Hospital-acquired influenza infections detected by a surveillance system over six seasons, from 2010/2011 to 2015/2016
Por:
Soldevila, N, Dominguez, A, Alseda, M, Alvarez, J, Arias, C, Balana, PJ, Barrabeig, I, Camps, N, Carol, M, Ferras, J, Ferrus, G, Follia, N, Godoy, P, Bach, P, Jane, M, Martinez, A, Minguell, S, Parron, I, Plasencia, E, Sala-Farre, MR, Torner, N, Torra, R, Torres, J, Cayla, J, Gorrindo, P, Rius, C, Marcos, MA, Mosquera, MDM, Vilella, A, Anton, A, Pumarola, T, Campins, M, Garcia, D, Espejo, E, Freixas, N, Garcia, MR, Maraver, E, Mas, D, Perez, R, Rebull, J, Pou, J, Garcia-Pardo, G, Olona, M, Barcenilla, F, Castellana, D, Navarro-Rubio, G, Force, LL
Publicada:
28 ene 2020
Resumen:
Background In addition to outbreaks of nosocomial influenza, sporadic nosocomial influenza infections also occur but are generally not reported in the literature. This study aimed to determine the epidemiologic characteristics of cases of nosocomial influenza compared with the remaining severe cases of severe influenza in acute hospitals in Catalonia (Spain) which were identified by surveillance. Methods An observational case-case epidemiological study was carried out in patients aged >= 18 years from Catalan 12 hospitals between 2010 and 2016. For each laboratory-confirmed influenza case (nosocomial or not) we collected demographic, virological and clinical characteristics. We defined patients with nosocomial influenza as those admitted to a hospital for a reason other than acute respiratory infection in whom ILI symptoms developed >= 48 h after admission and influenza virus infection was confirmed using RT-PCR. Mixed-effects regression was used to estimate the crude and adjusted OR. Results One thousand seven hundred twenty-two hospitalized patients with severe laboratory-confirmed influenza virus infection were included: 96 (5.6%) were classified as nosocomial influenza and more frequently had > 14 days of hospital stay (42.7% vs. 27.7%, P < .001) and higher mortality (18.8% vs. 12.6%, P < .02). The variables associated with nosocomial influenza cases in acute-care hospital settings were chronic renal disease (aOR 2.44 95% CI 1.44-4.15) and immunodeficiency (aOR 1.79 95% CI 1.04-3.06). Conclusions Nosocomial infections are a recurring problem associated with high rates of chronic diseases and death. These findings underline the need for adherence to infection control guidelines.
Filiaciones:
Soldevila, N:
CIBERESP, Barcelona, Spain
Univ Barcelona, Dept Med, Barcelona, Spain
Dominguez, A:
CIBERESP, Barcelona, Spain
Univ Barcelona, Dept Med, Barcelona, Spain
Alseda, M:
Publ Hlth Agcy Catalonia, Barcelona, Spain
Alvarez, J:
Publ Hlth Agcy Catalonia, Barcelona, Spain
Arias, C:
Publ Hlth Agcy Catalonia, Barcelona, Spain
Balana, PJ:
Publ Hlth Agcy Catalonia, Barcelona, Spain
Barrabeig, I:
Publ Hlth Agcy Catalonia, Barcelona, Spain
Camps, N:
Publ Hlth Agcy Catalonia, Barcelona, Spain
Carol, M:
Publ Hlth Agcy Catalonia, Barcelona, Spain
Ferras, J:
Publ Hlth Agcy Catalonia, Barcelona, Spain
Ferrus, G:
Publ Hlth Agcy Catalonia, Barcelona, Spain
Follia, N:
Publ Hlth Agcy Catalonia, Barcelona, Spain
Godoy, P:
Generalitat Catalunya, Epidemiol Serv, Agencia Salut Publ Catalunya, Barcelona, Spain
CIBERESP, Barcelona, Spain
IRBLLEIDA, Inst Recerca Biomed Lleida, Lleida, Spain
Publ Hlth Agcy Catalonia, Barcelona, Spain
Bach, P:
Publ Hlth Agcy Catalonia, Barcelona, Spain
Jane, M:
Generalitat Catalunya, Epidemiol Serv, Agencia Salut Publ Catalunya, Barcelona, Spain
CIBERESP, Barcelona, Spain
Publ Hlth Agcy Catalonia, Barcelona, Spain
Martinez, A:
Generalitat Catalunya, Epidemiol Serv, Agencia Salut Publ Catalunya, Barcelona, Spain
CIBERESP, Barcelona, Spain
Univ Barcelona, Dept Med, Barcelona, Spain
Publ Hlth Agcy Catalonia, Barcelona, Spain
Minguell, S:
Publ Hlth Agcy Catalonia, Barcelona, Spain
Parron, I:
Publ Hlth Agcy Catalonia, Barcelona, Spain
Plasencia, E:
Publ Hlth Agcy Catalonia, Barcelona, Spain
Sala-Farre, MR:
Publ Hlth Agcy Catalonia, Barcelona, Spain
Torner, N:
Generalitat Catalunya, Epidemiol Serv, Agencia Salut Publ Catalunya, Barcelona, Spain
CIBERESP, Barcelona, Spain
Univ Barcelona, Dept Med, Barcelona, Spain
Publ Hlth Agcy Catalonia, Barcelona, Spain
Torra, R:
Publ Hlth Agcy Catalonia, Barcelona, Spain
Torres, J:
Publ Hlth Agcy Catalonia, Barcelona, Spain
Cayla, J:
CIBERESP, Barcelona, Spain
Agencia Salut Publ Barcelona, Barcelona, Spain
Publ Hlth Agcy Barcelona, Barcelona, Spain
Gorrindo, P:
Publ Hlth Agcy Barcelona, Barcelona, Spain
Rius, C:
CIBERESP, Barcelona, Spain
Agencia Salut Publ Barcelona, Barcelona, Spain
Publ Hlth Agcy Barcelona, Barcelona, Spain
Marcos, MA:
Hosp Clin Barcelona, Barcelona, Spain
Mosquera, MDM:
Hosp Clin Barcelona, Barcelona, Spain
Vilella, A:
Hosp Clin Barcelona, Barcelona, Spain
Anton, A:
Hosp Univ Vall dHebron, Barcelona, Spain
Pumarola, T:
Hosp Univ Vall dHebron, Barcelona, Spain
Campins, M:
Hosp Univ Vall dHebron, Barcelona, Spain
Garcia, D:
Hosp Josep Trueta, Girona, Spain
Espejo, E:
Hosp Terrassa, Terrassa, Spain
Freixas, N:
Mutua Terrassa, Terrassa, Spain
Garcia, MR:
Mutua Terrassa, Terrassa, Spain
Maraver, E:
Hosp Altahia Manresa, Barcelona, Spain
Mas, D:
Hosp Altahia Manresa, Barcelona, Spain
Perez, R:
Hosp Altahia Manresa, Barcelona, Spain
Rebull, J:
Hosp Verge de la Cinta, Tortosa, Spain
Pou, J:
Hosp St Joan de Deu, Esplugues, Spain
Garcia-Pardo, G:
Hosp Joan 23, Tarragona, Spain
Olona, M:
Hosp Joan 23, Tarragona, Spain
Barcenilla, F:
Hosp Arnau Vilanova, Lleida, Spain
Castellana, D:
Hosp Arnau Vilanova, Lleida, Spain
Navarro-Rubio, G:
Consorci Sanitari Parc Tauli, Sabadell, Spain
Force, LL:
Hosp Mataro, Mataro, Spain
Gold, Green Published
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