Long-Term Biochemical and Cardiovascular Profiles 3-6 Years After Preeclampsia: Impact of Angiogenic Imbalance During Pregnancy
Por:
Costa, N, Platero, J, Garcia-Manau, P, Sanchez-Garcia, O, Pellicer, C, Jordi, M, Garcia, Z, Garrido-Gimenez, C, Ullmo, J, Nan, M, Mora, J, Garcia-Osuna, A, Choliz, M, Cruz-Lemini, M, Medina, MD, Llurba, E
Publicada:
26 nov 2025
Resumen:
Background/Objectives: Preeclampsia is associated with long-term cardiovascular and metabolic risks. This study aimed to evaluate metabolic and cardiovascular biochemical profiles in women with a history of preeclampsia and angiogenic imbalance during pregnancy. Methods: We conducted a cross-sectional study at Hospital de la Santa Creu i Sant Pau between August 2023 and July 2025. Participants had been prospectively enrolled during pregnancy (2018-2022) and were re-evaluated 3 to 6 years later. Blood and urine samples were collected after a 12-h fast to assess hematological, metabolic, and cardiovascular markers. Angiogenic profiles were determined using sFlt-1/PlGF ratios obtained during pregnancy. Multivariable linear regression models were used to assess associations with a history of PE and angiogenic imbalance, adjusting for relevant confounders. Results: 363 participants were included. 113 (31.1%) had a history of preeclampsia. Women with previous preeclampsia showed slightly higher high-sensitivity troponin T concentrations [4.0 (3.0-6.0) ng/L vs. 3.2 (3.0-5.0) ng/L, p = 0.03]. Women with sFlt-1/PlGF >= 38 exhibited significantly higher urinary protein [0.09 (0.07-0.18) g/L vs. 0.08 (0.07-0.13) g/L, p = 0.01], potassium [4.25 (4.07-4.40) mmol/L vs. 4.19 (4.02-4.37) mmol/L, p = 0.048], and LDH concentrations [168 (150-189) U/L vs. 163 (149-177) U/L, p = 0.046], and lower leukocyte counts [6150 (5348-7055) vs. 6250 (5430-7450) U/mL, p = 0.03]. Conclusions: Women with angiogenic imbalance during pregnancy display subtle alterations in renal and endothelial function markers years after delivery, whereas those with preeclampsia show slightly higher troponin concentrations. These findings, though clinically irrelevant, suggest that pregnancy-related vascular dysfunction may have different long-term manifestations depending on whether the maternal cardiovascular system was sufficiently compromised to develop overt preeclampsia.
Filiaciones:
Costa, N:
Inst Recerca St Pau IR ST PAU, St Quinti 77-79, Barcelona 08041, Spain
Inst Salud Carlos III, Spanish Network Maternal Neonatal Child & Dev Hlth, Primary Care Intervent Prevent Maternal & Child Ch, Madrid 28029, Spain
Platero, J:
Inst Recerca St Pau IR ST PAU, St Quinti 77-79, Barcelona 08041, Spain
Univ Autonoma Barcelona, Dept Pediat Obstet & Ginecol & Med Prevent & Salut, Bellaterra 08193, Spain
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Dept Obstet & Gynecol, Maternal Fetal Med Unit, St Antoni Maria Claret 167, Barcelona 08025, Spain
Garcia-Manau, P:
Inst Recerca St Pau IR ST PAU, St Quinti 77-79, Barcelona 08041, Spain
Univ Autonoma Barcelona, Dept Pediat Obstet & Ginecol & Med Prevent & Salut, Bellaterra 08193, Spain
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Dept Obstet & Gynecol, Maternal Fetal Med Unit, St Antoni Maria Claret 167, Barcelona 08025, Spain
Inst Salud Carlos III, Primary Care Intervent Prevent Maternal & Child Ch, Madrid 28029, Spain
Sanchez-Garcia, O:
Inst Recerca St Pau IR ST PAU, St Quinti 77-79, Barcelona 08041, Spain
Inst Salud Carlos III, Spanish Network Maternal Neonatal Child & Dev Hlth, Primary Care Intervent Prevent Maternal & Child Ch, Madrid 28029, Spain
Pellicer, C:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Dept Obstet & Gynecol, Maternal Fetal Med Unit, St Antoni Maria Claret 167, Barcelona 08025, Spain
Jordi, M:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Dept Obstet & Gynecol, Maternal Fetal Med Unit, St Antoni Maria Claret 167, Barcelona 08025, Spain
Garcia, Z:
Inst Recerca St Pau IR ST PAU, St Quinti 77-79, Barcelona 08041, Spain
Inst Salud Carlos III, Spanish Network Maternal Neonatal Child & Dev Hlth, Primary Care Intervent Prevent Maternal & Child Ch, Madrid 28029, Spain
Garrido-Gimenez, C:
Inst Recerca St Pau IR ST PAU, St Quinti 77-79, Barcelona 08041, Spain
Inst Salud Carlos III, Spanish Network Maternal Neonatal Child & Dev Hlth, Primary Care Intervent Prevent Maternal & Child Ch, Madrid 28029, Spain
Univ Autonoma Barcelona, Dept Pediat Obstet & Ginecol & Med Prevent & Salut, Bellaterra 08193, Spain
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Dept Obstet & Gynecol, Maternal Fetal Med Unit, St Antoni Maria Claret 167, Barcelona 08025, Spain
Ullmo, J:
Inst Recerca St Pau IR ST PAU, St Quinti 77-79, Barcelona 08041, Spain
Univ Autonoma Barcelona, Dept Pediat Obstet & Ginecol & Med Prevent & Salut, Bellaterra 08193, Spain
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Dept Obstet & Gynecol, Maternal Fetal Med Unit, St Antoni Maria Claret 167, Barcelona 08025, Spain
Nan, M:
Hosp Santa Creu & Sant Pau, Inst Invest Biomed St Pau IIB St Pau, Dept Clin Biochem, Barcelona 08041, Spain
Univ Autonoma Barcelona, Dept Biochem & Mol Biol, Fac Biociencies, Barcelona 08193, Spain
Mora, J:
Inst Salud Carlos III, Spanish Network Maternal Neonatal Child & Dev Hlth, Primary Care Intervent Prevent Maternal & Child Ch, Madrid 28029, Spain
Hosp Santa Creu & Sant Pau, Inst Invest Biomed St Pau IIB St Pau, Dept Clin Biochem, Barcelona 08041, Spain
Univ Autonoma Barcelona, Dept Biochem & Mol Biol, Fac Biociencies, Barcelona 08193, Spain
Garcia-Osuna, A:
Hosp Santa Creu & Sant Pau, Inst Invest Biomed St Pau IIB St Pau, Dept Clin Biochem, Barcelona 08041, Spain
Univ Autonoma Barcelona, Dept Biochem & Mol Biol, Fac Biociencies, Barcelona 08193, Spain
Choliz, M:
Univ Autonoma Barcelona, Dept Pediat Obstet & Ginecol & Med Prevent & Salut, Bellaterra 08193, Spain
Cruz-Lemini, M:
Inst Recerca St Pau IR ST PAU, St Quinti 77-79, Barcelona 08041, Spain
Inst Salud Carlos III, Spanish Network Maternal Neonatal Child & Dev Hlth, Primary Care Intervent Prevent Maternal & Child Ch, Madrid 28029, Spain
Univ Autonoma Barcelona, Dept Pediat Obstet & Ginecol & Med Prevent & Salut, Bellaterra 08193, Spain
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Dept Obstet & Gynecol, Maternal Fetal Med Unit, St Antoni Maria Claret 167, Barcelona 08025, Spain
Medina, MD:
Inst Recerca St Pau IR ST PAU, St Quinti 77-79, Barcelona 08041, Spain
Inst Salud Carlos III, Spanish Network Maternal Neonatal Child & Dev Hlth, Primary Care Intervent Prevent Maternal & Child Ch, Madrid 28029, Spain
Univ Autonoma Barcelona, Dept Pediat Obstet & Ginecol & Med Prevent & Salut, Bellaterra 08193, Spain
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Dept Obstet & Gynecol, Maternal Fetal Med Unit, St Antoni Maria Claret 167, Barcelona 08025, Spain
Llurba, E:
Inst Recerca St Pau IR ST PAU, St Quinti 77-79, Barcelona 08041, Spain
Inst Salud Carlos III, Spanish Network Maternal Neonatal Child & Dev Hlth, Primary Care Intervent Prevent Maternal & Child Ch, Madrid 28029, Spain
Univ Autonoma Barcelona, Dept Pediat Obstet & Ginecol & Med Prevent & Salut, Bellaterra 08193, Spain
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Dept Obstet & Gynecol, Maternal Fetal Med Unit, St Antoni Maria Claret 167, Barcelona 08025, Spain
Green Submitted, gold
|