Temporal dynamics of white matter hyperintensities related to Alzheimer's disease in adults with Down syndrome
Por:
Morcillo-Nieto, AO, Rozalem-Aranha, M, Maure-Blesa, L, Rodríguez-Baz, I, Arriola-Infante, JE, Franquesa-Mullerat, M, Zsadanyi, SE, Vaqué-Alcázar, L, Parra, JA, Zhao, ZL, Arranz, J, Videla, L, Barroeta, I, Soriano, LD, Benejam, B, Fernández, S, Hernandez, AS, Pertierra, L, Giménez, S, Alcolea, D, Belbin, O, Lleó, A, Carmona-Iragui, M, Fortea, J, Bejanin, A
Publicada:
4 feb 2026
Resumen:
INTRODUCTION: White matter hyperintensities (WMH) are common in Down syndrome (DS), yet their longitudinal evolution and associations with Alzheimer's disease (AD) remain unclear. METHODS: Longitudinal MRI study, including 80 DS adults and 53 euploid controls. WMH were segmented on serial FLAIR using a longitudinal pipeline. We assessed the effects of demographic, genetic factors, AD clinical stage, AD-related fluid, and cerebrovascular biomarkers on annual WMH volume changes. RESULTS: In DS, annual WMH changes were relatively stable until age 40, and then exhibited fluctuations, with a significant decrease at the group level. Declines were larger in symptomatic cases, particularly in periventricular and fronto-parieto-occipital regions. Higher baseline WMH and microbleeds presence related to greater WMH reduction. Visual ratings and adjustment for white matter volume supported the robustness of the results. DISCUSSION: WMH trajectories were heterogeneous in DS and declined over time with AD symptoms. This unexpected reduction may reflect different underlying pathological processes, including neurodegeneration or neuroinflammation.
Filiaciones:
Morcillo-Nieto, AO:
Hosp Santa Creu & Sant Pau, St Pau Memory Unit, IR St PAU, St Quinti 77-79, Barcelona 08041, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Madrid, Spain
Univ Autonoma Barcelona, Inst Neurociencies, Barcelona, Spain
Rozalem-Aranha, M:
Hosp Santa Creu & Sant Pau, St Pau Memory Unit, IR St PAU, St Quinti 77-79, Barcelona 08041, Spain
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Fac Med, Neuroradiol Sect,Dept Radiol, Barcelona, Spain
Maure-Blesa, L:
Hosp Santa Creu & Sant Pau, St Pau Memory Unit, IR St PAU, St Quinti 77-79, Barcelona 08041, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Madrid, Spain
Univ Autonoma Barcelona, Dept Med, Barcelona, Spain
Rodríguez-Baz, I:
Hosp Santa Creu & Sant Pau, St Pau Memory Unit, IR St PAU, St Quinti 77-79, Barcelona 08041, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Madrid, Spain
Arriola-Infante, JE:
Torrecardenas Univ Hosp, Dept Neurol, Almeria, Spain
Franquesa-Mullerat, M:
Hosp Santa Creu & Sant Pau, St Pau Memory Unit, IR St PAU, St Quinti 77-79, Barcelona 08041, Spain
Univ Autonoma Barcelona, Inst Neurociencies, Barcelona, Spain
Zsadanyi, SE:
Hosp Santa Creu & Sant Pau, St Pau Memory Unit, IR St PAU, St Quinti 77-79, Barcelona 08041, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Madrid, Spain
Univ Autonoma Barcelona, Inst Neurociencies, Barcelona, Spain
Vaqué-Alcázar, L:
Hosp Santa Creu & Sant Pau, St Pau Memory Unit, IR St PAU, St Quinti 77-79, Barcelona 08041, Spain
Univ Barcelona, Inst Neurosci, Fac Med & Hlth Sci, Dept Med, Barcelona, Spain
Inst Invest Biomed August Pi I Sunyer IDIBAPS, Barcelona, Spain
Parra, JA:
Hosp Santa Creu & Sant Pau, St Pau Memory Unit, IR St PAU, St Quinti 77-79, Barcelona 08041, Spain
Univ Autonoma Barcelona, Inst Neurociencies, Barcelona, Spain
Zhao, ZL:
Hosp Santa Creu & Sant Pau, St Pau Memory Unit, IR St PAU, St Quinti 77-79, Barcelona 08041, Spain
Univ Autonoma Barcelona, Inst Neurociencies, Barcelona, Spain
Arranz, J:
Hosp Santa Creu & Sant Pau, St Pau Memory Unit, IR St PAU, St Quinti 77-79, Barcelona 08041, Spain
Univ Autonoma Barcelona, Dept Med, Barcelona, Spain
Videla, L:
Hosp Santa Creu & Sant Pau, St Pau Memory Unit, IR St PAU, St Quinti 77-79, Barcelona 08041, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Madrid, Spain
Fundacio Catalana Sindrome, Barcelona Med Ctr, Barcelona, Spain
Barroeta, I:
Hosp Santa Creu & Sant Pau, St Pau Memory Unit, IR St PAU, St Quinti 77-79, Barcelona 08041, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Madrid, Spain
Soriano, LD:
Hosp Santa Creu & Sant Pau, St Pau Memory Unit, IR St PAU, St Quinti 77-79, Barcelona 08041, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Madrid, Spain
Benejam, B:
Hosp Santa Creu & Sant Pau, St Pau Memory Unit, IR St PAU, St Quinti 77-79, Barcelona 08041, Spain
Fundacio Catalana Sindrome, Barcelona Med Ctr, Barcelona, Spain
Fernández, S:
Fundacio Catalana Sindrome, Barcelona Med Ctr, Barcelona, Spain
Hernandez, AS:
Hosp Santa Creu & Sant Pau, St Pau Memory Unit, IR St PAU, St Quinti 77-79, Barcelona 08041, Spain
Pertierra, L:
Fleni, Neurol Dept, Cognit Neurol Neuropsychol & Neuropsychiat Unit, Buenos Aires, Argentina
Giménez, S:
Hosp Santa Creu & Sant Pau, St Pau Memory Unit, IR St PAU, St Quinti 77-79, Barcelona 08041, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Madrid, Spain
Hosp Santa Creu & Sant Pau, Multidisciplinary Sleep unit, IR St PAU, Barcelona, Spain
Alcolea, D:
Hosp Santa Creu & Sant Pau, St Pau Memory Unit, IR St PAU, St Quinti 77-79, Barcelona 08041, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Madrid, Spain
Belbin, O:
Hosp Santa Creu & Sant Pau, St Pau Memory Unit, IR St PAU, St Quinti 77-79, Barcelona 08041, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Madrid, Spain
Lleó, A:
Hosp Santa Creu & Sant Pau, St Pau Memory Unit, IR St PAU, St Quinti 77-79, Barcelona 08041, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Madrid, Spain
Carmona-Iragui, M:
Hosp Santa Creu & Sant Pau, St Pau Memory Unit, IR St PAU, St Quinti 77-79, Barcelona 08041, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Madrid, Spain
Fundacio Catalana Sindrome, Barcelona Med Ctr, Barcelona, Spain
Fortea, J:
Hosp Santa Creu & Sant Pau, St Pau Memory Unit, IR St PAU, St Quinti 77-79, Barcelona 08041, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Madrid, Spain
Fundacio Catalana Sindrome, Barcelona Med Ctr, Barcelona, Spain
Bejanin, A:
Hosp Santa Creu & Sant Pau, St Pau Memory Unit, IR St PAU, St Quinti 77-79, Barcelona 08041, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Madrid, Spain
Green Submitted, hybrid
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