Artificial Inclusion Bodies for Clinical Development
Por:
Sanchez, JM, Lopez-Laguna, H, Alamo, P, Serna, N, Sanchez-Chardi, A, Nolan, V, Cano-Garrido, O, Casanova, I, Unzueta, U, Vazquez, E, Mangues, R, Villaverde, A
Publicada:
1 feb 2020
Ahead of Print:
1 nov 2019
Resumen:
Bacterial inclusion bodies (IBs) are mechanically stable protein particles in the microscale, which behave as robust, slow-protein-releasing amyloids. Upon exposure to cultured cells or upon subcutaneous or intratumor injection, these protein materials secrete functional IB polypeptides, functionally mimicking the endocrine release of peptide hormones from secretory amyloid granules. Being appealing as delivery systems for prolonged protein drug release, the development of IBs toward clinical applications is, however, severely constrained by their bacterial origin and by the undefined and protein-to-protein, batch-to-batch variable composition. In this context, the de novo fabrication of artificial IBs (ArtIBs) by simple, cell-free physicochemical methods, using pure components at defined amounts is proposed here. By this, the resulting functional protein microparticles are intriguing, chemically defined biomimetic materials that replicate relevant functionalities of natural IBs, including mammalian cell penetration and local or remote release of functional ArtIB-forming protein. In default of severe regulatory issues, the concept of ArtIBs is proposed as a novel exploitable category of biomaterials for biotechnological and biomedical applications, resulting from simple fabrication and envisaging soft developmental routes to clinics.
Filiaciones:
Sanchez, JM:
Univ Autonoma Barcelona, Inst Biotecnol & Biomed, E-08193 Barcelona, Spain
Univ Nacl Cordoba, ICTA, CONICET, Inst Invest Biol & Tecnol IIBYT, Av Velez Sarsfield 1611,X 5016GCA, Cordoba, Argentina
UNC, FCEFyN, Dept Quim, Catedra Quim Biol, Av Velez Sarsfield 1611,X 5016GCA, Cordoba, Argentina
Lopez-Laguna, H:
Univ Autonoma Barcelona, Inst Biotecnol & Biomed, E-08193 Barcelona, Spain
Univ Autonoma Barcelona, Dept Genet & Microbiol, E-08193 Barcelona, Spain
CIBER Bioingn Biomat & Nanomed CIBER BBN, Madrid 28029, Spain
Alamo, P:
CIBER Bioingn Biomat & Nanomed CIBER BBN, Madrid 28029, Spain
Hosp Santa Creu & Sant Pau, Biomed Res Inst St Pau IIB St Pau, Barcelona 08041, Spain
Hosp Santa Creu & Sant Pau, Josep Carreras Res Inst, Barcelona 08041, Spain
Serna, N:
Univ Autonoma Barcelona, Inst Biotecnol & Biomed, E-08193 Barcelona, Spain
Univ Autonoma Barcelona, Dept Genet & Microbiol, E-08193 Barcelona, Spain
CIBER Bioingn Biomat & Nanomed CIBER BBN, Madrid 28029, Spain
Sanchez-Chardi, A:
Univ Autonoma Barcelona, Serv Microscopia, E-08193 Barcelona, Spain
Nolan, V:
Univ Nacl Cordoba, ICTA, CONICET, Inst Invest Biol & Tecnol IIBYT, Av Velez Sarsfield 1611,X 5016GCA, Cordoba, Argentina
UNC, FCEFyN, Dept Quim, Catedra Quim Biol, Av Velez Sarsfield 1611,X 5016GCA, Cordoba, Argentina
Cano-Garrido, O:
Univ Autonoma Barcelona, Inst Biotecnol & Biomed, E-08193 Barcelona, Spain
Univ Autonoma Barcelona, Dept Genet & Microbiol, E-08193 Barcelona, Spain
Univ Autonoma Barcelona, Nanoligent SL, Edifici EUREKA, E-08193 Barcelona, Spain
Casanova, I:
CIBER Bioingn Biomat & Nanomed CIBER BBN, Madrid 28029, Spain
Hosp Santa Creu & Sant Pau, Biomed Res Inst St Pau IIB St Pau, Barcelona 08041, Spain
Hosp Santa Creu & Sant Pau, Josep Carreras Res Inst, Barcelona 08041, Spain
Unzueta, U:
CIBER Bioingn Biomat & Nanomed CIBER BBN, Madrid 28029, Spain
Hosp Santa Creu & Sant Pau, Biomed Res Inst St Pau IIB St Pau, Barcelona 08041, Spain
Hosp Santa Creu & Sant Pau, Josep Carreras Res Inst, Barcelona 08041, Spain
Vazquez, E:
Univ Autonoma Barcelona, Inst Biotecnol & Biomed, E-08193 Barcelona, Spain
Univ Autonoma Barcelona, Dept Genet & Microbiol, E-08193 Barcelona, Spain
CIBER Bioingn Biomat & Nanomed CIBER BBN, Madrid 28029, Spain
Mangues, R:
CIBER Bioingn Biomat & Nanomed CIBER BBN, Madrid 28029, Spain
Hosp Santa Creu & Sant Pau, Biomed Res Inst St Pau IIB St Pau, Barcelona 08041, Spain
Hosp Santa Creu & Sant Pau, Josep Carreras Res Inst, Barcelona 08041, Spain
Villaverde, A:
Univ Autonoma Barcelona, Inst Biotecnol & Biomed, E-08193 Barcelona, Spain
Univ Autonoma Barcelona, Dept Genet & Microbiol, E-08193 Barcelona, Spain
CIBER Bioingn Biomat & Nanomed CIBER BBN, Madrid 28029, Spain
Gold, Green Published
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