The discriminative linguistic profiles of progressive supranuclear palsy and Parkinson's disease
Por:
Busteed, L, Horta-Barba, A, Reig, A, García-Sánchez, C, Pascual-Sedano, B, Gich, I, Ciffone, PR, Kulisevsky, J, Pagonabarraga, J
Publicada:
1 nov 2025
Ahead of Print:
1 nov 2025
Resumen:
Introduction: Speech and language disturbances are very frequent in progressive supranuclear palsy (PSP). Therefore, they are part of the diagnostic criteria set forth by the International Parkinson and Movement Disorder Society (MDS) for the disease and are considered a core clinical feature. However, more studies are needed to characterize the linguistic profile of PSP, thus being able to assist in the differential diagnosis. Additionally, studies assessing linguistic differences among PSP phenotypes are needed. The objective of this study is to analyze the language alterations presented by patients with PSP, as well as its different phenotypes, and differentiate them from those presented in patients with Parkinson's disease (PD). Methods: An extensive cognitive and linguistic assessment was administered to 13 PSP patients, 19 PD patients and 19 healthy controls (HC) with similar sociodemographic features. Language assessment included evaluation of: syntactic processing, object naming, and phonetic and semantic fluencies. We included a subgroup of 6 PSP patients, 19 PD patients and 19 HC for further analysis of language. This analysis included, in addition to the general evaluation, the assessment of alternating fluency, comprehension, naming, automatic speech, repetition, object recognition, verbal and written instructions, writing to dictation, and oral expression. Results: We found greater impairment on phonetic, semantic, and alternating fluencies, following verbal instructions, repetition, syntactic processing and writing (without phonetic paragraphia) in the PSP group compared to patients with PD and HC. Distinguishing linguistic features of PSP with a less marked reduction than the previously mentioned features were automatic speech, fluency of speech, and naming. Language analysis did not distinguish between PSP phenotypes. Conclusions: Language disturbances distinguish PSP from PD and HC but were not able to discriminate PSP phenotypes. (c) 2024 Sociedad Espanola de Neurolog & imath;a. Published by Elsevier Espana, S.L.U. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/ 4.0/).
Filiaciones:
Busteed, L:
Autonomous Univ Barcelona, Dept Med, Barcelona, Spain
Santa Creu i St Pau Hosp, Neurol Dept, Movement Disorders Unit, Barcelona, Spain
St Pau Biomed Res Inst IIB St Pau, Barcelona, Spain
Santa Creu i St Pau Hosp, Neuropsychol Unit, Barcelona, Spain
Horta-Barba, A:
Autonomous Univ Barcelona, Dept Med, Barcelona, Spain
Santa Creu i St Pau Hosp, Neurol Dept, Movement Disorders Unit, Barcelona, Spain
St Pau Biomed Res Inst IIB St Pau, Barcelona, Spain
Inst Salud Carlos III, Ctr Networked Biomed Res Neurodegenerat Dis CIBERN, Madrid, Spain
Univ Oberta Catalunya, Fac Hlth Sci, Barcelona, Spain
Reig, A:
Autonomous Univ Barcelona, Dept Med, Barcelona, Spain
García-Sánchez, C:
Autonomous Univ Barcelona, Dept Med, Barcelona, Spain
Santa Creu i St Pau Hosp, Neurol Dept, Movement Disorders Unit, Barcelona, Spain
St Pau Biomed Res Inst IIB St Pau, Barcelona, Spain
Santa Creu i St Pau Hosp, Neuropsychol Unit, Barcelona, Spain
Inst Salud Carlos III, Ctr Networked Biomed Res Neurodegenerat Dis CIBERN, Madrid, Spain
Pascual-Sedano, B:
Autonomous Univ Barcelona, Dept Med, Barcelona, Spain
Santa Creu i St Pau Hosp, Neurol Dept, Movement Disorders Unit, Barcelona, Spain
St Pau Biomed Res Inst IIB St Pau, Barcelona, Spain
Inst Salud Carlos III, Ctr Networked Biomed Res Neurodegenerat Dis CIBERN, Madrid, Spain
Univ Oberta Catalunya, Fac Hlth Sci, Barcelona, Spain
Gich, I:
Autonomous Univ Barcelona, Dept Med, Barcelona, Spain
St Pau Biomed Res Inst IIB St Pau, Barcelona, Spain
CIBER Epidemiol & Salud Publ, Madrid, Spain
Ciffone, PR:
Autonomous Univ Barcelona, Dept Med, Barcelona, Spain
Santa Creu i St Pau Hosp, Neuropsychol Unit, Barcelona, Spain
Kulisevsky, J:
Autonomous Univ Barcelona, Dept Med, Barcelona, Spain
Santa Creu i St Pau Hosp, Neurol Dept, Movement Disorders Unit, Barcelona, Spain
St Pau Biomed Res Inst IIB St Pau, Barcelona, Spain
Inst Salud Carlos III, Ctr Networked Biomed Res Neurodegenerat Dis CIBERN, Madrid, Spain
Univ Oberta Catalunya, Fac Hlth Sci, Barcelona, Spain
Pagonabarraga, J:
Autonomous Univ Barcelona, Dept Med, Barcelona, Spain
Santa Creu i St Pau Hosp, Neurol Dept, Movement Disorders Unit, Barcelona, Spain
St Pau Biomed Res Inst IIB St Pau, Barcelona, Spain
Inst Salud Carlos III, Ctr Networked Biomed Res Neurodegenerat Dis CIBERN, Madrid, Spain
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