Tricuspid transcatheter edge-to-edge repair for tricuspid valve regurgitation: a sex-based real-world analysis from the TRI-SPA registry
Por:
Ruberti, A, Cepas-Guillen, P, Echarte-Morales, J, Arzamendi, D, Moñivas, V, Carrasco-Chinchilla, F, Pan, MN, Nombela-Franco, L, Pascual, I, Sabatè-Tenas, M, Benito-González, T, Perez, R, Gómez-Blázquez, I, Amat-Santos, IJ, Flores-Umanzor, E, Cruz-González, I, Sánchez-Recalde, A, Alvarez, ABC, Barreiro-Perez, M, Sanchis, L, Li, CH, Caneiro-Queija, B, del Trigo, M, Martinez-Carmona, JD, Mesa-Rubio, D, Jimenez, P, Avanzas, P, Estevez-Loureiro, R, Freixa, X
Publicada:
1 ene 2026
Ahead of Print:
1 sep 2025
Resumen:
Aims Impact of sex-related differences on clinical outcomes after tricuspid transcatheter edge-to-edge repair (T-TEER) for severe tricuspid regurgitation (TR) remains underexplored. Methods and results This sub-analysis of the Transcatheter tRicuspid valve repaIr in SPAin (TRI-SPA) registry includes patients who underwent T-TEER for severe TR between June 2020 and May 2023 in Spain. Outcomes were compared by sex. The primary composite endpoint included all-cause mortality, heart failure-related hospitalization, and tricuspid valve re-intervention at 12 months. Secondary endpoints included significant TR recurrence and functional improvement. Among 310 patients (mean age 75.5 +/- 9.1 years) with severe TR treated with T-TEER, 70% were females. Males exhibited more prevalent coronary artery disease (30.4 vs. 12.8%; p < 0.001) and reduced right ventricular (RV) function compared with females (RV fractional area change 34.5 vs. 42.0%; p < 0.001). Women had larger left atrial volume (45.7 vs. 40.8 mL/m(2), p = 0.038). Procedural success was high and comparable among sexes (90.7 vs. 89.3% in females and males, respectively; p = 0.71). No significant difference emerged in relation to the primary composite endpoint (absolute event rate in males 27.5 vs. 16.3% in females; adjusted HR 0.61, 95% CI: 0.31-1.18; p = 0.142). At 12 months, comparable sustained TR reduction (grade <= 2+) rates (67.3% in males vs. 73.5% in females; p = 0.40) and functional improvement (NYHA I/II class 75.0 vs. 82.3%; p = 0.78) were observed. Conclusion In a real-world setting, T-TEER was equally safe and effective in both sexes, achieving comparable procedural success and durable TR reduction.
Filiaciones:
Ruberti, A:
Hosp Clin Barcelona, Cardiovasc Inst, Dept Cardiol, Barcelona 08036, Spain
Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona 08036, Spain
Univ Barcelona UB, Fac Med & Ciencies Salut, Barcelona 08036, Spain
Cepas-Guillen, P:
Hosp Clin Barcelona, Cardiovasc Inst, Dept Cardiol, Barcelona 08036, Spain
Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona 08036, Spain
Univ Barcelona UB, Fac Med & Ciencies Salut, Barcelona 08036, Spain
Echarte-Morales, J:
Univ Hosp Alvaro Cunqueiro, Dept Cardiol, Vigo 36316, Spain
Univ Vigo, Univ Hosp Alvaro Cunqueiro, Fdn Biomed Galicia Sur, Dept Cardiol,Cardiovasc Res Grp,Serv Galego Saude, Vigo 36312, Spain
Arzamendi, D:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst IIB St Pau, Dept Cardiol, Barcelona 08025, Spain
Moñivas, V:
Univ Hosp Puerta Hierro Majadahonda, Dept Cardiol, Madrid 28222, Spain
Carrasco-Chinchilla, F:
Hosp Univ Virgen Victoria, Unidad Gest Clin Corazon, Malaga 29010, Spain
Pan, MN:
Univ Cordoba, Ctr Invest Biomed Red Enfermedades Cardiovasc CIB, Inst Maimonides Invest Biomed Cordoba IMIBIC, Hosp Reina Sofia,Dept Cardiol, Cordoba 14004, Spain
Nombela-Franco, L:
Hosp Clin San Carlos, Cardiovasc Inst, IdISSC, Madrid 28040, Spain
Pascual, I:
Hosp Univ Cent Asturias, Heart Area, Oviedo 33011, Spain
Sabatè-Tenas, M:
Hosp Clin Barcelona, Cardiovasc Inst, Dept Cardiol, Barcelona 08036, Spain
Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona 08036, Spain
Univ Barcelona UB, Fac Med & Ciencies Salut, Barcelona 08036, Spain
Benito-González, T:
Univ Hosp Leon, Dept Cardiol, Leon 24008, Spain
Perez, R:
Univ Hosp, Dept Cardiol, La Coruna 15006, Spain
Gómez-Blázquez, I:
Univ Hosp 12 Octubre, Dept Cardiol, Madrid 28041, Spain
Amat-Santos, IJ:
Univ Clin Hosp, Ctr Invest Biomed Red Enfermedades Cardiovasc, Dept Cardiol, Valladolid 47010, Spain
Flores-Umanzor, E:
Hosp Clin Barcelona, Cardiovasc Inst, Dept Cardiol, Barcelona 08036, Spain
Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona 08036, Spain
Univ Barcelona UB, Fac Med & Ciencies Salut, Barcelona 08036, Spain
Cruz-González, I:
Hosp Univ Salamanca, Ctr Invest Biomed Red Enfermedades Cardiovasc, Dept Cardiol, Inst Invest Biomed Salamanca, Salamanca 37007, Spain
Sánchez-Recalde, A:
Hosp Univ Ramon & Cajal, Dept Cardiol, Madrid 28034, Spain
Alvarez, ABC:
Univ Clin Hosp, Ctr Invest Biomed Red Enfermedades Cardiovasc, Dept Cardiol, Santiago De Compostela 15706, Spain
Barreiro-Perez, M:
Univ Hosp Alvaro Cunqueiro, Dept Cardiol, Vigo 36316, Spain
Univ Vigo, Univ Hosp Alvaro Cunqueiro, Fdn Biomed Galicia Sur, Dept Cardiol,Cardiovasc Res Grp,Serv Galego Saude, Vigo 36312, Spain
Sanchis, L:
Hosp Clin Barcelona, Cardiovasc Inst, Dept Cardiol, Barcelona 08036, Spain
Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona 08036, Spain
Univ Barcelona UB, Fac Med & Ciencies Salut, Barcelona 08036, Spain
Li, CH:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst IIB St Pau, Dept Cardiol, Barcelona 08025, Spain
Caneiro-Queija, B:
Univ Hosp Alvaro Cunqueiro, Dept Cardiol, Vigo 36316, Spain
Univ Vigo, Univ Hosp Alvaro Cunqueiro, Fdn Biomed Galicia Sur, Dept Cardiol,Cardiovasc Res Grp,Serv Galego Saude, Vigo 36312, Spain
del Trigo, M:
Univ Hosp Puerta Hierro Majadahonda, Dept Cardiol, Madrid 28222, Spain
Martinez-Carmona, JD:
Hosp Univ Virgen Victoria, Unidad Gest Clin Corazon, Malaga 29010, Spain
Univ Malaga UMA, CIBERCV, Inst Invest Biomed Malaga IBIMA, Malaga 29010, Spain
Mesa-Rubio, D:
Univ Cordoba, Ctr Invest Biomed Red Enfermedades Cardiovasc CIB, Inst Maimonides Invest Biomed Cordoba IMIBIC, Hosp Reina Sofia,Dept Cardiol, Cordoba 14004, Spain
Jimenez, P:
Univ Hosp Leon, Dept Cardiol, Leon 24008, Spain
Avanzas, P:
Hlth Res Inst Principal Asturias ISPA, Oviedo 33011, Spain
Univ Oviedo, Med Dept, Oviedo 33011, Spain
Ctr Invest Biomed Red Enfermedades Cardiovasc CIB, Madrid 28029, Spain
Estevez-Loureiro, R:
Univ Hosp Alvaro Cunqueiro, Dept Cardiol, Vigo 36316, Spain
Univ Vigo, Univ Hosp Alvaro Cunqueiro, Fdn Biomed Galicia Sur, Dept Cardiol,Cardiovasc Res Grp,Serv Galego Saude, Vigo 36312, Spain
Freixa, X:
Hosp Clin Barcelona, Cardiovasc Inst, Dept Cardiol, Barcelona 08036, Spain
Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona 08036, Spain
Univ Barcelona UB, Fac Med & Ciencies Salut, Barcelona 08036, Spain
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