Associations of lifestyle factors with amyloid pathology in persons without dementia
Por:
Oomens, JE, Vos, SJB, Maserejian, NN, Boada, M, Didic, M, Engelborghs, S, Fladby, T, van der Flier, WM, Frisoni, GB, Fröhlich, L, Gill, KD, Grimmer, T, Hort, J, Itoh, Y, Iwatsubo, T, Klimkowicz-Mrowiec, A, Landau, SM, Lee, DY, Lleó, A, Martinez-Lage, P, de Mendonça, A, Meyer, PT, Parchi, P, Pardini, M, Parnetti, L, Popp, J, Rami, L, Reiman, EM, Rinne, JO, Rodrigue, KM, Sánchez-Juan, P, Santana, I, Scarmeas, N, Scheltens, P, Skoog, I, Sperling, RA, Stern, Y, Villeneuve, S, Waldemar, G, Wiltfang, J, Zetterberg, H, Alcolea, D, Allegri, RF, Altomare, D, Bateman, RJ, Baiardi, S, Baldeiras, I, Blennow, K, den Braber, A, van Buchem, MA, Byun, MS, Cerman, J, Chen, KW, Chipi, E, Day, GS, Drzezga, A, Ekblad, LL, Förster, S, Fortea, J, Freund-Levi, Y, Frings, L, Guedj, E, Habeck, CG, Handels, R, Hausner, L, Hellwig, S, Jiménez-Bonilla, JF, Juaristi, AI, Kandimalla, R, Kern, S, Kirsebom, BESB, Kornhuber, J, Legdeur, N, Levin, J, Maier, W, Marquié, M, Minatani, S, Morbelli, SD, Mroczko, B, Ntanasi, E, de Oliveira, CR, Orellana, A, Peters, O, Prabhakar, S, Ramakers, IH, Rodríguez-Rodriguez, E, Ruiz, A, Rüther, E, Sakhardande, J, Selnes, P, Silva, D, Soininen, H, Spiru, L, Takeda, A, Teunissen, CE, Tijms, BM, Vermunt, L, Wallin, ÅK, Wiels, W, Yannakoulia, M, Yi, D, Zettergren, A, Ossenkoppele, R, Verhey, FRJ, Visser, PJ, Jansen, WJ
Publicada:
1 nov 2025
Resumen:
Background: The association between lifestyle factors and Alzheimer's disease (AD) pathophysiology remains incompletely understood.
Objective: The aim of this study was to assess the association of alcohol consumption, smoking behavior, sleep quality and physical, cognitive, and social activity with cerebral amyloid pathology.
Methods: For this cross-sectional study, we selected participants from the Amyloid Biomarker Study data pooling initiative. We used generalized estimating equations to assess associations of dichotomized lifestyle measures with amyloid pathology.
Results: We included 9171 participants with normal cognition (NC) and 2555 participants with mild cognitive impairment (MCI) from the Amyloid Biomarker Study. Of participants with NC, 58% were women, 34% were APOE epsilon 4 carrier, and 27% had amyloid pathology. Of participants with MCI, 48% were women, 47% were APOE epsilon 4 carrier, and 57% had amyloid pathology. In NC, cognitively active participants were less likely to have amyloid pathology (OR = 0.77, 95%CI 0.66 - 0.89, p < 0.001). In MCI, participants who had ever smoked or had sleep problems were less likely to have amyloid pathology (OR = 0.85, 95%CI 0.73-0.99, p = 0.029; OR = 0.62, 95%CI 0.45-0.86, p = 0.004).
Conclusions: In NC, cognitive activity was associated with a lower frequency of amyloid pathology. In MCI, favorable lifestyle behaviors were not associated with a lower frequency of amyloid pathology. The results of the current study contribute to the broader evidence base on lifestyle and AD by further characterizing the role of lifestyle behaviors in AD pathology across different clinical stages.
Filiaciones:
Oomens, JE:
Maastricht Univ, Mental Hlth & Neurosci Res Inst, Alzheimer Ctr Limburg, Dept Psychiat & Neuropsychol, Maastricht, Netherlands
Vos, SJB:
Maastricht Univ, Mental Hlth & Neurosci Res Inst, Alzheimer Ctr Limburg, Dept Psychiat & Neuropsychol, Maastricht, Netherlands
Maserejian, NN:
Biogen, Dept Epidemiol, Cambridge, MA USA
Boada, M:
Univ Int Catalunya, Ace Alzheimer Ctr Barcelona, Barcelona, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Didic, M:
Hop Timone Adultes, AP HM, Serv Neurol & Neuropsychol, Marseille, France
Aix Marseille Univ, Inst Neurosci Syst, INSERM, Marseille, France
Engelborghs, S:
Univ Antwerp, Dept Biomed Sci, Antwerp, Belgium
Vrije Univ Brussel, Ctr Neurosci, NEUR Res Grp, Brussels, Belgium
Fladby, T:
Akershus Univ Hosp, Dept Neurol, Lorenskog, Norway
van der Flier, WM:
Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Amsterdam Neurosci, Dept Neurol,Amsterdam UMC Locat VUmc, Amsterdam, Netherlands
Vrije Univ Amsterdam, Epidemiol & Data Sci, Amsterdam UMC locat VUmc, Amsterdam, Netherlands
Frisoni, GB:
Univ Hosp, Memory Clin, Geneva, Switzerland
Univ Geneva, Geneva, Switzerland
Fröhlich, L:
Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Geriatr Psychiat, Mannheim, Germany
Gill, KD:
Postgrad Inst Med Educ & Res, Dept Biochem, Chandigarh, India
Grimmer, T:
Tech Univ Munich, Sch Med & Hlth, Klinikum Rechts Isar, Dept Psychiat & Psychotherapy, Munich, Germany
Hort, J:
Charles Univ Prague, Fac Med 2, Dept Neurol, Prague, Czech Republic
Motol Univ Hosp, Prague, Czech Republic
Itoh, Y:
Osaka Metropolitan Univ, Grad Sch Med, Dept Neurol, Osaka, Japan
Iwatsubo, T:
Univ Tokyo, Grad Sch Med, Tokyo, Japan
Univ Tokyo, Fac Med, Tokyo, Japan
Klimkowicz-Mrowiec, A:
Jagiellonian Univ Med Coll, Fac Med, Dept Internal Med & Gerontol, Krakow, Poland
Landau, SM:
Univ Calif Berkeley, Helen Wills Neurosci Inst, Berkeley, CA USA
Lee, DY:
Seoul Natl Univ, Dept Psychiat, Coll Med, Seoul, South Korea
Lleó, A:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Hosp Santa Creu & Sant Pau, Dept Neurol, Memory Unit, Barcelona, Spain
Martinez-Lage, P:
CITA Alzheimer Fdn, Ctr Res & Adv Therapies, Donostia San Sebastian, Spain
de Mendonça, A:
Univ Lisbon, Fac Med, Lisbon, Portugal
Meyer, PT:
Univ Freiburg, Fac Med, Med Ctr, Dept Nucl Med, Freiburg, Germany
Parchi, P:
IRCCS, Ist Sci Neurol Bologna, Padigl G, Bologna, Italy
Univ Bologna, Dept Biomed & Neuromotor Sci DIBINEM, Bologna, Italy
Pardini, M:
Univ Genoa, DINOGMI, Genoa, Italy
Parnetti, L:
Univ Perugia, Ctr Disturbi Memoria, Lab Neurochim Clin, Clin Neurol, Perugia, Italy
Popp, J:
Univ Hosp Psychiat Zurich, Dept Geriatr Psychiat, Zurich, Switzerland
Univ Zurich, Zurich, Switzerland
Univ Hosp Lausanne, Dept Psychiat, Old Age Psychiat, Lausanne, Switzerland
Univ Lausanne, Lausanne, Switzerland
Rami, L:
Hosp Clin Barcelona, IDIBAPS, Neurol Serv, Alzheimers Dis & Other Cognit Disorders Unit, Barcelona, Spain
Reiman, EM:
Banner Alzheimers Inst, Phoenix, AZ USA
Rinne, JO:
Univ Turku, Turku PET Ctr, Turku, Finland
Rodrigue, KM:
Univ Texas Dallas, Ctr Vital Longev, Sch Behav & Brain Sci, Richardson, TX USA
Sánchez-Juan, P:
ISCIII, CIEN Fdn, Alzheimers Ctr Reina Sofia, Madrid, Spain
Santana, I:
Univ Coimbra, Fac Med, Coimbra, Portugal
Univ Coimbra, Ctr Neurosci & Cell Biol CIBB, Coimbra, Portugal
Ctr Hosp & Univ Coimbra, Neurol Dept, Coimbra, Portugal
Ctr Hosp & Univ Coimbra, Lab Neurochem, Coimbra, Portugal
Scarmeas, N:
Natl & Kapodistrian Univ Athens, Sch Med, Aiginit Hosp, Dept Neurol 1, Athens, Greece
Columbia Univ, Dept Neurol, New York, NY USA
Scheltens, P:
Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Amsterdam Neurosci, Dept Neurol,Amsterdam UMC Locat VUmc, Amsterdam, Netherlands
Skoog, I:
Univ Gothenburg, Neuropsychiat Epidemiol Unit, Dept Psychiat & Neurochem, Inst Neurosci & Physiol,Sahlgrenska Acad, Gothenburg, Sweden
Sperling, RA:
Harvard Med Sch, Brigham & Womens Hosp, Dept Neurol, Ctr Alzheimer Res & Treatment, Boston, MA USA
Harvard Med Sch, Harvard Aging Brain Study, Dept Neurol, Boston, MA USA
Stern, Y:
Dept Neurol, Cognit Neurosci Div, New York, NY USA
Columbia Univ, Taub Inst, New York, NY USA
Villeneuve, S:
Montreal Neurol Inst, McConnell Brain Imaging Ctr, Montreal, PQ, Canada
McGill Univ, Dept Psychiat, Fac Med, Montreal, PQ, Canada
Douglas Mental Hlth Univ Inst, Montreal, PQ, Canada
Waldemar, G:
Rigshosp, Copenhagen Univ Hosp, Dept Neurol, Danish Dementia Res Ctr, Copenhagen, Denmark
Univ Copenhagen, Dept Clin Med, Copenhagen, Denmark
Wiltfang, J:
Univ Med Ctr Gottingen, Dept Psychiat & Psychotherapy, Gottingen, Germany
Univ Tubingen, Dept Neurodegenerat, Ctr Neurol, Tubingen, Germany
Univ Tubingen, Hertie Inst Clin Brain Res, Tubingen, Germany
Zetterberg, H:
Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, Molndal, Sweden
Sahlgrens Univ Hosp, Clin Neurochem Lab, Molndal, Sweden
UCL, Dept Neurodegenerat Dis, Queen Sq Inst Neurol, London, England
UK Dementia Res Inst, London, England
Hong Kong Ctr Neurodegenerat Dis, Hong Kong, Peoples R China
Univ Wisconsin Madison, Univ Wisconsin Sch Med & Publ Hlth, Wisconsin Alzheimers Dis Res Ctr, Madison, WI USA
Alcolea, D:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Hosp Santa Creu & Sant Pau, Dept Neurol, Memory Unit, Barcelona, Spain
Allegri, RF:
Inst Neurol Fleni, Dept Cognit Neurol, Buenos Aires, DF, Argentina
Altomare, D:
Univ Brescia, Dept Clin & Expt Sci, Neurol Unit, Brescia, Italy
Bateman, RJ:
Washington Univ, Dept Neurol, Sch Med, St Louis, MO USA
Washington Univ, Alzheimers Dis Res Ctr, Sch Med, St Louis, MO USA
Baiardi, S:
Univ Bologna, Dept Biomed & Neuromotor Sci DIBINEM, Bologna, Italy
Baldeiras, I:
Univ Coimbra, Fac Med, Coimbra, Portugal
Univ Coimbra, Ctr Neurosci & Cell Biol CIBB, Coimbra, Portugal
Ctr Hosp & Univ Coimbra, Neurol Dept, Coimbra, Portugal
Ctr Hosp & Univ Coimbra, Lab Neurochem, Coimbra, Portugal
Blennow, K:
Sahlgrens Univ Hosp, Clin Neurochem Lab, Molndal, Sweden
den Braber, A:
Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Amsterdam Neurosci, Dept Neurol,Amsterdam UMC Locat VUmc, Amsterdam, Netherlands
van Buchem, MA:
Univ Med Ctr Leiden, Dept Radiol, Leiden, Netherlands
Byun, MS:
Seoul Natl Univ, Dept Psychiat, Coll Med, Seoul, South Korea
Cerman, J:
Charles Univ Prague, Fac Med 2, Dept Neurol, Prague, Czech Republic
Motol Univ Hosp, Prague, Czech Republic
Chen, KW:
Banner Alzheimers Inst, Phoenix, AZ USA
Chipi, E:
Univ Perugia, Ctr Disturbi Memoria, Lab Neurochim Clin, Clin Neurol, Perugia, Italy
Day, GS:
Mayo Clin Florida, Dept Neurol, Jacksonville, FL USA
Drzezga, A:
Univ Hosp Cologne, Dept Nucl Med, Cologne, Germany
Ekblad, LL:
Univ Turku, Turku PET Ctr, Turku, Finland
Turku Univ Hosp, Dept Geriatr, Wellbeing Serv Cty Southwestern Finland, Turku, Finland
Förster, S:
Tech Univ Munich, Dept Nucl Med, Klinikum Rechts Isar, Munich, Germany
Klinikum Bayreuth, Dept Nucl Med, Bayreuth, Germany
Fortea, J:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Hosp Santa Creu & Sant Pau, Dept Neurol, Memory Unit, Barcelona, Spain
Freund-Levi, Y:
Orebro Univ, Sch Med Sci, Orebro, Sweden
Karolinska Inst, Div Clin Geriatr, Dept Neurobiol Care Sci & Soc, Ctr Alzheimer Res, Stockholm, Sweden
Kings Coll London, Dept Old Age Psychiat Psychol & Neurosci, London, England
Frings, L:
Univ Freiburg, Fac Med, Med Ctr, Dept Nucl Med, Freiburg, Germany
Guedj, E:
Aix Marseille Univ, Ctr Europeen Rech Imagerie Med CERIMED, Timone Hosp, Nucl Med Dept,AP HM,CNRS,Cent Marseille,Inst Fres, Marseille, France
Habeck, CG:
Columbia Univ, Dept Neurol, Taub Inst Res Alzheimers Dis & Aging Brain, Irving Med Ctr, New York, NY USA
Handels, R:
Maastricht Univ, Mental Hlth & Neurosci Res Inst, Alzheimer Ctr Limburg, Dept Psychiat & Neuropsychol, Maastricht, Netherlands
Hausner, L:
Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Geriatr Psychiat, Mannheim, Germany
Hellwig, S:
Univ Freiburg, Dept Psychiat, Fac Med, Freiburg, Germany
Univ Freiburg, Psychotherapy Med Ctr, Fac Med, Freiburg, Germany
Jiménez-Bonilla, JF:
Marques de Valdecilla Univ Hosp, Dept Nucl Med, Santander, Spain
IDIVAL, Santander, Spain
Juaristi, AI:
CITA Alzheimer Fdn, Ctr Res & Adv Therapies, Donostia San Sebastian, Spain
Kandimalla, R:
Emory Univ, Dept Radiat Oncol, Atlanta, GA USA
Indian Inst Chem Technol, Appl Biol, Council Sci & Ind Res, Hyderabad, Telangana, India
Mahatma Gandhi Mem Hosp, Kakatiya Med Coll, Dept Biochem, Warangal, Telangana, India
Kern, S:
Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, Molndal, Sweden
Sahlgrens Univ Hosp, Dept Psychiat Cognit & Old Age Psychiat, Vastra Gotalandsregion, Sweden
Kirsebom, BESB:
Univ Hosp North Norway, Dept Neurol, Tromso, Norway
Arctic Univ Norway, Dept Psychol, Tromso, Norway
Kornhuber, J:
Friedrich Alexander Univ Erlangen Nuremberg, Univ Hosp, Dept Psychiat & Psychotherapy, Erlangen, Germany
Legdeur, N:
Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Amsterdam Neurosci, Dept Neurol,Amsterdam UMC Locat VUmc, Amsterdam, Netherlands
Levin, J:
Ludwig Maximilians Univ Munchen, LMU Univ Hosp, Dept Neurol, Munich, Germany
German Ctr Neurodegenerat Dis, Site Munich, Munich, Germany
Munich Cluster Syst Neurol SyNergy, Munich, Germany
Maier, W:
Univ Bonn, Dept Neurodegenerat Dis & Geriatr Psychiat, Bonn, Germany
Marquié, M:
Univ Int Catalunya, Ace Alzheimer Ctr Barcelona, Barcelona, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Minatani, S:
Osaka Metropolitan Univ, Grad Sch Med, Dept Neurol, Osaka, Japan
Morbelli, SD:
Univ Genoa, Dept Hlth Sci DISSAL, Genoa, Italy
IRCCS, Osped Policlin San Martino, Genoa, Italy
Mroczko, B:
Med Univ Bialystok, Dept Neurodegenerat Diagnost, Bialystok, Poland
Univ Hosp Bialystok, Dept Biochem Diagnost, Bialystok, Poland
Ntanasi, E:
Harokopio Univ, Dept Nutr & Diatet, Athens, Greece
de Oliveira, CR:
Univ Coimbra, Ctr Neurosci & Cell Biol CIBB, Coimbra, Portugal
Orellana, A:
Univ Int Catalunya, Ace Alzheimer Ctr Barcelona, Barcelona, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Peters, O:
Charite Univ Med Berlin CBF, Berlin, Germany
Prabhakar, S:
Postgrad Inst Med Educ & Res, Nehru Hosp, Dept Neurol, Chandigarh, India
Ramakers, IH:
Maastricht Univ, Mental Hlth & Neurosci Res Inst, Alzheimer Ctr Limburg, Dept Psychiat & Neuropsychol, Maastricht, Netherlands
Rodríguez-Rodriguez, E:
Hosp Univ Marques de Valdecilla, Neurol Dept, Santander, Spain
Univ Cantabria, IDIVAL, Santander, Spain
CIBERNED, Santander, Spain
Ruiz, A:
Univ Int Catalunya, Ace Alzheimer Ctr Barcelona, Barcelona, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Rüther, E:
Georg August Univ, Univ Med Ctr, Dept Psychiat & Psychotherapy, Gottingen, Germany
Sakhardande, J:
Dept Neurol, Cognit Neurosci Div, New York, NY USA
Columbia Univ, Taub Inst, New York, NY USA
Selnes, P:
Akershus Univ Hosp, Dept Neurol, Lorenskog, Norway
Silva, D:
Univ Lisbon, Fac Med, Lisbon, Portugal
Soininen, H:
Univ Eastern Finland, Inst Clin Med, Dept Neurol, Kuopio, Finland
Kuopio Univ Hosp, Dept Neurol, Neuroctr, Kuopio, Finland
Spiru, L:
Carol Davila Univ Med & Pharm, Geriatr, Gerontol, Old Age Psychiat,Gerosci,Gerontechnol, Bucharest, Romania
Ana Aslan Int Fdn, Excellence Ctr Memory Dis Brain Hlth & Longev Med, Bucharest, Romania
Takeda, A:
Osaka Metropolitan Univ, Grad Sch Med, Dept Neurol, Osaka, Japan
Teunissen, CE:
Vrije Univ Amsterdam, Neurochem Lab, Dept Lab Med, Amsterdam Neurosci,Amsterdam UMC Locat VUmc, Amsterdam, Netherlands
Tijms, BM:
Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Amsterdam Neurosci, Dept Neurol,Amsterdam UMC Locat VUmc, Amsterdam, Netherlands
Vermunt, L:
Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Amsterdam Neurosci, Dept Neurol,Amsterdam UMC Locat VUmc, Amsterdam, Netherlands
Wallin, ÅK:
Lund Univ, Dept Clin Sci, Cognit Disorder Res Unit, Malmo, Sweden
Wiels, W:
Vrije Univ Brussel, Fac Med & Pharm, Brussels, Belgium
Onze Lieve Vrouw Hosp, Dept Neurol, Aalst, Belgium
Yannakoulia, M:
Harokopio Univ, Dept Nutr & Diatet, Athens, Greece
Yi, D:
Seoul Natl Univ, Inst Human Behav Med, Med Res Ctr, Seoul, South Korea
Zettergren, A:
Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, Molndal, Sweden
Ossenkoppele, R:
Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Amsterdam Neurosci, Dept Neurol,Amsterdam UMC Locat VUmc, Amsterdam, Netherlands
Lund Univ, Dept Clin Sci, Cognit Disorder Res Unit, Malmo, Sweden
Verhey, FRJ:
Maastricht Univ, Mental Hlth & Neurosci Res Inst, Alzheimer Ctr Limburg, Dept Psychiat & Neuropsychol, Maastricht, Netherlands
Visser, PJ:
Maastricht Univ, Mental Hlth & Neurosci Res Inst, Alzheimer Ctr Limburg, Dept Psychiat & Neuropsychol, Maastricht, Netherlands
Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Amsterdam Neurosci, Dept Neurol,Amsterdam UMC Locat VUmc, Amsterdam, Netherlands
Karolinska Inst, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden
Jansen, WJ:
Maastricht Univ, Mental Hlth & Neurosci Res Inst, Alzheimer Ctr Limburg, Dept Psychiat & Neuropsychol, Maastricht, Netherlands
Banner Alzheimers Inst, Phoenix, AZ USA
Green Submitted, hybrid
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