Characterizing circadian rest-activity rhythm patterns across Alzheimer's disease continuum in Down syndrome
Por:
Giménez, S, Vaqué-Alcázar, L, Clos, S, Benejam, B, Carmona-Iragui, M, Maure-Blesa, L, Videla, L, Zhu, N, Altuna, M, Arranz, J, Barroeta, I, Rodríguez-Baz, I, Bejanin, A, Bueno, A, Fernandez, S, Soriano, LD, Pertierra, L, Alcolea, D, Miller, B, Grinberg, LT, Ruiz, J, Lisgaras, CP, Wu, H-, Lleó, A, Osorio, RS, Blessing, EM, Fortea, J
Publicada:
29 abr 2026
Resumen:
INTRODUCTION: Sleep and circadian rest-activity rhythm (RAR) disruption may bidirectionally relate to Alzheimer's disease (AD). Down syndrome (DS), the most common genetic cause of AD, presents sleep disorders, yet RAR patterns across the DS-associated AD continuum remain uncharacterized. METHODS: We analyzed 7-day wrist actigraphy in 140 adults with DS (108 asymptomatic; 32 AD dementia) and 41 unimpaired controls. General linear models, adjusted for age, sex, sleep efficiency, and obstructive sleep apnea (OSA) severity, tested group differences, with interaction terms included to evaluate group-specific associations. RESULTS: DS showed lower relative amplitude and higher nocturnal activity, already in asymptomatic individuals. Rhythm strength declined further with AD progression, while regularity and phase timing remained preserved until dementia. Findings were independent of sleep duration and OSA. DISCUSSION: Adults with DS showed early RAR disturbance that progressed across the AD continuum, paralleling sporadic AD. Circadian RAR features may be scalable biomarkers of AD progression.
Filiaciones:
Giménez, S:
Hosp Santa Creu i St Pau, Biomed Res Inst St, Resp Dept, Multidisciplinary Sleep Unit,Pau IIB SANT PAU, Barcelona, Spain
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau IIB St Pau,IIB SANT PAU, Dept Neurol,St Pau Memory Unit, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Madrid, Spain
Univ Calif San Francisco, Global Brain Hlth Inst, San Francisco, CA USA
Vaqué-Alcázar, L:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau IIB St Pau,IIB SANT PAU, Dept Neurol,St Pau Memory Unit, Barcelona, Spain
Univ Barcelona, Inst Invest Biomed August Pi Sunyer IDIBAPS i, Fac Med & Hlth Sci, Inst Neurosci,Dept Med, Barcelona, Spain
Clos, S:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau IIB St Pau,IIB SANT PAU, Dept Neurol,St Pau Memory Unit, Barcelona, Spain
Benejam, B:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau IIB St Pau,IIB SANT PAU, Dept Neurol,St Pau Memory Unit, Barcelona, Spain
Barcelona Med Ctr, Fundacio Catalana Sindrome, Barcelona, Spain
Carmona-Iragui, M:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau IIB St Pau,IIB SANT PAU, Dept Neurol,St Pau Memory Unit, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Madrid, Spain
Barcelona Med Ctr, Fundacio Catalana Sindrome, Barcelona, Spain
Maure-Blesa, L:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau IIB St Pau,IIB SANT PAU, Dept Neurol,St Pau Memory Unit, Barcelona, Spain
Videla, L:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau IIB St Pau,IIB SANT PAU, Dept Neurol,St Pau Memory Unit, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Madrid, Spain
Barcelona Med Ctr, Fundacio Catalana Sindrome, Barcelona, Spain
Zhu, N:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau IIB St Pau,IIB SANT PAU, Dept Neurol,St Pau Memory Unit, Barcelona, Spain
Altuna, M:
CITA Alzheimer Fdn, Ctr Res & Memory Clin, San Sebastian, Spain
Debabarrena Integrated Hlth Org, Osakidetza Basque Hlth Serv, Mendaro, Spain
Araba Univ Hosp Txagorritxu, Hosp Araba, Bioaraba Hlth Res Inst, Dept Neurol, Vitoria, Spain
Arranz, J:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau IIB St Pau,IIB SANT PAU, Dept Neurol,St Pau Memory Unit, Barcelona, Spain
Barroeta, I:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau IIB St Pau,IIB SANT PAU, Dept Neurol,St Pau Memory Unit, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Madrid, Spain
Rodríguez-Baz, I:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau IIB St Pau,IIB SANT PAU, Dept Neurol,St Pau Memory Unit, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Madrid, Spain
Bejanin, A:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau IIB St Pau,IIB SANT PAU, Dept Neurol,St Pau Memory Unit, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Madrid, Spain
Bueno, A:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau IIB St Pau,IIB SANT PAU, Dept Neurol,St Pau Memory Unit, Barcelona, Spain
Fernandez, S:
Barcelona Med Ctr, Fundacio Catalana Sindrome, Barcelona, Spain
Soriano, LD:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau IIB St Pau,IIB SANT PAU, Dept Neurol,St Pau Memory Unit, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Madrid, Spain
Pertierra, L:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau IIB St Pau,IIB SANT PAU, Dept Neurol,St Pau Memory Unit, Barcelona, Spain
Fleni Memory Clin, Neuropsychol & Neuropsychiat Unit, Cognit Neurol, Buenos Aires, Argentina
Alcolea, D:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau IIB St Pau,IIB SANT PAU, Dept Neurol,St Pau Memory Unit, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Madrid, Spain
Miller, B:
Univ Calif San Francisco, Global Brain Hlth Inst, San Francisco, CA USA
Univ Calif San Francisco, Edward & Pearl Fein Memory & Aging Ctr, San Francisco, CA USA
Grinberg, LT:
Univ Calif San Francisco, Global Brain Hlth Inst, San Francisco, CA USA
Mayo Clin, Dept Lab Med & Pathol & Neurosci, Jacksonville, FL USA
Ruiz, J:
NYU Langone Hlth, Dept Psychiat, New York, NY USA
Lisgaras, CP:
NYU Langone Hlth, Dept Psychiat, New York, NY USA
New York State Off Mental Hlth, Nathan S Kline Inst Psychiat Res, Orangeburg, NY USA
Wu, H-:
NYU, Courant Inst Math Sci, Dept Math, New York, NY USA
Lleó, A:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau IIB St Pau,IIB SANT PAU, Dept Neurol,St Pau Memory Unit, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Madrid, Spain
Osorio, RS:
NYU Langone Hlth, Dept Psychiat, New York, NY USA
New York State Off Mental Hlth, Nathan S Kline Inst Psychiat Res, Orangeburg, NY USA
Blessing, EM:
NYU Langone Hlth, Dept Psychiat, New York, NY USA
New York State Off Mental Hlth, Nathan S Kline Inst Psychiat Res, Orangeburg, NY USA
Fortea, J:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau IIB St Pau,IIB SANT PAU, Dept Neurol,St Pau Memory Unit, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Madrid, Spain
Barcelona Med Ctr, Fundacio Catalana Sindrome, Barcelona, Spain
Green Submitted, hybrid
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