Cryopreserved Total Skin Allografts From Living Donors for Complex Wound Management: A New Paradigm in Regenerative Wound Care
Por:
Fonseca, M, Cañete, A, Mandriaza, L, Gomez, J, Masiá, J, Marcelain, K, Ibaceta, D, Erazo, C, Gámez, B, Rius, M, Disi, F
Publicada:
1 sep 2025
Resumen:
Skin allografts are essential in managing complex wounds, yet their availability is limited by low post-mortem donation rates. Skin harvested during body contouring surgeries offers a novel and sustainable source to expand tissue supply. We conducted a retrospective descriptive study at the Tarapac & aacute; Skin and Tissue Bank from January 2022 to December 2024. All donations from body contouring surgeries were processed as cryopreserved total skin allografts following national tissue banking standards. Variables included donor demographics, harvested area, units produced, microbiological results, and discard rates. To describe clinical performance, we present our group's initial clinical series of treated patients. From 248 living donors (mean age 41.3 years), 81 293 cm2 of skin generated 2050 units. The discard rate was 27%, mainly due to a storage failure and isolated microbial contamination. Clinically, all patients achieved complete initial graft take, followed by gradual necrotic eschar formation at an average of 21 days. Eschar removal revealed vital tissue firmly adhered to the recipient bed, rich in fibroblasts and neovascular structures. Subsequent management included either escharectomy with split-thickness autografting over the neodermis, or spontaneous eschar lysis and skin regeneration, with the graft functioning as a dermal regenerator. This model increases tissue availability while providing allografts with both coverage and dermal regenerative properties.
Filiaciones:
Fonseca, M:
Univ Autonoma Barcelona, Barcelona, Spain
Tarapaca Skin & Tissue Bank, Iquique, Chile
Cañete, A:
Tarapaca Skin & Tissue Bank, Iquique, Chile
Dr Ernesto Torres Galdames Hosp, Organ & Tissue Procurement & Transplantat Unit, Iquique, Chile
Mandriaza, L:
Tarapaca Skin & Tissue Bank, Iquique, Chile
Gomez, J:
Tarapaca Skin & Tissue Bank, Iquique, Chile
Dr Ernesto Torres Galdames Hosp, Organ & Tissue Procurement & Transplantat Unit, Iquique, Chile
Masiá, J:
Univ Autonoma Barcelona, Barcelona, Spain
Hosp Santa Creu & Sant Pau, Hosp del Mar, Dept Plast Surg, Barcelona, Spain
Marcelain, K:
Univ Chile, Fac Med, Dept Basic Clin Oncol, Santiago, Chile
Ibaceta, D:
Tarapaca Skin & Tissue Bank, Iquique, Chile
Erazo, C:
Univ Desarrollo, Fac Med Clin Alemana, Santiago, Chile
Univ Chile, Clin Hosp, Santiago, Chile
Gámez, B:
Univ Chile, Clin Hosp, Santiago, Chile
Rius, M:
Univ Desarrollo, Fac Med Clin Alemana, Santiago, Chile
Disi, F:
Dr Ernesto Torres Galdames Hosp, Dept Pathol, Iquique, Chile
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