Self-disintegrating protein-leaking microparticles for topical protein delivery
Por:
Volta-Durán, E, Sánchez, JM, Favaro, MTP, Martinez-Cuentra, G, Contreras, E, di Somma, A, López-Laguna, H, Unzueta, U, Casanova, I, Mangues, R, Villaverde, A, Vázquez, E
Publicada:
1 nov 2025
Ahead of Print:
1 sep 2025
Resumen:
Advanced drug delivery systems, if engineered to enhance drug stability and extend its kinetic bioavailability, are expected to expand the spectrum of local therapeutic approaches for dermatological conditions. In this context, the objective of this study was to explore whether artificial secretory granules, namely nontoxic, microscale granular Zn-assisted protein depots that leak the forming protein in a time-prolonged way, could be suited as functional agents in topical delivery. A model, recombinant form of the human fibroblast growth factor 2 (FGF2), formulated as secretory granules, promoted efficient tissue repair and wound healing in a rat skin injury model faster than the natural repair process. The kinetic and histological analysis of FGF-2-treated wounds revealed that the package of the protein as secretory granules improves skin regeneration over the soluble version, and that it conduces to a more ordered construction of the extracellular matrix with limited risk of fibrosis. On the other hand, the addition of a claudin-binding peptide (c-CPE) as a fused protein segment slightly delays wound healing but offers functional and histological particularities that modulate the skin regeneration process. Altogether, the data presented here validates this endocrine-like protein drug delivery from synthetic disintegrating protein depots as a powerful and versatile platform for topical application in dermatological disorders.
Filiaciones:
Volta-Durán, E:
Univ Autonoma Barcelona, Inst Biotecnol Biomed, Barcelona, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Bioingn Biomat & Nanomed, Barcelona 08034, Spain
Univ Autonoma Barcelona, Dept Gene Microbiol & Microbiol, Barcelona, Spain
Univ Politecn Cataluna, Dept Opt & Optometria, C Violinista Vellsola 37, Terrassa 08222, Barcelona, Spain
Sánchez, JM:
Univ Autonoma Barcelona, Inst Biotecnol Biomed, Barcelona, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Bioingn Biomat & Nanomed, Barcelona 08034, Spain
Univ Autonoma Barcelona, Dept Gene Microbiol & Microbiol, Barcelona, Spain
CONICET Univ Nacl Cordoba, Inst Invest Biol & Tecnol IIByT, RA-5016 Cordoba, Argentina
Univ Nacl Cordoba, Fac Ciencias Exactas Fis & Nat, Dept Quim, Catedra Quim Biol,ICTA, Ave Velez Sarsfield 1611, RA-5016 Cordoba, Argentina
Favaro, MTP:
Univ Autonoma Barcelona, Inst Biotecnol Biomed, Barcelona, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Bioingn Biomat & Nanomed, Barcelona 08034, Spain
Univ Autonoma Barcelona, Dept Gene Microbiol & Microbiol, Barcelona, Spain
Martinez-Cuentra, G:
Univ Autonoma Barcelona, Inst Neuroci, Dept Biol Cel Lular Fisiol & Immunol, Fac Biociencias,Unidad Citol & Histol, Bellaterra, Barcelona, Spain
Contreras, E:
Univ Autonoma Barcelona, Inst Biotecnol Biomed, Barcelona, Spain
Univ Autonoma Barcelona, Inst Neuroci, Dept Biol Cel Lular Fisiol & Immunol, Fac Biociencias,Unidad Citol & Histol, Bellaterra, Barcelona, Spain
di Somma, A:
Univ Autonoma Barcelona, Inst Biotecnol Biomed, Barcelona, Spain
Univ Naples Federico II, Dept Chem Sci, Via Vicinale Cupa Cintia 26, I-80126 Naples, Italy
López-Laguna, H:
Univ Autonoma Barcelona, Inst Biotecnol Biomed, Barcelona, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Bioingn Biomat & Nanomed, Barcelona 08034, Spain
Univ Autonoma Barcelona, Dept Gene Microbiol & Microbiol, Barcelona, Spain
Univ Int Catalunya, Fac Med & Hlth Sci, Dept Biomed Sci, Sant Cugat Del Valles, Spain
Unzueta, U:
Inst Salud Carlos III, Ctr Invest Biomed Red Bioingn Biomat & Nanomed, Barcelona 08034, Spain
Univ Autonoma Barcelona, Dept Gene Microbiol & Microbiol, Barcelona, Spain
Inst Recerca Sant Pau IR Sant Pau, Barcelona 08041, Spain
Josep Carreras Leukaemia Res Inst IJC, Badalona 08916, Spain
Casanova, I:
CONICET Univ Nacl Cordoba, Inst Invest Biol & Tecnol IIByT, RA-5016 Cordoba, Argentina
Inst Recerca Sant Pau IR Sant Pau, Barcelona 08041, Spain
Josep Carreras Leukaemia Res Inst IJC, Badalona 08916, Spain
Mangues, R:
CONICET Univ Nacl Cordoba, Inst Invest Biol & Tecnol IIByT, RA-5016 Cordoba, Argentina
Inst Recerca Sant Pau IR Sant Pau, Barcelona 08041, Spain
Josep Carreras Leukaemia Res Inst IJC, Badalona 08916, Spain
Villaverde, A:
Univ Autonoma Barcelona, Inst Biotecnol Biomed, Barcelona, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Bioingn Biomat & Nanomed, Barcelona 08034, Spain
Univ Autonoma Barcelona, Dept Gene Microbiol & Microbiol, Barcelona, Spain
Vázquez, E:
Univ Autonoma Barcelona, Inst Biotecnol Biomed, Barcelona, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Bioingn Biomat & Nanomed, Barcelona 08034, Spain
Univ Autonoma Barcelona, Dept Gene Microbiol & Microbiol, Barcelona, Spain
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