Plasma lipid profiles discriminate bacterial from viral infection in febrile children
Por:
Wang, XZ, Nijman, R, Camuzeaux, S, Sands, C, Jackson, H, Kaforou, M, Emonts, M, Herberg, JA, Maconochie, I, Carrol, ED, Paulus, SC, Zenz, W, Van der Flier, M, de Groot, R, Schlapbach, LJ, Pollard, AJ, Fink, C, Kuijpers, TT, Anderson, S, Lewis, MR, Levin, M, McClure, M, Gormley, S, Hamilton, S, Hourmat, B, Hoggart, C, Sancho-Shimizu, V, Wright, V, Abdulla, A, Agapow, P, Bartlett, M, Bellos, E, Eleftherohorinou, H, Galassini, R, Inwald, D, Mashbat, M, Menikou, S, Mustafa, S, Nadel, S, Rahman, R, Thakker, C, Coin, LMJ, Bokhand, S, Power, S, Barham, H, Pathan, N, Ridout, J, White, D, Thurston, S, Faust, S, Patel, S, McCorkell, J, Davies, P, Crate, L, Navarra, H, Carter, S, Ramaiah, R, Patel, R, Tuffrey, C, Gribbin, A, McCready, S, Peters, M, Hardy, K, Standing, F, O'Neill, L, Abelake, E, Deep, A, Nsirim, E, Willis, L, Young, Z, Royad, C, White, S, Fortune, PM, Hudnott, P, Gonzalez, FA, Barral-Arca, R, Cebey-Lopez, M, Curras-Tuala, MJ, Garcia, N, Vicente, LG, Gomez-Carballa, A, Rial, JG, Beiroa, AG, Grande, AJ, Iglesias, PL, Santos, AEM, Martinon-Torres, F, MartinonTorres, N, Sanchez, JMM, Gutierrez, BM, Perez, BM, Pacheco, PO, Pardo-Seco, J, Pischedda, S, RiveroCalle, I, Rodriguez-Tenreiro, C, Redondo-Collazo, L, Ellacuriagal, AS, Fernandez, SS, Silva, MDSP, Vega, A, Trillo, LV, Salas, A, Reyes, SB, Leon, MCL, Mingorance, AN, Barrios, XG, Vergara, EO, Torre, AC, Vivanco, A, Fernandez, R, Sanchez, FG, Forte, MS, Rojo, P, Contreras, JR, Palacios, A, Ibarrondo, CE, Cooke, EF, Navarro, M, Alvarez, CA, Lozano, MJ, Carreras, E, Sanagustin, SB, Neth, O, Padilla, MDCM, Tato, LMP, Guillen, S, Silveira, LF, Moreno, D, van Furth, AMT, Boeddha, NP, Driessen, GJA, Emonts, M, Hazelzet, JA, Pajkrt, D, Sanders, EAM, Van De Beek, D, van der Ende, A, Philipsen, HLA, Adeel, AOA, Breukels, MA, Brinkman, DMC, de Korte, CCMM, de Vries, E, de Waal, WJ, Dekkers, R, Dings-Lammertink, A, Doedens, RA, Donker, AE, Dousma, M, Faber, TE, Gerrits, GPJM, Gerver, JAM, Heidema, J, Homan-van der Veen, J, Jacobs, MAM, Jansen, NJG, Kawczynski, P, Klucovska, K, Kneyber, MCJ, Koopman-Keemink, Y, Langenhorst, VJ, Leusink, J, Loza, BF, Merth, IT, Miedema, CJ, Neeleman, C, Noordzij, JG, Obihara, CC, van Overbeek-van Gils, ALT, Poortman, GH, Potgieter, ST, Potjewijd, J, Rosias, PPR, Sprong, T, ten Tussher, GW, Thio, BJ, Tramper-Stranders, GA, van Deuren, M, van der Meer, H, van Kuppevelt, AJM, van Wermeskerken, AM, Verwijs, WA, Wolfs, TFW, Agyeman, P, Aebi, C, Giannoni, E, Stocker, M, Posfay-Barbe, KM, Heininger, U, Bernhard-Stirnemann, S, Niederer-Loher, A, Kahlert, C, Hasters, P, Relly, C, Baer, W, Berger, C, Frederick, H, Jennings, R, Johnston, J, Kenwright, R, Pinnock, E, Agbeko, R, Secka, F, Bojang, K, Sarr, I, Kebbeh, N, Sey, G, Momodou, SK, Cole, F, Thomas, G, Antonio, M, Klobassa, DS, Binder, A, Schweintzger, NA, Sagmeister, M, Baumgart, H, Baumgartner, M, Behrends, U, Biebl, A, Birnbacher, R, Blanke, JG, Boelke, C, Breuling, K, Brunner, J, Buller, M, Dahlem, P, Dietrich, B, Eber, E, Elias, J, Emhofer, J, Etschmaier, R, Farr, S, Girtler, Y, Grigorow, I, Heimann, K, Ihm, U, Jaros, Z, Kalhoff, H, Kaulfersch, W, Kemen, C, Klocker, N, Koster, B, Kohlmaier, B, Komini, E, Kramer, L, Neubert, A, Ortner, D, Pescollderungg, L, Pfurtscheller, K, Reiter, K, Ristic, G, Rodl, S, Sellner, A, Sonnleitner, A, Sperl, M, Stelzl, W, Till, H, Trobisch, A, Vierzig, A, Vogel, U, Weingarten, C, Welke, S, Wimmer, A, Wintergerst, U, Wuller, D, Zaunschirm, A, Ziuraite, I, Zukovskaja, V
Publicada:
27 nov 2019
Resumen:
Fever is the most common reason that children present to Emergency Departments. Clinical signs and symptoms suggestive of bacterial infection are often non-specific, and there is no definitive test for the accurate diagnosis of infection. The 'omics' approaches to identifying biomarkers from the host-response to bacterial infection are promising. In this study, lipidomic analysis was carried out with plasma samples obtained from febrile children with confirmed bacterial infection (n = 20) and confirmed viral infection (n = 20). We show for the first time that bacterial and viral infection produces distinct profile in the host lipidome. Some species of glycerophosphoinositol, sphingomyelin, lysophosphatidylcholine and cholesterol sulfate were higher in the confirmed virus infected group, while some species of fatty acids, glycerophosphocholine, glycerophosphoserine, lactosylceramide and bilirubin were lower in the confirmed virus infected group when compared with confirmed bacterial infected group. A combination of three lipids achieved an area under the receiver operating characteristic (ROC) curve of 0.911 (95% CI 0.81 to 0.98). This pilot study demonstrates the potential of metabolic biomarkers to assist clinicians in distinguishing bacterial from viral infection in febrile children, to facilitate effective clinical management and to the limit inappropriate use of antibiotics.
Filiaciones:
Wang, XZ:
Imperial Coll London, Dept Infect Dis, London W2 1PG, England
Nijman, R:
Imperial Coll London, Dept Infect Dis, London W2 1PG, England
Camuzeaux, S:
Imperial Coll London, Natl Phenome Ctr, IRDB Bldg,Du Cane Rd, London W12 0NN, England
Imperial Coll London, Imperial Clin Phenotyping Ctr, Dept Metab Digest & Reprod, IRDB Bldg,Du Cane Rd, London W12 0NN, England
Sands, C:
Imperial Coll London, Natl Phenome Ctr, IRDB Bldg,Du Cane Rd, London W12 0NN, England
Imperial Coll London, Imperial Clin Phenotyping Ctr, Dept Metab Digest & Reprod, IRDB Bldg,Du Cane Rd, London W12 0NN, England
Jackson, H:
Imperial Coll London, Dept Infect Dis, London W2 1PG, England
Kaforou, M:
Imperial Coll London, Dept Infect Dis, London W2 1PG, England
Emonts, M:
Newcastle Upon Tyne Hosp NHS Fdn Trust, Great North Childrens Hosp, Paediat Immunol, Infect Dis & Allergy, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England
Newcastle Univ, Translat & Clin Res Inst, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England
Newcastle Upon Tyne Hosp NHS Trust, NIHR Newcastle Biomed Res Ctr, Newcastle Upon Tyne NE4 5PL, Tyne & Wear, England
Newcastle Univ, Newcastle Upon Tyne NE4 5PL, Tyne & Wear, England
Sophia Childrens Univ Hosp, Erasmus Med Ctr, Rotterdam, Netherlands
Newcastle Univ, Inst Cellular Med, Newcastle Upon Tyne, Tyne & Wear, England
Great North Childrens Hosp, Newcastle Upon Tyne Hosp Fdn Trust, Paediat Infect Dis & Immunol Dept, Newcastle Upon Tyne, Tyne & Wear, England
Herberg, JA:
Imperial Coll London, Dept Infect Dis, London W2 1PG, England
Maconochie, I:
Imperial Coll NHS Healthcare Trust, St Marys Hosp, Dept Paediat Emergency Med, London W2 1NY, England
Carrol, ED:
Univ Liverpool, Inst Infect & Global Hlth, Liverpool L69 7BE, Merseyside, England
Alder Hey Childrens NHS Fdn Trust, Dept Infect Dis, Liverpool L12 2AP, Merseyside, England
Liverpool Hlth Partners, Liverpool L3 5TF, Merseyside, England
Paulus, SC:
Alder Hey Childrens NHS Fdn Trust, Dept Infect Dis, Liverpool L12 2AP, Merseyside, England
Liverpool Hlth Partners, Liverpool L3 5TF, Merseyside, England
Zenz, W:
Med Univ Graz, Dept Gen Paediat, Auenbruggerpl 34-2, A-8036 Graz, Austria
Van der Flier, M:
Univ Med Ctr Utrecht, Wilhelmina Childrens Hosp, Pediat Infect Dis & Immunol, NL-3508 AB Utrecht, Netherlands
Radboud Univ Nijmegen, Med Ctr, Amalia Childrens Hosp, Pediat Infect Dis & Immunol, NL-6500 HB Nijmegen, Netherlands
Radboud Univ Nijmegen, Med Ctr, Radboud Inst Mol Life Sci, Dept Lab Med,Lab Med Immunol,Sect Pediat Infect D, NL-6500 HB Nijmegen, Netherlands
de Groot, R:
Radboud Univ Nijmegen, Med Ctr, Amalia Childrens Hosp, Pediat Infect Dis & Immunol, NL-6500 HB Nijmegen, Netherlands
Radboud Univ Nijmegen, Med Ctr, Radboud Inst Mol Life Sci, Dept Lab Med,Lab Med Immunol,Sect Pediat Infect D, NL-6500 HB Nijmegen, Netherlands
Schlapbach, LJ:
Univ Queensland, Child Hlth Res Ctr, Paediatirc Criticial Care Res Grp, Brisbane, Qld, Australia
Queensland Childrens Hosp, Paediat Intens Care Res Grp, Brisbane, Qld, Australia
Pollard, AJ:
Univ Oxford, Dept Paediat, Oxford OX3 9DU, England
NIHR Oxford Biomed Res Ctr, Oxford OX3 9DU, England
Fink, C:
Univ Warwick, Micropathol Ltd, Warwick CV4 7EZ, England
Kuijpers, TT:
Emma Childrens Hosp, Acad Med Ctr, Div Pediat Hematol Immunol & Infect Dis, NL-1105 AZ Amsterdam, Netherlands
Anderson, S:
London Sch Hyg & Trop Med, Med Res Council Unit, Banjul, Gambia
Lewis, MR:
Imperial Coll London, Natl Phenome Ctr, IRDB Bldg,Du Cane Rd, London W12 0NN, England
Imperial Coll London, Imperial Clin Phenotyping Ctr, Dept Metab Digest & Reprod, IRDB Bldg,Du Cane Rd, London W12 0NN, England
Levin, M:
Imperial Coll London, Dept Infect Dis, London W2 1PG, England
McClure, M:
Imperial Coll London, Dept Infect Dis, London W2 1PG, England
Gormley, S:
Imperial Coll London, Dept Infect Dis, London W2 1PG, England
Hamilton, S:
Imperial Coll London, Dept Infect Dis, London W2 1PG, England
Hourmat, B:
Imperial Coll London, Dept Infect Dis, London W2 1PG, England
Hoggart, C:
Imperial Coll London, Dept Infect Dis, London W2 1PG, England
Sancho-Shimizu, V:
Imperial Coll London, Dept Infect Dis, London W2 1PG, England
Wright, V:
Imperial Coll London, Dept Infect Dis, London W2 1PG, England
Abdulla, A:
Imperial Coll London, Dept Infect Dis, London W2 1PG, England
Agapow, P:
Imperial Coll London, Dept Infect Dis, London W2 1PG, England
Bartlett, M:
Imperial Coll London, Dept Infect Dis, London W2 1PG, England
Bellos, E:
Imperial Coll London, Dept Infect Dis, London W2 1PG, England
Eleftherohorinou, H:
Imperial Coll London, Dept Infect Dis, London W2 1PG, England
Galassini, R:
Imperial Coll London, Dept Infect Dis, London W2 1PG, England
Inwald, D:
Imperial Coll London, Dept Infect Dis, London W2 1PG, England
Mashbat, M:
Imperial Coll London, Dept Infect Dis, London W2 1PG, England
Menikou, S:
Imperial Coll London, Dept Infect Dis, London W2 1PG, England
Mustafa, S:
Imperial Coll London, Dept Infect Dis, London W2 1PG, England
Nadel, S:
Imperial Coll London, Dept Infect Dis, London W2 1PG, England
Rahman, R:
Imperial Coll London, Dept Infect Dis, London W2 1PG, England
Thakker, C:
Imperial Coll London, Dept Infect Dis, London W2 1PG, England
Coin, LMJ:
Imperial Coll London, Dept Infect Dis, London W2 1PG, England
Bokhand, S:
Poole Hosp NHS Fdn Trust, Poole, Dorset, England
Power, S:
Poole Hosp NHS Fdn Trust, Poole, Dorset, England
Barham, H:
Poole Hosp NHS Fdn Trust, Poole, Dorset, England
Pathan, N:
Cambridge Univ Hosp NHS Trust, Cambridge, England
Ridout, J:
Cambridge Univ Hosp NHS Trust, Cambridge, England
White, D:
Cambridge Univ Hosp NHS Trust, Cambridge, England
Thurston, S:
Cambridge Univ Hosp NHS Trust, Cambridge, England
Faust, S:
Univ Hosp Southampton, Southampton, Hants, England
Patel, S:
Univ Hosp Southampton, Southampton, Hants, England
McCorkell, J:
Univ Hosp Southampton, Southampton, Hants, England
Davies, P:
Nottingham Univ Hosp NHS Trust, Nottingham, England
Crate, L:
Nottingham Univ Hosp NHS Trust, Nottingham, England
Navarra, H:
Nottingham Univ Hosp NHS Trust, Nottingham, England
Carter, S:
Nottingham Univ Hosp NHS Trust, Nottingham, England
Ramaiah, R:
Univ Hosp Leicester NHS Trust, Leicester, Leics, England
Patel, R:
Univ Hosp Leicester NHS Trust, Leicester, Leics, England
Tuffrey, C:
Portsmouth Hosp NHS Trust, Portsmouth, Hants, England
Gribbin, A:
Portsmouth Hosp NHS Trust, Portsmouth, Hants, England
McCready, S:
Portsmouth Hosp NHS Trust, Portsmouth, Hants, England
Peters, M:
Great Ormond St Hosp Sick Children, London, England
Hardy, K:
Great Ormond St Hosp Sick Children, London, England
Standing, F:
Great Ormond St Hosp Sick Children, London, England
O'Neill, L:
Great Ormond St Hosp Sick Children, London, England
Abelake, E:
Great Ormond St Hosp Sick Children, London, England
Deep, A:
Kings Coll Hosp NHS Fdn Trust, London, England
Nsirim, E:
Kings Coll Hosp NHS Fdn Trust, London, England
Willis, L:
Oxford Univ Hosp NHS Fdn Trust, Oxford, England
Young, Z:
Oxford Univ Hosp NHS Fdn Trust, Oxford, England
Royad, C:
Kettering Gen Hosp NHS Fdn Trust, Kettering, England
White, S:
Kettering Gen Hosp NHS Fdn Trust, Kettering, England
Fortune, PM:
Cent Manchester NHS Trust, Manchester, Lancs, England
Hudnott, P:
Cent Manchester NHS Trust, Manchester, Lancs, England
Gonzalez, FA:
Hosp Clin Univ Santiago Compostela, Dept Pediat, Translat Pediat & Infect Dis, Galicia 15706, Spain
Barral-Arca, R:
Hosp Clin Univ Santiago Compostela, Dept Pediat, Translat Pediat & Infect Dis, Galicia 15706, Spain
Univ Santiago Compostela, Fac Med, Inst Ciencias Forenses, Dept Anat Patolox & Ciencias Forenses,Unidade Xen, Galicia, Spain
Hosp Clin Univ Santiago, Inst Invest Sanitarias IDIS, GenPop Res Grp, Galicia, Spain
Cebey-Lopez, M:
Hosp Clin Univ Santiago Compostela, Dept Pediat, Translat Pediat & Infect Dis, Galicia 15706, Spain
Curras-Tuala, MJ:
Imperial Coll London, Natl Phenome Ctr, IRDB Bldg,Du Cane Rd, London W12 0NN, England
Imperial Coll London, Imperial Clin Phenotyping Ctr, Dept Metab Digest & Reprod, IRDB Bldg,Du Cane Rd, London W12 0NN, England
Hosp Clin Univ Santiago Compostela, Dept Pediat, Translat Pediat & Infect Dis, Galicia 15706, Spain
Garcia, N:
Hosp Clin Univ Santiago Compostela, Dept Pediat, Translat Pediat & Infect Dis, Galicia 15706, Spain
Vicente, LG:
Hosp Clin Univ Santiago Compostela, Dept Pediat, Translat Pediat & Infect Dis, Galicia 15706, Spain
Gomez-Carballa, A:
Hosp Clin Univ Santiago Compostela, Dept Pediat, Translat Pediat & Infect Dis, Galicia 15706, Spain
Univ Santiago Compostela, Fac Med, Inst Ciencias Forenses, Dept Anat Patolox & Ciencias Forenses,Unidade Xen, Galicia, Spain
Hosp Clin Univ Santiago, Inst Invest Sanitarias IDIS, GenPop Res Grp, Galicia, Spain
Rial, JG:
Hosp Clin Univ Santiago Compostela, Dept Pediat, Translat Pediat & Infect Dis, Galicia 15706, Spain
Beiroa, AG:
Hosp Clin Univ Santiago Compostela, Dept Pediat, Translat Pediat & Infect Dis, Galicia 15706, Spain
Grande, AJ:
Hosp Clin Univ Santiago Compostela, Dept Pediat, Translat Pediat & Infect Dis, Galicia 15706, Spain
Iglesias, PL:
Hosp Clin Univ Santiago Compostela, Dept Pediat, Translat Pediat & Infect Dis, Galicia 15706, Spain
Santos, AEM:
Hosp Clin Univ Santiago Compostela, Dept Pediat, Translat Pediat & Infect Dis, Galicia 15706, Spain
Martinon-Torres, F:
Inst Invest Sanitaria Santiago, Genet Vaccines & Pediat Infect Dis Res Grp GENVIP, Galicia, Spain
USC, Galicia, Spain
Hosp Clin Univ Santiago Compostela, Dept Pediat, Translat Pediat & Infect Dis, Galicia 15706, Spain
MartinonTorres, N:
Hosp Clin Univ Santiago Compostela, Dept Pediat, Translat Pediat & Infect Dis, Galicia 15706, Spain
Sanchez, JMM:
Hosp Clin Univ Santiago Compostela, Dept Pediat, Translat Pediat & Infect Dis, Galicia 15706, Spain
Gutierrez, BM:
Hosp Clin Univ Santiago Compostela, Dept Pediat, Translat Pediat & Infect Dis, Galicia 15706, Spain
Perez, BM:
Hosp Clin Univ Santiago Compostela, Dept Pediat, Translat Pediat & Infect Dis, Galicia 15706, Spain
Pacheco, PO:
Hosp Clin Univ Santiago Compostela, Dept Pediat, Translat Pediat & Infect Dis, Galicia 15706, Spain
Pardo-Seco, J:
Hosp Clin Univ Santiago Compostela, Dept Pediat, Translat Pediat & Infect Dis, Galicia 15706, Spain
Univ Santiago Compostela, Fac Med, Inst Ciencias Forenses, Dept Anat Patolox & Ciencias Forenses,Unidade Xen, Galicia, Spain
Hosp Clin Univ Santiago, Inst Invest Sanitarias IDIS, GenPop Res Grp, Galicia, Spain
Pischedda, S:
Hosp Clin Univ Santiago Compostela, Dept Pediat, Translat Pediat & Infect Dis, Galicia 15706, Spain
Univ Santiago Compostela, Fac Med, Inst Ciencias Forenses, Dept Anat Patolox & Ciencias Forenses,Unidade Xen, Galicia, Spain
Hosp Clin Univ Santiago, Inst Invest Sanitarias IDIS, GenPop Res Grp, Galicia, Spain
RiveroCalle, I:
Hosp Clin Univ Santiago Compostela, Dept Pediat, Translat Pediat & Infect Dis, Galicia 15706, Spain
Rodriguez-Tenreiro, C:
Hosp Clin Univ Santiago Compostela, Dept Pediat, Translat Pediat & Infect Dis, Galicia 15706, Spain
Redondo-Collazo, L:
Hosp Clin Univ Santiago Compostela, Dept Pediat, Translat Pediat & Infect Dis, Galicia 15706, Spain
Ellacuriagal, AS:
Hosp Clin Univ Santiago Compostela, Dept Pediat, Translat Pediat & Infect Dis, Galicia 15706, Spain
Univ Santiago Compostela, Fac Med, Inst Ciencias Forenses, Dept Anat Patolox & Ciencias Forenses,Unidade Xen, Galicia, Spain
Hosp Clin Univ Santiago, Inst Invest Sanitarias IDIS, GenPop Res Grp, Galicia, Spain
Fernandez, SS:
Hosp Clin Univ Santiago Compostela, Dept Pediat, Translat Pediat & Infect Dis, Galicia 15706, Spain
Silva, MDSP:
Hosp Clin Univ Santiago Compostela, Dept Pediat, Translat Pediat & Infect Dis, Galicia 15706, Spain
Vega, A:
Hosp Clin Univ Santiago Compostela, Dept Pediat, Translat Pediat & Infect Dis, Galicia 15706, Spain
USC, Inst Invest Sanitarias IDIS, Ctr Invest Biomed Red Enfermedades Raras CIBERER, Fdn Publ Galega Med Xenom,Serv Galego Saude SERGA, Santiago De Compostela, Spain
USC, Ctr Invest Biomed Red Enfermedades Raras CIBERER, Grp Med Xenom, Santiago De Compostela, Spain
Trillo, LV:
Hosp Clin Univ Santiago Compostela, Dept Pediat, Translat Pediat & Infect Dis, Galicia 15706, Spain
Salas, A:
Hosp Clin Univ Santiago Compostela, Dept Pediat, Translat Pediat & Infect Dis, Galicia 15706, Spain
Univ Santiago Compostela, Fac Med, Inst Ciencias Forenses, Dept Anat Patolox & Ciencias Forenses,Unidade Xen, Galicia, Spain
Hosp Clin Univ Santiago, Inst Invest Sanitarias IDIS, GenPop Res Grp, Galicia, Spain
Reyes, SB:
Hosp Clin Univ Virgen Arrixaca, Murcia, Spain
Leon, MCL:
Hosp Clin Univ Virgen Arrixaca, Murcia, Spain
Mingorance, AN:
Hosp Clin Univ Virgen Arrixaca, Murcia, Spain
Barrios, XG:
Hosp Clin Univ Virgen Arrixaca, Murcia, Spain
Vergara, EO:
Hosp Donostia, San Sebastian, Spain
Torre, AC:
Hosp Univ Cent Asturias, Asturias, Spain
Vivanco, A:
Hosp Univ Cent Asturias, Asturias, Spain
Fernandez, R:
Hosp Univ Cent Asturias, Asturias, Spain
Sanchez, FG:
Complejo Hosp Torrecardenas, Almeria, Spain
Forte, MS:
Complejo Hosp Torrecardenas, Almeria, Spain
Rojo, P:
Hosp Univ 12 Octubre, Madrid, Spain
Contreras, JR:
Hosp Univ 12 Octubre, Madrid, Spain
Palacios, A:
Hosp Univ 12 Octubre, Madrid, Spain
Ibarrondo, CE:
Hosp Univ 12 Octubre, Madrid, Spain
Cooke, EF:
Hosp Univ 12 Octubre, Madrid, Spain
Navarro, M:
Hosp Gen Univ Gregorio Maranon, Madrid, Spain
Alvarez, CA:
Hosp Gen Univ Gregorio Maranon, Madrid, Spain
Lozano, MJ:
Hosp Gen Univ Gregorio Maranon, Madrid, Spain
Carreras, E:
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Sanagustin, SB:
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Neth, O:
Hosp Univ Virgen Rocio, Seville, Spain
Padilla, MDCM:
Complejo Hosp Jaen, Jaen, Spain
Tato, LMP:
Hosp Univ Getafe, Madrid, Spain
Guillen, S:
Hosp Univ Getafe, Madrid, Spain
Silveira, LF:
Hosp Univ & Politecn La Fe, Valencia, Spain
Moreno, D:
Hosp Reg Univ Carlos Haya, Malaga, Spain
van Furth, AMT:
Vrije Univ, Univ Med Ctr, Amsterdam, Netherlands
Boeddha, NP:
Sophia Childrens Univ Hosp, Erasmus Med Ctr, Rotterdam, Netherlands
Driessen, GJA:
Sophia Childrens Univ Hosp, Erasmus Med Ctr, Rotterdam, Netherlands
Emonts, M:
Newcastle Upon Tyne Hosp NHS Fdn Trust, Great North Childrens Hosp, Paediat Immunol, Infect Dis & Allergy, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England
Newcastle Univ, Translat & Clin Res Inst, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England
Newcastle Upon Tyne Hosp NHS Trust, NIHR Newcastle Biomed Res Ctr, Newcastle Upon Tyne NE4 5PL, Tyne & Wear, England
Newcastle Univ, Newcastle Upon Tyne NE4 5PL, Tyne & Wear, England
Sophia Childrens Univ Hosp, Erasmus Med Ctr, Rotterdam, Netherlands
Newcastle Univ, Inst Cellular Med, Newcastle Upon Tyne, Tyne & Wear, England
Great North Childrens Hosp, Newcastle Upon Tyne Hosp Fdn Trust, Paediat Infect Dis & Immunol Dept, Newcastle Upon Tyne, Tyne & Wear, England
Hazelzet, JA:
Sophia Childrens Univ Hosp, Erasmus Med Ctr, Rotterdam, Netherlands
Pajkrt, D:
Emma Childrens Hosp, Acad Med Ctr, Div Pediat Hematol Immunol & Infect Dis, NL-1105 AZ Amsterdam, Netherlands
Sanders, EAM:
Wilhelmina Childrens Hosp, Univ Med Ctr Utrecht, Utrecht, Netherlands
Van De Beek, D:
Univ Amsterdam, Acad Med Ctr, Amsterdam, Netherlands
van der Ende, A:
Univ Amsterdam, Acad Med Ctr, Amsterdam, Netherlands
Philipsen, HLA:
Vrije Univ, Univ Med Ctr, Amsterdam, Netherlands
Adeel, AOA:
Kennemer Gasthuis, Haarlem, Netherlands
Breukels, MA:
Elkerliek Hosp, Helmond, Netherlands
Brinkman, DMC:
Alrijne Hosp, Leiderdorp, Netherlands
de Korte, CCMM:
Beatrix Hosp, Gorinchem, Netherlands
de Vries, E:
Jeroen Bosch Hosp, Shertogenbosch, Netherlands
Diakonessen Hosp, Utrecht, Netherlands
de Waal, WJ:
Maasziekenhuis Pantein, Boxmeer, Netherlands
Dekkers, R:
Maasziekenhuis Pantein, Boxmeer, Netherlands
Dings-Lammertink, A:
Gelre Hosp, Zutphen, Netherlands
Doedens, RA:
Martini Hosp, Groningen, Netherlands
Donker, AE:
Maxima Med Ctr, Veldhoven, Netherlands
Dousma, M:
Gemini Hosp, Den Helder, Netherlands
Faber, TE:
Med Ctr Leeuwarden, Leeuwarden, Netherlands
Gerrits, GPJM:
Canisius Wilhelmina Hosp, Nijmegen, Netherlands
Gerver, JAM:
Rode Kruis Hosp, Beverwijk, Netherlands
Heidema, J:
St Antonius Hosp, Nieuwegein, Netherlands
Homan-van der Veen, J:
Deventer Hosp, Deventer, Netherlands
Jacobs, MAM:
Slingeland Hosp, Doetinchem, Netherlands
Jansen, NJG:
Wilhelmina Childrens Hosp, Univ Med Ctr Utrecht, Utrecht, Netherlands
Kawczynski, P:
Refaja Hosp, Stadskanaal, Netherlands
Klucovska, K:
Bethesda Hosp, Hoogeveen, Netherlands
Kneyber, MCJ:
Beatrix Childrens Hosp, Univ Med Ctr Groningen, Groningen, Netherlands
Koopman-Keemink, Y:
Juliana Childrens Hosp, Haga Hosp, The Hague, Netherlands
Langenhorst, VJ:
Isala Hosp, Zwolle, Netherlands
Leusink, J:
Bernhoven Hosp, Uden, Netherlands
Loza, BF:
VieCuri Med Ctr, Venlo, Netherlands
Merth, IT:
Ziekenhuisgrp Twente, Almelo Hengelo, Netherlands
Miedema, CJ:
Catharina Hosp, Eindhoven, Netherlands
Neeleman, C:
Vrije Univ, Univ Med Ctr, Amsterdam, Netherlands
Noordzij, JG:
Reinier Graaf Gasthuis, Delft, Netherlands
Obihara, CC:
ETZ Elisabeth, Tilburg, Netherlands
van Overbeek-van Gils, ALT:
Scheper Hosp, Emmen, Netherlands
Poortman, GH:
St Jansdal Hosp, Hardewijk, Netherlands
Potgieter, ST:
Laurentius Hosp, Roermond, Netherlands
Potjewijd, J:
Isala Diaconessenhuis, Meppel, Netherlands
Rosias, PPR:
Zuyderland Med Ctr, Sittard Geleen, Netherlands
Sprong, T:
Canisius Wilhelmina Hosp, Nijmegen, Netherlands
ten Tussher, GW:
Westfriesgasthuis, Hoorn, Netherlands
Thio, BJ:
Med Spectrum Twente, Enschede, Netherlands
Tramper-Stranders, GA:
St Franciscus Gasthuis, Rotterdam, Netherlands
van Deuren, M:
Vrije Univ, Univ Med Ctr, Amsterdam, Netherlands
van der Meer, H:
Hosp Clin Univ Santiago Compostela, Dept Pediat, Translat Pediat & Infect Dis, Galicia 15706, Spain
van Kuppevelt, AJM:
Zuwe Hofpoort Hosp, Woerden, Netherlands
van Wermeskerken, AM:
Flevo Hosp, Almere, Netherlands
Wolfs, TFW:
Newcastle Univ, Inst Cellular Med, Newcastle Upon Tyne, Tyne & Wear, England
Agyeman, P:
Univ Bern, Inselspital, Bern Univ Hosp, Dept Pediat, Bern, Switzerland
Aebi, C:
Univ Bern, Inselspital, Bern Univ Hosp, Dept Pediat, Bern, Switzerland
Giannoni, E:
Lausanne Univ Hosp, Serv Neonatol, Lausanne, Switzerland
Lausanne Univ Hosp, Infect Dis Serv, Lausanne, Switzerland
Stocker, M:
Childrens Hosp Lucerne, Dept Pediat, Luzern, Switzerland
Posfay-Barbe, KM:
Univ Hosp Geneva, Childrens Hosp Geneva, Pediat Infect Dis Unit, Geneva, Switzerland
Heininger, U:
Univ Basel, Childrens Hosp, Infect Dis & Vaccinol, Basel, Switzerland
Bernhard-Stirnemann, S:
Childrens Hosp Aarau, Aarau, Switzerland
Niederer-Loher, A:
Childrens Hosp Eastern Switzerland St Gallen, Div Infect Dis & Hosp Epidemiol, St Gallen, Switzerland
Kahlert, C:
Childrens Hosp Eastern Switzerland St Gallen, Div Infect Dis & Hosp Epidemiol, St Gallen, Switzerland
Hasters, P:
Univ Hosp Zurich, Dept Neonatol, Zurich, Switzerland
Relly, C:
Univ Childrens Hosp Zurich, Div Infect Dis & Hosp Epidemiol, Zurich, Switzerland
Univ Childrens Hosp Zurich, Childrens Res Ctr, Zurich, Switzerland
Baer, W:
Childrens Hosp Chur, Chur, Switzerland
Berger, C:
Univ Bern, Inselspital, Bern Univ Hosp, Dept Pediat, Bern, Switzerland
Univ Childrens Hosp Zurich, Div Infect Dis & Hosp Epidemiol, Zurich, Switzerland
Univ Childrens Hosp Zurich, Childrens Res Ctr, Zurich, Switzerland
Frederick, H:
Alder Hey Childrens Hosp, Clin Res Business Unit, Eaton Rd, Liverpool L12 2AP, Merseyside, England
Jennings, R:
Alder Hey Childrens Hosp, Clin Res Business Unit, Eaton Rd, Liverpool L12 2AP, Merseyside, England
Johnston, J:
Alder Hey Childrens Hosp, Clin Res Business Unit, Eaton Rd, Liverpool L12 2AP, Merseyside, England
Kenwright, R:
Alder Hey Childrens Hosp, Clin Res Business Unit, Eaton Rd, Liverpool L12 2AP, Merseyside, England
Pinnock, E:
Univ Warwick, Micropathol Ltd, Warwick CV4 7EZ, England
Agbeko, R:
Newcastle Upon Tyne Hosp NHS Trust, NIHR Newcastle Biomed Res Ctr, Newcastle Upon Tyne NE4 5PL, Tyne & Wear, England
Newcastle Univ, Newcastle Upon Tyne NE4 5PL, Tyne & Wear, England
Imperial Coll NHS Healthcare Trust, St Marys Hosp, Dept Paediat Emergency Med, London W2 1NY, England
Secka, F:
London Sch Hyg & Trop Med, Med Res Council Unit, Banjul, Gambia
Bojang, K:
London Sch Hyg & Trop Med, Med Res Council Unit, Banjul, Gambia
Sarr, I:
London Sch Hyg & Trop Med, Med Res Council Unit, Banjul, Gambia
Kebbeh, N:
London Sch Hyg & Trop Med, Med Res Council Unit, Banjul, Gambia
Sey, G:
London Sch Hyg & Trop Med, Med Res Council Unit, Banjul, Gambia
Momodou, SK:
London Sch Hyg & Trop Med, Med Res Council Unit, Banjul, Gambia
Cole, F:
London Sch Hyg & Trop Med, Med Res Council Unit, Banjul, Gambia
Thomas, G:
London Sch Hyg & Trop Med, Med Res Council Unit, Banjul, Gambia
Antonio, M:
London Sch Hyg & Trop Med, Med Res Council Unit, Banjul, Gambia
Klobassa, DS:
Univ Med Ctr Utrecht, Wilhelmina Childrens Hosp, Pediat Infect Dis & Immunol, NL-3508 AB Utrecht, Netherlands
Binder, A:
Univ Med Ctr Utrecht, Wilhelmina Childrens Hosp, Pediat Infect Dis & Immunol, NL-3508 AB Utrecht, Netherlands
Schweintzger, NA:
Univ Med Ctr Utrecht, Wilhelmina Childrens Hosp, Pediat Infect Dis & Immunol, NL-3508 AB Utrecht, Netherlands
Sagmeister, M:
Univ Med Ctr Utrecht, Wilhelmina Childrens Hosp, Pediat Infect Dis & Immunol, NL-3508 AB Utrecht, Netherlands
Baumgart, H:
Med Univ Graz, Div Gen Pediat Surg, Dept Pediat & Adolescence Surg, Graz, Austria
Baumgartner, M:
Gen Hosp Steyr, Dept Pediat, Steyr, Austria
Behrends, U:
TUM, Dept Pediat Surg, Dept Pediat, Munich, Germany
Biebl, A:
Johannes Kepler Univ Linz, Kepler Univ Clin, Med Fac, Dept Pediat, Linz, Austria
Birnbacher, R:
LKH Villach, Dept Pediat & Adolesecent Med, Villach, Austria
Blanke, JG:
Hosp Ludmillenstift, Dept Pediat & Adolescent Med & Neonatol, Meppen, Germany
Boelke, C:
Oberschwabenklinik, Hosp Childrens & Youth Med, Ravensburg, Germany
Breuling, K:
TUM, Dept Pediat Surg, Dept Pediat, Munich, Germany
Brunner, J:
Med Univ Innsbruck, Dept Pediat, Innsbruck, Austria
Buller, M:
Sana Hanse Klinikum Wismar, Clin Paediat & Adolescents Med, Wismar, Germany
Dahlem, P:
Med Ctr Coburg, Dept Pediat, Coburg, Germany
Dietrich, B:
Univ Med Rostock, Dept Pediat UKJ, Rostock, Germany
Eber, E:
Med Univ Graz, Dept Pulmonol, Graz, Austria
Elias, J:
Univ Wurzburg, Inst Hyg & Microbiol, Wurzburg, Germany
Emhofer, J:
Gen Hosp Steyr, Dept Pediat, Steyr, Austria
Etschmaier, R:
Med Univ Graz, Clin Inst Med & Chem Lab Diagnost, Graz, Austria
Farr, S:
Orthoped Hosp Speising, Dept Pediat Orthoped & Adult Foot & Ankle Surg, Vienna, Austria
Girtler, Y:
Reg Hosp Bolzano, Dept Paediat, Bolzano, Italy
Grigorow, I:
Gen Hosp Hochsteiermark Leoben, Dept Pediat & Adolescent Med, Leoben, Austria
Heimann, K:
Rhein Westfal TH Aachen, Childrens Univ Hosp, Dept Neonatol & Paediat Intens Care, Aachen, Germany
Ihm, U:
Donauspital Vienna, Dept Paediat Surg, Paediat Intens Care Unit, Vienna, Austria
Jaros, Z:
Gen Publ Hosp, Dept Pediat, Zwettl, Austria
Kalhoff, H:
Pediat Clin Dortmund, Dortmund, Germany
Kaulfersch, W:
Klinikum Klagenfurt Worthersee, Dept Pediat & Adolescent Med, Klagenfurt, Austria
Kemen, C:
Catholic Childrens Hosp Wilhelmstift, Dept Pediat, Hamburg, Germany
Klocker, N:
Krankenhaus Dornbirn, Dept Pediat, Dornbirn, Austria
Koster, B:
Maerk Kliniken, Childrens Hosp Luedenscheid, Luedenscheid, Germany
Kohlmaier, B:
Med Univ Graz, Dept Gen Paediat, Graz, Austria
Komini, E:
Schwarzwald Baar Hosp, Dept Paediat, Villingen Schwenningen, Germany
Kramer, L:
TUM, Dept Pediat Surg, Dept Pediat, Munich, Germany
Neubert, A:
Univ Hosp Erlangen, Dept Paediat & Adolescents Med, Erlangen, Germany
Ortner, D:
Med Univ Salzburg, Dept Pediat & Adolescent Med, Salzburg, Austria
Pescollderungg, L:
Reg Hosp Bolzano, Dept Paediat, Bolzano, Italy
Pfurtscheller, K:
Med Univ Graz, Paediat Intens Care Unit, Graz, Austria
Reiter, K:
Ludwig Maximilians Univ Munchen, Dr von Hauner Childrens Hosp, Munich, Germany
Ristic, G:
Mother & Child Hlth Care Inst Serbia, Belgrade, Serbia
Rodl, S:
Med Univ Graz, Paediat Intens Care Unit, Graz, Austria
Sellner, A:
Med Univ Graz, Dept Gen Paediat, Graz, Austria
Sonnleitner, A:
Med Univ Graz, Dept Gen Paediat, Graz, Austria
Sperl, M:
Med Univ Graz, Div Pediat Orthoped, Dept Pediat & Adolescence Surg, Graz, Austria
Stelzl, W:
Landeskrankenhaus Feldkirch, Acad Teaching Hosp, Dept Pediat, Feldkirch, Austria
Till, H:
Med Univ Graz, Div Gen Pediat Surg, Dept Pediat & Adolescence Surg, Graz, Austria
Trobisch, A:
Med Univ Graz, Dept Gen Paediat, Graz, Austria
Vierzig, A:
Univ Cologne, Univ Childrens Hosp, Cologne, Germany
Vogel, U:
Med Univ Graz, Dept Pulmonol, Graz, Austria
Weingarten, C:
Wilheminenspital, Dept Pediat & Adolescent Med, Vienna, Austria
Welke, S:
Municipal Hosp Karlsruhe, Dept Pediat Surg, Karlsruhe, Germany
Wimmer, A:
Hosp Sisters Mercy Ried, Dept Pediat & Adolescent Med, Ried, Austria
Wintergerst, U:
Hosp St Josef, Braunau, Austria
Wuller, D:
Christophorus Kliniken Coesfeld Clin Pediat, Coesfeld, Germany
Zaunschirm, A:
Karl Landsteiner Univ Hlth Sci, Univ Hosp Krems, Dept Paediat, Krems, Austria
Ziuraite, I:
Affiliate Vilnius Univ Hosp Santariskiu Klin, Childrens Hosp, Vilnius, Lithuania
Zukovskaja, V:
Affiliate Vilnius Univ Hosp Santariskiu Klin, Childrens Hosp, Vilnius, Lithuania
Streekziekenhuis Koningin Beatrix, Winterswijk, Netherlands.
Gold, Green Published
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