Reduction of Red and Processed Meat Intake and Cancer Mortality and Incidence A Systematic Review and Meta-analysis of Cohort Studies
Por:
Han, MA, Zeraatkar, D, Guyatt, GH, Vernooij, RWM, El Dib, R, Zhang, Y, Algarni, A, Leung, G, Storman, D, Valli, C, Rabassa, M, Rehman, N, Parvizian, MK, Zworth, M, Bartoszko, JJ, Lopes, LC, Sit, D, Bala, MM, Alonso-Coello, P, Johnston, BC
Publicada:
19 nov 2019
Resumen:
Background: Cancer incidence has continuously increased over the past few centuries and represents a major health burden worldwide.
Purpose: To evaluate the possible causal relationship between intake of red and processed meat and cancer mortality and incidence.
Data Sources: Embase, Cochrane Central Register of Controlled Trials, Web of Science, CINAHL, and ProQuest from inception until July 2018 and MEDLINE from inception until April 2019 without language restrictions.
Study Selection: Cohort studies that included more than 1000 adults and reported the association between consumption of unprocessed red and processed meat and cancer mortality and incidence.
Data Extraction: Teams of 2 reviewers independently extracted data and assessed risk of bias; 1 reviewer evaluated the certainty of evidence, which was confirmed or revised by the senior reviewer.
Data Synthesis: Of 118 articles (56 cohorts) with more than 6 million participants, 73 articles were eligible for the dose-response meta-analyses, 30 addressed cancer mortality, and 80 reported cancer incidence. Low-certainty evidence suggested that an intake reduction of 3 servings of unprocessed meat per week was associated with a very small reduction in overall cancer mortality over a lifetime. Evidence of low to very low certainty suggested that each intake reduction of 3 servings of processed meat per week was associated with very small decreases in overall cancer mortality over a lifetime; prostate cancer mortality; and incidence of esophageal, colorectal, and breast cancer.
Limitation: Limited causal inferences due to residual confounding in observational studies, risk of bias due to limitations in diet assessment and adjustment for confounders, recall bias in dietary assessment, and insufficient data for planned subgroup analyses.
Conclusion: The possible absolute effects of red and processed meat consumption on cancer mortality and incidence are very small, and the certainty of evidence is low to very low.
Primary Funding Source: None. (PROSPERO: CRD42017074074)
Filiaciones:
Han, MA:
Chosun Univ, Gwangju, South Korea
Chosun Univ, Coll Med, Dept Prevent Med, 309 Pilmun Daero, Gwangju 61452, South Korea
Zeraatkar, D:
McMaster Univ, Hamilton, ON, Canada
McMaster Univ, Hlth Sci Ctr, 1280 Main St West, Hamilton, ON L8S 4L8, Canada
Guyatt, GH:
McMaster Univ, Hamilton, ON, Canada
McMaster Univ, Hlth Sci Ctr, 1280 Main St West, Hamilton, ON L8S 4L8, Canada
Vernooij, RWM:
Dalhousie Univ, Halifax, NS, Canada
Netherlands Comprehens Canc Org, Utrecht, Netherlands
Netherlands Comprehens Canc Org, Dept Res, Godebaldkwartier 419, NL-3511 DT Utrecht, Netherlands
El Dib, R:
Dalhousie Univ, Halifax, NS, Canada
Univ Estadual Paulista, Sci & Technol Inst, Sao Paulo, Brazil
Univ Estadual Paulista, Inst Sci & Technol, Ave Engenheiro Francisco Jose Longo 777, BR-12245000 Sao Jose Dos Campos, Sao Paolo, Brazil
Zhang, Y:
Beijing Univ Chinese Med, Beijing, Peoples R China
Beijing Univ, Ctr Evidence Based Chinese Med, 11 Beisanhuan Dong Lu, Beijing 100029, Peoples R China
Algarni, A:
Aseer Cent Hosp, Abha, Saudi Arabia
Aseer Cent Hosp, Dept Internal Med, 4076 Al Muruj,Unit 3, Abha 62523, Saudi Arabia
Leung, G:
McMaster Univ, Hamilton, ON, Canada
McMaster Univ, Hlth Sci Ctr, 1280 Main St West, Hamilton, ON L8S 4L8, Canada
Storman, D:
Jagiellonian Univ, Coll Med, Krakow, Poland
Univ British Columbia, 107-1165 West 13th Ave, Vancouver, BC V6H 1N4, Canada
Jagiellonian Univ, Coll Med, Dept Hyg & Dietet, 7 Kopernika St, PL-31034 Krakow, Poland
Valli, C:
Iberoamer Cochrane Ctr Barcelona, Biomed Res Inst St Pau, Barcelona, Spain
CIBER Epidemiol & Salud Publ, Barcelona, Spain
Rabassa, M:
Iberoamer Cochrane Ctr Barcelona, Biomed Res Inst St Pau, Barcelona, Spain
CIBER Epidemiol & Salud Publ, Barcelona, Spain
Inst Invest Biomed St Pau IIB St Pau CIBERESP, Iberoamer Cochrane Ctr, Carrer St Antoni Maria Claret 167, Barcelona 08025, Spain
Rehman, N:
McMaster Univ, Hamilton, ON, Canada
McMaster Univ, Hlth Sci Ctr, 1280 Main St West, Hamilton, ON L8S 4L8, Canada
Parvizian, MK:
McMaster Univ, Hamilton, ON, Canada
McMaster Univ, Hlth Sci Ctr, 1280 Main St West, Hamilton, ON L8S 4L8, Canada
Zworth, M:
McMaster Univ, Hamilton, ON, Canada
McMaster Univ, Hlth Sci Ctr, 1280 Main St West, Hamilton, ON L8S 4L8, Canada
Bartoszko, JJ:
McMaster Univ, Hamilton, ON, Canada
McMaster Univ, Hlth Sci Ctr, 1280 Main St West, Hamilton, ON L8S 4L8, Canada
Lopes, LC:
Univ Sorocaba, Sao Paulo, Brazil
Univ Sorocaba UNISO, Rodovia Raposo Tavares,Km 92,5, BR-18023000 Sao Paulo, Brazil
Sit, D:
Univ British Columbia, 107-1165 West 13th Ave, Vancouver, BC V6H 1N4, Canada
Bala, MM:
Jagiellonian Univ, Coll Med, Krakow, Poland
Jagiellonian Univ, Coll Med, Dept Hyg & Dietet, 7 Kopernika St, PL-31034 Krakow, Poland
Alonso-Coello, P:
McMaster Univ, Hamilton, ON, Canada
Iberoamer Cochrane Ctr Barcelona, Biomed Res Inst St Pau, Barcelona, Spain
CIBER Epidemiol & Salud Publ, Barcelona, Spain
Inst Invest Biomed St Pau IIB St Pau CIBERESP, Iberoamer Cochrane Ctr, Carrer St Antoni Maria Claret 167, Barcelona 08025, Spain
Johnston, BC:
McMaster Univ, Hamilton, ON, Canada
Dalhousie Univ, Halifax, NS, Canada
Dalhousie Univ, Clin Res Ctr, Dept Community Hlth & Epidemiol, 5790 Univ Ave,Room 404, Halifax, NS B3J 0E4, Canada
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