Effect of a physical activity and healthy eating lifestyle intervention in pregnancy on fetal growth trajectories: The DALI randomised controlled trial
Por:
Dieberger, AM, van Poppel, MNM, Desoye, G, Simmons, D, Harreiter, J, Devlieger, R, Medina, C, Lawlor, DA, Elhakeem, A
Publicada:
1 may 2025
Ahead of Print:
1 ene 2025
Resumen:
BackgroundObesity during pregnancy is related to fetal overgrowth. Effective interventions that can mitigate this risk are needed.ObjectivesThis study aimed to investigate the effect of a lifestyle intervention for pregnant women with obesity on fetal growth trajectories.MethodsIn the DALI trial, pregnant women with a body mass index >= 29.0 kg/m2 and without gestational diabetes at baseline were randomized to counselling on physical activity (PA), healthy eating (HE) or a combination (PA + HE), or to usual care (UC). Fetal growth trajectories were modelled based on a combination of estimated fetal weight (EFW) from repeated ultrasound scans and weight measured at birth. Differences in fetal growth trajectories between groups were assessed.ResultsThree hundred eighty-four women were included. Those in the PA + HE intervention had slower EFW gain from 32 weeks onwards, with differences (PA + HE vs. UC) at 32, 36 and 40 weeks of -54.1 g (-146.7 to 38.9 g), -84.9 g (-194.0 to 24.7 g), and -99.8 g (-227.1 to 28.1 g), respectively. Effects appeared stronger in males, with a difference at 40 weeks of -185.8 g (-362.5 g to -9.2 g) versus -23.4 g (-190.4 g to 143.5 g) in females.ConclusionsA lifestyle intervention for pregnant women with obesity resulted in attenuated fetal growth, which only reached significance in male offspring. Future larger trials are needed to confirm these findings and elucidate underlying pathways.
Filiaciones:
Dieberger, AM:
Med Univ Graz, Dept Obstet & Gynaecol, Graz, Austria
van Poppel, MNM:
Graz Univ, Inst Human Movement Sci Sport & Hlth, Graz, Austria
Desoye, G:
Med Univ Graz, Dept Obstet & Gynaecol, Graz, Austria
Simmons, D:
Western Sydney Univ, Macarthur Clin Sch, Campbelltown, NSW, Australia
Harreiter, J:
Med Univ Vienna, Dept Med 3, Div Endocrinol & Metab, Vienna, Austria
Landesklinikum Scheibbs, Dept Med, Scheibbs, Austria
Devlieger, R:
Katholieke Univ Leuven, Fac Med, Dept Dev & Regenerat, Leuven, Belgium
Univ Hosp Leuven, Dept Obstet & Gynaecol, Leuven, Belgium
Medina, C:
Hosp St Creu i St Pau, Dept Obstet & Gynaecol, Barcelona, Spain
Lawlor, DA:
Univ Bristol, MRC Integrat Epidemiol Unit, Bristol, England
Univ Bristol, Bristol Med Sch, Populat Hlth Sci, Bristol, England
Elhakeem, A:
Univ Bristol, MRC Integrat Epidemiol Unit, Bristol, England
Univ Bristol, Bristol Med Sch, Populat Hlth Sci, Bristol, England
Green Submitted, Green Accepted, Green Published, hybrid
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