Outcomes of pediatric and adult patients with relapsed/refractory cortical (CD1a+) T-cell acute lymphoblastic leukemia. The Spanish experience from SEHOP and PETHEMA groups
Por:
Rivera-Pérez, C, Morgades, M, Alonso-Saladrigues, A, Montesinos, P, Murciano, T, Gil, C, Adán, R, Esteve, J, Fuentes, C, Amigo, ML, González-Martínez, B, Coll, R, Dapena, JL, De Llano, MPQ, Fuster, JL, García-Cadenas, I, Tasso, M, Barba, P, Rives, S, Ribera, JM
Publicada:
24 mar 2026
Resumen:
Patients with relapsed/refractory T-cell acute lymphoblastic leukemia (R/R T-ALL) have very poor prognosis. CAR T-cell therapy is being explored in these patients with encouraging results. Specifically, CD1a-directed CAR T-cells are being explored in clinical trials to treat cortical T-ALL (CD1a+), but there are no data on outcome in this subgroup of patients before this therapy. This retrospective, observational study aimed to describe the characteristics and outcomes of patients with R/R CD1a + T-ALL. We included pediatric and adult patients diagnosed with R/R CD1a + T-ALL in 25 sites of Spain between March 2006 and May 2022. The primary outcome of the study was overall survival (OS). Forty-three patients, 28 adults and 15 children, with R/R CD1a + T-ALL were included. Median (range) age at inclusion was 24 years (5-57), and 82.5% were male. After a median (range) follow-up of 7.0 years (5.1-13.6), 6 (14.0%) patients were alive and in complete remission (CR) and 37 (86.0%) had died. Five-year OS was 16% (95% CI; 7-29%). Bone marrow relapse, an interval < 12 months between first CR and relapse, and lack of allogeneic hematopoietic stem cell transplantation during salvage treatment were associated with worse OS. Our results confirm that patients with R/R CD1a + T-ALL have a very poor prognosis, highlighting the need for new treatment alternatives in these patients.
Filiaciones:
Rivera-Pérez, C:
Hosp St Joan Deu Barcelona, Pediat Canc Ctr Barcelona PCCB, Stem Cell Transplant Dept, Barcelona, Spain
Univ Barcelona, Fac Med, Barcelona, Spain
Morgades, M:
Hosp Badalona Germans Trias & Pujol, Inst Catala Oncol, Clin Hematol Dept, Badalona, Spain
Alonso-Saladrigues, A:
Univ Barcelona, Fac Med, Barcelona, Spain
Hosp St Joan Deu Barcelona, Pediat Canc Ctr Barcelona PCCB, Leukemia & Lymphoma Dept, Barcelona, Spain
Inst Recerca St Joan Deu, Barcelona, Spain
Montesinos, P:
Hosp Univ & Politecn La Fe, Hematol Dept, Valencia, Spain
Murciano, T:
Hosp Univ Vall dHebron, Pediat Oncol & Hematol Dept, Barcelona, Spain
Vall dHebron Res Inst VHIR, Barcelona, Spain
Gil, C:
Hosp Gen Univ Dr Balmis, Hematol Dept, Hosp Gen Universitari Dr, Alacant, Spain
Adán, R:
Hosp Univ Cruces, Pediat Hematol & Oncol Unit, Baracaldo, Spain
Biobizkaia Hlth Res Inst, Pediat Oncol Res Grp, Baracaldo, Spain
Esteve, J:
Hosp Clin Barcelona, Hematol Dept, Barcelona, Spain
Univ Barcelona, IDIBAPS, Barcelona, Spain
Fuentes, C:
Hosp Univ & Politecn La Fe, Pediat Oncol & Hematol Dept, Valencia, Spain
Amigo, ML:
Hosp Gen Univ Morales Meseguer, Hematol Dept, Murcia, Spain
González-Martínez, B:
Hosp Univ La Paz, Pediat Hematol & Oncol Dept, Madrid, Spain
Coll, R:
Hosp Univ Dr Josep Trueta, Inst Catala Oncol, Hematol Dept, Hosp Universitari Dr, Girona, Spain
Dapena, JL:
Hosp St Joan Deu Barcelona, Pediat Canc Ctr Barcelona PCCB, Stem Cell Transplant Dept, Barcelona, Spain
De Llano, MPQ:
Hosp Univ Virgen Victoria, Hematol Dept, Malaga, Spain
Fuster, JL:
Hosp Clin Univ Virgen Arrixaca Palmar, Murcia, Spain
Inst Murciano Invest Biosanit IMIB, El Palmar, Spain
García-Cadenas, I:
Hosp Santa Creu & Sant Pau, Hematol Dept, Barcelona, Spain
Tasso, M:
Hosp Gen Univ Dr Balmis, Pediat Oncol & Hematol Dept, Alacant, Spain
ISABIAL, Alacant, Spain
Barba, P:
Hosp Univ Vall dHebron, Hematol Dept, Barcelona, Spain
Rives, S:
Hosp St Joan Deu Barcelona, Pediat Canc Ctr Barcelona PCCB, Leukemia & Lymphoma Dept, Barcelona, Spain
Inst Recerca St Joan Deu, Barcelona, Spain
Ribera, JM:
Hosp Badalona Germans Trias & Pujol, Inst Catala Oncol, Clin Hematol Dept, Badalona, Spain
Josep Carreras Leukemia Res Inst, Badalona, Spain
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