Stage III NSCLC Treatment Patterns in Spain: A Population-Based Study of the GOECP-SEOR
Por:
Sosa-Fajardo, P, Martín-Martín, M, Luna-Tirado, J, Lopez-Guerra, JL, Gomis-Sellés, E, Lopez-Mata, M, Valtueña-Peydro, G, Santos-Rodríguez, M, Alvarez-González, AM, Potdevin-Stein, G, Martín-Barrientos, P, Kannemann, A, Farré-Bernado, N, González-Portillo, E, Manso-Lema, A, Rodríguez-Roldán, M, González-Ruiz, MA, Wals-Zurita, A, Linares-Mesa, NA, Garduño-Sánchez, S, Barrionuevo-Castillo, P, Moreno-Fuentes, B, Martos-Alcalde, M, Simon-Silva, P, Peña-Perea, MT, Blanco-Villar, ML, Vera-Barragán, V, Ocanto-Martínez, A, Mateos-Domínguez, M, Vallejo-Ocaña, C, Hernanz-Lucas, R, Castro-Gomez, JE, Peña-Huertas, M, Duque-Santana, V, Zapatero-Ortuño, J, García-Torres, C, Valencia-Nieto, P, Diezhandino-García, P, Eito-Valdovinos, C, Olarte-García, A, Guerrero-Gomez, LL, Sánchez-García, S, Bobo-Jaureguizar, A, Sotoca-Ruiz, A, Vázquez-Barreiro, B, Cameselle-Gallego, G, Flamarique-Andueza, S, Rico-Oses, M, Guijarro-Verdu, M, Montijano-Linde, M, Guzmán-Gomez, L, Bezares-Alarcon, AB, Cigarral-García, C, Moreno-Ceano, P, Serrano-Andreu, J, Murcia-Mejía, M, Pagola-Divasson, M, Casas-Duran, F, Almendros-Blanco, P, Pedraza-Fernández, S, González-Ferreira, JA, Alcántara, P, Couñago, F
Publicada:
27 nov 2025
Resumen:
Objective: We aimed to provide real-world insights into the management of non-small cell lung cancer stage III (NSCLC-SIII) in Spain. Methods: The GOECP-SEOR group conducted an observational, retrospective, multicenter study in which data from patients diagnosed with NSCLC-SIII treated in Spanish radiotherapy departments (RTDs) were collected. Results: A total of 1505 NSCLC-SIII patients from 35 RTDs from 2018 to 2021 were recruited. A total of 871 patients (57.9%) received concurrent chemoradiotherapy (cCRT), and 390 patients (25.91%) received maintenance durvalumab. The immunotherapy (IT) was well tolerated, with Common Terminology Criteria for Adverse Events (CTCAE) Grade 0-2 toxicity observed in 85% of the patients (295 patients). The median overall survival (OS) was 26 months (95% CI 9.4-Not Reached NR). There was a statistically significant difference when patients were stratified by IT, with a median OS of 40 months (95% CI 22.1-NR) in the IT maintenance cohort compared with 19.4 months (95% CI 7.1-58.1) in the non-IT cohort. Differences were also noted in progression-free survival (PFS), with a median PFS of 20.8 months (95% CI 9.6-NR) in the IT cohort versus 8.4 months (95% CI 3.1-25.1) in the non-IT cohort. These differences remained significant according to the multivariate model (OS: HR 0.45 [95% CI 0.36-0.56], p < 0.001; PFS: HR 0.5 [95% CI 0.42-0.59], p < 0.001). Conclusions: The management of NSCLC-SIII patients can vary, leading to differences in treatment outcomes. The treatment of lung cancer in NSCLC-SIII patients in RTDs across Spain aligns with international guidelines and expert recommendations.
Filiaciones:
Sosa-Fajardo, P:
Hosp Univ Virgen Rocio, Serv Oncol Radioterap, Seville, Spain
Martín-Martín, M:
Hosp Univ Ramon & Cajal, Serv Oncol Radioterap, Madrid, Spain
Luna-Tirado, J:
Fdn Jimenez Diaz, Serv Oncol Radioterap, E-28040 Madrid, Spain
Lopez-Guerra, JL:
Hosp Univ Virgen Rocio, Serv Oncol Radioterap, Seville, Spain
Gomis-Sellés, E:
Hosp Univ Virgen Rocio, Serv Oncol Radioterap, Seville, Spain
Lopez-Mata, M:
Hosp Clin Univ Lozano Blesa, Serv Gastroenterol, Zaragoza 50009, Spain
Valtueña-Peydro, G:
Hosp Clin Univ Lozano Blesa, Serv Gastroenterol, Zaragoza 50009, Spain
Santos-Rodríguez, M:
Hosp Gen Univ Gregorio Maranon, Serv Oncol Radioterap, Madrid, Spain
Alvarez-González, AM:
Hosp Gen Univ Gregorio Maranon, Serv Oncol Radioterap, Madrid, Spain
Potdevin-Stein, G:
Hosp Univ Gran Canaria Doctor Negrin, Serv Oncol Radioterap, Las Palmas Gran Canaria, Spain
Fdn Valle Lili, Unidad Radiol, Cali 760031, Colombia
Martín-Barrientos, P:
Hosp Univ Gran Canaria Doctor Negrin, Serv Oncol Radioterap, Las Palmas Gran Canaria, Spain
Kannemann, A:
Hosp Univ Gran Canaria Doctor Negrin, Serv Oncol Radioterap, Las Palmas Gran Canaria, Spain
Farré-Bernado, N:
Hosp Santa Creu I St Pau, Serv Epidemiol, Barcelona 08025, Spain
González-Portillo, E:
Hosp Univ La Paz, Serv Oncol Radioterap, Madrid, Spain
Manso-Lema, A:
Hosp Univ La Paz, Serv Oncol Radioterap, Madrid, Spain
Rodríguez-Roldán, M:
Hosp Univ La Paz, Serv Oncol Radioterap, Madrid, Spain
González-Ruiz, MA:
Hosp Univ Virgen Macarena, Serv Oncol Radioterap, Seville, Spain
Wals-Zurita, A:
Hosp Univ Virgen Macarena, Serv Oncol Radioterap, Seville, Spain
Linares-Mesa, NA:
Hosp Univ Juan Ramon Jimenez, Serv Traumatol & Cirugia Ortoped, Huelva, Spain
Garduño-Sánchez, S:
Hosp Univ Juan Ramon Jimenez, Serv Traumatol & Cirugia Ortoped, Huelva, Spain
Barrionuevo-Castillo, P:
Complejo Hosp Jaen, Serv Dermatol, Jaen 23007, Spain
Moreno-Fuentes, B:
Complejo Hosp Jaen, Serv Dermatol, Jaen 23007, Spain
Martos-Alcalde, M:
Complejo Hosp Jaen, Serv Dermatol, Jaen 23007, Spain
Simon-Silva, P:
Hosp Univ Torrecardenas, Serv Pediat, Almeria, Spain
Peña-Perea, MT:
Hosp Univ Torrecardenas, Serv Pediat, Almeria, Spain
Blanco-Villar, ML:
Hosp Univ Torrecardenas, Serv Pediat, Almeria, Spain
Vera-Barragán, V:
Complejo Hosp Univ Badajoz, Serv Oncol Radioterap, Badajoz, Spain
Ocanto-Martínez, A:
Hosp Univ Torrejon, Serv Neumol, Madrid, Spain
Mateos-Domínguez, M:
Hosp Univ Torrejon, Serv Neumol, Madrid, Spain
Vallejo-Ocaña, C:
Hosp Univ Ramon & Cajal, Serv Oncol Radioterap, Madrid, Spain
Hernanz-Lucas, R:
Hosp Univ Ramon & Cajal, Serv Oncol Radioterap, Madrid, Spain
Castro-Gomez, JE:
Complejo Hospitalario Univ Ourense, Orense 32005, Spain
Peña-Huertas, M:
Hosp Quironsalud Madrid, Serv Oncol Radioterap, Madrid, Spain
Univ Europea Madrid, Dept Especialidades Med & Psicol, Fac Ciencias Biomed, C Tajo Sn, Madrid 28670, Spain
Duque-Santana, V:
Hosp Quironsalud Madrid, Serv Oncol Radioterap, Madrid, Spain
Univ Europea Madrid, Dept Especialidades Med & Psicol, Fac Ciencias Biomed, C Tajo Sn, Madrid 28670, Spain
Zapatero-Ortuño, J:
Hosp Univ Rey Juan Carlos, Dept Gynecol, Mostoles, Madrid, Spain
García-Torres, C:
Hosp Univ Rey Juan Carlos, Dept Gynecol, Mostoles, Madrid, Spain
Valencia-Nieto, P:
Hosp Clin Univ Valladolid, Serv Neurol, Valladolid 47003, Spain
Diezhandino-García, P:
Hosp Clin Univ Valladolid, Serv Neurol, Valladolid 47003, Spain
Eito-Valdovinos, C:
Clin IMQ Zorrotzaurre, Serv Anestesiol & Reanimac, Bilbao, Spain
Olarte-García, A:
Clin IMQ Zorrotzaurre, Serv Anestesiol & Reanimac, Bilbao, Spain
Guerrero-Gomez, LL:
Hosp La Princesa, Serv Oncol Radioterap, Madrid, Spain
Sánchez-García, S:
Hosp La Princesa, Serv Oncol Radioterap, Madrid, Spain
Bobo-Jaureguizar, A:
Hosp Ruber Int, Serv Oncol Radioterap, Madrid, Spain
Sotoca-Ruiz, A:
Hosp Ruber Int, Serv Oncol Radioterap, Madrid, Spain
Vázquez-Barreiro, B:
Hosp Meixoeiro, Serv Oncol Radioterap, Vigo, Spain
Cameselle-Gallego, G:
Hosp Meixoeiro, Serv Oncol Radioterap, Vigo, Spain
Flamarique-Andueza, S:
Hosp Univ Navarra, Serv Oncol Radioterap, Pamplona, Spain
Rico-Oses, M:
Hosp Univ Navarra, Serv Oncol Radioterap, Pamplona, Spain
Guijarro-Verdu, M:
Hosp Univ San Francisco Asis, Serv Oncol Radioterap, GenesisCare Madrid, Madrid, Spain
Montijano-Linde, M:
Hosp Univ San Francisco Asis, Serv Oncol Radioterap, GenesisCare Madrid, Madrid, Spain
Guzmán-Gomez, L:
Fdn Jimenez Diaz, Serv Oncol Radioterap, E-28040 Madrid, Spain
Bezares-Alarcon, AB:
GenesisCare Campo Gibraltar, Serv Oncol Radioterap, Cadiz, Spain
Cigarral-García, C:
Hosp Clin Univ Salamanca, Serv Oncol Radioterap, Salamanca, Spain
Moreno-Ceano, P:
Hosp Univ Reg Malaga, Malaga 29010, Spain
Serrano-Andreu, J:
Clin Univ Navarra, Obstet & Gynecol, Madrid 28027, Spain
Murcia-Mejía, M:
Hosp St Joan de Reus, Oncol Dept, Tarragona 43204, Spain
Pagola-Divasson, M:
Hosp Univ Cruces, Serv Oncol Radioterap, Baracaldo, Bizkaia, Spain
Casas-Duran, F:
Hosp Clin Barcelona, Serv Oncol Radioterap, E-08036 Barcelona, Spain
Almendros-Blanco, P:
Hosp Gen Univ Valencia, Serv Neurocirugia, E-46014 Valencia, Spain
Pedraza-Fernández, S:
Hosp 12 Octubre, Serv Oncol Radioterap, Madrid, Spain
González-Ferreira, JA:
GenesisCare Sevilla, Serv Oncol Radioterap, Seville, Spain
Alcántara, P:
Hosp Clin San Carlos, Serv Cardiol, Madrid 28040, Spain
Couñago, F:
Hosp Univ San Francisco Asis, GenesisCare Madrid, Serv Oncol Radioterap, Madrid, Spain
Green Submitted, gold
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