Hidradenitis suppurativa in patients with inflammatory bowel disease: a national multicenter study from the GETECCU-ENEIDA Registry
Por:
Madero-Velázquez, L, de Francisco, R, Herreros, B, Yagüe, C, Bujanda, L, Calvet, X, Ponferrada, A, Aguas, M, Rodríguez-Moranta, F, Marín-Jiménez, I, Catalá, L, Gargallo-Pueyo, C, Huguet, J, Mesonero, F, Monfort, D, Sierra-Ausín, M, Igualada, L, Ricart-Gomez, E, González-Vivo, M, García, MJ, Camba, AH, Elorza, A, Zabalza-San Martín, L, Ramos, L, Martín-Arranz, MD, Ruiz-Núñez, I, Martínez-Montiel, P, Soto, P, Roig, C, Molina, M, Mañosa, M, Alba, C, Barreiro-de Acosta, M, Gisbert, JP, de la Piscina, PR, Lorente, R, Zabana, Y, Botella, B, Riestra, S, Belen-Galipienso, O, Busquets, D, Argüelles, F, Pascual, JC, Zapater, P, Domènech, E, Gutiérrez, A
Publicada:
1 feb 2026
Resumen:
Background: Hidradenitis suppurativa (HS) is a chronic, recurrent skin disease that may be associated with inflammatory bowel disease (IBD). Objectives: This study aimed to describe the features and therapeutic requirements of IBD and HS in patients who present both entities and the risk factors for HS development in patients with IBD. Methods: Case-controlled, retrospective study of all patients diagnosed with IBD-HS in the ENEIDA registry. Cases were paired 1:2 with controls (IBD without HS). Design: This was a retrospective, case-control study. Results: A total of 819 patients were included: 273 patients with IBD-HS and 546 controls. Female sex (62% vs 44%, p = 0.0001), active smoking (45% vs 18%, p = 0.0001), Crohn's disease (CD; 83% vs 55%, p = 0.0001), perianal disease (59% vs 33%, p = 0.0001), extraintestinal manifestations (38% vs 17%, p = 0.0001), and psychiatric disorders (18% vs 2%, p < 0.05) were more frequent among patients with IBD-HS than in controls. The average body mass index was greater in the IBD-HS group. The most frequently HS-affected locations were axillary (57%) and genital (43%) areas. Use of biologicals and CD-related perianal surgery was more common among patients with CD-HS (77% vs 66%, p = 0.003; 37% vs 13%, p < 0.001), compared to controls with only CD. Conclusion: Patients with IBD-HS exhibit a distinctive phenotype with higher therapeutic requirements for the subset of patients with CD-HS compared to those without HS. Assessment of this comorbidity should be considered in patients with suggestive skin lesions and IBD to improve the outcomes of both conditions.
Filiaciones:
Madero-Velázquez, L:
Hosp Gen Univ Dr Balmis, Gastroenterol Dept, ISABIAL, Alicante, Spain
de Francisco, R:
Hosp Univ Cent Asturias, Gastroenterol Dept, Inst Invest Sanitaria Principado Asturias, Oviedo, Spain
Herreros, B:
Hosp Marina Baixa, Gastroenterol Dept, Villajoyosa, Alicante, Spain
Yagüe, C:
Hosp Univ Miguel Servet, Gastroenterol Dept, Zaragoza, Spain
Bujanda, L:
Univ Pais Vasco UPV EHU, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Inst Invest Sanitaria Biogipuzkoa, Hosp Univ Donostia,Gastroenterol Dept, San Sebastian, Spain
Calvet, X:
Univ Autonoma Barcelona, Inst Invest & Innovacio Parc Tauli, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Parc Tauli Hosp Univ,Gastroenterol Dept, Barcelona, Spain
Ponferrada, A:
Hosp Univ Infanta Leonor, Gastroenterol Dept, Madrid, Spain
Aguas, M:
Hosp Univ & Politecn La Fe, Gastroenterol Dept, IIS La Fe, Valencia, Spain
Rodríguez-Moranta, F:
Hosp Univ Bellvitge, Inst Invest Biomed Bellvitge, Gastroenterol Dept, LHospitalet De Llobregat, Barcelona, Spain
Marín-Jiménez, I:
Univ Complutense Madrid, Hosp Gregorio Maranon, Gastroenterol Dept, Inst Invest Sanitaria Gregorio Maranon, Madrid, Spain
Catalá, L:
Hosp Gen Univ Elche, Gastroenterol Dept, Alicante, Spain
Gargallo-Pueyo, C:
Hosp Clin Univ Lozano Blesa, Gastroenterol Dept, IIS Aragon, Zaragoza, Spain
Huguet, J:
Consorcio Hosp Gen Univ Valencia, Gastroenterol Dept, Valencia, Spain
Mesonero, F:
Hosp Univ Ramon y Cajal, Gastroenterol Dept, Madrid, Spain
Monfort, D:
Hosp Univ Consorci Sanitari Terrassa, Gastroenterol Dept, Barcelona, Spain
Sierra-Ausín, M:
Complejo Asistencial Univ Leon, Gastroenterol Dept, Leon, Spain
Igualada, L:
Hosp Fdn Alcorcon, Gastroenterol Dept, Madrid, Spain
Ricart-Gomez, E:
Hosp Clin Barcelona, Inst Invest Biomed August Pi i Sunyer, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Fundacio Recerca Clin Barcelona,Gastroenterol Dept, Barcelona, Spain
González-Vivo, M:
Hosp del Mar, Gastroenterol Dept, Barcelona, Spain
García, MJ:
Hosp Univ Marques de Valdecilla, Gastroenterol Dept, Inst Invest Marques de Valdecilla, Santander, Spain
Camba, AH:
Hosp Univ Nuestra Senora de la Candelaria, Gastroenterol Dept, Santa Cruz De Tenerife, Spain
Elorza, A:
Hosp Univ Galdakao, Biobizkaia Hlth Res Inst, Gastroenterol Dept, Galdakao, Spain
Zabalza-San Martín, L:
Hosp Univ Navarra, Gastroenterol Dept, Inst Invest Sanitaria Navarra, Pamplona, Spain
Ramos, L:
Hosp Univ Canarias, Gastroenterol Dept, San Cristobal la Laguna, Santa Cruz De T, Spain
Martín-Arranz, MD:
Hosp Univ La Paz, Gastroenterol Dept, Madrid, Spain
Ruiz-Núñez, I:
Hosp Univ Rio Hortega, Gastroenterol Dept, Valladolid, Spain
Martínez-Montiel, P:
Hosp Univ 12 Octubre, Gastroenterol Dept, Madrid, Spain
Soto, P:
UCO, IMIBIC, Gastroenterol Dept, Hosp Univ Reina Sofia, Cordoba, Spain
Roig, C:
Hosp Santa Creu & Sant Pau, Gastroenterol Dept, Barcelona, Spain
Molina, M:
Hosp Gen Univ Castellon, Gastroenterol Dept, Castellon De La Plana, Spain
Mañosa, M:
Hosp Germans Trias i Pujol, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Gastroenterol Dept, Badalona, Spain
Alba, C:
Hosp Clin San Carlos, Gastroenterol Dept, Madrid, Spain
Barreiro-de Acosta, M:
Complexo Hosp Univ Santiago De Compostela, Santiago De Compostela Hlth Res Inst, Gastroenterol Dept, Santiago De Compostela, Spain
Gisbert, JP:
Univ Autonoma Madrid, Hosp Univ La Princesa,Gastroenterol Dept, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Inst Invest Sanitaria Princesa IIS Princesa, Madrid, Spain
de la Piscina, PR:
Hosp Univ Araba, Gastroenterol Dept, Araba, Spain
Lorente, R:
Hosp Gen Univ Ciudad Real, Gastroenterol Dept, Ciudad Real, Spain
Zabana, Y:
Univ Barcelona, Hosp Univ Mutua Terrassa, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Gastroenterol Dept, Terrassa, Barcelona, Spain
Botella, B:
Hosp Infanta Cristina, Gastroenterol Dept, Madrid, Spain
Riestra, S:
Hosp Univ Cent Asturias, Gastroenterol Dept, Inst Invest Sanitaria Principado Asturias, Oviedo, Spain
Belen-Galipienso, O:
Hosp Gen Univ Dr Balmis, Gastroenterol Dept, ISABIAL, Alicante, Spain
Busquets, D:
Hosp Univ Dr Josep Trueta, Gastroenterol Dept, IDIBGI, Girona, Spain
Argüelles, F:
Univ Seville, Hosp Univ Virgen Macarena, Gastroenterol Dept, Seville, Spain
Pascual, JC:
Hosp Gen Univ Dr Balmis, Dermatol Dept, ISABIAL, Alicante, Spain
Zapater, P:
Univ Miguel Hernandez de Elche, Hosp Gen Univ Dr Balmis, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Clin Pharmacol Dept,ISABIAL, Alicante, Spain
Domènech, E:
Univ Autonoma Barcelona, Hosp Germans Trias i Pujol, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Gastroenterol Dept, Badalona, Spain
Gutiérrez, A:
Hosp Gen Univ Dr Balmis Alicante, Dept Gastroenterol, Pintor Baeza 12, Alicante 03010, Spain
Univ Miguel Hernandez de Elche, Ctr Invest Biomed Red Enfermedades Hepat & Digest, ISABIAL, Alicante, Spain
Green Submitted, gold
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