The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer


Por: Figlioli, G, Bogliolo, M, Catucci, I, Caleca, L, Lasheras, SV, Pujol, R, Kiiski, JI, Muranen, TA, Barnes, DR, Dennis, J, Michailidou, K, Bolla, MK, Leslie, G, Aalfs, CM, Adank, MA, Adlard, J, Agata, S, Cadoo, K, Agnarsson, BA, Ahearn, T, Aittomaki, K, Ambrosone, CB, Andrews, L, Anton-Culver, H, Antonenkova, NN, Arndt, V, Arnold, N, Aronson, KJ, Arun, BK, Asseryanis, E, Auber, B, Auvinen, P, Azzollini, J, Balmana, J, Barkardottir, RB, Barrowdale, D, Barwell, J, Freeman, LEB, Beauparlant, CJ, Beckmann, MW, Behrens, S, Benitez, J, Berger, R, Bermisheva, M, Blanco, AM, Blomqvist, C, Bogdanova, NV, Bojesen, A, Bojesen, SE, Bonanni, B, Borg, A, Brady, AF, Brauch, H, Brenner, H, Bruning, T, Burwinkel, B, Buys, SS, Caldes, T, Caliebe, A, Caligo, MA, Campa, D, Campbell, IG, Canzian, F, Castelao, JE, Chang-Claude, J, Chanock, SJ, Claes, KBM, Clarke, CL, Collavoli, A, Conner, TA, Cox, DG, Cybulski, C, Czene, K, Daly, MB, de la Hoya, M, Devilee, P, Diez, O, Ding, YC, Dite, GS, Ditsch, N, Domchek, SM, Dorfling, CM, dos-Santos-Silva, I, Durda, K, Dwek, M, Eccles, DM, Ekici, AB, Eliassen, AH, Ellberg, C, Eriksson, M, Evans, DG, Fasching, PA, Figueroa, J, Flyger, H, Foulkes, WD, Friebel, TM, Friedman, E, Gabrielson, M, Gaddam, P, Gago-Dominguez, M, Gao, C, Gapstur, SM, Garber, J, Garcia-Closas, M, Garcia-Saenz, JA, Gaudet, MM, Gayther, SA, Giles, GG, Glendon, G, Godwin, AK, Goldberg, MS, Goldgar, DE, Guenel, P, Gutierrez-Barrera, AM, Haeberle, L, Haiman, CA, Hakansson, N, Hall, P, Hamann, U, Harrington, PA, Hein, A, Heyworth, J, Hillemanns, P, Hollestelle, A, Hopper, JL, Hosgood, HD, Howell, A, Hu, CL, Hulick, PJ, Hunter, DJ, Imyanitov, EN, Isaacs, C, Jakimovska, M, Jakubowska, A, James, P, Janavicius, R, Janni, W, John, EM, Jones, ME, Jung, A, Kaaks, R, Karlan, BY, Khusnutdinova, E, Kitahara, CM, Konstantopoulou, I, Koutros, S, Kraft, P, Lambrechts, D, Lazaro, C, Le Marchand, L, Lester, J, Lesueur, F, Lilyquist, J, Loud, JT, Lu, KRH, Luben, RN, Lubinski, J, Mannermaa, A, Manoochehri, M, Manoukian, S, Margolin, S, Martens, JWM, Maurer, T, Mavroudis, D, Mebirouk, N, Meindl, A, Menon, U, Miller, A, Montagna, M, Nathanson, KL, Neuhausen, SL, Newman, WG, Nguyen-Dumont, T, Nielsen, FC, Nielsen, S, Nikitina-Zake, L, Offit, K, Olah, E, Olopade, OI, Olshan, AF, Olson, JE, Olsson, H, Osorio, A, Ottini, L, Peissel, B, Peixoto, A, Peto, J, Plaseska-Karanfilska, D, Pocza, T, Presneau, N, Pujana, MA, Punie, K, Rack, B, Rantala, J, Rashid, MU, Rau-Murthy, R, Rennert, G, Lejbkowicz, F, Rhenius, V, Romero, A, Rookus, MA, Ross, EA, Rossing, M, Rudaitis, V, Ruebner, M, Saloustros, E, Sanden, K, Santamarina, M, Scheuner, MT, Schmutzler, RK, Schneider, M, Scott, C, Senter, L, Shah, M, Sharma, P, Shu, XO, Simard, J, Singer, CF, Sohn, C, Soucy, P, Southey, MC, Spinelli, JJ, Steele, L, Stoppa-Lyonnet, D, Tapper, WJ, Teixeira, MR, Terry, MB, Thomassen, M, Thompson, J, Thull, DL, Tischkowitz, M, Tollenaar, RAEM, Torres, D, Troester, MA, Truong, T, Tung, N, Untch, M, Vachon, CM, van Rensburg, EJ, van Veen, EM, Vega, A, Viel, A, Wappenschmidt, B, Weitzel, JN, Wendt, C, Wieme, G, Wolk, A, Yang, XHR, Zheng, W, Ziogas, A, Zorn, KK, Dunning, AM, Lush, M, Wang, Q, McGuffog, L, Parsons, MT, Pharoah, PDP, Fostira, F, Toland, AE, Andrulis, IL, Ramus, SJ, Swerdlow, AJ, Greene, MH, Chung, WK, Milne, RL, Chenevix-Trench, G, Dork, T, Schmidt, MK, Easton, DF, Radice, P, Hahnen, E, Antoniou, AC, Couch, FJ, Nevanlinna, H, Surralles, J, Peterlongo, P, Balleine, R, Baxter, R, Braye, S, Carpenter, J, Dahlstrom, J, Forbes, J, Lee, CS, Marsh, D, Morey, A, Pathmanathan, N, Scott, R, Simpson, P, Spigelman, A, Wilcken, N, Yip, D, Zeps, N, Belotti, M, Bertrand, O, Birot, AM, Buecher, B, Caputo, S, Dupre, A, Fourme, E, Gauthier-Villars, M, Golmard, L, Le Mentec, M, Moncoutier, V, de Pauw, A, Saule, C, Boutry-Kryza, N, Calender, A, Giraud, S, Leone, M, Bressac-de-Paillerets, B, Caron, O, Guillaud-Bataille, M, Bignon, YJ, Uhrhammer, N, Bonadona, V, Lasset, C, Berthet, P, Castera, L, Vaur, D, Bourdon, V, Nogues, C, Noguchi, T, Popovici, C, Remenieras, A, Sobol, H, Coupier, I, Pujol, P, Adenis, C, Dumont, A, Revillion, F, Muller, D, Barouk-Simonet, E, Bonnet, F, Bubien, V, Longy, M, Sevenet, N, Gladieff, L, Guimbaud, R, Feillel, V, Toulas, C, Dreyfus, H, Leroux, CD, Peysselon, M, Rebischung, C, Legrand, C, Baurand, A, Bertolone, G, Coron, F, Faivre, L, Jacquot, C, Lizard, S, Kientz, C, Lebrun, M, Prieur, F, Fert-Ferrer, S, Mari, V, Venat-Bouvet, L, Bezieau, S, Delnatte, C, Mortemousque, I, Colas, C, Coulet, F, Soubrier, F, Warcoin, M, Bronner, M, Sokolowska, J, Collonge-Rame, MA, Damette, A, Gesta, P, Lallaoui, H, Chiesa, J, Molina-Gomes, D, Ingster, O, Manouvrier-Hanu, S, Lejeune, S, Aghmesheh, M, Greening, S, Amor, D, Gattas, M, Botes, L, Buckley, M, Friedlander, M, Koehler, J, Meiser, B, Saleh, M, Salisbury, E, Trainer, A, Tucker, K, Antill, Y, Dobrovic, A, Fellows, A, Fox, S, Harris, M, Nightingale, S, Phillips, K, Sambrook, J, Thorne, H, Armitage, S, Arnold, L, Kefford, R, Kirk, J, Rickard, E, Bastick, P, Beesley, J, Hayward, N, Spurdle, A, Walker, L, Beilby, J, Saunders, C, Bennett, I, Blackburn, A, Bogwitz, M, Gaff, C, Lindeman, G, Pachter, N, Scott, C, Sexton, A, Visvader, J, Taylor, J, Winship, I, Brennan, M, Brown, M, French, J, Edwards, S, Burgess, M, Burke, J, Patterson, B, Butow, P, Culling, B, Caldon, L, Callen, D, Chauhan, D, Eisenbruch, M, Heiniger, L, Chauhan, M, Christian, A, Dixon, J, Kidd, A, Cohen, P, Colley, A, Fenton, G, Crook, A, Dickson, R, Field, M, Cui, J, Cummings, M, Dawson, SJ, DeFazio, A, Delatycki, M, Dudding, T, Edkins, T, Farshid, G, Flanagan, J, Fong, P, Forrest, L, Gallego-Ortega, D, George, P, Gill, G, Kollias, J, Haan, E, Hart, S, Jenkins, M, Hunt, C, Lakhani, S, Lipton, L, Lobb, L, Mann, G, McLachlan, SA, O'Connell, S, O'Sullivan, S, Pieper, E, Robinson, B, Saunus, J, Scott, E, Shelling, A, Williams, R, Young, MA, ABCTB Investigators, GEMO Study Collaborators, KConFab

Publicada: 1 nov 2019
Resumen:
Breast cancer is a common disease partially caused by genetic risk factors. Germline pathogenic variants in DNA repair genes BRCA1, BRCA2, PAM, ATM, and CHEK2 are associated with breast cancer risk. FANCM, which encodes for a DNA translocase, has been proposed as a breast cancer predisposition gene, with greater effects for the ER-negative and triple-negative breast cancer (TNBC) subtypes. We tested the three recurrent protein-truncating variants FANCM:p.Arg658*, p.Gln1701*, and pArg1931* for association with breast cancer risk in 67,112 cases, 53,766 controls, and 26,662 carriers of pathogenic variants of BRCA1 or BRCA2. These three variants were also studied functionally by measuring survival and chromosome fragility in FANCM(-/-) patient-derived immortalized fibroblasts treated with diepoxybutane or olaparib. We observed that FANCM:p.Arg658* was associated with increased risk of ER-negative disease and TNBC (OR = 2.44, P = 0.034 and OR = 3.79; P = 0.009, respectively). In a country-restricted analysis, we confirmed the associations detected for FANCM:p.Arg658* and found that also FANCM:p.Arg1931* was associated with ER-negative breast cancer risk (OR = 1.96; P = 0.006). The functional results indicated that all three variants were deleterious affecting cell survival and chromosome stability with FANCM:p.Arg658* causing more severe phenotypes. In conclusion, we confirmed that the two rare FANCM deleterious variants p.Arg658* and p.Arg1931* are risk factors for ER-negative and TNBC subtypes. Overall our data suggest that the effect of truncating variants on breast cancer risk may depend on their position in the gene. Cell sensitivity to olaparib exposure, identifies a possible therapeutic option to treat FANCM-associated tumors.

Filiaciones:
Figlioli, G:
 IFOM FIRC Inst Mol Oncol, Genome Diagnost Program, Milan, Italy

Bogliolo, M:
 Univ Autonoma Barcelona, Dept Genet & Microbiol, Barcelona, Spain

 Ctr Biomed Network Res Rare Dis CIBERER, Madrid, Spain

 St Pau Hosp, Inst Biomed Res, Barcelona, Spain

Catucci, I:
 IFOM FIRC Inst Mol Oncol, Genome Diagnost Program, Milan, Italy

Caleca, L:
 Fdn IRCCS Ist Nazl Tumori, Dept Res, Unit Mol Bases Genet Risk & Genet Testing, Milan, Italy

Lasheras, SV:
 Univ Autonoma Barcelona, Dept Genet & Microbiol, Barcelona, Spain

Pujol, R:
 Univ Autonoma Barcelona, Dept Genet & Microbiol, Barcelona, Spain

 Ctr Biomed Network Res Rare Dis CIBERER, Madrid, Spain

 St Pau Hosp, Inst Biomed Res, Barcelona, Spain

Kiiski, JI:
 Univ Helsinki, Helsinki Univ Hosp, Dept Obstet & Gynecol, Helsinki, Finland

Muranen, TA:
 Univ Helsinki, Helsinki Univ Hosp, Dept Obstet & Gynecol, Helsinki, Finland

Barnes, DR:
 Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England

Dennis, J:
 Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England

Michailidou, K:
 Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England

 Cyprus Inst Neurol & Genet, Dept Electron Microscopy Mol Pathol, Nicosia, Cyprus

 Cyprus Sch Mol Med, Nicosia, Cyprus

Bolla, MK:
 Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England

Leslie, G:
 Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England

Aalfs, CM:
 Amsterdam UMC, Dept Clin Genet, Lokatie AMC, Amsterdam, Netherlands

Adank, MA:
 Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Family Canc Clin, Amsterdam, Netherlands

Adlard, J:
 Chapel Allerton Hosp, Yorkshire Reg Genet Serv, Leeds, W Yorkshire, England

Agata, S:
 Veneto Inst Oncol IOV IRCCS, Immunol & Mol Oncol Unit, Padua, Italy

Cadoo, K:
 Mem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USA

Agnarsson, BA:
 Landspitali Univ Hosp, Dept Pathol, Reykjavik, Iceland

 Univ Iceland, Sch Med, Reykjavik, Iceland

Ahearn, T:
 NCI, NIH, US Dept HHS, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA

Aittomaki, K:
 Univ Helsinki, Helsinki Univ Hosp, Dept Clin Genet, Helsinki, Finland

Ambrosone, CB:
 Roswell Park Canc Inst, Buffalo, NY 14263 USA

Andrews, L:
 Bright Alliance Bldg, Nelune Comprehens Canc Care Ctr, Randwick, NSW, Australia

Anton-Culver, H:
 Univ Calif Irvine, Genet Epidemiol Res Inst, Dept Epidemiol, Irvine, CA USA

Antonenkova, NN:
 NN Alexandrov Res Inst Oncol & Med Radiol, Minsk, BELARUS

Arndt, V:
 German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany

Arnold, N:
 Christian Albrechts Univ Kiel, Univ Hosp Schleswig Holstein, Dept Gynaecol & Obstet, Campus Kiel, Kiel, Germany

 Christian Albrechts Univ Kiel, Univ Hosp Schleswig Holstein, Inst Clin Mol Biol, Campus Kiel, Kiel, Germany

Aronson, KJ:
 Queens Univ, Dept Publ Hlth Sci, Kingston, ON, Canada

 Queens Univ, Canc Res Inst, Kingston, ON, Canada

Arun, BK:
 Univ Texas MD Anderson Canc Ctr, Dept Breast Med Oncol, Houston, TX 77030 USA

Asseryanis, E:
 Med Univ Vienna, Dept OB GYN, Vienna, Austria

 Med Univ Vienna, Comprehens Canc Ctr, Vienna, Austria

Auber, B:
 Hannover Med Sch, Inst Human Genet, Hannover, Germany

Auvinen, P:
 Kuopio Univ Hosp, Canc Ctr, Kuopio, Finland

 Univ Eastern Finland, Inst Clin Med, Oncol, Kuopio, Finland

 Univ Eastern Finland, Translat Canc Res Area, Kuopio, Finland

Azzollini, J:
 Fdn IRCCS Ist Nazl Tumori Milano, Dept Med Oncol & Hematol, Unit Med Genet, Milan, Italy

Balmana, J:
 Vall dHebron Inst Oncol, High Risk & Canc Prevent Grp, Barcelona, Spain

 Univ Hosp Vall dHebron, Dept Med Oncol, Barcelona, Spain

Barkardottir, RB:
 Landspitali Univ Hosp, Dept Pathol, Reykjavik, Iceland

 Univ Iceland, Fac Med, BMC Biomed Ctr, Reykjavik, Iceland

Barrowdale, D:
 Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England

Barwell, J:
 Univ Hosp Leicester NHS Trust, Leicestershire Clin Genet Serv, Leicester, Leics, England

Freeman, LEB:
 NCI, NIH, US Dept HHS, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA

Beauparlant, CJ:
 Univ Laval, Res Ctr, Genom Ctr, Ctr Hosp Univ Quebec, Quebec City, PQ, Canada

Beckmann, MW:
 Friedrich Alexander Univ Erlangen Nuremberg, Univ Hosp Erlangen, Comprehens Canc Ctr ER EMN, Dept Gynecol & Obstet, Erlangen, Germany

Behrens, S:
 German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany

Benitez, J:
 Spanish Natl Canc Res Ctr CNIO, Human Canc Genet Programme, Human Genet Grp, Madrid, Spain

 Spanish Network Rare Dis CIBERER, Madrid, Spain

 Spanish Natl Canc Res Ctr CNIO, Genotyping Unit CEGEN, Human Canc Genet Programme, Madrid, Spain

Berger, R:
 Chaim Sheba Med Ctr, Inst Oncol, Ramat Gan, Israel

Bermisheva, M:
 Russian Acad Sci, Inst Biochem & Genet, Ufa Fed Res Ctr, Ufa, Russia

Blanco, AM:
 Univ Calif San Francisco, Canc Genet & Prevent Program, San Francisco, CA 94143 USA

Blomqvist, C:
 Univ Helsinki, Helsinki Univ Hosp, Dept Oncol, Helsinki, Finland

 Orebro Univ Hosp, Dept Oncol, Orebro, Sweden

Bogdanova, NV:
 NN Alexandrov Res Inst Oncol & Med Radiol, Minsk, BELARUS

 Hannover Med Sch, Dept Radiat Oncol, Hannover, Germany

 Hannover Med Sch, Gynaecol Res Unit, Hannover, Germany

Bojesen, A:
 Aarhus Univ Hosp, Dept Clin Genet, Aarhus, Denmark

Bojesen, SE:
 Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Copenhagen Gen Populat Study, Herlev, Denmark

 Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Dept Clin Biochem, Herlev, Denmark

 Univ Copenhagen, Fac Hlth & Med Sci, Copenhagen, Denmark

Bonanni, B:
 European Inst Oncol IRCCS, Div Canc Prevent & Genet, IEO, Milan, Italy

Borg, A:
 Lund Univ, Lund, Sweden

 Skane Univ Hosp, Dept Oncol, Lund, Sweden

Brady, AF:
 London North West Univ Hosp NHS Trust, Kennedy Galton Ctr, North West Thames Reg Genet Serv, Northwick Pk Hosp, Harrow, Middx, England

Brauch, H:
 Dr Margarete Fischer Bosch Inst Clin Pharmacol, Stuttgart, Germany

 Univ Tubingen, iFIT Cluster Excellence, Tubingen, Germany

 German Canc Res Ctr, German Canc Consortium DKTK, Heidelberg, Germany

Brenner, H:
 German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany

 German Canc Res Ctr, German Canc Consortium DKTK, Heidelberg, Germany

 German Canc Res Ctr, Heidelberg, Germany

 Natl Ctr Tumor Dis NCT, Div Prevent Oncol, Heidelberg, Germany

Bruning, T:
 Inst Ruhr Univ Bochum, Inst Prevent & Occupat Med German Social Accid In, Bochum, Germany

Burwinkel, B:
 German Canc Res Ctr, Mol Epidemiol Grp, C080, Heidelberg, Germany

 Heidelberg Univ, Univ Womens Clin Heidelberg, Mol Biol Breast Canc, Heidelberg, Germany

Buys, SS:
 Huntsman Canc Inst, Dept Med, Salt Lake City, UT USA

Caldes, T:
 Hosp Clin San Carlos, Inst Invest Sanitaria San Carlos IdISSC, Ctr Invest Biomed Red Canc CIBERONC, Med Oncol Dept, Madrid, Spain

Caliebe, A:
 Christian Albrechts Univ Kiel, Univ Hosp Schleswig Holstein, Inst Human Genet, Campus Kiel, Kiel, Germany

Caligo, MA:
 Univ Hosp Pisa, Dept Lab Med, Sect Mol Genet, Pisa, Italy

Campa, D:
 German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany

 Univ Pisa, Dept Biol, Pisa, Italy

Campbell, IG:
 Peter MacCallum Canc Ctr, Res Div, Melbourne, Vic, Australia

 Univ Melbourne, Sir Peter MacCallum Dept Oncol, Melbourne, Vic, Australia

Canzian, F:
 German Canc Res Ctr, Genom Epidemiol Grp, Heidelberg, Germany

Castelao, JE:
 IISGS, Oncol & Genet Unit, Xerencia Xest Integrada Vigo SERGAS, Vigo, Spain

Chang-Claude, J:
 German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany

 Univ Med Ctr Hamburg Eppendorf, Univ Canc Ctr Hamburg, Canc Epidemiol Grp, Hamburg, Germany

Chanock, SJ:
 NCI, NIH, US Dept HHS, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA

Claes, KBM:
 Univ Ghent, Ctr Med Genet, Ghent, Belgium

Clarke, CL:
 Univ Sydney, Westmead Inst Med Res, Sydney, NSW, Australia

Collavoli, A:
 Univ & Univ Hosp Pisa, Dept Lab Med, Sect Genet Oncol, Pisa, Italy

Conner, TA:
 Huntsman Canc Inst, Salt Lake City, UT USA

Cox, DG:
 Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England

 Canc Res Ctr Lyon, U1052, INSERM, Lyon, France

Cybulski, C:
 Pomeranian Med Univ, Dept Genet & Pathol, Szczecin, Poland

Czene, K:
 Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

Daly, MB:
 Fox Chase Canc Ctr, Dept Clin Genet, 7701 Burholme Ave, Philadelphia, PA 19111 USA

de la Hoya, M:
 Hosp Clin San Carlos, Inst Invest Sanitaria San Carlos IdISSC, Ctr Invest Biomed Red Canc CIBERONC, Med Oncol Dept, Madrid, Spain

Devilee, P:
 Leiden Univ, Dept Pathol, Med Ctr, Leiden, Netherlands

 Leiden Univ, Dept Human Genet, Med Ctr, Leiden, Netherlands

Diez, O:
 Vall dHebron Inst Oncol VHIO, Oncogenet Grp, Barcelona, Spain

 Univ Hosp Vall dHebron, Area Clin & Mol Genet, Barcelona, Spain

Ding, YC:
 City Hope Natl Med Ctr, Dept Populat Sci, Beckman Res Inst, Duarte, CA USA

Dite, GS:
 Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Melbourne, Vic, Australia

Ditsch, N:
 Ludwig Maximilian Univ Munich, Dept Gynecol & Obstet, Munich, Germany

Domchek, SM:
 Univ Penn, Dept Med, Abramson Canc Ctr, Perelman Sch Med, Philadelphia, PA 19104 USA

Dorfling, CM:
 Univ Pretoria, Dept Genet, Arcadia, South Africa

dos-Santos-Silva, I:
 London Sch Hyg & Trop Med, Dept Noncommunicable Dis Epidemiol, London, England

Durda, K:
 Pomeranian Med Univ, Dept Genet & Pathol, Szczecin, Poland

Dwek, M:
 Univ Westminster, Fac Sci & Technol, Dept Biomed Sci, London, England

Eccles, DM:
 Univ Southampton, Canc Sci Acad Unit, Fac Med, Southampton, Hants, England

Ekici, AB:
 Friedrich Alexander Univ Erlangen Nuremberg, Univ Hosp Erlangen, Comprehens Canc Ctr Erlangen EMN, Inst Human Genet, Erlangen, Germany

Eliassen, AH:
 Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA 02115 USA

 Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA

Ellberg, C:
 Lund Univ, Dept Canc Epidemiol, Clin Sci, Lund, Sweden

Eriksson, M:
 Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

Evans, DG:
 Univ Manchester, Fac Biol Med & Hlth, Sch Biol Sci, Div Evolut & Genom Med, Manchester, Lancs, England

 Manchester Univ NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, Manchester Ctr Genom Med, Manchester, Lancs, England

Fasching, PA:
 Friedrich Alexander Univ Erlangen Nuremberg, Univ Hosp Erlangen, Comprehens Canc Ctr ER EMN, Dept Gynecol & Obstet, Erlangen, Germany

 Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Div Hematol & Oncol, Los Angeles, CA 90095 USA

Figueroa, J:
 NCI, NIH, US Dept HHS, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA

 Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Med Sch, Edinburgh, Midlothian, Scotland

 Canc Res UK Edinburgh Ctr, Edinburgh, Midlothian, Scotland

Flyger, H:
 Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Dept Breast Surg, Herlev, Denmark

Foulkes, WD:
 McGill Univ, Dept Human Genet, Program Canc Genet, Montreal, PQ, Canada

 McGill Univ, Dept Oncol, Program Canc Genet, Montreal, PQ, Canada

Friebel, TM:
 Harvard TH Chan Sch Publ Hlth, Boston, MA USA

 Dana Farber Canc Inst, Boston, MA 02115 USA

Friedman, E:
 Chaim Sheba Med Ctr, Susanne Levy Gertner Oncogenet Unit, Ramat Gan, Israel

 Tel Aviv Univ, Sackler Fac Med, Ramat Aviv, Israel

Gabrielson, M:
 Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

Gaddam, P:
 Mem Sloan Kettering Canc Ctr, Dept Canc Biol & Genet, Clin Genet Res Lab, 1275 York Ave, New York, NY 10021 USA

Gago-Dominguez, M:
 Complejo Hosp Univ Santiago, Galician Fdn Genom Med, Inst Invest Sanitaria Santiago de Compostela IDIS, Genom Med Grp,SERGAS, Santiago De Compostela, Spain

 Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA

Gao, C:
 Harvard TH Chan Sch Publ Hlth, Program Genet Epidemiol & Stat Genet, Boston, MA USA

Gapstur, SM:
 Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA

Garber, J:
 Dana Farber Canc Inst, Canc Risk & Prevent Clin, Boston, MA 02115 USA

Garcia-Closas, M:
 NCI, NIH, US Dept HHS, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA

Garcia-Saenz, JA:
 Hosp Clin San Carlos, Inst Invest Sanitaria San Carlos IdISSC, Ctr Invest Biomed Red Canc CIBERONC, Med Oncol Dept, Madrid, Spain

Gaudet, MM:
 Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA

Gayther, SA:
 Cedars Sinai Med Ctr, Samuel Oschin Comprehens Canc Inst, Ctr Bioinformat & Funct Genom, Los Angeles, CA 90048 USA

Giles, GG:
 Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Melbourne, Vic, Australia

 Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia

 Monash Univ, Dept Epidemiol & Prevent Med, Melbourne, Vic, Australia

Glendon, G:
 Mt Sinai Hosp, Fred A Litwin Ctr Canc Genet, Lunenfeld Tanenbaum Res Inst, Toronto, ON, Canada

Godwin, AK:
 Kansas Univ, Med Ctr, Dept Pathol & Lab Med, Kansas City, KS USA

Goldberg, MS:
 McGill Univ, Dept Med, Montreal, PQ, Canada

 McGill Univ, Royal Victoria Hosp, Div Clin Epidemiol, Montreal, PQ, Canada

Goldgar, DE:
 Univ Utah, Sch Med, Dept Dermatol, Huntsman Canc Inst, Salt Lake City, UT USA

Guenel, P:
 Univ Paris Sud, Univ Paris Saclay, Ctr Res Epidemiol & Populat Hlth CESP, INSERM,Canc & Environm Grp, Villejuif, France

Gutierrez-Barrera, AM:
 Univ Texas MD Anderson Canc Ctr, Dept Breast Med Oncol, Houston, TX 77030 USA

 Univ Texas MD Anderson Canc Ctr, Clin Genet Program, Houston, TX 77030 USA

Haeberle, L:
 Friedrich Alexander Univ Erlangen Nuremberg, Univ Hosp Erlangen, Comprehens Canc Ctr Erlangen EMN, Dept Gynaecol & Obstet, Erlangen, Germany

Haiman, CA:
 Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA USA

Hakansson, N:
 Karolinska Inst, Inst Environm Med, Stockholm, Sweden

Hall, P:
 Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

 Soder Sjukhuset, Dept Oncol, Stockholm, Sweden

Hamann, U:
 German Canc Res Ctr, Mol Genet Breast Canc, Heidelberg, Germany

Harrington, PA:
 Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Oncol, Cambridge, England

Hein, A:
 Friedrich Alexander Univ Erlangen Nuremberg, Univ Hosp Erlangen, Comprehens Canc Ctr ER EMN, Dept Gynecol & Obstet, Erlangen, Germany

Heyworth, J:
 Univ Western Australia, Sch Populat & Global Hlth, Perth, WA, Australia

Hillemanns, P:
 Hannover Med Sch, Gynaecol Res Unit, Hannover, Germany

Hollestelle, A:
 Erasmus MC Canc Inst, Dept Med Oncol, Family Canc Clin, Rotterdam, Netherlands

Hopper, JL:
 Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Melbourne, Vic, Australia

Hosgood, HD:
 Albert Einstein Coll Med, Dept Epidemiol & Publ Hlth, Bronx, NY 10467 USA

Howell, A:
 Univ Manchester, Div Canc Sci, Manchester, Lancs, England

Hu, CL:
 Mayo Clin, Dept Lab Med & Pathol, Rochester, MN USA

Hulick, PJ:
 NorthShore Univ HealthSyst, Ctr Med Genet, Evanston, IL USA

 Univ Chicago, Pritzker Sch Med, Chicago, IL 60637 USA

Hunter, DJ:
 Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA

 Harvard TH Chan Sch Publ Hlth, Program Genet Epidemiol & Stat Genet, Boston, MA USA

 Univ Oxford, Nuffield Dept Populat Hlth, Oxford, England

Imyanitov, EN:
 NN Petrov Inst Oncol, St Petersburg, Russia

Isaacs, C:
 Georgetown Univ, Lombardi Comprehens Canc Ctr, Washington, DC USA

Jakimovska, M:
 Macedonian Acad Sci & Arts, Res Ctr Genet Engn & Biotechnol Georgi D Efremov, Skopje, North Macedonia

Jakubowska, A:
 Pomeranian Med Univ, Dept Genet & Pathol, Szczecin, Poland

 Pomeranian Med Univ, Independent Lab Mol Biol & Genet Diagnost, Szczecin, Poland

James, P:
 Univ Melbourne, Sir Peter MacCallum Dept Oncol, Melbourne, Vic, Australia

 Peter MacCallum Canc Ctr, Parkville Familial Canc Ctr, Melbourne, Vic, Australia

Janavicius, R:
 Vilnius Univ Hosp, Hematol Oncol & Transfus Med Ctr, Dept Mol & Regenerat Med, Santariskiu Clin, Vilnius, Lithuania

 State Res Inst, Innovat Med Ctr, Vilnius, Lithuania

Janni, W:
 Univ Hosp Ulm, Dept Gynaecol & Obstet, Ulm, Germany

John, EM:
 Stanford Univ, Sch Med, Dept Med Oncol, Stanford, CA 94305 USA

 Stanford Univ, Stanford Canc Inst, Stanford, CA 94305 USA

Jones, ME:
 Inst Canc Res, Div Genet & Epidemiol, London, England

Jung, A:
 German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany

Kaaks, R:
 German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany

Karlan, BY:
 Cedars Sinai Med Ctr, Womens Canc Program, Samuel Oschin Comprehens Canc Inst, Los Angeles, CA 90048 USA

Khusnutdinova, E:
 Russian Acad Sci, Inst Biochem & Genet, Ufa Fed Res Ctr, Ufa, Russia

 Bashkir State Med Univ, Dept Med Genet, Ufa, Russia

Kitahara, CM:
 NCI, Radiat Epidemiol Branch, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA

Konstantopoulou, I:
 Natl Ctr Sci Res Demokritos, Mol Diagnost Lab, INRASTES, Athens, Greece

Koutros, S:
 NCI, NIH, US Dept HHS, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA

Kraft, P:
 Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA

 Harvard TH Chan Sch Publ Hlth, Program Genet Epidemiol & Stat Genet, Boston, MA USA

Lambrechts, D:
 VIB, VIB Ctr Canc Biol, Leuven, Belgium

 Univ Leuven, Dept Human Genet, Lab Translat Genet, Leuven, Belgium

Lazaro, C:
 IDIBELL Bellvitge Biomed Res Inst, Catalan Inst Oncol, Mol Diagnost Unit, CIBERONC,Hereditary Canc Program, Barcelona, Spain

Le Marchand, L:
 Univ Hawaii, Canc Ctr, Epidemiol Program, Honolulu, HI 96822 USA

Lester, J:
 Aarhus Univ Hosp, Dept Clin Genet, Aarhus, Denmark

Lesueur, F:
 Inserm U900, Genet Epidemiol Canc Team, Paris, France

 PSL Univ, Paris, France

 Inst Curie, Paris, France

 Mines ParisTech, Fontainebleau, France

Lilyquist, J:
 Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA

Loud, JT:
 NCI, Clin Genet Branch, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA

Lu, KRH:
 Univ Texas MD Anderson Canc Ctr, Dept Gynecol Oncol, Houston, TX 77030 USA

 Univ Texas MD Anderson Canc Ctr, Clin Canc Genet Program, Houston, TX 77030 USA

Luben, RN:
 Univ Cambridge, Dept Publ Hlth & Primary Care, Clin Gerontol, Cambridge, England

Lubinski, J:
 Pomeranian Med Univ, Dept Genet & Pathol, Szczecin, Poland

Mannermaa, A:
 Univ Eastern Finland, Translat Canc Res Area, Kuopio, Finland

 Univ Eastern Finland, Inst Clin Med Pathol & Forens Med, Kuopio, Finland

 Kuopio Univ Hosp, Imaging Ctr, Dept Clin Pathol, Kuopio, Finland

Manoochehri, M:
 German Canc Res Ctr, Mol Genet Breast Canc, Heidelberg, Germany

Manoukian, S:
 Fdn IRCCS Ist Nazl Tumori Milano, Dept Med Oncol & Hematol, Unit Med Genet, Milan, Italy

Margolin, S:
 Soder Sjukhuset, Dept Oncol, Stockholm, Sweden

 Soder Sjukhuset, Dept Clin Sci & Educ, Karolinska Inst, Stockholm, Sweden

Martens, JWM:
 Erasmus MC Canc Inst, Dept Med Oncol, Family Canc Clin, Rotterdam, Netherlands

Maurer, T:
 Univ Med Ctr Hamburg Eppendorf, Univ Canc Ctr Hamburg, Canc Epidemiol Grp, Hamburg, Germany

Mavroudis, D:
 Univ Hosp Heraklion, Dept Med Oncol, Iraklion, Greece

Mebirouk, N:
 Inserm U900, Genet Epidemiol Canc Team, Paris, France

 PSL Univ, Paris, France

 Inst Curie, Paris, France

 Mines ParisTech, Fontainebleau, France

Meindl, A:
 Ludwig Maximilian Univ Munich, Dept Gynecol & Obstet, Munich, Germany

Menon, U:
 UCL, Inst Clin Trials & Methodol, MRC Clin Trials Unit UCL, London, England

Miller, A:
 Roswell Park Canc Inst, NRG Oncol, Clin Trials Dev Div, Buffalo, NY 14263 USA

Montagna, M:
 Veneto Inst Oncol IOV IRCCS, Immunol & Mol Oncol Unit, Padua, Italy

Nathanson, KL:
 Univ Penn, Dept Med, Abramson Canc Ctr, Perelman Sch Med, Philadelphia, PA 19104 USA

Neuhausen, SL:
 City Hope Natl Med Ctr, Dept Populat Sci, Beckman Res Inst, Duarte, CA USA

Newman, WG:
 Univ Manchester, Fac Biol Med & Hlth, Sch Biol Sci, Div Evolut & Genom Med, Manchester, Lancs, England

 Manchester Univ NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, Manchester Ctr Genom Med, Manchester, Lancs, England

Nguyen-Dumont, T:
 Monash Univ, Sch Clin Sci, Precis Med, Monash Hlth, Clayton, Vic, Australia

 Univ Melbourne, Dept Clin Pathol, Melbourne, Vic, Australia

Nielsen, FC:
 Copenhagen Univ Hosp, Rigshosp, Ctr Genom Med, Copenhagen, Denmark

Nielsen, S:
 Univ Chicago, Ctr Clin Canc Genet, Chicago, IL 60637 USA

Nikitina-Zake, L:
 Latvian Biomed Res & Study Ctr, Riga, Latvia

Offit, K:
 Mem Sloan Kettering Canc Ctr, Dept Canc Biol & Genet, Clin Genet Res Lab, 1275 York Ave, New York, NY 10021 USA

 Mem Sloan Kettering Canc Ctr, Dept Med, Clin Genet Serv, 1275 York Ave, New York, NY 10021 USA

Olah, E:
 Natl Inst Oncol, Dept Mol Genet, Budapest, Hungary

Olopade, OI:
 Univ Chicago, Ctr Clin Canc Genet, Chicago, IL 60637 USA

Olshan, AF:
 Univ North Carolina Chapel Hill, Dept Epidemiol, Lineberger Comprehens Canc Ctr, Chapel Hill, NC USA

Olson, JE:
 Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA

Olsson, H:
 Lund Univ, Dept Canc Epidemiol, Clin Sci, Lund, Sweden

Osorio, A:
 Spanish Natl Canc Res Ctr CNIO, Human Canc Genet Programme, Human Genet Grp, Madrid, Spain

 Spanish Network Rare Dis CIBERER, Madrid, Spain

Ottini, L:
 Univ Roma La Sapienza, Dept Mol Med, Rome, Italy

Peissel, B:
 Fdn IRCCS Ist Nazl Tumori Milano, Dept Med Oncol & Hematol, Unit Med Genet, Milan, Italy

Peixoto, A:
 Portuguese Oncol Inst, Dept Genet, Porto, Portugal

Peto, J:
 London Sch Hyg & Trop Med, Dept Noncommunicable Dis Epidemiol, London, England

Plaseska-Karanfilska, D:
 Macedonian Acad Sci & Arts, Res Ctr Genet Engn & Biotechnol Georgi D Efremov, Skopje, North Macedonia

Pocza, T:
 Natl Inst Oncol, Dept Mol Genet, Budapest, Hungary

Presneau, N:
 Univ Westminster, Fac Sci & Technol, Dept Biomed Sci, London, England

Pujana, MA:
 IDIBELL Bellvitge Biomed Res Inst, Catalan Inst Oncol, Oncobell, CIBERONC,ProCURE, Barcelona, Spain

Punie, K:
 Univ Hosp Leuven, Multidisciplinary Breast Ctr, Leuven Canc Inst, Dept Gen Med Oncol, Leuven, Belgium

Rack, B:
 Univ Hosp Ulm, Dept Gynaecol & Obstet, Ulm, Germany

Rantala, J:
 Karolinska Inst, Clin Genet, Stockholm, Sweden

Rashid, MU:
 German Canc Res Ctr, Mol Genet Breast Canc, Heidelberg, Germany

 Shaukat Khanum Mem Canc Hosp & Res Ctr, Dept Basic Sci, Lahore, Pakistan

Rau-Murthy, R:
 Mem Sloan Kettering Canc Ctr, Dept Med, Clin Genet Serv, 1275 York Ave, New York, NY 10021 USA

Rennert, G:
 Carmel Hosp, Haifa, Israel

 Technion, Fac Med, Clalit Natl Canc Control Ctr, Haifa, Israel

Lejbkowicz, F:
 Carmel Hosp, Haifa, Israel

 Technion, Fac Med, Clalit Natl Canc Control Ctr, Haifa, Israel

Rhenius, V:
 Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Oncol, Cambridge, England

Romero, A:
 Hosp Univ Puerta de Hierro, Med Oncol Dept, Madrid, Spain

Rookus, MA:
 Netherlands Canc Inst, Dept Epidemiol, Amsterdam, Netherlands

Ross, EA:
 Fox Chase Canc Ctr, Biostat & Bioinformat Facil, 7701 Burholme Ave, Philadelphia, PA 19111 USA

Rossing, M:
 Copenhagen Univ Hosp, Rigshosp, Ctr Genom Med, Copenhagen, Denmark

Rudaitis, V:
 Vilnius Univ, Med Fac, Inst Clin Med, Vilnius, Lithuania

Ruebner, M:
 Friedrich Alexander Univ Erlangen Nuremberg, Univ Hosp Erlangen, Comprehens Canc Ctr Erlangen EMN, Dept Gynaecol & Obstet, Erlangen, Germany

Saloustros, E:
 Univ Hosp Larissa, Dept Oncol, Larisa, Greece

Sanden, K:
 Univ Wisconsin, Canc Ctr ProHlth Care, Waukesha, WI USA

Santamarina, M:
 Spanish Network Rare Dis CIBERER, Madrid, Spain

 Fdn Publ Galega Med Xen, Santiago De Compostela, Spain

 Inst Invest Sanitaria Santiago de Compostela, Santiago De Compostela, Spain

Scheuner, MT:
 Univ Calif San Francisco, Canc Genet & Prevent Program, San Francisco, CA 94143 USA

Schmutzler, RK:
 Univ Hosp Cologne, Ctr Hereditary Breast & Ovarian Canc, Cologne, Germany

 Univ Cologne, Ctr Mol Med Cologne, Cologne, Germany

Schneider, M:
 Friedrich Alexander Univ Erlangen Nuremberg, Univ Hosp Erlangen, Comprehens Canc Ctr Erlangen EMN, Dept Gynaecol & Obstet, Erlangen, Germany

Scott, C:
 Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA

 Royal Melbourne Hosp, Parkville, Vic, Australia

Senter, L:
 Ohio State Univ, Comprehens Canc Ctr, Dept Internal Med, Div Human Genet, Columbus, OH 43210 USA

Shah, M:
 Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Oncol, Cambridge, England

Sharma, P:
 Univ Kansas, Dept Internal Med, Div Oncol, Med Ctr, Westwood, KS USA

Shu, XO:
 Vanderbilt Univ, Sch Med, Div Epidemiol, Dept Med,Vanderbilt Epidemiol Ctr, Nashville, TN 37212 USA

Simard, J:
 Univ Laval, Res Ctr, Genom Ctr, Ctr Hosp Univ Quebec, Quebec City, PQ, Canada

Singer, CF:
 Med Univ Vienna, Dept OB GYN, Vienna, Austria

 Med Univ Vienna, Comprehens Canc Ctr, Vienna, Austria

Sohn, C:
 Heidelberg Univ, Natl Ctr Tumor Dis, Heidelberg, Germany

Soucy, P:
 Univ Laval, Res Ctr, Genom Ctr, Ctr Hosp Univ Quebec, Quebec City, PQ, Canada

Southey, MC:
 Monash Univ, Sch Clin Sci, Precis Med, Monash Hlth, Clayton, Vic, Australia

 Univ Melbourne, Dept Clin Pathol, Melbourne, Vic, Australia

Spinelli, JJ:
 BC Canc, Populat Oncol, Vancouver, BC, Canada

 Univ British Columbia, Sch Populat & Publ Hlth, Vancouver, BC, Canada

Steele, L:
 City Hope Natl Med Ctr, Dept Populat Sci, Beckman Res Inst, Duarte, CA USA

Stoppa-Lyonnet, D:
 Inst Curie, Serv Genet, Paris, France

 INSERM U830, Dept Tumour Biol, Paris, France

 Univ Paris 05, Paris, France

Tapper, WJ:
 Univ Southampton, Fac Med, Southampton, Hants, England

Teixeira, MR:
 Portuguese Oncol Inst, Dept Genet, Porto, Portugal

 Univ Porto, Biomed Sci Inst ICBAS, Porto, Portugal

Terry, MB:
 Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY USA

Thomassen, M:
 Odense Univ Hosp, Dept Clin Genet, Odence C, Denmark

Thompson, J:
 NorthShore Univ HealthSyst, Ctr Med Genet, Evanston, IL USA

Thull, DL:
 Univ Pittsburgh, Magee Womens Hosp, Sch Med, Dept Med, Pittsburgh, PA 15213 USA

Tischkowitz, M:
 McGill Univ, Dept Human Genet, Program Canc Genet, Montreal, PQ, Canada

 McGill Univ, Dept Oncol, Program Canc Genet, Montreal, PQ, Canada

 Univ Cambridge, Dept Med Genet, Cambridge, England

Tollenaar, RAEM:
 Leiden Univ, Dept Surg, Med Ctr, Leiden, Netherlands

Torres, D:
 German Canc Res Ctr, Mol Genet Breast Canc, Heidelberg, Germany

 Pontificia Univ Javeriana, Inst Human Genet, Bogota, Colombia

Troester, MA:
 Univ North Carolina Chapel Hill, Dept Epidemiol, Lineberger Comprehens Canc Ctr, Chapel Hill, NC USA

Truong, T:
 Univ Paris Sud, Univ Paris Saclay, Ctr Res Epidemiol & Populat Hlth CESP, INSERM,Canc & Environm Grp, Villejuif, France

Tung, N:
 Beth Israel Deaconess Med Ctr, Dept Med Oncol, Boston, MA 02215 USA

Untch, M:
 Helios Clin Berlin Buch, Dept Gynecol & Obstet, Berlin, Germany

Vachon, CM:
 Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA

van Rensburg, EJ:
 Univ Pretoria, Dept Genet, Arcadia, South Africa

van Veen, EM:
 Univ Manchester, Fac Biol Med & Hlth, Sch Biol Sci, Div Evolut & Genom Med, Manchester, Lancs, England

 Manchester Univ NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, Manchester Ctr Genom Med, Manchester, Lancs, England

Vega, A:
 Spanish Network Rare Dis CIBERER, Madrid, Spain

 Fdn Publ Galega Med Xen, Santiago De Compostela, Spain

 Inst Invest Sanitaria Santiago de Compostela, Santiago De Compostela, Spain

Viel, A:
 IRCCS, Div Funct Oncogen & Genet, Ctr Riferimento Oncol Aviano CRO, Aviano, Italy

Wappenschmidt, B:
 Univ Hosp Cologne, Ctr Hereditary Breast & Ovarian Canc, Cologne, Germany

 Univ Cologne, Ctr Mol Med Cologne, Cologne, Germany

Weitzel, JN:
 City Hope Natl Med Ctr, Clin Canc Genet, Duarte, CA USA

Wendt, C:
 Soder Sjukhuset, Dept Oncol, Stockholm, Sweden

 Soder Sjukhuset, Dept Clin Sci & Educ, Karolinska Inst, Stockholm, Sweden

Wieme, G:
 Univ Ghent, Ctr Med Genet, Ghent, Belgium

Wolk, A:
 Karolinska Inst, Inst Environm Med, Stockholm, Sweden

 Uppsala Univ, Dept Surg Sci, Uppsala, Sweden

Yang, XHR:
 NCI, NIH, US Dept HHS, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA

Zheng, W:
 Vanderbilt Univ, Sch Med, Div Epidemiol, Dept Med,Vanderbilt Epidemiol Ctr, Nashville, TN 37212 USA

Ziogas, A:
 Univ Calif Irvine, Genet Epidemiol Res Inst, Dept Epidemiol, Irvine, CA USA

Zorn, KK:
 Univ Pittsburgh, Magee Womens Hosp, Sch Med, Pittsburgh, PA 15213 USA

Dunning, AM:
 Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Oncol, Cambridge, England

Lush, M:
 Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England

Wang, Q:
 Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England

McGuffog, L:
 Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England

Parsons, MT:
 QIMR Berghofer Med Res Inst, Dept Genet & Computat Biol, Brisbane, Qld, Australia

Pharoah, PDP:
 Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England

 Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Oncol, Cambridge, England

Fostira, F:
 Natl Ctr Sci Res Demokritos, Mol Diagnost Lab, INRASTES, Athens, Greece

Toland, AE:
 Ohio State Univ, Dept Canc Biol & Genet, Columbus, OH 43210 USA

Andrulis, IL:
 Mt Sinai Hosp, Fred A Litwin Ctr Canc Genet, Lunenfeld Tanenbaum Res Inst, Toronto, ON, Canada

 Univ Toronto, Dept Mol Genet, Toronto, ON, Canada

Ramus, SJ:
 Univ NSW Sydney, Fac Med, Sch Womens & Childrens Hlth, Sydney, NSW, Australia

 Garvan Inst Med Res, Kinghorn Canc Ctr, Sydney, NSW, Australia

Swerdlow, AJ:
 Inst Canc Res, Div Genet & Epidemiol, London, England

 Inst Canc Res, Div Breast Canc Res, London, England

Greene, MH:
 NCI, Clin Genet Branch, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA

Chung, WK:
 Columbia Univ, Dept Pediat & Med, New York, NY USA

Milne, RL:
 Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Melbourne, Vic, Australia

 Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia

 Monash Univ, Sch Clin Sci, Precis Med, Monash Hlth, Clayton, Vic, Australia

Chenevix-Trench, G:
 QIMR Berghofer Med Res Inst, Dept Genet & Computat Biol, Brisbane, Qld, Australia

Dork, T:
 Hannover Med Sch, Gynaecol Res Unit, Hannover, Germany

Schmidt, MK:
 Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Div Mol Pathol, Amsterdam, Netherlands

 Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Div Psychosocial Res & Epidemiol, Amsterdam, Netherlands

Easton, DF:
 Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England

 Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Oncol, Cambridge, England

Radice, P:
 Fdn IRCCS Ist Nazl Tumori, Dept Res, Unit Mol Bases Genet Risk & Genet Testing, Milan, Italy

Hahnen, E:
 Univ Hosp Cologne, Ctr Hereditary Breast & Ovarian Canc, Cologne, Germany

 Univ Cologne, Ctr Mol Med Cologne, Cologne, Germany

Antoniou, AC:
 Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England

Couch, FJ:
 Mayo Clin, Dept Lab Med & Pathol, Rochester, MN USA

Nevanlinna, H:
 Univ Helsinki, Helsinki Univ Hosp, Dept Obstet & Gynecol, Helsinki, Finland

Surralles, J:
 Univ Autonoma Barcelona, Dept Genet & Microbiol, Barcelona, Spain

 Ctr Biomed Network Res Rare Dis CIBERER, Madrid, Spain

 St Pau Hosp, Inst Biomed Res, Barcelona, Spain

 St Pau Hosp, Dept Genet, Barcelona, Spain

Peterlongo, P:
 IFOM FIRC Inst Mol Oncol, Genome Diagnost Program, Milan, Italy

Balleine, R:
 Pathol West ICPMR, Westmead, NSW, Australia

 Westmead Hosp, Westmead, NSW, Australia

Baxter, R:
 Univ Sydney, Royal North Shore Hosp, Kolling Inst Med Res, Sydney, NSW, Australia

Braye, S:
 John Hunter Hosp, Pathol North, Newcastle, NSW 2305, Australia

Carpenter, J:
 Univ Sydney, Westmead Inst Med Res, Sydney, NSW, Australia

Dahlstrom, J:
 Canberra Hosp, Dept Anat Pathol, Act Pathol, Canberra, ACT, Australia

 Australian Natl Univ, ANU Med Sch, Canberra, ACT, Australia

Forbes, J:
 Univ Newcastle, Calvary Mater Newcastle Hosp, Australian New Zealand Breast Canc Trials Grp, Dept Surg Oncol, Newcastle, NSW, Australia

 Univ Newcastle, Sch Med & Publ Hlth, Newcastle, NSW, Australia

Lee, CS:
 Univ Western Sydney, Sch Sci & Hlth, Sydney, NSW, Australia

Marsh, D:
 Univ Sydney, Royal North Shore Hosp, Kolling Inst Med Res, Hormones & Canc Grp, Sydney, NSW, Australia

 Royal North Shore Hosp, St Leonards, NSW, Australia

Morey, A:
 SydPath St Vincents Hosp, Sydney, NSW, Australia

Pathmanathan, N:
 Westmead Hosp, Westmead Breast Canc Inst, Dept Tissue Pathol & Diagnost Oncol, Pathol West, Sydney, NSW, Australia

Scott, R:
 Hunter Med Res Inst, Ctr Informat Based Med, Sydney, NSW 2305, Australia

 Univ Newcastle, Fac Hlth, Prior Res Ctr Canc, Sch Biomed Sci & Pharm, Callaghan, NSW, Australia

 John Hunter Hosp, New Lambton Hts, NSW 2305, Australia

Simpson, P:
 Univ Queensland, UQ Ctr Clin Res, Brisbane, Qld, Australia

 Univ Queensland, Sch Med, Brisbane, Qld, Australia

Spigelman, A:
 St Vincents Hosp, Kinghorn Canc Ctr, Hereditary Canc Clin, Sydney, NSW 2010, Australia

Wilcken, N:
 Westmead Hosp, Crown Princess Mary Canc Ctr, Westmead, NSW, Australia

 Univ Sydney, Sydney Med Sch Westmead, Sydney, NSW, Australia

Yip, D:
 Canberra Hosp, Dept Anat Pathol, Act Pathol, Canberra, ACT, Australia

 Canberra Hosp, Dept Med Oncol, Garran, ACT, Australia

Zeps, N:
 St John God Perth Northern Hosp, Perth, WA, Australia

Belotti, M:
 Inst Curie, Serv Genet, Paris, France

Bertrand, O:
 Inst Curie, Serv Genet, Paris, France

Birot, AM:
 Inst Curie, Serv Genet, Paris, France

Buecher, B:
 Inst Curie, Serv Genet, Paris, France

Caputo, S:
 Inst Curie, Serv Genet, Paris, France

Dupre, A:
 Inst Curie, Serv Genet, Paris, France

Fourme, E:
 Inst Curie, Serv Genet, Paris, France

Gauthier-Villars, M:
 Inst Curie, Serv Genet, Paris, France

Golmard, L:
 Inst Curie, Serv Genet, Paris, France

Le Mentec, M:
 Inst Curie, Serv Genet, Paris, France

Moncoutier, V:
 Inst Curie, Serv Genet, Paris, France

de Pauw, A:
 Inst Curie, Serv Genet, Paris, France

Saule, C:
 Inst Curie, Serv Genet, Paris, France

Boutry-Kryza, N:
 Hosp Civils Lyon, Unite Mixte Genet Constitut Canc Frequents, Lyon, France

 Ctr Leon Berard, Lyon, France

Calender, A:
 Hosp Civils Lyon, Unite Mixte Genet Constitut Canc Frequents, Lyon, France

 Ctr Leon Berard, Lyon, France

Giraud, S:
 Hosp Civils Lyon, Unite Mixte Genet Constitut Canc Frequents, Lyon, France

 Ctr Leon Berard, Lyon, France

Leone, M:
 Hosp Civils Lyon, Unite Mixte Genet Constitut Canc Frequents, Lyon, France

 Ctr Leon Berard, Lyon, France

Bressac-de-Paillerets, B:
 Inst Gustave Roussy, Villejuif, France

Caron, O:
 Inst Gustave Roussy, Villejuif, France

Guillaud-Bataille, M:
 Inst Gustave Roussy, Villejuif, France

Bignon, YJ:
 Ctr Jean Perrin, Clermont Ferrand, France

Uhrhammer, N:
 Ctr Jean Perrin, Clermont Ferrand, France

Bonadona, V:
 Ctr Leon Berard, Lyon, France

Lasset, C:
 Ctr Leon Berard, Lyon, France

Berthet, P:
 Ctr Francois Baclesse, Caen, France

Castera, L:
 Ctr Francois Baclesse, Caen, France

Vaur, D:
 Ctr Francois Baclesse, Caen, France

Bourdon, V:
 Inst Paoli Calmettes, Marseille, France

Nogues, C:
 Inst Paoli Calmettes, Marseille, France

Noguchi, T:
 Inst Paoli Calmettes, Marseille, France

Popovici, C:
 Inst Paoli Calmettes, Marseille, France

Remenieras, A:
 Inst Paoli Calmettes, Marseille, France

Sobol, H:
 Inst Paoli Calmettes, Marseille, France

Coupier, I:
 CHU Arnaud de Villeneuve, Montpellier, France

Pujol, P:
 CHU Arnaud de Villeneuve, Montpellier, France

Adenis, C:
 Ctr Oscar Lambret, Lille, France

Dumont, A:
 Ctr Oscar Lambret, Lille, France

Revillion, F:
 Ctr Oscar Lambret, Lille, France

Muller, D:
 Ctr Paul Strauss, Strasbourg, France

Barouk-Simonet, E:
 Inst Bergonie, Bordeaux, France

Bonnet, F:
 Inst Bergonie, Bordeaux, France

Bubien, V:
 Inst Bergonie, Bordeaux, France

Longy, M:
 Inst Bergonie, Bordeaux, France

Sevenet, N:
 Inst Bergonie, Bordeaux, France

Gladieff, L:
 Inst Claudius Regaud, Toulouse, France

Guimbaud, R:
 Inst Claudius Regaud, Toulouse, France

Feillel, V:
 Inst Claudius Regaud, Toulouse, France

Toulas, C:
 CHU, Grenoble, France

Dreyfus, H:
 CHU, Grenoble, France

Leroux, CD:
 CHU, Grenoble, France

Peysselon, M:
 CHU, Grenoble, France

Rebischung, C:
 CHU, Grenoble, France

Legrand, C:
 CHU, Dijon, France

Baurand, A:
 CHU, Dijon, France

Bertolone, G:
 CHU, Dijon, France

Coron, F:
 CHU, Dijon, France

Faivre, L:
 CHU, Dijon, France

Jacquot, C:
 CHU, Dijon, France

Lizard, S:
 CHU, St Etienne, France

Kientz, C:
 CHU, St Etienne, France

Lebrun, M:
 CHU, St Etienne, France

Prieur, F:
 CHU, St Etienne, France

Fert-Ferrer, S:
 Hop Hotel Dieu, Ctr Hosp, Chambery, France

Mari, V:
 Ctr Antoine Lacassagne, Nice, France

Venat-Bouvet, L:
 CHU, Limoges, France

Bezieau, S:
 CHU, Nantes, France

Delnatte, C:
 CHU, Nantes, France

Mortemousque, I:
 CHU Bretonneau, Tours, France

 Ctr Hosp Bourges, Bourges, France

Colas, C:
 Grp Hosp Pitie Salpetriere, Paris, France

Coulet, F:
 Grp Hosp Pitie Salpetriere, Paris, France

Soubrier, F:
 Grp Hosp Pitie Salpetriere, Paris, France

Warcoin, M:
 Grp Hosp Pitie Salpetriere, Paris, France

Bronner, M:
 CHU Vandoeuvre Les, Nancy, France

Sokolowska, J:
 CHU Vandoeuvre Les, Nancy, France

Collonge-Rame, MA:
 CHU, Besancon, France

Damette, A:
 CHU, Besancon, France

Gesta, P:
 CHU Poitiers, Ctr Hosp Angouleme, Niort, France

 Ctr Hosp Niort, Niort, France

Lallaoui, H:
 Ctr Hosp La Rochelle, La Rochelle, France

Chiesa, J:
 CHU Nimes, Caremeau, France

Molina-Gomes, D:
 CHI, Poissy, France

Ingster, O:
 CHU, Angers, France

Manouvrier-Hanu, S:
 CHRU, De Lille, France

Lejeune, S:
 CHRU, De Lille, France

Aghmesheh, M:
 Wollongong Hosp, Illawarra Canc Care Ctr, Wollongong, NSW, Australia

Greening, S:
 Wollongong Hosp, Illawarra Canc Care Ctr, Wollongong, NSW, Australia

Amor, D:
 Royal Childrens Hosp, Melbourne, Vic, Australia

Gattas, M:
 Royal Childrens Hosp, Melbourne, Vic, Australia

Botes, L:
 Prince Wales Hosp, Randwick, NSW, Australia

Buckley, M:
 Prince Wales Hosp, Randwick, NSW, Australia

Friedlander, M:
 Prince Wales Hosp, Randwick, NSW, Australia

Koehler, J:
 Prince Wales Hosp, Randwick, NSW, Australia

Meiser, B:
 Prince Wales Hosp, Randwick, NSW, Australia

Saleh, M:
 Prince Wales Hosp, Randwick, NSW, Australia

Salisbury, E:
 Prince Wales Hosp, Randwick, NSW, Australia

Trainer, A:
 Prince Wales Hosp, Randwick, NSW, Australia

Tucker, K:
 Prince Wales Hosp, Randwick, NSW, Australia

Antill, Y:
 Peter MacCallum Canc Ctr, East Melbourne, Vic, Australia

Dobrovic, A:
 Peter MacCallum Canc Ctr, East Melbourne, Vic, Australia

Fellows, A:
 Peter MacCallum Canc Ctr, East Melbourne, Vic, Australia

Fox, S:
 Peter MacCallum Canc Ctr, East Melbourne, Vic, Australia

Harris, M:
 Peter MacCallum Canc Ctr, East Melbourne, Vic, Australia

Nightingale, S:
 Peter MacCallum Canc Ctr, East Melbourne, Vic, Australia

Phillips, K:
 Peter MacCallum Canc Ctr, East Melbourne, Vic, Australia

Sambrook, J:
 Peter MacCallum Canc Ctr, East Melbourne, Vic, Australia

Thorne, H:
 Peter MacCallum Canc Ctr, East Melbourne, Vic, Australia

Armitage, S:
 Royal Brisbane & Womens Hosp, Herston, Qld 4029, Australia

Arnold, L:
 Royal Brisbane & Womens Hosp, Herston, Qld 4029, Australia

Kefford, R:
 Westmead Hosp, Westmead, NSW, Australia

Kirk, J:
 Westmead Hosp, Westmead, NSW, Australia

Rickard, E:
 Westmead Hosp, Westmead, NSW, Australia

Bastick, P:
 St George Hosp, Kogarah, NSW, Australia

Beesley, J:
 Queensland Inst Med Res, Herston, Qld, Australia

Hayward, N:
 Queensland Inst Med Res, Herston, Qld, Australia

Spurdle, A:
 Queensland Inst Med Res, Herston, Qld, Australia

Walker, L:
 Queensland Inst Med Res, Herston, Qld, Australia

Beilby, J:
 Queen Elizabeth Med Ctr, Nedlands, WA, Australia

Saunders, C:
 Queen Elizabeth Med Ctr, Nedlands, WA, Australia

Bennett, I:
 Silverton Pl, Brisbane, Qld, Australia

Blackburn, A:
 Australian Natl Univ, Canberra, ACT, Australia

Bogwitz, M:
 Royal Melbourne Hosp, Parkville, Vic, Australia

Gaff, C:
 Royal Melbourne Hosp, Parkville, Vic, Australia

Lindeman, G:
 Royal Melbourne Hosp, Parkville, Vic, Australia

Pachter, N:
 Royal Melbourne Hosp, Parkville, Vic, Australia

Scott, C:
 Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA

 Royal Melbourne Hosp, Parkville, Vic, Australia

Sexton, A:
 Royal Melbourne Hosp, Parkville, Vic, Australia

Visvader, J:
 Royal Melbourne Hosp, Parkville, Vic, Australia

Taylor, J:
 Royal Melbourne Hosp, Parkville, Vic, Australia

Winship, I:
 Royal Melbourne Hosp, Parkville, Vic, Australia

Brennan, M:
 NSW Breast Canc Inst, Westmead, NSW, Australia

Brown, M:
 Univ Queensland, Queensland, Qld, Australia

French, J:
 Univ Queensland, Queensland, Qld, Australia

Edwards, S:
 Univ Queensland, Queensland, Qld, Australia

Burgess, M:
 Austin Hlth, Heidelberg, Vic, Australia

Burke, J:
 Royal Hobart Hosp, Hobart, Tas, Australia

Patterson, B:
 Royal Hobart Hosp, Hobart, Tas, Australia

Butow, P:
 Royal Prince Alfred Hosp, Camperdown, NSW, Australia

Culling, B:
 Royal Prince Alfred Hosp, Camperdown, NSW, Australia

Caldon, L:
 Garvan Inst Med Res, Darlinghurst, NSW, Australia

Callen, D:
 Univ Adelaide, Hanson Inst, Rundle Mall, SA, Australia

Chauhan, D:
 Univ Sydney, Sydney, NSW, Australia

Eisenbruch, M:
 Univ Sydney, Sydney, NSW, Australia

Heiniger, L:
 Univ Sydney, Sydney, NSW, Australia

Chauhan, M:
 Kinghorn Canc Ctr, Sydney, NSW, Australia

Christian, A:
 Wellington Hosp, Wellington, New Zealand

Dixon, J:
 Wellington Hosp, Wellington, New Zealand

Kidd, A:
 Wellington Hosp, Wellington, New Zealand

Cohen, P:
 St John God Subiaco Hosp, Subiaco, New Zealand

Colley, A:
 Liverpool Hlth Serv, Liverpool, Merseyside, England

Fenton, G:
 Liverpool Hlth Serv, Liverpool, Merseyside, England

Crook, A:
 Royal North Shore Hosp, St Leonards, NSW, Australia

Dickson, R:
 Royal North Shore Hosp, St Leonards, NSW, Australia

Field, M:
 Royal North Shore Hosp, St Leonards, NSW, Australia

Cui, J:
 Monash Univ, Melbourne, Vic, Australia

Cummings, M:
 Univ Queensland, Med Sch, Herston, NSW, Australia

Dawson, SJ:
 Univ Cambridge, Cambridge, England

DeFazio, A:
 Westmead Hosp, Westmead, NSW, Australia

 Westmead Inst Canc Res, Westmead, NSW, Australia

Delatycki, M:
 Heidelberg Repatriat Hosp, Heidelberg Hts, Vic, Australia

Dudding, T:
 Hunter Area Hlth Serv, Waratah, Australia

Edkins, T:
 Princess Margret Hosp Children, Perth, WA, Australia

Farshid, G:
 IMVS, Adelaide, SA, Australia

Flanagan, J:
 Imperial Coll London, London, England

Fong, P:
 Auckland City Hosp, Auckland, New Zealand

Forrest, L:
 Parkville Familial Canc Ctr, Melbourne, Vic, Australia

Gallego-Ortega, D:
 Kinghorn Canc Ctr, Darlinghurst, NSW, Australia

George, P:
 Canterbury Hlth Labs, Christchurch, New Zealand

Gill, G:
 Royal Adelaide Hosp, Adelaide, SA, Australia

Kollias, J:
 Royal Adelaide Hosp, Adelaide, SA, Australia

Haan, E:
 Womens & Childrens Hosp, Adelaide, NSW, Australia

Hart, S:
 Monash Med Ctr, Bentleigh, Vic, Australia

Jenkins, M:
 Univ Melbourne, Melbourne, Vic, Australia

Hunt, C:
 Monash Med Ctr, Melbourne, Vic, Australia

Lakhani, S:
 Royal Brisbane & Womens Hosp, Herston, Qld 4029, Australia

 Queensland Inst Med Res, Herston, Qld, Australia

Lipton, L:
 Western Hosp, Footscray, Vic, Australia

Lobb, L:
 Univ Sydney, Sydney, NSW, Australia

Mann, G:
 Westmead Millennium Inst, Westmead, NSW, Australia

McLachlan, SA:
 St Vincents Hosp, Fitzroy, Vic, Australia

O'Connell, S:
 Southern Hlth Familial Canc Ctr, Clayton, Vic, Australia

O'Sullivan, S:
 Agnes Walsh House, Subiaco, WA, Australia

Pieper, E:
 Parkville Familial Canc Ctr, Melbourne, Vic, Australia

 Genom Med, Melbourne, Vic, Australia

Robinson, B:
 Christchurch Hosp, Christchurch, New Zealand

Saunus, J:
 Univ Queensland, Med Sch, Herston, NSW, Australia

 Womens Hosp Med Ctr, Herston, Qld, Australia

Scott, E:
 South View Clin, Kogarah, NSW, Australia

Shelling, A:
 Univ Auckland, Auckland, New Zealand

Williams, R:
 St Vincents Hosp, Darlinghurst, NSW, Australia

Young, MA:
 Genome One, Darlinghurst, NSW, Australia
ISSN: 23744677
Editorial
NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND, Alemania
Tipo de documento: Article
Volumen: 5 Número:
Páginas:
WOS Id: 000493912600001
ID de PubMed: 31700994
imagen Gold, Green Published, Green Accepted

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