CIBER-CLAP (CIBERCV Cardioprotection Large Animal Platform): A multicenter preclinical network for testing reproducibility in cardiovascular interventions
Por:
Rossello, X, Rodriguez-Sinovas, A, Vilahur, G, Crisostomo, V, Jorge, I, Zaragoza, C, Zamorano, JL, Bermejo, J, Ordonez, A, Bosca, L, Vazquez, J, Badimon, L, Sanchez-Margallo, FM, Fernandez-Aviles, F, Garcia-Dorado, D, Ibanez, B
Publicada:
30 dic 2019
Resumen:
Despite many cardioprotective interventions have shown to protect the heart against ischemia/reperfusion injury in the experimental setting, only few of them have succeeded in translating their findings into positive proof-of-concept clinical trials. Controversial and inconsistent experimental and clinical evidence supports the urgency of a disruptive paradigm shift for testing cardioprotective therapies. There is a need to evaluate experimental reproducibility before stepping into the clinical arena. The CIBERCV (acronym for Spanish network-center for cardiovascular biomedical research) has set up the "Cardioprotection Large Animal Platform" (CIBER-CLAP) to perform experimental studies testing the efficacy and reproducibility of promising cardioprotective interventions based on a pre-specified design and protocols, randomization, blinding assessment and other robust methodological features. Our first randomized, control-group, open-label blinded endpoint experimental trial assessing local ischemic preconditioning (IPC) in a pig model of acute myocardial infarction (n = 87) will be carried out in three separate sets of experiments performed in parallel by three laboratories. Each set aims to assess: (A) CMR-based outcomes; (B) histopathological-based outcomes; and (C) protein-based outcomes. Three core labs will assess outcomes in a blinded fashion (CMR imaging, histopathology and proteomics) and 2 methodological core labs will conduct the randomization and statistical analysis.
Filiaciones:
Rossello, X:
Ctr Invest Biomed Red Enfermedades Cardiovasc CIB, Madrid, Spain
CNIC, Madrid, Spain
Rodriguez-Sinovas, A:
Ctr Invest Biomed Red Enfermedades Cardiovasc CIB, Madrid, Spain
Vall dHebron Inst Recerca, Lab Invest Enfermedades Cardiovasc, Barcelona, Spain
Vilahur, G:
Ctr Invest Biomed Red Enfermedades Cardiovasc CIB, Madrid, Spain
Hosp Santa Creu & Sant Pau, Programa ICCC, Inst Recerca, IIB St Pau, Barcelona, Spain
Crisostomo, V:
Ctr Invest Biomed Red Enfermedades Cardiovasc CIB, Madrid, Spain
Ctr Cirugia Minima Invas Jesus Uson, Caceres, Spain
Jorge, I:
Ctr Invest Biomed Red Enfermedades Cardiovasc CIB, Madrid, Spain
CNIC, Madrid, Spain
Zaragoza, C:
Ctr Invest Biomed Red Enfermedades Cardiovasc CIB, Madrid, Spain
Hosp Univ Ramon y Cajal, IRYCIS, Serv Cardiol, Madrid, Spain
Univ Francisco Vitoria, Madrid, Spain
Zamorano, JL:
Ctr Invest Biomed Red Enfermedades Cardiovasc CIB, Madrid, Spain
Hosp Univ Ramon y Cajal, IRYCIS, Serv Cardiol, Madrid, Spain
Bermejo, J:
Ctr Invest Biomed Red Enfermedades Cardiovasc CIB, Madrid, Spain
Univ Complutense Madrid, Hosp Gen Univ Gregorio Maranon, Inst Invest Sanitaria Gregorio Maranon, Dept Cardiol, Madrid, Spain
Univ Complutense Madrid, Fac Med, Madrid, Spain
Ordonez, A:
Ctr Invest Biomed Red Enfermedades Cardiovasc CIB, Madrid, Spain
Inst Biomed Sevilla, Seville, Spain
Bosca, L:
Ctr Invest Biomed Red Enfermedades Cardiovasc CIB, Madrid, Spain
Inst Invest Biomed Alberto Sols Ctr Mixto CSIC UA, Madrid, Spain
Vazquez, J:
Ctr Invest Biomed Red Enfermedades Cardiovasc CIB, Madrid, Spain
CNIC, Madrid, Spain
Badimon, L:
Ctr Invest Biomed Red Enfermedades Cardiovasc CIB, Madrid, Spain
Hosp Santa Creu & Sant Pau, Programa ICCC, Inst Recerca, IIB St Pau, Barcelona, Spain
Sanchez-Margallo, FM:
Ctr Invest Biomed Red Enfermedades Cardiovasc CIB, Madrid, Spain
Ctr Cirugia Minima Invas Jesus Uson, Caceres, Spain
Fernandez-Aviles, F:
Ctr Invest Biomed Red Enfermedades Cardiovasc CIB, Madrid, Spain
Univ Complutense Madrid, Hosp Gen Univ Gregorio Maranon, Inst Invest Sanitaria Gregorio Maranon, Dept Cardiol, Madrid, Spain
Univ Complutense Madrid, Fac Med, Madrid, Spain
Garcia-Dorado, D:
Ctr Invest Biomed Red Enfermedades Cardiovasc CIB, Madrid, Spain
Vall dHebron Inst Recerca, Lab Invest Enfermedades Cardiovasc, Barcelona, Spain
Ibanez, B:
Ctr Invest Biomed Red Enfermedades Cardiovasc CIB, Madrid, Spain
CNIC, Madrid, Spain
IIS Fdn Jimenez Diaz Hosp, Cardiol Dept, Madrid, Spain
Gold, Green Published
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