Role of aspirin therapy in modulating uterine artery resistance and placental growth between first and second trimesters of pregnancy
Por:
Trilla, C, Platero, J, Mora, J, Nan, MN, Medina, C, Alejos, O, Parra, J, Llurba, E
Publicada:
1 nov 2025
Ahead of Print:
1 sep 2025
Resumen:
Objective To evaluate the impact of low-dose aspirin (LDA) on placental size and uterine artery pulsatility index (UtA-PI) by analyzing longitudinal changes between the first and second trimesters in pregnancies at high risk for early-onset pre-eclampsia (PE).Methods This was a prospective observational cohort study of 631 singleton pregnancies. Women at high risk of early-onset PE (delivery <= 33 + 6 weeks) were identified using maternal factors or a multivariate screening protocol and were prescribed LDA. Placental size was assessed using two- and three-dimensional ultrasonography, and UtA-PI was measured using transabdominal Doppler, with measurements obtained in the first and second trimesters. Differences in placental measurements and UtA-PI between high-risk women receiving LDA and low-risk untreated women were analyzed.Results Among the 631 participants, 53 (8.4%) women were prescribed LDA for the prevention of early-onset PE. Placental size in the first trimester was significantly smaller in the LDA group compared with the untreated group, as exemplified by placental volume (mean +/- SD, 68.46 +/- 25.19 cm3 vs 76.31 +/- 23.63 cm3; P = 0.022), and this trend persisted into the second trimester. However, no significant differences in placental growth from the first to the second trimester were observed between the groups. UtA-PI was significantly higher in the LDA group in both trimesters, but a greater decrease in UtA-PI multiples of the median values between trimesters was noted in these women (mean +/- SD, -14.0 +/- 0.28% vs -4.5 +/- 0.31%; P = 0.021). Perinatal outcomes were similar between the groups, with the exception of a higher rate of Cesarean delivery in the LDA group (38.5% vs 21.1%; P = 0.008).Conclusions Women at high risk for early-onset PE have a smaller placenta and higher UtA-PI in the first and second trimesters. Treatment of high-risk women with LDA did not affect placental growth but was associated with a greater reduction in UtA-PI, suggesting a positive effect of LDA on placental perfusion. These findings provide insight into the mechanism of action of LDA in the prevention of PE. (c) 2025 The Author(s). Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.
Filiaciones:
Trilla, C:
Hosp Santa Creu i St Pau, Inst Invest Biomed St Pau IIB St Pau, Dept Obstet & Gynecol, Barcelona, Spain
Univ Autonoma Barcelona, Fac Med, Barcelona, Spain
Inst Salud Carlos III, Primary Care Intervent Prevent Maternal & Child Ch, Madrid, Spain
Platero, J:
Hosp Santa Creu i St Pau, Inst Invest Biomed St Pau IIB St Pau, Dept Obstet & Gynecol, Barcelona, Spain
Mora, J:
Univ Autonoma Barcelona, Fac Med, Barcelona, Spain
Hosp Santa Creu i St Pau, Dept Biochem, Barcelona, Spain
Nan, MN:
Hosp Santa Creu i St Pau, Dept Biochem, Barcelona, Spain
Medina, C:
Hosp Santa Creu i St Pau, Inst Invest Biomed St Pau IIB St Pau, Dept Obstet & Gynecol, Barcelona, Spain
Univ Autonoma Barcelona, Fac Med, Barcelona, Spain
Inst Salud Carlos III, Primary Care Intervent Prevent Maternal & Child Ch, Madrid, Spain
Alejos, O:
Hosp Santa Creu i St Pau, Inst Invest Biomed St Pau IIB St Pau, Dept Obstet & Gynecol, Barcelona, Spain
Univ Autonoma Barcelona, Fac Med, Barcelona, Spain
Parra, J:
Hosp Santa Creu i St Pau, Inst Invest Biomed St Pau IIB St Pau, Dept Obstet & Gynecol, Barcelona, Spain
Univ Autonoma Barcelona, Fac Med, Barcelona, Spain
Llurba, E:
Hosp Santa Creu i St Pau, Inst Invest Biomed St Pau IIB St Pau, Dept Obstet & Gynecol, Barcelona, Spain
Univ Autonoma Barcelona, Fac Med, Barcelona, Spain
Inst Salud Carlos III, Primary Care Intervent Prevent Maternal & Child Ch, Madrid, Spain
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