Red and Processed Meat Consumption and Risk for All-Cause Mortality and Cardiometabolic Outcomes A Systematic Review and Meta-analysis of Cohort Studies
Por:
Zeraatkar, D, Han, MA, Guyatt, GH, Vernooij, RWM, El Dib, R, Cheung, K, Milio, K, Zworth, M, Bartoszko, JJ, Valli, C, Rabassa, M, Lee, Y, Zajac, J, Prokop-Dorner, A, Lo, C, Bala, MM, Alonso-Coello, P, Hanna, SE, Johnston, BC
Publicada:
19 nov 2019
Resumen:
Background: Dietary guidelines generally recommend limiting intake of red and processed meat. However, the quality of evidence implicating red and processed meat in adverse health outcomes remains unclear.
Purpose: To evaluate the association between red and processed meat consumption and all-cause mortality, cardiometabolic outcomes, quality of life, and satisfaction with diet among adults.
Data Sources: EMBASE (Elsevier), Cochrane Central Register of Controlled Trials (Wiley), Web of Science (Clarivate Analytics), CINAHL (EBSCO), and ProQuest from inception until July 2018 and MEDLINE from inception until April 2019, without language restrictions, as well as bibliographies of relevant articles.
Study Selection: Cohort studies with at least 1000 participants that reported an association between unprocessed red or processed meat intake and outcomes of interest.
Data Extraction: Teams of 2 reviewers independently extracted data and assessed risk of bias. One investigator assessed certainty of evidence, and the senior investigator confirmed the assessments.
Data Synthesis: Of 61 articles reporting on 55 cohorts with more than 4 million participants, none addressed quality of life or satisfaction with diet. Low-certainty evidence was found that a reduction in unprocessed red meat intake of 3 servings per week is associated with a very small reduction in risk for cardiovascular mortality, stroke, myocardial infarction (MI), and type 2 diabetes. Likewise, low-certainty evidence was found that a reduction in processed meat intake of 3 servings per week is associated with a very small decrease in risk for all-cause mortality, cardiovascular mortality, stroke, MI, and type 2 diabetes.
Limitation: Inadequate adjustment for known confounders, residual confounding due to observational design, and recall bias associated with dietary measurement.
Conclusion: The magnitude of association between red and processed meat consumption and all-cause mortality and adverse cardiometabolic outcomes is very small, and the evidence is of low certainty.
Primary Funding Source: None. (PROSPERO: CRD42017074074)
Filiaciones:
Zeraatkar, D:
McMaster Univ, Hamilton, ON, Canada
McMaster Univ, Dept Hlth Res Methods Evidence & Impact, 1280 Main St West, Hamilton, ON L8S 4K1, Canada
Han, MA:
Chosun Univ, Gwangju, South Korea
Chosun Univ, Dept Prevent Med, Coll Med, 309 Philmun Daero, Gwangju 61452, South Korea
Guyatt, GH:
McMaster Univ, Hamilton, ON, Canada
McMaster Univ, Dept Hlth Res Methods Evidence & Impact, 1280 Main St West, Hamilton, ON L8S 4K1, Canada
Vernooij, RWM:
Netherlands Comprehens Canc Org IKNL, Utrecht, Netherlands
Dalhousie Univ, Halifax, NS, Canada
Netherlands Comprehens Canc Org, Dept Res, Godebaldkwartier 419, NL-3511 DT Utrecht, Netherlands
El Dib, R:
Dalhousie Univ, Halifax, NS, Canada
Univ Estadual Paulista, Sci & Technol Inst, Sao Paulo, Brazil
Inst Sci & Technol, Ave Engenheiro Francisco Jose Longo 77, BR-12245000 Sao Jose Dos Campos, Brazil
Cheung, K:
McMaster Univ, Hamilton, ON, Canada
114 Loganberry Crescent, Toronto, ON M2H 3H1, Canada
Milio, K:
McMaster Univ, Hamilton, ON, Canada
592 Regal Pl, Waterloo, ON N2V 2G3, Canada
Zworth, M:
McMaster Univ, Hamilton, ON, Canada
28 York Downs Dr, Toronto, ON M3H 1J1, Canada
Bartoszko, JJ:
McMaster Univ, Hamilton, ON, Canada
McMaster Univ, Dept Hlth Res Methods Evidence & Impact, 1280 Main St West, Hamilton, ON L8S 4K1, Canada
Valli, C:
Biomed Res Inst San Pau IIB St Pau, Barcelona, Spain
IIB St Pau CIBERESP, Iberoamer Cochrane Ctr, Carrer St Antoni Maria Claret 167, Barcelona 08025, Spain
Rabassa, M:
Biomed Res Inst San Pau IIB St Pau, Barcelona, Spain
IIB St Pau CIBERESP, Iberoamer Cochrane Ctr, Carrer St Antoni Maria Claret 167, Barcelona 08025, Spain
Lee, Y:
McMaster Univ, Hamilton, ON, Canada
30 White Lodge Crescent, Richmond Hill, ON L4C 9A1, Canada
Zajac, J:
Jagiellonian Univ, Med Coll, Krakow, Poland
Jagiellonian Univ, Med Coll, Dept Hyg & Dietet, Kopernika 7 St, PL-31034 Krakow, Poland
Prokop-Dorner, A:
Jagiellonian Univ, Med Coll, Krakow, Poland
Jagiellonian Univ, Med Coll, Dept Hyg & Dietet, Kopernika 7 St, PL-31034 Krakow, Poland
Lo, C:
Univ British Columbia, Vancouver, BC, Canada
556 Amarone Court, Mississauga, ON L5W 0A7, Canada
Bala, MM:
Jagiellonian Univ, Med Coll, Krakow, Poland
Jagiellonian Univ, Med Coll, Dept Hyg & Dietet, Kopernika 7 St, PL-31034 Krakow, Poland
Alonso-Coello, P:
Biomed Res Inst San Pau IIB St Pau, Barcelona, Spain
CIBER Epidemiol & Salud Publ CIBERESP, Barcelona, Spain
IIB St Pau CIBERESP, Iberoamer Cochrane Ctr, Carrer St Antoni Maria Claret 167, Barcelona 08025, Spain
Hanna, SE:
McMaster Univ, Hamilton, ON, Canada
McMaster Univ, Dept Hlth Res Methods Evidence & Impact, 1280 Main St West, Hamilton, ON L8S 4K1, Canada
Johnston, BC:
McMaster Univ, Hamilton, ON, Canada
Dalhousie Univ, Halifax, NS, Canada
Dalhousie Univ, Dept Community Hlth & Epidemiol, Fac Med, Room 404,5790 Univ Ave, Halifax, NS B3J 0E4, Canada
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