Machine learning in Alzheimer's disease genetics
Por:
Bracher-Smith, M, Melograna, F, Ulm, B, Bellenguez, C, Grenier-Boley, B, Duroux, D, Nevado, AJ, Holmans, P, Tijms, BM, Hulsman, M, de Rojas, I, Campos-Martin, R, van der Lee, S, Castillo, A, Küçükali, F, Peters, O, Schneider, A, Dichgans, M, Rujescu, D, Scherbaum, N, Deckert, J, Riedel-Heller, S, Hausner, L, Molina-Porcel, L, Düzel, E, Grimmer, T, Wiltfang, J, Heilmann-Heimbach, S, Moebus, S, Tegos, T, Scarmeas, N, Dols-Icardo, O, Moreno, F, Pérez-Tur, J, Bullido, MJ, Pastor, P, Sánchez-Valle, R, Alvarez, V, Boada, M, García-González, P, Puerta, R, Mir, P, Real, LM, Piñol-Ripoll, G, García-Alberca, JM, Rodriguez-Rodriguez, E, Soininen, H, Heikkinen, S, de Mendonça, A, Mehrabian, S, Traykov, L, Hort, J, Vyhnalek, M, Sandau, N, Thomassen, JQ, Pijnenburg, YAL, Holstege, H, van Swieten, J, Ramakers, I, Verhey, F, Scheltens, P, Graff, C, Papenberg, G, Giedraitis, V, Williams, J, Amouyel, P, Boland, A, Deleuze, JF, Nicolas, G, Dufouil, C, Pasquier, F, Hanon, O, Debette, S, Grünblatt, E, Popp, J, Ghidoni, R, Galimberti, D, Arosio, B, Mecocci, P, Solfrizzi, V, Parnetti, L, Squassina, A, Tremolizzo, L, Borroni, B, Wagner, M, Nacmias, B, Spallazzi, M, Seripa, D, Rainero, I, Daniele, A, Piras, F, Masullo, C, Rossi, G, Jessen, F, Kehoe, P, Magda, T, Sánchez-Juan, P, Sleegers, K, Ingelsson, M, Hiltunen, M, Sims, R, van der Flier, W, Andreassen, OA, Ruiz, A, Ramirez, A, Frikke-Schmidt, R, Amin, N, Roshchupkin, G, Lambert, JC, Van Steen, K, van Duijn, C, Escott-Price, V
Publicada:
22 jul 2025
Resumen:
Traditional statistical approaches have advanced our understanding of the genetics of complex diseases, yet are limited to linear additive models. Here we applied machine learning (ML) to genome-wide data from 41,686 individuals in the largest European consortium on Alzheimer's disease (AD) to investigate the effectiveness of various ML algorithms in replicating known findings, discovering novel loci, and predicting individuals at risk. We utilised Gradient Boosting Machines (GBMs), biological pathway-informed Neural Networks (NNs), and Model-based Multifactor Dimensionality Reduction (MB-MDR) models. ML approaches successfully captured all genome-wide significant genetic variants identified in the training set and 22% of associations from larger meta-analyses. They highlight 6 novel loci which replicate in an external dataset, including variants which map to ARHGAP25, LY6H, COG7, SOD1 and ZNF597. They further identify novel association in AP4E1, refining the genetic landscape of the known SPPL2A locus. Our results demonstrate that machine learning methods can achieve predictive performance comparable to classical approaches in genetic epidemiology and have the potential to uncover novel loci that remain undetected by traditional GWAS. These insights provide a complementary avenue for advancing the understanding of AD genetics.
Filiaciones:
Bracher-Smith, M:
Cardiff Univ, Sch Med, Cardiff, Wales
Cardiff Univ, Sch Med, Div Psychol Med & Clin Neurosci, Ctr Neuropsychiat Genet & Genom, Cardiff, Wales
Melograna, F:
Katholieke Univ Leuven, Dept Human Genet, BIO3 Syst Med, Leuven, Belgium
Univ Liege, BIO3 Syst Genet, GIGA R Mol & Computat Biol, Liege, Belgium
Ulm, B:
Univ Oxford, Nuffield Dept Populat Hlth, Oxford, England
Univ Oxford, Ctr Artificial Intelligence Precis Med, Oxford, England
Bellenguez, C:
Univ Lille, Inst Pasteur Lille, RIDAGE Facteurs Risque & Determinants Mol Malad L, CHU Lille,LabEx DISTALZ,U1167,Inserm, Lille, France
Grenier-Boley, B:
Univ Lille, Inst Pasteur Lille, RIDAGE Facteurs Risque & Determinants Mol Malad L, CHU Lille,LabEx DISTALZ,U1167,Inserm, Lille, France
Duroux, D:
Univ Liege, BIO3 Syst Genet, GIGA R Mol & Computat Biol, Liege, Belgium
Nevado, AJ:
Univ Oxford, Ctr Artificial Intelligence Precis Med, Oxford, England
Holmans, P:
Cardiff Univ, Sch Med, Div Psychol Med & Clin Neurosci, Ctr Neuropsychiat Genet & Genom, Cardiff, Wales
Tijms, BM:
Amsterdam UMC, Dept Neurol, Alzheimer Ctr Amsterdam, Amsterdam Neurosci,Vrije Univ Amsterdam, Amsterdam, Netherlands
Vrije Univ, Ctr Neurogen & Cognit Res, Amsterdam Neurosci, Dept Complex Trait Genet, Amsterdam, Netherlands
Hulsman, M:
Amsterdam UMC, Dept Neurol, Alzheimer Ctr Amsterdam, Amsterdam Neurosci,Vrije Univ Amsterdam, Amsterdam, Netherlands
Vrije Univ, Ctr Neurogen & Cognit Res, Amsterdam Neurosci, Dept Complex Trait Genet, Amsterdam, Netherlands
de Rojas, I:
Univ Int Catalunya, Res Ctr & Memory Clin, ACE Alzheimer Ctr Barcelona, Catalunya, Spain
Inst Salud Carlos III, Networking Res Ctr Neurodegenerat Dis CIBERNED, Madrid, Spain
Campos-Martin, R:
UNAJ, ENyS, CONICET, HEC, Buenos Aires, Argentina
van der Lee, S:
Amsterdam UMC, Dept Neurol, Alzheimer Ctr Amsterdam, Amsterdam Neurosci,Vrije Univ Amsterdam, Amsterdam, Netherlands
Vrije Univ, Ctr Neurogen & Cognit Res, Amsterdam Neurosci, Dept Complex Trait Genet, Amsterdam, Netherlands
Castillo, A:
Cardiff Univ, Sch Med, Div Psychol Med & Clin Neurosci, Ctr Neuropsychiat Genet & Genom, Cardiff, Wales
Küçükali, F:
VIB, Complex Genet Alzheimers Dis Grp, VIB Ctr Mol Neurol, Antwerp, Belgium
Univ Antwerp, Dept Biomed Sci, Antwerp, Belgium
Peters, O:
German Ctr Neurodegenerat Dis DZNE, Berlin, Germany
Charite Univ Med Berlin, Hindenburgdamm 30, D-12203 Berlin, Germany
Free Univ Berlin, Hindenburgdamm 30, D-12203 Berlin, Germany
Humboldt Univ, Hindenburgdamm 30, D-12203 Berlin, Germany
Berlin Inst Hlth, Inst Psychiat & Psychotherapy, Hindenburgdamm 30, D-12203 Berlin, Germany
Schneider, A:
German Ctr Neurodegenerat Dis DZNE, Bonn, Germany
Univ Hosp Bonn, Dept Cognit Disorders & Old Age Psychiat, Venusberg Campus 1, D-53127 Bonn, Germany
Dichgans, M:
Ludwig Maximilians Univ Munchen, Univ Hosp, Inst Stroke & Dementia Res ISD, Munich, Germany
German Ctr Neurodegenerat Dis DZNE, Munich, Germany
Munich Cluster Syst Neurol SyNergy, Munich, Germany
Rujescu, D:
Med Univ Vienna, Comprehens Ctr Clin Neurosci & Mental Hlth C3NMH, Dept Psychiat & Psychotherapy, Vienna, Austria
Scherbaum, N:
Univ Duisburg Essen, Germany Med Fac, Dept Psychiat & Psychotherapy, LVR Klinikum Essen, Essen, Germany
Deckert, J:
Univ Hosp Wurzburg, Ctr Mental Hlth, Department Psychiat Psychosomat & Psychotherapy, Wurzburg, Germany
Riedel-Heller, S:
Univ Leipzig, Inst Social Med Occupat Hlth & Publ Hlth, D-04103 Leipzig, Germany
Hausner, L:
Heidelberg Univ, Fac Mannheim, Cent Inst Mental Hlth Mannheim, Dept Geriatr Psychiat, Heidelberg, Germany
Molina-Porcel, L:
Hosp Clin Barcelona, Alzheimers Dis & Other Cognit Disorders Unit, FRCB, Neurol Serv,IDIBAPS, Barcelona, Spain
Univ Barcelona, Barcelona, Spain
IDIBAPS, Neurol Tissue Bank Biobank, Hosp Clin, FRCB, Barcelona, Spain
Düzel, E:
German Ctr Neurodegenerat Dis DZNE, Magdeburg, Germany
Otto Von Guericke Univ, Inst Cognit Neurol & Dementia Res IKND, Magdeburg, Germany
Grimmer, T:
Tech Univ Munich, Sch Med & Hlth, Dept Psychiat & Psychotherapy, Ctr Cognit Disorders,Klinikum Rechts Isar, Munich, Germany
Wiltfang, J:
Univ Med Ctr Goettingen, Dept Psychiat & Psychotherapy, Gottingen, Germany
German Ctr Neurodegenerat Dis DZNE, Gottingen, Germany
IBiMED, Med Sci Dept, Dept Med Sci, Aveiro, Portugal
Heilmann-Heimbach, S:
Univ Bonn, Sch Med, Inst Human Genet, Bonn, Germany
Univ Hosp Bonn, Bonn, Germany
Moebus, S:
Univ Duisburg Essen, Inst Urban Publ Hlth, Univ Hosp, Essen, Germany
Scarmeas, N:
Columbia Univ, Taub Inst Res Alzheimers Dis & Aging Brain, Gertrude H Sergievsky Ctr, Dept Neurol, New York, NY USA
Natl & Kapodistrian Univ Athens, Med Sch, Aiginit Hosp, Dept Neurol 1, Athens, Greece
Dols-Icardo, O:
Univ Autonoma Barcelona, Inst Recerca St Pau, Hosp Santa Creu & Sant Pau, Dept Neurol,St Pau Mem Unit, Barcelona, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Moreno, F:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Hosp Univ Donostia, Dept Neurol, San Sebastian, Spain
Inst Biogipuzkoa, Neurosci Area, San Sebastian, Spain
Pérez-Tur, J:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
CSIC, Unitat Genet Mol, Inst Biomed Valencia, Valencia, Spain
Bullido, MJ:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
UAM, CSIC, Ctr Biol Mol Severo Ochoa, Madrid, Spain
Inst Invest Sanitaria Hosp La Paz IdiPaz, Madrid, Spain
Univ Autonoma Madrid, Madrid, Spain
Pastor, P:
Fundacio Docencia & Recerca MutuaTerrassa, Terrassa, Barcelona, Spain
Hosp Univ Mutua Terrassa, Dept Neurol, Memory Disorders Unit, Terrassa, Barcelona, Spain
Sánchez-Valle, R:
Univ Barcelona, Alzheimers Dis & Other Cognit Disorders Unit, Inst Invest Biomed August Pi i Sunyer, Hosp Clin Barcelona,Serv Neurol, Barcelona, Spain
Alvarez, V:
Hosp Univ Cent Asturias, Lab Genet, Oviedo, Spain
Inst Invest Sanitaria Principado Asturias ISPA, Asturias, Spain
Boada, M:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Univ Int Catalunya, Ace Alzheimer Ctr Barcelona, Barcelona, Spain
García-González, P:
Univ Int Catalunya, Res Ctr & Mem Clin, ACE Alzheimer Ctr Barcelona, Barcelona, Spain
Puerta, R:
Univ Int Catalunya, Res Ctr & Mem Clin, ACE Alzheimer Ctr Barcelona, Barcelona, Spain
Mir, P:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Univ Seville, Hosp Univ Virgen del Rocio, Unidad Trastornos Movimiento, CSIC,Serv Neurol & Neurofisiol Inst Biomed IBIS, Seville, Spain
Real, LM:
Hosp Univ Valme, Unidad Clin Enfermedades Infecciosas & Microbiol, Seville, Spain
Univ Malaga, Dept Especialidades Quirurg Bioquim & Inmunol, Fac Med, Malaga, Spain
Piñol-Ripoll, G:
Hosp Univ Santa Maria Lleida, Unitat Trastorns Cognitius, Lleida, Spain
Inst Recerca Biomed Lleida IRBLLeida, Lleida, Spain
García-Alberca, JM:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Univ Malaga, Dept Especialidades Quirurg Bioquim & Inmunol, Fac Med, Malaga, Spain
Andalusian Inst Neurosci, Alzheimer Res Ctr & Memory Clin, Malaga, Spain
Rodriguez-Rodriguez, E:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Univ Cantabria, Neurol Serv, Marques de Valdecilla Univ Hosp, Santander, Spain
IDIVAL, Santander, Spain
Soininen, H:
Univ Eastern Finland, Inst Clin Med Neurol, Kuopio, Finland
Heikkinen, S:
Univ Eastern Finland, Inst Biomed, Kuopio, Finland
de Mendonça, A:
Univ Lisbon, Fac Med, Lisbon, Portugal
Mehrabian, S:
Med Univ Sofia, Clin Neurol, UH Alexandrovska, Sofia, Bulgaria
Traykov, L:
Med Univ Sofia, Dept Neurol, Sofia, Bulgaria
Hort, J:
Charles Univ Prague, Fac Med 2, Dept Neurol, Mem Clin, Prague, Czech Republic
Motol Univ Hosp, Prague, Czech Republic
Vyhnalek, M:
Charles Univ Prague, Fac Med 2, Dept Neurol, Mem Clin, Prague, Czech Republic
Motol Univ Hosp, Prague, Czech Republic
St Annes Univ Hosp Brno, Int Clin Res Ctr, Brno, Czech Republic
Sandau, N:
Rigshosp, Dept Clin Biochem, Copenhagen Univ Hosp, Copenhagen, Denmark
Thomassen, JQ:
Rigshosp, Dept Clin Biochem, Copenhagen Univ Hosp, Copenhagen, Denmark
Pijnenburg, YAL:
Amsterdam UMC, Dept Neurol, Alzheimer Ctr Amsterdam, Amsterdam Neurosci,Vrije Univ Amsterdam, Amsterdam, Netherlands
Holstege, H:
Amsterdam UMC, Dept Neurol, Alzheimer Ctr Amsterdam, Amsterdam Neurosci,Vrije Univ Amsterdam, Amsterdam, Netherlands
Vrije Univ Amsterdam, Dept Clin Genet, Med Ctr, Amsterdam, Netherlands
van Swieten, J:
ErasmusMC, Dept Neurol, Rotterdam, Netherlands
Ramakers, I:
Maastricht Univ, Dept Psychiat & Neuropsychol, Alzheimer Ctr Limburg, Maastricht, Netherlands
Verhey, F:
Maastricht Univ, Dept Psychiat & Neuropsychol, Alzheimer Ctr Limburg, Maastricht, Netherlands
Scheltens, P:
Amsterdam UMC, Dept Neurol, Alzheimer Ctr Amsterdam, Amsterdam Neurosci,Vrije Univ Amsterdam, Amsterdam, Netherlands
Graff, C:
Karolinska Univ Hosp Solna, Unit Hereditary Dementias, Theme Aging, S-17164 Stockholm, Sweden
Papenberg, G:
Karolinska Inst, Aging Res Ctr, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden
Stockholm Univ, Stockholm, Sweden
Giedraitis, V:
Uppsala Univ, Dept Publ Hlth & Carins Sci, Uppsala, Sweden
Williams, J:
Cardiff Univ, Sch Med, Cardiff, Wales
Cardiff Univ, Sch Med, Div Psychol Med & Clin Neurosci, Ctr Neuropsychiat Genet & Genom, Cardiff, Wales
Amouyel, P:
Univ Lille, Inst Pasteur Lille, RIDAGE Facteurs Risque & Determinants Mol Malad L, CHU Lille,LabEx DISTALZ,U1167,Inserm, Lille, France
Boland, A:
Univ Paris Saclay, Ctr Natl Rech Genom Humaine, CEA, F-91057 Evry, France
Deleuze, JF:
Univ Paris Saclay, Ctr Natl Rech Genom Humaine, CEA, F-91057 Evry, France
Nicolas, G:
Normandie Univ, Univ Rouen Normandie, Inserm, U1245, F-76000 Rouen, France
CHU Rouen, Dept Genet, F-76000 Rouen, France
CNRMAJ, F-76000 Rouen, France
Dufouil, C:
Univ Bordeaux, UMR 1219, Bordeaux Populat Hlth Res Ctr, Inserm,ISPED,CIC 1401 EC, Bordeaux, France
CHU Bordeaux, Pole Sante Publ, Bordeaux, France
Pasquier, F:
Univ Lille, CHU Clin & Res Mem Res Ctr CMRR Distalz Lille, Inserm 1171, Lille, France
Hanon, O:
Univ Paris, Hop Broca, APHP, EA 4468, Paris, France
Debette, S:
Univ Bordeaux, INSERM, Bordeaux Populat Hlth Res Ctr, Bordeaux, France
Univ Bordeaux, Dept Neurol, Bordeaux, France
Grünblatt, E:
Univ Zurich, Univ Hosp Psychiat Zurich, Dept Childand Adolescent Psychiat & Psychotherapy, Zurich, Switzerland
Univ Zurich, Neurosci Ctr Zurich, Zurich, Switzerland
Swiss Fed Inst Technol, Zurich, Switzerland
Univ Zurich, Zurich Ctr Integrat Human Physiol, Zurich, Switzerland
Popp, J:
CHU Vaudois, Dept Psychiat, Old Age Psychiat, Lausanne, Switzerland
Lausanne Univ Hosp, Dept Psychiat, Old Age Psychiat, Lausanne, Switzerland
Univ Hosp Psychiat Zurich, Dept Geriatr Psychiat, Zurich, Switzerland
Ghidoni, R:
IRCCS Ist Ctr San Giovanni Dio Fatebenefratell, Mol Markers Lab, Brescia, Italy
Galimberti, D:
Fdn IRCCS Ca Granda Osped Policlin, Neurodegenerat Dis Unit, Milan, Italy
Univ Milan, Dept Biomed Surg & Dent Sci, Milan, Italy
Arosio, B:
Univ Milan, Dept Clin Sci & Community Hlth, I-20122 Milan, Italy
Fdn IRCCS Ca Granda Osped Maggiore Policlin, Geriatr Unit, I-20122 Milan, Italy
Mecocci, P:
Univ Perugia, Dept Med & Surg, Inst Gerontol & Geriatr, Perugia, Italy
Karolinska Inst, Div Clin Geriatr, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden
Solfrizzi, V:
Univ Bari A Moro, Interdisciplinary Dept Med, Geriatr Med & Memory Unit, Bari, Italy
Parnetti, L:
Univ Perugia, Sect Neurol, Lab Clin Neurochem, Ctr Mem Disturbances, Perugia, Italy
Squassina, A:
Univ Cagliari, Sect Neurosci & Clin Pharmacol, Dept Biomed Sci, Cagliari, Italy
Tremolizzo, L:
San Gerardo Hosp, Neurol Unit, Monza, Italy
Univ Milano Bicocca, Milan, Italy
Borroni, B:
IRCCS Ist Ctr San Giovanni Dio Fatebenefratell, Mol Markers Lab, Brescia, Italy
Univ Brescia, Dept Clin & Expt Sci, Brescia, Italy
ASST Spedali Civili Brescia, Dept Continu Care & Frailty, Cognit & Behav Neurol, Brescia, Italy
Wagner, M:
German Ctr Neurodegenerat Dis DZNE, Bonn, Germany
Univ Hosp Bonn, Med Fac, Dept Cognit Disorders & Old Age Psychiat, Bonn, Germany
Nacmias, B:
Univ Florence, Dept Neurosci Psychol Drug Res & Child Hlth, Florence, Italy
IRCCS Fdn Don Carlo Gnocchi, Florence, Italy
Spallazzi, M:
Univ Hosp Parma, Unit Neurol, Dept Med & Surg, Parma, Italy
Seripa, D:
Vito Fazzi Hosp, Dept Hematol & Stem Cell Transplant, Lecce, Italy
Rainero, I:
Univ Torino, Det Neurosci Rita Levi Montalcini, Turin, Italy
Daniele, A:
Univ Cattolica Sacro Cuore, Dept Neurosci, Rome, Italy
IRCCS Fdn Policli Univ A Gemelli, NeurologyUnit, Rome, Italy
Piras, F:
IRCCS Santa Lucia Fdn, Lab Neuropsychiat, Rome, Italy
Masullo, C:
Univ Cattolica Sacro Cuore, Inst Neurol, Rome, Italy
Rossi, G:
Fdn IRCCS Ist Neurol Carlo Besta, Unit Neurol Neuropathol 5, Milan, Italy
Jessen, F:
Univ Cologne, Univ Hosp Cologne, Cologne, Germany
German Ctr Neurodegenerat Dis DZNE, Bonn, Germany
Univ Cologne, Fac Med, Dept Psychiat & Psychotherapy, Cologne, Germany
Univ Cologne, Cluster Excellence Cellular Stress Responses Agin, Cologne, Germany
Kehoe, P:
Univ Bristol, Bristol Med Sch, Translat Hlth Sci, Bristol, England
Magda, T:
Univ Tunis El Manar, Lab Genet Immunol & Human Pathol, Fac Sci Tunis, Tunis 2092, Tunisia
Sánchez-Juan, P:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Alzheimers Ctr Reina Sofia CIEN Fdn ISCII, Madrid 28031, Spain
Sleegers, K:
VIB, Complex Genet Alzheimers Dis Grp, VIB Ctr Mol Neurol, Antwerp, Belgium
Univ Antwerp, Dept Biomed Sci, Antwerp, Belgium
Ingelsson, M:
Uppsala Univ, Dept Publ Hlth & Caring Sci Geriatr, Uppsala, Sweden
Univ Hlth Network, Krembil Brain Inst, Toronto, ON, Canada
Univ Toronto, Dept Med & Lab Med, Tanz Ctr Res Neurodegenerat Dis, Toronto, ON, Canada
Univ Toronto, Dept Pathobiol, Tanz Ctr Res Neurodegenerat Dis, Toronto, ON, Canada
Hiltunen, M:
Univ Eastern Finland, Inst Biomed, Kuopio, Finland
Sims, R:
Cardiff Univ, Sch Med, Div Psychol Med & Clin Neurosci, Ctr Neuropsychiat Genet & Genom, Cardiff, Wales
van der Flier, W:
Amsterdam UMC, Dept Neurol, Alzheimer Ctr Amsterdam, Amsterdam Neurosci,Vrije Univ Amsterdam, Amsterdam, Netherlands
Andreassen, OA:
Oslo Univ Hosp, Div Mental Hlth & Addict, NORMENT Ctr, Oslo, Norway
Univ Oslo, Inst Clin Med, Oslo, Norway
Ruiz, A:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Res Ctr & Mem Clin Fundacio ACE, Barcelona, Spain
Univ Texas Hlth Sci Ctr, Biggs Inst Alzheimers & Neurodegenerat Dis, San Antonio, TX USA
Ramirez, A:
Univ Cologne, Fac Med, Div Neurogenet & Mol Psychiat, Dept Psychiat & Psychotherapy, Cologne, Germany
Univ Cologne, Univ Hosp Cologne, Cologne, Germany
German Ctr Neurodegenerat Dis DZNE, Bonn, Germany
Univ Hosp Bonn, Med Fac, Dept Cognit Disorders & Old Age Psychiat, Bonn, Germany
Glenn Biggs Inst Alzheimers & Neurodegenerat Dis, Dept Psychiat, San Antonio, TX USA
Univ Cologne, Cologne Excellence Cluster Cellular Stress Respon, Cologne, Germany
Frikke-Schmidt, R:
Rigshosp, Dept Clin Biochem, Copenhagen Univ Hosp, Copenhagen, Denmark
Univ Copenhagen, Dept Clin Med, Copenhagen, Denmark
Amin, N:
Univ Oxford, Nuffield Dept Populat Hlth, Oxford, England
Roshchupkin, G:
Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands
Erasmus MC, Dept Radiol & Nucl Med, Rotterdam, Netherlands
Lambert, JC:
Univ Lille, Inst Pasteur Lille, RIDAGE Facteurs Risque & Determinants Mol Malad L, CHU Lille,LabEx DISTALZ,U1167,Inserm, Lille, France
Van Steen, K:
Katholieke Univ Leuven, Dept Human Genet, BIO3 Syst Med, Leuven, Belgium
Univ Liege, BIO3 Syst Genet, GIGA R Mol & Computat Biol, Liege, Belgium
van Duijn, C:
Univ Oxford, Nuffield Dept Populat Hlth, Oxford, England
Univ Oxford, Ctr Artificial Intelligence Precis Med, Oxford, England
ErasmusMC, Dept Epidemiol, Rotterdam, Netherlands
Escott-Price, V:
Cardiff Univ, Sch Med, Cardiff, Wales
Cardiff Univ, Sch Med, Div Psychol Med & Clin Neurosci, Ctr Neuropsychiat Genet & Genom, Cardiff, Wales
Aristotle Univ Thessaloniki, Sch Med, Depat Neurol 1, Thessaloniki, Makedonia, Greece
Green Submitted, Green Published, gold
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