A Proposed Approach to Chronic Airway Disease (CAD) Using Therapeutic Goals and Treatable Traits: A Look to the Future
Por:
de Llano, LP, Miravitlles, M, Golpe, R, Alvarez-Gutierrez, FJ, Cisneros, C, Almonacid, C, Martinez-Moragon, E, Gonzalez-Barcala, FJ, Ramos-Barbon, D, Plaza, V, Lopez-Campos, JL, de-Torres, JP, Casanova, C, Rivero, JLG, Hermosa, JR, Rubio, MC, Soler-Cataluna, JJ, Cosio, BG
Publicada:
1 ene 2020
Resumen:
Chronic airflow obstruction affects a wide range of airway diseases, the most frequent of which are asthma, COPD, and bronchiectasis; they are clearly identifiable in their extremes, but quite frequently overlap in some of their pathophysiological and clinical characteristics. This has generated the description of new mixed or overlapping disease phenotypes with no clear biological grounds. In this special article, a group of experts provides their perspective and proposes approaching the treatment of chronic airway disease (CAD) through the identification of a series of therapeutic goals (TG) linked to treatable traits (TT) - understood as clinical, physiological, or biological characteristics that are quantifiable using biomarkers. This therapeutic approach needs validating in a clinical trial with the strategy of identification of TG and treatment according to TT for each patient independently of their prior diagnosis.
Filiaciones:
de Llano, LP:
Univ Hosp Lucus Augusti, Pneumol Serv, EOXI Cervo, Lugo, Monforte, Spain
Miravitlles, M:
Vall dHebron Inst Recerca VHIR, Pneumol Serv, CIBERES, Vall dHebron Barcelona Hosp Campus, Barcelona, Spain
Golpe, R:
Univ Hosp Lucus Augusti, Pneumol Serv, EOXI Cervo, Lugo, Monforte, Spain
Alvarez-Gutierrez, FJ:
Hosp Univ Virgen del Rocio, Pneumol Serv, Seville, Spain
Cisneros, C:
La Princesa Univ Hosp, Pneumol Serv, Res Inst La Princesa IIP, Madrid, Spain
Almonacid, C:
Raman y Cajal Hosp, Ramon y Cajal Hlth Res Inst IRYCIS, Pneumol Serv, Madrid, Spain
Martinez-Moragon, E:
Hosp Univ Dr Peset, Pneumol Serv, Valencia, Spain
Gonzalez-Barcala, FJ:
Univ Santiago de Compostela, Univ Clin Hosp Santiago de Compostela, Fac Med, Pneumol Serv,CIBERES, Santiago De Compostela, Spain
Ramos-Barbon, D:
Hosp Santa Creu i St Pau, Pneumol Serv, Barcelona, Spain
Plaza, V:
Hosp Santa Creu i St Pau, Pneumol Serv, Barcelona, Spain
Lopez-Campos, JL:
Hosp Univ Virgen del Rocio, Pneumol Serv, Seville, Spain
de-Torres, JP:
Queens Univ, Div Respirol & Sleep Med, Kingston, ON, Canada
Casanova, C:
Hosp Univ Nuestra Senora Candelaria, Pneumol Serv, Santa Cruz De Tenerife, Spain
Rivero, JLG:
Hosp Laredo, Pneumol Serv, Laredo, Spain
Hermosa, JR:
Univ Complutense Madrid, Hosp Clin San Carlos, Pneumol Serv, Madrid, Spain
Univ Complutense Madrid, Hosp Clin San Carlos, Fac Med, Madrid, Spain
Rubio, MC:
Univ Complutense Madrid, Hosp Clin San Carlos, Pneumol Serv, Madrid, Spain
Univ Complutense Madrid, Hosp Clin San Carlos, Fac Med, Madrid, Spain
Soler-Cataluna, JJ:
Hosp Arnau Vilanova, Pneumol Serv, Valencia, Spain
Cosio, BG:
Son Espases Univ Hosp, CIBERES, Pneumol Serv, Clin Quiron Rotger,IdISBa, Palma De Mallorca, Spain
Gold, Green Published
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