidemiol Unit, Bristol BS8 2BN, Avon, England

 Univ Bristol Sch Med, Populat Hlth Sci, Bristol BS8 2BY, Avon, England

Deary, IJ:
 Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh EH8 9JZ, Midlothian, Scotland

 Univ Edinburgh, Dept Psychol, 7 George Sq, Edinburgh EH8 9JZ, Midlothian, Scotland

Dorajoo, R:
 Agcy Sci Technol & Res, Genome Inst Singapore, Human Genet, Singapore 138672, Singapore

van Duijn, CM:
 Univ Oxford, Nuffield Dept Populat Hlth, Oxford OX3 7LF, England

 Erasmus MC, Dept Epidemiol, NL-3015 CN Rotterdam, Netherlands

Ellinghaus, D:
 Christian Albrechts Univ Kiel, Inst Clin Mol Biol, D-24105 Kiel, Germany

Erdmann, J:
 Univ Lubeck, Inst Cardiogenet, D-23562 Lubeck, Germany

Eriksson, JG:
 Univ Helsinki, Dept Gen Practice & Primary Hlth Care, Tukholmankatu 8 B, Helsinki 00014, Finland

 Natl Inst Hlth & Welf, Helsinki, Finland

 Univ Helsinki, Unit Gen Practice, Cent Hosp, Helsinki, Finland

 Folkhalsan Res Ctr, Helsinki, Finland

 Vasa Cent Hosp, Vaasa, Finland

Evangelou, E:
 Imperial Coll London, Dept Epidemiol & Biostat, London W2 1PG, England

 Univ Ioannina, Dept Hyg & Epidemiol, Med Sch, Ioannina 45110, Greece

Evans, MK:
 NIA, Lab Epidemiol & Populat Sci, NIH, Baltimore, MD 21224 USA

Faul, JD:
 Univ Michigan, Inst Social Res, Survey Res Ctr, Ann Arbor, MI 48014 USA

Feenstra, B:
 Statens Serum Inst, Dept Epidemiol Res, DK-2300 Copenhagen, Denmark

Feitosa, M:
 Washington Univ, Sch Med, Dept Genet, Div Stat Genom, St Louis, MO 63110 USA

Foisy, S:
 Montreal Heart Inst, Montreal, PQ, Canada

Franke, A:
 Christian Albrechts Univ Kiel, Inst Clin Mol Biol, D-24105 Kiel, Germany

Friedlander, Y:
 Hebrew Univ Jerusalem, Hadassah Med Ctr, Braun Sch Publ Hlth, Jerusalem, Israel

Gasparini, P:
 Univ Trieste, Dept Med Surg & Hlth Sci, Trieste, Italy

 IRCCS Burlo Garofolo, Inst Maternal & Child Hlth, Med Genet, Trieste, Italy

Gieger, C:
 German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Epidemiol, Res Unit Mol Epidemiol, D-85764 Neuherberg, Germany

 German Ctr Diabet Res DZD, Munich, Germany

Gonzalez, C:
 Inst Nacl Salud Publ, Ctr Invest Salud Poblac, Ctr Estudios Diabet, Unidad Invest Diabet & Riesgo Cardiovasc, Cuernavaca 01120, Morelos, Mexico

Goyette, P:
 Montreal Heart Inst, Montreal, PQ, Canada

Grant, SFA:
 Univ Penn, Perelman Sch Med, Dept Genet, Philadelphia, PA 19104 USA

 Childrens Hosp Philadelphia, Div Human Genet, Ctr Appl Genom, Philadelphia, PA 19104 USA

 Univ Penn, Perelman Sch Med, Dept Pediat, Philadelphia, PA 19104 USA

Griffiths, LR:
 Queensland Univ Technol, Inst Hlth & Biomed Innovat, Sch Biomed Sci, Genom Res Ctr, Brisbane, Qld 4059, Australia

Groop, L:
 Univ Helsinki, Finnish Inst Mol Med, Helsinki, Finland

 Lund Univ, Skane Univ Hosp, Diabet Ctr, Dept Clin Sci Diabet & Endocrinol, S-20502 Malmo, Sweden

Gudnason, V:
 Iceland Heart Assoc, IS-201 Kopavogur, Iceland

 Univ Iceland, Sch Hlth Sci, Fac Med, IS-101 Reykjavik, Iceland

Gyllensten, U:
 Uppsala Univ, Sci Life Lab, Dept Immunol Genet & Pathol, S-75108 Uppsala, Sweden

Hakonarson, H:
 Childrens Hosp Philadelphia, Div Human Genet, Ctr Appl Genom, Philadelphia, PA 19104 USA

 Univ Penn, Perelman Sch Med, Dept Pediat, Philadelphia, PA 19104 USA

Hamsten, A:
 Ctr Mol Med, Dept Med Solna, Cardiovasc Med Unit, S-17176 Stockholm, Sweden

van der Harst, P:
 Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, NL-9713 GZ Groningen, Netherlands

Heng, CK:
 Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Paediat, Singapore, Singapore

 Natl Univ Hlth Syst, Khoo Teck Puat Natl Univ, Childrens Med Inst, Singapore, Singapore

Hicks, AA:
 Univ Lubeck, Affiliated Inst, Inst Biomed, Eurac Res, I-39100 Bolzano, Italy

Hochner, H:
 Hebrew Univ Jerusalem, Hadassah Med Ctr, Braun Sch Publ Hlth, Jerusalem, Israel

Huikuri, H:
 Univ Oulu, Med Res Ctr Oulu, Res Unit Internal Med, Oulu 90014, Finland

 Oulu Univ Hosp, Oulu 90014, Finland

Hunt, SC:
 Weill Cornell Med Qatar, Dept Genet Med, Doha, Qatar

 Univ Utah, Sch Med, Dept Internal Med, Div Epidemiol, Salt Lake City, UT 84108 USA

Jaddoe, VWV:
 Erasmus MC, Dept Epidemiol, NL-3015 CN Rotterdam, Netherlands

 Erasmus MC, Generat R Study Grp, NL-3015 CN Rotterdam, Netherlands

 Erasmus MC, Dept Pediat, NL-3015 CN Rotterdam, Netherlands

De Jager, PL:
 Columbia Univ, Med Ctr, Dept Neurol, Ctr Translat & Computat Neuroimmunol, 650 West 168th St,PH19-311, New York, NY 10032 USA

 Broad Inst, Cell Circuits Program, Cambridge, MA 02142 USA

Johannesson, M:
 Stockholm Sch Econ, Dept Econ, SE-11383 Stockholm, Sweden

Johansson, A:
 Uppsala Univ, Sci Life Lab, Dept Immunol Genet & Pathol, S-75108 Uppsala, Sweden

Jonas, JB:
 Capital Med Univ, Beijing Ophthalmol & Visual Sci Key Lab, Beijing Inst Ophthalmol, Beijing Tongren Eye Ctr,Beijing Tongren Hosp, Beijing 100005, Peoples R China

 Heidelberg Univ, Dept Ophthalmol, Med Fac Mannheim, D-698167 Mannheim, Germany

Jukema, JW:
 Leiden Univ, Med Ctr, Dept Cardiol, NL-2300 RC Leiden, Netherlands

Junttila, J:
 Univ Oulu, Med Res Ctr Oulu, Res Unit Internal Med, Oulu 90014, Finland

 Oulu Univ Hosp, Oulu 90014, Finland

Kaprio, J:
 Univ Helsinki, Finnish Inst Mol Med, Helsinki, Finland

 Univ Helsinki, Dept Publ Hlth, FI-00014 Helsinki, Finland

Kardia, SLR:
 Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA

Karpe, F:
 Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford OX3 7LJ, England

 Oxford Univ Hosp NHS Fdn Trust, John Radcliffe Hosp, Oxford NIHR Biomed Res Ctr, Oxford OX3 9DU, England

Kumari, M:
 Univ Essex, Inst Social & Econ Res, Colchester CO4 3SQ, Essex, England

Laakso, M:
 Univ Eastern Finland, Inst Clin Med, Internal Med, Kuopio, Finland

 Kuopio Univ Hosp, Kuopio, Finland

van der Laan, SW:
 Univ Utrecht, Univ Med Ctr Utrecht, Div Labs & Pharm, Lab Clin Chem & Hematol, NL-3584 CX Utrecht, Netherlands

Lahti, J:
 Univ Helsinki, Fac Med, Dept Psychol & Logoped, Helsinki 00014, Finland

 Univ Helsinki, Helsinki Coll Adv Studies, Helsinki 00014, Finland

Laudes, M:
 Univ Hosp Schleswig Holstein UKSH, Campus Kiel, D-24105 Kiel, Germany

Lea, RA:
 Queensland Univ Technol, Inst Hlth & Biomed Innovat, Sch Biomed Sci, Genom Res Ctr, Brisbane, Qld 4059, Australia

Lieb, W:
 Univ Kiel, Inst Epidemiol, D-24105 Kiel, Schleswig Holst, Germany

 Univ Kiel, PopGen Biobank, D-24105 Kiel, Schleswig Holst, Germany

Lumley, T:
 Univ Auckland, Dept Stat, Auckland, New Zealand

Martin, NG:
 QIMR Berghofer Inst Med Res, Brisbane, Qld, Australia

Marz, W:
 Heidelberg Univ, Med Fac Mannheim, Dept Med 5, Nephrol,Hypertensiol,Rheumatol,Endocrinol,Diabeto, D-68167 Mannheim, Germany

 Med Univ Graz, Clin Inst Med & Chem Lab Diagnost, Graz, Austria

 Synlab Holding Deutschland GmbH, Synlab Acad, Mannheim, Germany

Matullo, G:
 Univ Turin, IIGM, I-10126 Turin, Italy

 Univ Turin, Dept Med Sci, I-10126 Turin, Italy

McCarthy, MI:
 Univ Oxford, Wellcome Ctr Human Genet, Oxford OX3 7BN, England

 Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford OX3 7LJ, England

 Oxford Univ Hosp NHS Fdn Trust, John Radcliffe Hosp, Oxford NIHR Biomed Res Ctr, Oxford OX3 9DU, England

Medland, SE:
 QIMR Berghofer Inst Med Res, Brisbane, Qld, Australia

Merriman, TR:
 Univ Otago, Dept Biochem, Dunedin 9054, New Zealand

Metspalu, A:
 Univ Tartu, Estonian Genome Ctr, EE-51010 Tartu, Estonia

Meyer, BF:
 King Faisal Specialist Hosp & Res Ctr, Dept Genet, Riyadh 11211, Saudi Arabia

Mohlke, KL:
 Univ N Carolina, Dept Genet, Chapel Hill, NC 27599 USA

Montgomery, GW:
 QIMR Berghofer Inst Med Res, Brisbane, Qld, Australia

 Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia

Mook-Kanamori, D:
 Leiden Univ, Dept Clin Epidemiol, Med Ctr, NL-2333 ZA Leiden, Netherlands

 Leiden Univ, Dept Publ Hlth Primary Care, Med Ctr, NL-2333 ZA Leiden, Netherlands

Munroe, PB:
 Queen Mary Univ London, Barts & London Sch Med & Dent, NIHR Barts Cardiovasc Biomed Res Ctr, London EC1M 6BQ, England

 Queen Mary Univ London, William Harvey Res Inst, Barts & London Sch Med & Dent, Dept Clin Pharmacol, London EC1M 6BQ, England

North, KE:
 Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27514 USA

Nyholt, DR:
 QIMR Berghofer Inst Med Res, Brisbane, Qld, Australia

 Queensland Univ Technol, Inst Hlth & Biomed Innovat, Sch Biomed Sci, Kelvin Grove, Qld 4059, Australia

O'connell, JR:
 Univ Maryland, Sch Med, Dept Med, Div Endocrinol Diabet & Nutr, Baltimore, MD 21201 USA

 Univ Maryland, Sch Med, Dept Med, Program Personalized & Genom Med, Baltimore, MD 21201 USA

Ober, C:
 Univ Chicago, Dept Human Genet, Chicago, IL 60637 USA

Oldehinkel, AJ:
 Univ Groningen, Univ Med Ctr Groningen, Interdisciplinary Ctr Psychopathol & Emot Regulat, Dept Psychiat, NL-9700 RB Groningen, Netherlands

Palmas, W:
 Columbia Univ, Dept Med, Med Ctr, New York, NY USA

Palmer, C:
 Univ Dundee, Sch Med, Pat Macpherson Ctr Pharmacogenet & Pharmacogen, Dundee DD1 9SY, Scotland

Pasterkamp, GG:
 Univ Utrecht, Univ Med Ctr Utrecht, Div Labs & Pharm, Lab Clin Chem & Hematol, NL-3584 CX Utrecht, Netherlands

Patin, E:
 Inst Pasteur, Human Evolutionary Genet Unit, F-75015 Paris, France

 CNRS, UMR2000, F-75015 Paris, France

 Inst Pasteur, Ctr Bioinformat Biostat & Integrat Biol, F-75015 Paris, France

Pennell, CE:
 Univ Newcastle, Fac Med & Hlth, Sch Med & Publ Hlth, Newcastle, NSW, Australia

 Univ Western Australia, Div Obstet & Gynaecol, Perth, WA 6009, Australia

Perusse, L:
 Laval Univ, Dept Kinesiol, Quebec City, PQ G1V 0A6, Canada

 Laval Univ, Inst Nutr & Funct Foods, Quebec City, PQ G1V 0A6, Canada

Peyser, PA:
 Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA

Pirastu, M:
 Natl Res Council Italy, Inst Genet & Biomed Res Support Unity, I-07100 Sassari, Italy

Polderman, TJC:
 Vrije Univ Amsterdam, Ctr Neurogenom & Cognit Res, Dept Complex Trait Genet, NL-1081 HV Amsterdam, Netherlands

Porteous, DJ:
 Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh EH8 9JZ, Midlothian, Scotland

 Univ Edinburgh, Inst Genet & Mol Med, Ctr Genom & Expt Med, Edinburgh EH4 2XU, Midlothian, Scotland

Posthuma, D:
 Vrije Univ Amsterdam, Ctr Neurogenom & Cognit Res, Dept Complex Trait Genet, NL-1081 HV Amsterdam, Netherlands

 Vrije Univ Amsterdam Med Ctr, Amsterdam Neurosci, Dept Clin Genet, NL-1081 HV Amsterdam, Netherlands

Psaty, BM:
 Univ Washington, Cardiovasc Hlth Res Unit, Dept Epidemiol, Seattle, WA 98101 USA

 Univ Washington, Cardiovasc Hlth Res Unit, Dept Med, Seattle, WA 98101 USA

 Univ Washington, Cardiovasc Hlth Res Unit, Dept Hlth Serv, Seattle, WA 98101 USA

 Kaiser Permanente, Washington Hlth Res Inst, Seattle, WA 98101 USA

Rioux, JD:
 Montreal Heart Inst, Montreal, PQ, Canada

 Univ Montreal, Fac Med, Dept Med, Montreal, PQ H3T 1J4, Canada

Rivadeneira, F:
 Erasmus MC, Dept Internal Med, NL-3015 CN Rotterdam, Netherlands

 Erasmus MC, Dept Epidemiol, NL-3015 CN Rotterdam, Netherlands

 Erasmus MC, Generat R Study Grp, NL-3015 CN Rotterdam, Netherlands

Rotimi, C:
 NHGRI, Ctr Res Genom & Global Hlth, NIH, Bethesda, MD 20892 USA

Rotter, JI:
 Harbor UCLA Med Ctr, Inst Translat Genom & Populat Sci, LABioMed, Div Genom Outcomes,Dept Pediat, Torrance, CA 90502 USA

Rudan, I:
 Univ Edinburgh, Usher Inst, Ctr Global Hlth Res, Edinburgh EH8 9AG, Midlothian, Scotland

Den Ruijter, HM:
 Univ Utrecht, Univ Med Ctr Utrecht, Div Heart & Lungs, Lab Expt Cardiol, NL-3584 CX Utrecht, Netherlands

Sanghera, DK:
 Univ Oklahoma, Hlth Sci Ctr, Coll Med, Dept Pediat, Oklahoma City, OK 73104 USA

 Oklahoma Ctr Neurosci, Oklahoma City, OK 73104 USA

Sattar, N:
 Univ Glasgow, Inst Cardiovasc & Med Sci, Glasgow G12 8TA, Lanark, Scotland

Schmidt, R:
 Med Univ Graz, Clin Div Neurogeriatr, Dept Neurol, A-8036 Graz, Austria

Schulze, MB:
 German Inst Human Nutr Potsdam Rehbrucke, Dept Mol Epidemiol, Nuthetal, Germany

 German Ctr Diabet Res DZD, Munich, Germany

 Univ Potsdam, Inst Nutr Sci, Nuthetal, Germany

Schunkert, H:
 DZHK, Munich Heart Alliance, D-80636 Munich, Germany

Scott, RA:
 Univ Cambridge, Sch Clin Med, MRC Epidemiol Unit, Cambridge CB2 0QQ, England

Shuldiner, AR:
 Univ Maryland, Sch Med, Dept Med, Div Endocrinol Diabet & Nutr, Baltimore, MD 21201 USA

 Univ Maryland, Sch Med, Dept Med, Program Personalized & Genom Med, Baltimore, MD 21201 USA

 Regeneron Pharmaceut Inc, Regeneron Genet Ctr, Tarrytown, NY 10591 USA

Sim, X:
 Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore 117549, Singapore

Small, N:
 Univ Bradford, Fac Hlth Studies, Bradford BD7 1DP, W Yorkshire, England

Smith, JA:
 Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA

 Univ Michigan, Inst Social Res, Survey Res Ctr, Ann Arbor, MI 48014 USA

Sotoodehnia, N:
 Univ Washington, Div Cardiol, Cardiovasc Hlth Res Unit, Seattle, WA 98101 USA

Tai, ES:
 Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore 117549, Singapore

 Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Med, Singapore 119228, Singapore

 Natl Univ Singapore, Duke NUS Med Sch, Singapore 169857, Singapore

Teumer, A:
 DZHK German Ctr Cardiovasc Res, Partner Site Greifswald, D-17475 Greifswald, Germany

 Univ Med Greifswald, Inst Community Med, D-17475 Greifswald, Germany

Timpson, NJ:
 Univ Bristol, MRC Integrat Epidemiol Unit, Bristol BS8 2BN, Avon, England

 Univ Bristol, Bristol Med Sch, Dept Populat Hlth Sci, Bristol BS8 2PR, Avon, England

 Univ Bristol, Avon Longitudinal Study Parents & Children ALSPAC, Bristol BS8 2PR, Avon, England

Toniolo, D:
 San Raffaele Res Inst, Milan, Italy

Tregouet, DA:
 Sorbonne Univ, INSERM, UMR S 1166, F-75013 Paris, France

Tuomi, T:
 Univ Helsinki, Inst Mol Med Finland, Helsinki, Finland

 Folkhalsan Res Ctr, Helsinki, Finland

 Univ Helsinki, Helsinki Univ Hosp, Abdominal Ctr, Endocrinol, Helsinki, Finland

 Univ Helsinki, Res Program Diabet & Endocrinol, Helsinki, Finland

Vollenweider, P:
 Lausanne Univ Hosp, Dept Med, Internal Med, CH-1011 Lausanne, Switzerland

Wang, CA:
 Univ Newcastle, Fac Med & Hlth, Sch Med & Publ Hlth, Newcastle, NSW, Australia

 Univ Western Australia, Div Obstet & Gynaecol, Perth, WA 6009, Australia

Weir, DR:
 Univ Michigan, Inst Social Res, Survey Res Ctr, Ann Arbor, MI 48014 USA

Whitfield, JB:
 QIMR Berghofer Inst Med Res, Brisbane, Qld, Australia

Wijmenga, C:
 Univ Groningen, Univ Med Ctr Groningen, Dept Genet, NL-9700 RB Groningen, Netherlands

Wong, TY:
 Singapore Natl Eye Ctr, Singapore Eye Res Inst, Singapore 169856, Singapore

 Duke NUS Med Sch, Ophthalmol & Visual Sci Acad Clin Program Eye ACP, Singapore 169857, Singapore

Wright, J:
 Bradford Teaching Hosp NHS Trust, Bradford Inst Hlth Res, Bradford BD9 6RJ, W Yorkshire, England

Yang, J:
 Rush Univ, Med Ctr, Rush Alzheimers Dis Ctr, Chicago, IL 60612 USA

 Rush Univ, Med Ctr, Dept Neurol Sci, Chicago, IL 60612 USA

Yu, L:
 Rush Univ, Med Ctr, Rush Alzheimers Dis Ctr, Chicago, IL 60612 USA

 Rush Univ, Med Ctr, Dept Neurol Sci, Chicago, IL 60612 USA

Zemel, BS:
 Univ Penn, Perelman Sch Med, Dept Pediat, Philadelphia, PA 19104 USA

 Childrens Hosp Philadelphia, Div Gastroenterol Hepatol & Nutr, Philadelphia, PA 19146 USA

Zonderman, AB:
 NIA, Lab Epidemiol & Populat Sci, NIH, Baltimore, MD 21224 USA

Perola, M:
 Natl Inst Hlth & Welf, Unit Genom & Biomarkers, Helsinki 00271, Finland

Magnusson, PKE:
 Karolinska Inst, Dept Med Epidemiol & Biostat, S-17177 Stockholm, Sweden

Uitterlinden, AG:
 Erasmus MC, Dept Internal Med, NL-3015 CN Rotterdam, Netherlands

 Erasmus MC, Dept Epidemiol, NL-3015 CN Rotterdam, Netherlands

 Erasmus MC, Generat R Study Grp, NL-3015 CN Rotterdam, Netherlands

Kooner, JS:
 Ealing Gen Hosp, Dept Cardiol, Middlesex UB1 3HW, England

 Imperial Coll London, MRC PHE Ctr Environm & Hlth, London W2 1PG, England

 Imperial Coll Healthcare NHS Trust, London W12 0HS, England

 Imperial Coll London, Natl Heart & Lung Inst, London W12 0NN, England

Chasman, DI:
 Brigham & Womens Hosp, Div Prevent Med, Boston, MA 02215 USA

 Harvard Med Sch, Boston, MA 02115 USA

Loos, RJF:
 Ichan Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA

 Icahn Sch Med Mt Sinai, Mindich Child Hlth & Dev Inst, New York, NY 10029 USA

Franceschini, N:
 Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27514 USA

Franke, L:
 Univ Groningen, Univ Med Ctr Groningen, Dept Genet, NL-9700 RB Groningen, Netherlands

Haley, CS:
 Univ Edinburgh, Inst Genet & Mol Med, MRC Human Genet Unit, Edinburgh EH4 2XU, Midlothian, Scotland

 Univ Edinburgh, Roslin Inst, Easter Bush EH25 9RG, Midlothian, Scotland

 Univ Edinburgh, Royal Dick Sch Vet Studies, Easter Bush EH25 9RG, Midlothian, Scotland

Hayward, C:
 Univ Edinburgh, Inst Genet & Mol Med, MRC Human Genet Unit, Edinburgh EH4 2XU, Midlothian, Scotland

Walters, RG:
 Univ Oxford, Nuffield Dept Populat Hlth, Oxford OX3 7LF, England

Perry, JRB:
 Univ Cambridge, Sch Clin Med, MRC Epidemiol Unit, Cambridge CB2 0QQ, England

Esko, T:
 Univ Tartu, Estonian Genome Ctr, EE-51010 Tartu, Estonia

 Broad Inst, Program Med & Populat Genet, Cambridge, MA 02142 USA

Helgason, A:
 Amgen Inc, DeCODE Genet, IS-101 Reykjavik, Iceland

 Univ Iceland, Dept Anthropol, IS-101 Reykjavik, Iceland

Stefansson, K:
 Amgen Inc, DeCODE Genet, IS-101 Reykjavik, Iceland

 Univ Iceland, Sch Hlth Sci, Fac Med, IS-101 Reykjavik, Iceland

Joshi, PK:
 Univ Edinburgh, Usher Inst, Ctr Global Hlth Res, Edinburgh EH8 9AG, Midlothian, Scotland

Kubo, M:
 RIKEN, Lab Genotyping Dev, Ctr Integrat Med Sci, Yokohama, Kanagawa 2300045, Japan

Wilson, JF:
 Univ Edinburgh, Usher Inst, Ctr Global Hlth Res, Edinburgh EH8 9AG, Midlothian, Scotland

 Univ Edinburgh, Inst Genet & Mol Med, MRC Human Genet Unit, Edinburgh EH4 2XU, Midlothian, Scotland
ISSN: 20411723





Nature Communications
Editorial
NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND, Reino Unido
Tipo de documento: Article
Volumen: 10 Número:
Páginas:
WOS Id: 000493438700005
ID de PubMed: 31673082
imagen Gold, Green Published, Green Accepted

MÉTRICAS