Evaluation of breast cancer screening programmes: Candidate performance indicators and their association with breast cancer mortality
Por:
Canelo-Aybar, C, Alonso-Coello, P, Muratov, S, Tarride, JE, Dimitrova, N, Giusti, F, Borisch, B, Castells, X, Duffy, SW, Fitzpatrick, P, Follmann, M, Giordano, L, Hofvind, S, Lebeau, A, Quinn, C, Torresin, A, Rossi, PG, Schünemann, H, Nyström, L, Broeders, M
Publicada:
1 dic 2025
Ahead of Print:
1 nov 2025
Resumen:
Aim: Evaluation of a breast cancer (BC) screening programme is necessary to ensure its quality. Performance measurements might be prioritized considering the association with outcomes related to BC mortality. We piloted an approach to explore the association of selected performance measurements with incidence-based BC mortality (IBM). Methods: We performed an ecological analysis of aggregated data from regional or national population-based cancer registries and BC screening programmes in Europe, using 13 performance indicators. We built a panel data (longitudinal cross-sectional) regression model to estimate the association between screening performance measurements and IBM rates. Results: We included data of 9 programmes and registries from Italy, Spain, Norway, Ireland and the Czech Republic. The number of screening years included in the dataset ranged from 5 to 20 years. In adjusted panel analyses, higher screening coverage, breast cancer detection rates (BCDR prevalent and subsequent rounds), node-negative proportion, and episode sensitivity were associated with lower incidence-based mortality (IBM), whereas a higher interval cancer rate was associated with higher IBM. The association for recall rate in subse-quent examinations was small and imprecise. Conclusion: Our pilot approach suggests association of several performance indicators with IBM. These indicators were related to the implementation of the screening programme (screening coverage), sensitivity (BC detection rate), and efficiency (recall rate). Further studies with larger datasets and individual data may confirm these findings.
Filiaciones:
Canelo-Aybar, C:
Iberoamerican Cochrane Ctr, Barcelona, Spain
Inst Recerca Sant Pau IR SANt PAU, Barcelona, Spain
Alonso-Coello, P:
Inst Recerca Sant Pau IR SANt PAU, Barcelona, Spain
Hlth Inst Carlos III ISCIII, CIBER Biomed Res Ctr Epidemiol & Publ Hlth CIBERES, Madrid, Spain
Radboud Univ Nijmegen, Med Ctr, IQ Hlth Sci Dept, POB 9101, NL-6500 HB Nijmegen, Netherlands
Muratov, S:
McMaster Univ, Fac Hlth Sci, Dept Hlth Res Methods Evidence & Impact, Hamilton, ON, Canada
Tarride, JE:
McMaster Univ, Fac Hlth Sci, Dept Hlth Res Methods Evidence & Impact, Hamilton, ON, Canada
Dimitrova, N:
European Commiss, Joint Res Ctr, Via E Fermi 2749,TP 127, I-21027 Ispra, VA, Italy
Int Agcy Res Canc, Lyon, France
Giusti, F:
European Commiss, Joint Res Ctr, Via E Fermi 2749,TP 127, I-21027 Ispra, VA, Italy
Borisch, B:
Univ Geneva, Inst Global Hlth, Geneva, Switzerland
Castells, X:
IMIM Hosp Mar Med Res Inst, Barcelona, Spain
Duffy, SW:
Queen Mary Univ London, Wolfson Inst Populat Hlth, Ctr Prevent Detect & Diag, London, England
Fitzpatrick, P:
Natl Screening Serv, Dublin, Ireland
UCD, Sch Publ Hlth Physiotherapy & Sports Sci, Dublin, Ireland
Follmann, M:
German Canc Soc, Berlin, Germany
Giordano, L:
CPO Piedmont AOU Citta Salute & Sci, Turin, Italy
Hofvind, S:
Canc Registry Norway, Oslo, Norway
Lebeau, A:
Univ Med Ctr Hamburg Eppendorf, Hamburg, Germany
Private Grp Practice Pathol, Lubeck, Germany
Quinn, C:
St Vincents Univ Hosp, Dublin, Ireland
Univ Coll Dublin, Dublin, Ireland
Torresin, A:
Univ Statale Milano UNIMI, Dept Phys, Milan, Italy
Rossi, PG:
IRCCS, AUSL Reggio Emilia, Reggio Emilia, Italy
Schünemann, H:
McMaster Univ, Fac Hlth Sci, Dept Hlth Res Methods Evidence & Impact, Hamilton, ON, Canada
Nyström, L:
Umea Univ, Dept Epidemiol & Global Hlth, Umea, Sweden
Broeders, M:
Radboud Univ Nijmegen, Med Ctr, IQ Hlth Sci Dept, Nijmegen, Netherlands
Dutch Expert Ctr Screening, Nijmegen, Netherlands
Inst Recerca Sant Pau IR SANT PAU, Sant Quinti 77-79, Barcelona 08041, Spain
Green Submitted, gold
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