Study of brain perfusion in adults with Down syndrome along the Alzheimer's disease continuum
Por:
Franquesa-Mullerat, M, Morcillo-Nieto, AO, Arriola-Infante, JE, Zsadanyi, SE, Vaqué-Alcázar, L, Rozalem-Aranha, M, Arranz, J, Rodríguez-Baz, I, Maure-Blesa, L, Videla, L, Barroeta, I, Soriano, LD, Benejam, B, Fernández, S, Hernandez, AS, Giménez, S, Alcolea, D, Belbin, O, Lleó, A, Carmona-Iragui, M, Fortea, J, Bejanin, A
Publicada:
1 sep 2025
Resumen:
INTRODUCTION We assessed pseudo-continuous arterial spin labeling (pCASL) sensitivity to detect changes in cerebral blood flow (CBF) in adults with Down syndrome (DS) along the Alzheimer's disease (AD) continuum and explored the similarity with sporadic AD (sAD) hypoperfusion profile. METHODS Fifty-one euploid cognitively unimpaired individuals, 54 adults with DS (34.54% symptomatic for AD), and 25 sAD patients underwent 3T magnetic resonance imaging. pCASL images were preprocessed using ASLprep. Analyses explored, globally and regionally, the effects of demographic variables, clinical stages, and AD biomarkers. RESULTS Age and sex differently impacted CBF in euploids versus the DS population. Asymptomatic DS showed temporo-parietal hypoperfusion, extending into frontal areas in symptomatic cases. This pattern closely resembled sAD's pattern and correlated with AD biomarkers. DISCUSSION Adults with DS present CBF changes before symptom onset, primarily affecting posterior regions as in sAD. pCASL is a sensitive imaging modality that captures early AD-related functional abnormalities in DS.
Filiaciones:
Franquesa-Mullerat, M:
Hosp Santa Creu & Sant Pau, IR SANT PAU, St Pau Memory Unit, St Quinti 77-79, Barcelona 08041, Spain
Univ Autonoma Barcelona UAB, Inst Neurociencies, Bellaterra, Spain
Morcillo-Nieto, AO:
Hosp Santa Creu & Sant Pau, IR SANT PAU, St Pau Memory Unit, St Quinti 77-79, Barcelona 08041, Spain
Univ Autonoma Barcelona UAB, Inst Neurociencies, Bellaterra, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Madrid, Spain
Arriola-Infante, JE:
Hosp Santa Creu & Sant Pau, IR SANT PAU, St Pau Memory Unit, St Quinti 77-79, Barcelona 08041, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Madrid, Spain
Zsadanyi, SE:
Hosp Santa Creu & Sant Pau, IR SANT PAU, St Pau Memory Unit, St Quinti 77-79, Barcelona 08041, Spain
Univ Autonoma Barcelona UAB, Inst Neurociencies, Bellaterra, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Madrid, Spain
Vaqué-Alcázar, L:
Hosp Santa Creu & Sant Pau, IR SANT PAU, St Pau Memory Unit, St Quinti 77-79, Barcelona 08041, Spain
Univ Barcelona, Inst Neurosci, Fac Med & Hlth Sci, Dept Med, Barcelona, Spain
Inst Invest Biomed August Pi i Sunyer IDIBAPS, Dept Psychobiol, Barcelona, Spain
Rozalem-Aranha, M:
Hosp Santa Creu & Sant Pau, IR SANT PAU, St Pau Memory Unit, St Quinti 77-79, Barcelona 08041, Spain
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Fac Med, Dept Radiol,6Neuroradiol Sect, Barcelona, Spain
Arranz, J:
Hosp Santa Creu & Sant Pau, IR SANT PAU, St Pau Memory Unit, St Quinti 77-79, Barcelona 08041, Spain
Univ Autonoma Barcelona UAB, Dept Med, Bellaterra, Spain
Rodríguez-Baz, I:
Hosp Santa Creu & Sant Pau, IR SANT PAU, St Pau Memory Unit, St Quinti 77-79, Barcelona 08041, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Madrid, Spain
Maure-Blesa, L:
Hosp Santa Creu & Sant Pau, IR SANT PAU, St Pau Memory Unit, St Quinti 77-79, Barcelona 08041, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Madrid, Spain
Univ Autonoma Barcelona UAB, Dept Med, Bellaterra, Spain
Videla, L:
Hosp Santa Creu & Sant Pau, IR SANT PAU, St Pau Memory Unit, St Quinti 77-79, Barcelona 08041, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Madrid, Spain
Fundacio Catalana Sindrome, Barcelona Med Ctr, Barcelona, Spain
Barroeta, I:
Hosp Santa Creu & Sant Pau, IR SANT PAU, St Pau Memory Unit, St Quinti 77-79, Barcelona 08041, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Madrid, Spain
Benejam, B:
Hosp Santa Creu & Sant Pau, IR SANT PAU, St Pau Memory Unit, St Quinti 77-79, Barcelona 08041, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Madrid, Spain
Fundacio Catalana Sindrome, Barcelona Med Ctr, Barcelona, Spain
Fernández, S:
Fundacio Catalana Sindrome, Barcelona Med Ctr, Barcelona, Spain
Hernandez, AS:
Hosp Santa Creu & Sant Pau, IR SANT PAU, St Pau Memory Unit, St Quinti 77-79, Barcelona 08041, Spain
Giménez, S:
Hosp Santa Creu & Sant Pau, IR SANT PAU, St Pau Memory Unit, St Quinti 77-79, Barcelona 08041, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Madrid, Spain
Hosp Santa Creu & Sant Pau, Inst Invest Biomed St Pau IIB SANT PAU, Resp Dept, Multidisciplinary Sleep Unit, Barcelona, Spain
Alcolea, D:
Hosp Santa Creu & Sant Pau, IR SANT PAU, St Pau Memory Unit, St Quinti 77-79, Barcelona 08041, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Madrid, Spain
Belbin, O:
Hosp Santa Creu & Sant Pau, IR SANT PAU, St Pau Memory Unit, St Quinti 77-79, Barcelona 08041, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Madrid, Spain
Lleó, A:
Hosp Santa Creu & Sant Pau, IR SANT PAU, St Pau Memory Unit, St Quinti 77-79, Barcelona 08041, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Madrid, Spain
Carmona-Iragui, M:
Hosp Santa Creu & Sant Pau, IR SANT PAU, St Pau Memory Unit, St Quinti 77-79, Barcelona 08041, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Madrid, Spain
Fundacio Catalana Sindrome, Barcelona Med Ctr, Barcelona, Spain
Fortea, J:
Hosp Santa Creu & Sant Pau, IR SANT PAU, St Pau Memory Unit, St Quinti 77-79, Barcelona 08041, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Madrid, Spain
Fundacio Catalana Sindrome, Barcelona Med Ctr, Barcelona, Spain
Bejanin, A:
Hosp Santa Creu & Sant Pau, IR SANT PAU, St Pau Memory Unit, St Quinti 77-79, Barcelona 08041, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Madrid, Spain
Green Submitted
|