Comparison of antimicrobial consumption indicators in the emergency department
Por:
Ruiz-Ramos, J, Monje-López, AE, Escolà-Vergé, L, Herrera-Mateo, S, Hernández-Ontiveros, H, Duch-Llorach, P, Fernández-de-Gamara-Martinez, E, Rivera-Martinez, MA, Pereira-Batista, CS, López-Contreras, J
Publicada:
1 oct 2025
Ahead of Print:
1 oct 2025
Resumen:
Background: Monitoring antimicrobial use in the emergency department is complex due to the wide variety of existing indicators. We evaluated the differences between various indicators used to evaluate antimicrobial use in these units. Methods: Retrospective analysis of administrative data from all adult patients admitted to an emergency unit (2019-2024). Aggregated quarterly data included the percentage of patients treated, DDDs/100 admissions, DDD/100 patients-day and DOT/100 admissions. An autoregressive integrated moving average (ARIMA) model was used to investigate the association between DDD/100 admissions and the other antimicrobial use indicators. Findings: Annual median antimicrobial drug use measured by DDDs/100 admissions was 11.7 (IQR 10.8-12.4). Significant differences in antimicrobial consumption correlation were noted when comparing DDD/100 admissions and DDD/100 patient-days for cephalosporins, lincosamides, and carbapenems. Significant differences in the comparison between DDD and DOT were found for imipenem, clindamycin, piperacillin-tazobactam, gentamicin, and vancomycin. Conclusions: Aggregate antimicrobial use measured by DDDs or DOTs is consistent, though discrepancies in correlation may occur for antibiotics with multiple daily doses. DDD/100 admissions is a suitable indicator, but complementing it with DDD/100 patient-days, DOT, and percentage of patients receiving antibiotics provides valuable information for monitoring antimicrobial use. (c) 2025 Sociedad Espanola de Enfermedades Infecciosas y Microbiolog & imath;a Cl & imath;nica. Published by Elsevier Espana, S.L.U. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
Filiaciones:
Ruiz-Ramos, J:
Hosp Santa Creu i St Pau, Pharm Dept, Barcelona, Spain
Univ Autonoma Barcelona, Dept Med, Barcelona, Spain
Monje-López, AE:
Hosp Santa Creu i St Pau, Pharm Dept, Barcelona, Spain
Univ Autonoma Barcelona, Dept Med, Barcelona, Spain
Escolà-Vergé, L:
Hosp Santa Creu i St Pau, Infect Dis Serv, Barcelona, Spain
Herrera-Mateo, S:
Hosp Santa Creu i St Pau, Emergency Dept, Barcelona, Spain
Hernández-Ontiveros, H:
Hosp Santa Creu i St Pau, Emergency Dept, Barcelona, Spain
Duch-Llorach, P:
Hosp Santa Creu i St Pau, Infect Dis Serv, Barcelona, Spain
Fernández-de-Gamara-Martinez, E:
Hosp Santa Creu i St Pau, Pharm Dept, Barcelona, Spain
Rivera-Martinez, MA:
Hosp Santa Creu i St Pau, Microbiol Dept, Barcelona, Spain
Pereira-Batista, CS:
Hosp Santa Creu i St Pau, Microbiol Dept, Barcelona, Spain
López-Contreras, J:
Hosp Santa Creu i St Pau, Infect Dis Serv, Barcelona, Spain
|