Early detection of subtle motor dysfunction in cognitively normal subjects with amyloid-beta positivity
Por:
Mollica, MA, Tort-Merino, A, Navarra, J, Fernandez-Prieto, I, Valech, N, Olives, J, Leon, M, Lleo, A, Martinez-Lage, P, Sanchez-Valle, R, Molinuevo, JL, Rami, L
Publicada:
1 dic 2019
Resumen:
Since the current neuropsychological assessments are not sensitive to subtle deficits that may be present in cognitively normal subjects with amyloid-beta positivity, more accurate and efficient measures are needed. Our aim was to investigate the presence of subtle motor deficits in this population and its relationship with cerebrospinal fluid (CSF) amyloid-beta levels. We adapted the Finger Tapping Task to measure tapping speed and intrasubject variability. Seventy-two right-handed participants completed the study. Subjects were divided into three groups according to their CSF biomarker profile: 37 control participants (negative CSF AD biomarkers, CTR), 20 cognitively normal subjects with amyloid-beta positivity (abnormal levels of CSF A beta(42), A beta+) and 15 AD patients. All subjects underwent lumbar puncture for the CSF analysis, apolipoprotein E genotyping and completed the Finger Tapping Task, a neuropsychological battery and cardiovascular risk factor and physical activity assessments. An overall difference between groups was found both in tapping speed [F(2,66) = 19.37, p < .01] and in intrasubject variability [F(2,66) = 11.40, p < .01]. More specifically, the A beta+ group showed lower speed [F(1,52) = 5.33, p < .05] and greater intrasubject variability [F(1,52) = 8.48, p < .01] than the CTR group, and higher speed than the AD group [F(1,30) = 13.61, p < .01]. Speed (beta = .263, p < .05) and intrasubject variability (beta = -.558, p < .01) were significantly associated with CSF amyloid-beta levels. The present findings suggest that subtle motor difficulties can be detected in cognitively healthy subjects with amyloid-beta positivity and be related to CSF A beta(42) levels. An accurate assessment of motor functions could help on identifying individuals at the earliest stage of the Alzheimer's continuum. (C) 2019 Elsevier Ltd. All rights reserved.
Filiaciones:
Mollica, MA:
Hosp Clin Barcelona, Neurol Serv, Alzheimers Dis & Other Cognit Disorders Unit, Villarroel 170, Barcelona 08036, Spain
Tort-Merino, A:
Hosp Clin Barcelona, Neurol Serv, Alzheimers Dis & Other Cognit Disorders Unit, Villarroel 170, Barcelona 08036, Spain
Navarra, J:
St Joan Deu Fdn, Inst Recerca St Joan Deu, Psychiat & Psychol Serv, Barcelona, Spain
Univ Barcelona, Dept Cognit Dev & Educ Psychol, Barcelona, Spain
Fernandez-Prieto, I:
St Joan Deu Fdn, Inst Recerca St Joan Deu, Psychiat & Psychol Serv, Barcelona, Spain
Univ Barcelona, Dept Cognit Dev & Educ Psychol, Barcelona, Spain
Univ Balearic Isl, Dept Psychol, Neuropsychol & Cognit Grp, Palma De Mallorca, Spain
Univ Balearic Isl, Res Inst Hlth Sci iUNICS, Palma De Mallorca, Spain
Valech, N:
Hosp Clin Barcelona, Neurol Serv, Alzheimers Dis & Other Cognit Disorders Unit, Villarroel 170, Barcelona 08036, Spain
Olives, J:
Hosp Clin Barcelona, Neurol Serv, Alzheimers Dis & Other Cognit Disorders Unit, Villarroel 170, Barcelona 08036, Spain
Leon, M:
Hosp Clin Barcelona, Neurol Serv, Alzheimers Dis & Other Cognit Disorders Unit, Villarroel 170, Barcelona 08036, Spain
Lleo, A:
Hosp Santa Creu & Sant Pau, Memory Unit, Dept Neurol, Barcelona, Spain
Inst Biomed Res, Barcelona, Spain
CIBERNED, Ctr Networked Biomed Res Neurodegenerat Dis, Madrid, Spain
Martinez-Lage, P:
CITA Alzheimer Fdn, Ctr Res & Adv Therapies Alzheimers Dis, San Sebastian, Spain
Sanchez-Valle, R:
Hosp Clin Barcelona, Neurol Serv, Alzheimers Dis & Other Cognit Disorders Unit, Villarroel 170, Barcelona 08036, Spain
August Pi i Sunyer Biomed Res Inst IDIBAPS, Barcelona, Spain
Molinuevo, JL:
Hosp Clin Barcelona, Neurol Serv, Alzheimers Dis & Other Cognit Disorders Unit, Villarroel 170, Barcelona 08036, Spain
August Pi i Sunyer Biomed Res Inst IDIBAPS, Barcelona, Spain
Rami, L:
Hosp Clin Barcelona, Neurol Serv, Alzheimers Dis & Other Cognit Disorders Unit, Villarroel 170, Barcelona 08036, Spain
August Pi i Sunyer Biomed Res Inst IDIBAPS, Barcelona, Spain
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