Machine learning in Alzheimer's disease genetics


Por: Bracher-Smith, M, Melograna, F, Ulm, B, Bellenguez, C, Grenier-Boley, B, Duroux, D, Nevado, AJ, Holmans, P, Tijms, BM, Hulsman, M, de Rojas, I, Campos-Martin, R, van der Lee, S, Castillo, A, Küçükali, F, Peters, O, Schneider, A, Dichgans, M, Rujescu, D, Scherbaum, N, Deckert, J, Riedel-Heller, S, Hausner, L, Molina-Porcel, L, Düzel, E, Grimmer, T, Wiltfang, J, Heilmann-Heimbach, S, Moebus, S, Tegos, T, Scarmeas, N, Dols-Icardo, O, Moreno, F, Pérez-Tur, J, Bullido, MJ, Pastor, P, Sánchez-Valle, R, Alvarez, V, Boada, M, García-González, P, Puerta, R, Mir, P, Real, LM, Piñol-Ripoll, G, García-Alberca, JM, Rodriguez-Rodriguez, E, Soininen, H, Heikkinen, S, de Mendonça, A, Mehrabian, S, Traykov, L, Hort, J, Vyhnalek, M, Sandau, N, Thomassen, JQ, Pijnenburg, YAL, Holstege, H, van Swieten, J, Ramakers, I, Verhey, F, Scheltens, P, Graff, C, Papenberg, G, Giedraitis, V, Williams, J, Amouyel, P, Boland, A, Deleuze, JF, Nicolas, G, Dufouil, C, Pasquier, F, Hanon, O, Debette, S, Grünblatt, E, Popp, J, Ghidoni, R, Galimberti, D, Arosio, B, Mecocci, P, Solfrizzi, V, Parnetti, L, Squassina, A, Tremolizzo, L, Borroni, B, Wagner, M, Nacmias, B, Spallazzi, M, Seripa, D, Rainero, I, Daniele, A, Piras, F, Masullo, C, Rossi, G, Jessen, F, Kehoe, P, Magda, T, Sánchez-Juan, P, Sleegers, K, Ingelsson, M, Hiltunen, M, Sims, R, van der Flier, W, Andreassen, OA, Ruiz, A, Ramirez, A, Frikke-Schmidt, R, Amin, N, Roshchupkin, G, Lambert, JC, Van Steen, K, van Duijn, C, Escott-Price, V

Publicada: 22 jul 2025
Resumen:
Traditional statistical approaches have advanced our understanding of the genetics of complex diseases, yet are limited to linear additive models. Here we applied machine learning (ML) to genome-wide data from 41,686 individuals in the largest European consortium on Alzheimer's disease (AD) to investigate the effectiveness of various ML algorithms in replicating known findings, discovering novel loci, and predicting individuals at risk. We utilised Gradient Boosting Machines (GBMs), biological pathway-informed Neural Networks (NNs), and Model-based Multifactor Dimensionality Reduction (MB-MDR) models. ML approaches successfully captured all genome-wide significant genetic variants identified in the training set and 22% of associations from larger meta-analyses. They highlight 6 novel loci which replicate in an external dataset, including variants which map to ARHGAP25, LY6H, COG7, SOD1 and ZNF597. They further identify novel association in AP4E1, refining the genetic landscape of the known SPPL2A locus. Our results demonstrate that machine learning methods can achieve predictive performance comparable to classical approaches in genetic epidemiology and have the potential to uncover novel loci that remain undetected by traditional GWAS. These insights provide a complementary avenue for advancing the understanding of AD genetics.

Filiaciones:
Bracher-Smith, M:
 Cardiff Univ, Sch Med, Cardiff, Wales

 Cardiff Univ, Sch Med, Div Psychol Med & Clin Neurosci, Ctr Neuropsychiat Genet & Genom, Cardiff, Wales

Melograna, F:
 Katholieke Univ Leuven, Dept Human Genet, BIO3 Syst Med, Leuven, Belgium

 Univ Liege, BIO3 Syst Genet, GIGA R Mol & Computat Biol, Liege, Belgium

Ulm, B:
 Univ Oxford, Nuffield Dept Populat Hlth, Oxford, England

 Univ Oxford, Ctr Artificial Intelligence Precis Med, Oxford, England

Bellenguez, C:
 Univ Lille, Inst Pasteur Lille, RIDAGE Facteurs Risque & Determinants Mol Malad L, CHU Lille,LabEx DISTALZ,U1167,Inserm, Lille, France

Grenier-Boley, B:
 Univ Lille, Inst Pasteur Lille, RIDAGE Facteurs Risque & Determinants Mol Malad L, CHU Lille,LabEx DISTALZ,U1167,Inserm, Lille, France

Duroux, D:
 Univ Liege, BIO3 Syst Genet, GIGA R Mol & Computat Biol, Liege, Belgium

Nevado, AJ:
 Univ Oxford, Ctr Artificial Intelligence Precis Med, Oxford, England

Holmans, P:
 Cardiff Univ, Sch Med, Div Psychol Med & Clin Neurosci, Ctr Neuropsychiat Genet & Genom, Cardiff, Wales

Tijms, BM:
 Amsterdam UMC, Dept Neurol, Alzheimer Ctr Amsterdam, Amsterdam Neurosci,Vrije Univ Amsterdam, Amsterdam, Netherlands

 Vrije Univ, Ctr Neurogen & Cognit Res, Amsterdam Neurosci, Dept Complex Trait Genet, Amsterdam, Netherlands

Hulsman, M:
 Amsterdam UMC, Dept Neurol, Alzheimer Ctr Amsterdam, Amsterdam Neurosci,Vrije Univ Amsterdam, Amsterdam, Netherlands

 Vrije Univ, Ctr Neurogen & Cognit Res, Amsterdam Neurosci, Dept Complex Trait Genet, Amsterdam, Netherlands

de Rojas, I:
 Univ Int Catalunya, Res Ctr & Memory Clin, ACE Alzheimer Ctr Barcelona, Catalunya, Spain

 Inst Salud Carlos III, Networking Res Ctr Neurodegenerat Dis CIBERNED, Madrid, Spain

Campos-Martin, R:
 UNAJ, ENyS, CONICET, HEC, Buenos Aires, Argentina

van der Lee, S:
 Amsterdam UMC, Dept Neurol, Alzheimer Ctr Amsterdam, Amsterdam Neurosci,Vrije Univ Amsterdam, Amsterdam, Netherlands

 Vrije Univ, Ctr Neurogen & Cognit Res, Amsterdam Neurosci, Dept Complex Trait Genet, Amsterdam, Netherlands

Castillo, A:
 Cardiff Univ, Sch Med, Div Psychol Med & Clin Neurosci, Ctr Neuropsychiat Genet & Genom, Cardiff, Wales

Küçükali, F:
 VIB, Complex Genet Alzheimers Dis Grp, VIB Ctr Mol Neurol, Antwerp, Belgium

 Univ Antwerp, Dept Biomed Sci, Antwerp, Belgium

Peters, O:
 German Ctr Neurodegenerat Dis DZNE, Berlin, Germany

 Charite Univ Med Berlin, Hindenburgdamm 30, D-12203 Berlin, Germany

 Free Univ Berlin, Hindenburgdamm 30, D-12203 Berlin, Germany

 Humboldt Univ, Hindenburgdamm 30, D-12203 Berlin, Germany

 Berlin Inst Hlth, Inst Psychiat & Psychotherapy, Hindenburgdamm 30, D-12203 Berlin, Germany

Schneider, A:
 German Ctr Neurodegenerat Dis DZNE, Bonn, Germany

 Univ Hosp Bonn, Dept Cognit Disorders & Old Age Psychiat, Venusberg Campus 1, D-53127 Bonn, Germany

Dichgans, M:
 Ludwig Maximilians Univ Munchen, Univ Hosp, Inst Stroke & Dementia Res ISD, Munich, Germany

 German Ctr Neurodegenerat Dis DZNE, Munich, Germany

 Munich Cluster Syst Neurol SyNergy, Munich, Germany

Rujescu, D:
 Med Univ Vienna, Comprehens Ctr Clin Neurosci & Mental Hlth C3NMH, Dept Psychiat & Psychotherapy, Vienna, Austria

Scherbaum, N:
 Univ Duisburg Essen, Germany Med Fac, Dept Psychiat & Psychotherapy, LVR Klinikum Essen, Essen, Germany

Deckert, J:
 Univ Hosp Wurzburg, Ctr Mental Hlth, Department Psychiat Psychosomat & Psychotherapy, Wurzburg, Germany

Riedel-Heller, S:
 Univ Leipzig, Inst Social Med Occupat Hlth & Publ Hlth, D-04103 Leipzig, Germany

Hausner, L:
 Heidelberg Univ, Fac Mannheim, Cent Inst Mental Hlth Mannheim, Dept Geriatr Psychiat, Heidelberg, Germany

Molina-Porcel, L:
 Hosp Clin Barcelona, Alzheimers Dis & Other Cognit Disorders Unit, FRCB, Neurol Serv,IDIBAPS, Barcelona, Spain

 Univ Barcelona, Barcelona, Spain

 IDIBAPS, Neurol Tissue Bank Biobank, Hosp Clin, FRCB, Barcelona, Spain

Düzel, E:
 German Ctr Neurodegenerat Dis DZNE, Magdeburg, Germany

 Otto Von Guericke Univ, Inst Cognit Neurol & Dementia Res IKND, Magdeburg, Germany

Grimmer, T:
 Tech Univ Munich, Sch Med & Hlth, Dept Psychiat & Psychotherapy, Ctr Cognit Disorders,Klinikum Rechts Isar, Munich, Germany

Wiltfang, J:
 Univ Med Ctr Goettingen, Dept Psychiat & Psychotherapy, Gottingen, Germany

 German Ctr Neurodegenerat Dis DZNE, Gottingen, Germany

 IBiMED, Med Sci Dept, Dept Med Sci, Aveiro, Portugal

Heilmann-Heimbach, S:
 Univ Bonn, Sch Med, Inst Human Genet, Bonn, Germany

 Univ Hosp Bonn, Bonn, Germany

Moebus, S:
 Univ Duisburg Essen, Inst Urban Publ Hlth, Univ Hosp, Essen, Germany

Scarmeas, N:
 Columbia Univ, Taub Inst Res Alzheimers Dis & Aging Brain, Gertrude H Sergievsky Ctr, Dept Neurol, New York, NY USA

 Natl & Kapodistrian Univ Athens, Med Sch, Aiginit Hosp, Dept Neurol 1, Athens, Greece

Dols-Icardo, O:
 Univ Autonoma Barcelona, Inst Recerca St Pau, Hosp Santa Creu & Sant Pau, Dept Neurol,St Pau Mem Unit, Barcelona, Spain

 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain

Moreno, F:
 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain

 Hosp Univ Donostia, Dept Neurol, San Sebastian, Spain

 Inst Biogipuzkoa, Neurosci Area, San Sebastian, Spain

Pérez-Tur, J:
 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain

 CSIC, Unitat Genet Mol, Inst Biomed Valencia, Valencia, Spain

Bullido, MJ:
 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain

 UAM, CSIC, Ctr Biol Mol Severo Ochoa, Madrid, Spain

 Inst Invest Sanitaria Hosp La Paz IdiPaz, Madrid, Spain

 Univ Autonoma Madrid, Madrid, Spain

Pastor, P:
 Fundacio Docencia & Recerca MutuaTerrassa, Terrassa, Barcelona, Spain

 Hosp Univ Mutua Terrassa, Dept Neurol, Memory Disorders Unit, Terrassa, Barcelona, Spain

Sánchez-Valle, R:
 Univ Barcelona, Alzheimers Dis & Other Cognit Disorders Unit, Inst Invest Biomed August Pi i Sunyer, Hosp Clin Barcelona,Serv Neurol, Barcelona, Spain

Alvarez, V:
 Hosp Univ Cent Asturias, Lab Genet, Oviedo, Spain

 Inst Invest Sanitaria Principado Asturias ISPA, Asturias, Spain

Boada, M:
 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain

 Univ Int Catalunya, Ace Alzheimer Ctr Barcelona, Barcelona, Spain

García-González, P:
 Univ Int Catalunya, Res Ctr & Mem Clin, ACE Alzheimer Ctr Barcelona, Barcelona, Spain

Puerta, R:
 Univ Int Catalunya, Res Ctr & Mem Clin, ACE Alzheimer Ctr Barcelona, Barcelona, Spain

Mir, P:
 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain

 Univ Seville, Hosp Univ Virgen del Rocio, Unidad Trastornos Movimiento, CSIC,Serv Neurol & Neurofisiol Inst Biomed IBIS, Seville, Spain

Real, LM:
 Hosp Univ Valme, Unidad Clin Enfermedades Infecciosas & Microbiol, Seville, Spain

 Univ Malaga, Dept Especialidades Quirurg Bioquim & Inmunol, Fac Med, Malaga, Spain

Piñol-Ripoll, G:
 Hosp Univ Santa Maria Lleida, Unitat Trastorns Cognitius, Lleida, Spain

 Inst Recerca Biomed Lleida IRBLLeida, Lleida, Spain

García-Alberca, JM:
 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain

 Univ Malaga, Dept Especialidades Quirurg Bioquim & Inmunol, Fac Med, Malaga, Spain

 Andalusian Inst Neurosci, Alzheimer Res Ctr & Memory Clin, Malaga, Spain

Rodriguez-Rodriguez, E:
 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain

 Univ Cantabria, Neurol Serv, Marques de Valdecilla Univ Hosp, Santander, Spain

 IDIVAL, Santander, Spain

Soininen, H:
 Univ Eastern Finland, Inst Clin Med Neurol, Kuopio, Finland

Heikkinen, S:
 Univ Eastern Finland, Inst Biomed, Kuopio, Finland

de Mendonça, A:
 Univ Lisbon, Fac Med, Lisbon, Portugal

Mehrabian, S:
 Med Univ Sofia, Clin Neurol, UH Alexandrovska, Sofia, Bulgaria

Traykov, L:
 Med Univ Sofia, Dept Neurol, Sofia, Bulgaria

Hort, J:
 Charles Univ Prague, Fac Med 2, Dept Neurol, Mem Clin, Prague, Czech Republic

 Motol Univ Hosp, Prague, Czech Republic

Vyhnalek, M:
 Charles Univ Prague, Fac Med 2, Dept Neurol, Mem Clin, Prague, Czech Republic

 Motol Univ Hosp, Prague, Czech Republic

 St Annes Univ Hosp Brno, Int Clin Res Ctr, Brno, Czech Republic

Sandau, N:
 Rigshosp, Dept Clin Biochem, Copenhagen Univ Hosp, Copenhagen, Denmark

Thomassen, JQ:
 Rigshosp, Dept Clin Biochem, Copenhagen Univ Hosp, Copenhagen, Denmark

Pijnenburg, YAL:
 Amsterdam UMC, Dept Neurol, Alzheimer Ctr Amsterdam, Amsterdam Neurosci,Vrije Univ Amsterdam, Amsterdam, Netherlands

Holstege, H:
 Amsterdam UMC, Dept Neurol, Alzheimer Ctr Amsterdam, Amsterdam Neurosci,Vrije Univ Amsterdam, Amsterdam, Netherlands

 Vrije Univ Amsterdam, Dept Clin Genet, Med Ctr, Amsterdam, Netherlands

van Swieten, J:
 ErasmusMC, Dept Neurol, Rotterdam, Netherlands

Ramakers, I:
 Maastricht Univ, Dept Psychiat & Neuropsychol, Alzheimer Ctr Limburg, Maastricht, Netherlands

Verhey, F:
 Maastricht Univ, Dept Psychiat & Neuropsychol, Alzheimer Ctr Limburg, Maastricht, Netherlands

Scheltens, P:
 Amsterdam UMC, Dept Neurol, Alzheimer Ctr Amsterdam, Amsterdam Neurosci,Vrije Univ Amsterdam, Amsterdam, Netherlands

Graff, C:
 Karolinska Univ Hosp Solna, Unit Hereditary Dementias, Theme Aging, S-17164 Stockholm, Sweden

Papenberg, G:
 Karolinska Inst, Aging Res Ctr, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden

 Stockholm Univ, Stockholm, Sweden

Giedraitis, V:
 Uppsala Univ, Dept Publ Hlth & Carins Sci, Uppsala, Sweden

Williams, J:
 Cardiff Univ, Sch Med, Cardiff, Wales

 Cardiff Univ, Sch Med, Div Psychol Med & Clin Neurosci, Ctr Neuropsychiat Genet & Genom, Cardiff, Wales

Amouyel, P:
 Univ Lille, Inst Pasteur Lille, RIDAGE Facteurs Risque & Determinants Mol Malad L, CHU Lille,LabEx DISTALZ,U1167,Inserm, Lille, France

Boland, A:
 Univ Paris Saclay, Ctr Natl Rech Genom Humaine, CEA, F-91057 Evry, France

Deleuze, JF:
 Univ Paris Saclay, Ctr Natl Rech Genom Humaine, CEA, F-91057 Evry, France

Nicolas, G:
 Normandie Univ, Univ Rouen Normandie, Inserm, U1245, F-76000 Rouen, France

 CHU Rouen, Dept Genet, F-76000 Rouen, France

 CNRMAJ, F-76000 Rouen, France

Dufouil, C:
 Univ Bordeaux, UMR 1219, Bordeaux Populat Hlth Res Ctr, Inserm,ISPED,CIC 1401 EC, Bordeaux, France

 CHU Bordeaux, Pole Sante Publ, Bordeaux, France

Pasquier, F:
 Univ Lille, CHU Clin & Res Mem Res Ctr CMRR Distalz Lille, Inserm 1171, Lille, France

Hanon, O:
 Univ Paris, Hop Broca, APHP, EA 4468, Paris, France

Debette, S:
 Univ Bordeaux, INSERM, Bordeaux Populat Hlth Res Ctr, Bordeaux, France

 Univ Bordeaux, Dept Neurol, Bordeaux, France

Grünblatt, E:
 Univ Zurich, Univ Hosp Psychiat Zurich, Dept Childand Adolescent Psychiat & Psychotherapy, Zurich, Switzerland

 Univ Zurich, Neurosci Ctr Zurich, Zurich, Switzerland

 Swiss Fed Inst Technol, Zurich, Switzerland

 Univ Zurich, Zurich Ctr Integrat Human Physiol, Zurich, Switzerland

Popp, J:
 CHU Vaudois, Dept Psychiat, Old Age Psychiat, Lausanne, Switzerland

 Lausanne Univ Hosp, Dept Psychiat, Old Age Psychiat, Lausanne, Switzerland

 Univ Hosp Psychiat Zurich, Dept Geriatr Psychiat, Zurich, Switzerland

Ghidoni, R:
 IRCCS Ist Ctr San Giovanni Dio Fatebenefratell, Mol Markers Lab, Brescia, Italy

Galimberti, D:
 Fdn IRCCS Ca Granda Osped Policlin, Neurodegenerat Dis Unit, Milan, Italy

 Univ Milan, Dept Biomed Surg & Dent Sci, Milan, Italy

Arosio, B:
 Univ Milan, Dept Clin Sci & Community Hlth, I-20122 Milan, Italy

 Fdn IRCCS Ca Granda Osped Maggiore Policlin, Geriatr Unit, I-20122 Milan, Italy

Mecocci, P:
 Univ Perugia, Dept Med & Surg, Inst Gerontol & Geriatr, Perugia, Italy

 Karolinska Inst, Div Clin Geriatr, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden

Solfrizzi, V:
 Univ Bari A Moro, Interdisciplinary Dept Med, Geriatr Med & Memory Unit, Bari, Italy

Parnetti, L:
 Univ Perugia, Sect Neurol, Lab Clin Neurochem, Ctr Mem Disturbances, Perugia, Italy

Squassina, A:
 Univ Cagliari, Sect Neurosci & Clin Pharmacol, Dept Biomed Sci, Cagliari, Italy

Tremolizzo, L:
 San Gerardo Hosp, Neurol Unit, Monza, Italy

 Univ Milano Bicocca, Milan, Italy

Borroni, B:
 IRCCS Ist Ctr San Giovanni Dio Fatebenefratell, Mol Markers Lab, Brescia, Italy

 Univ Brescia, Dept Clin & Expt Sci, Brescia, Italy

 ASST Spedali Civili Brescia, Dept Continu Care & Frailty, Cognit & Behav Neurol, Brescia, Italy

Wagner, M:
 German Ctr Neurodegenerat Dis DZNE, Bonn, Germany

 Univ Hosp Bonn, Med Fac, Dept Cognit Disorders & Old Age Psychiat, Bonn, Germany

Nacmias, B:
 Univ Florence, Dept Neurosci Psychol Drug Res & Child Hlth, Florence, Italy

 IRCCS Fdn Don Carlo Gnocchi, Florence, Italy

Spallazzi, M:
 Univ Hosp Parma, Unit Neurol, Dept Med & Surg, Parma, Italy

Seripa, D:
 Vito Fazzi Hosp, Dept Hematol & Stem Cell Transplant, Lecce, Italy

Rainero, I:
 Univ Torino, Det Neurosci Rita Levi Montalcini, Turin, Italy

Daniele, A:
 Univ Cattolica Sacro Cuore, Dept Neurosci, Rome, Italy

 IRCCS Fdn Policli Univ A Gemelli, NeurologyUnit, Rome, Italy

Piras, F:
 IRCCS Santa Lucia Fdn, Lab Neuropsychiat, Rome, Italy

Masullo, C:
 Univ Cattolica Sacro Cuore, Inst Neurol, Rome, Italy

Rossi, G:
 Fdn IRCCS Ist Neurol Carlo Besta, Unit Neurol Neuropathol 5, Milan, Italy

Jessen, F:
 Univ Cologne, Univ Hosp Cologne, Cologne, Germany

 German Ctr Neurodegenerat Dis DZNE, Bonn, Germany

 Univ Cologne, Fac Med, Dept Psychiat & Psychotherapy, Cologne, Germany

 Univ Cologne, Cluster Excellence Cellular Stress Responses Agin, Cologne, Germany

Kehoe, P:
 Univ Bristol, Bristol Med Sch, Translat Hlth Sci, Bristol, England

Magda, T:
 Univ Tunis El Manar, Lab Genet Immunol & Human Pathol, Fac Sci Tunis, Tunis 2092, Tunisia

Sánchez-Juan, P:
 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain

 Alzheimers Ctr Reina Sofia CIEN Fdn ISCII, Madrid 28031, Spain

Sleegers, K:
 VIB, Complex Genet Alzheimers Dis Grp, VIB Ctr Mol Neurol, Antwerp, Belgium

 Univ Antwerp, Dept Biomed Sci, Antwerp, Belgium

Ingelsson, M:
 Uppsala Univ, Dept Publ Hlth & Caring Sci Geriatr, Uppsala, Sweden

 Univ Hlth Network, Krembil Brain Inst, Toronto, ON, Canada

 Univ Toronto, Dept Med & Lab Med, Tanz Ctr Res Neurodegenerat Dis, Toronto, ON, Canada

 Univ Toronto, Dept Pathobiol, Tanz Ctr Res Neurodegenerat Dis, Toronto, ON, Canada

Hiltunen, M:
 Univ Eastern Finland, Inst Biomed, Kuopio, Finland

Sims, R:
 Cardiff Univ, Sch Med, Div Psychol Med & Clin Neurosci, Ctr Neuropsychiat Genet & Genom, Cardiff, Wales

van der Flier, W:
 Amsterdam UMC, Dept Neurol, Alzheimer Ctr Amsterdam, Amsterdam Neurosci,Vrije Univ Amsterdam, Amsterdam, Netherlands

Andreassen, OA:
 Oslo Univ Hosp, Div Mental Hlth & Addict, NORMENT Ctr, Oslo, Norway

 Univ Oslo, Inst Clin Med, Oslo, Norway

Ruiz, A:
 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain

 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Res Ctr & Mem Clin Fundacio ACE, Barcelona, Spain

 Univ Texas Hlth Sci Ctr, Biggs Inst Alzheimers & Neurodegenerat Dis, San Antonio, TX USA

Ramirez, A:
 Univ Cologne, Fac Med, Div Neurogenet & Mol Psychiat, Dept Psychiat & Psychotherapy, Cologne, Germany

 Univ Cologne, Univ Hosp Cologne, Cologne, Germany

 German Ctr Neurodegenerat Dis DZNE, Bonn, Germany

 Univ Hosp Bonn, Med Fac, Dept Cognit Disorders & Old Age Psychiat, Bonn, Germany

 Glenn Biggs Inst Alzheimers & Neurodegenerat Dis, Dept Psychiat, San Antonio, TX USA

 Univ Cologne, Cologne Excellence Cluster Cellular Stress Respon, Cologne, Germany

Frikke-Schmidt, R:
 Rigshosp, Dept Clin Biochem, Copenhagen Univ Hosp, Copenhagen, Denmark

 Univ Copenhagen, Dept Clin Med, Copenhagen, Denmark

Amin, N:
 Univ Oxford, Nuffield Dept Populat Hlth, Oxford, England

Roshchupkin, G:
 Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands

 Erasmus MC, Dept Radiol & Nucl Med, Rotterdam, Netherlands

Lambert, JC:
 Univ Lille, Inst Pasteur Lille, RIDAGE Facteurs Risque & Determinants Mol Malad L, CHU Lille,LabEx DISTALZ,U1167,Inserm, Lille, France

Van Steen, K:
 Katholieke Univ Leuven, Dept Human Genet, BIO3 Syst Med, Leuven, Belgium

 Univ Liege, BIO3 Syst Genet, GIGA R Mol & Computat Biol, Liege, Belgium

van Duijn, C:
 Univ Oxford, Nuffield Dept Populat Hlth, Oxford, England

 Univ Oxford, Ctr Artificial Intelligence Precis Med, Oxford, England

 ErasmusMC, Dept Epidemiol, Rotterdam, Netherlands

Escott-Price, V:
 Cardiff Univ, Sch Med, Cardiff, Wales

 Cardiff Univ, Sch Med, Div Psychol Med & Clin Neurosci, Ctr Neuropsychiat Genet & Genom, Cardiff, Wales

Aristotle Univ Thessaloniki, Sch Med, Depat Neurol 1, Thessaloniki, Makedonia, Greece
ISSN: 20411723





Nature Communications
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NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND, Reino Unido
Tipo de documento: Article
Volumen: 16 Número: 1
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WOS Id: 001545630600001
ID de PubMed: 40691194
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