Age-standardized comparison of coronary artery disease, stroke incidence, and all-cause mortality between people living with HIV and the general population in Spain
Por:
Camps-Vilaró, A, Teira, R, Subirana, I, Dégano, IR, Domingo, P, Curran, A, Montero-Alonso, M, Romero, A, Marrugat, J, Galindo, MJ
Publicada:
1 nov 2025
Ahead of Print:
1 oct 2025
Resumen:
Objectives: We compared 15-year incidence of coronary artery disease (CAD), stroke, and all-cause mortality between people living with HIV (PLWH) and the Spanish general population. Methods: We compared two Spanish cohorts-VACH (PLWH) and REGICOR (general population). We followed adults aged 25-74 years, free of CAD or stroke, for a mean of 15 years. We used age-standardized 15-year incidence of CAD, stroke, and all-cause mortality and compared cohorts with log-rank tests and Cox models adjusted for confounders. Results: We included 6829 PLWH and 10,218 general population. In men aged 25-54 years with HIV, the adjusted standardized incidence rates of CAD and stroke were similar to those in the general population. In addition, PLWH had significantly higher crude all-cause standardized mortality rates than the general population: men 2790 (2536-3044) vs 1104 (1015-1192) and women 2011 (1632-2391) vs 588 (528-648) (all P-values <0.001). Moreover, the adjusted hazard ratio of all-cause mortality was much higher in PLWH younger than 55 years (hazard ratio 3.08 [2.42-3.90] in men and 4.71 [3.13-7.09] in women). Conclusions: The adjusted risk of CAD and stroke among PLWH is similar to that of the general population. However, PLWH younger than 55 years still face a more than three-fold higher risk of death from any cause. (c) 2025 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ )
Filiaciones:
Camps-Vilaró, A:
Hosp Mar Res Inst, REGICOR Study Grp, Barcelona, Spain
Univ Vic, Cent Univ Catalonia, Fac Med, Vic, Spain
Teira, R:
Hosp Sierrallana, Infect Dis Unit, Torrelavega, Spain
Subirana, I:
Inst Salud Carlos III, CIBER Enfermedades Cardiovasc, Madrid, Spain
Hosp Mar Res Inst, Cardiovasc Epidemiol & Genet Res Grp, Barcelona, Spain
Dégano, IR:
Hosp Mar Res Inst, REGICOR Study Grp, Barcelona, Spain
Inst Res & Innovat Life Sci & Hlth Cent Catalonia, Vic, Spain
Domingo, P:
Hosp Santa Creu i St Pau, Inst Recerca Hosp Santa I Creu St Pau, Infect Dis Unit, Barcelona, Spain
Curran, A:
Hosp Valle De Hebron, Infect Dis Unit, Barcelona, Spain
Montero-Alonso, M:
Hosp Mar Res Inst, REGICOR Study Grp, Barcelona, Spain
Hosp Univ & Politecn La Fe, Infect Dis Unit, Valencia, Spain
Romero, A:
Hosp Mar Res Inst, REGICOR Study Grp, Barcelona, Spain
Hosp Clin Puerto Real, Infect Dis Unit, Cadiz, Spain
Marrugat, J:
Hosp Mar Res Inst, REGICOR Study Grp, Barcelona, Spain
Inst Salud Carlos III, CIBER Enfermedades Cardiovasc, Madrid, Spain
Galindo, MJ:
Hosp Clin Univ Valencia, Infect Dis Unit, Valencia, Spain
Green Submitted, gold
|