Impact of Alzheimer's disease on sleep in adults with Down syndrome
Por:
Giménez, S, Vaqué-Alcázar, L, Zhu, NL, Benejam, B, Arranz, J, Maure-Blesa, L, Videla, L, Carmona-Iragui, M, Barroeta, I, Rebillat, AS, Rodriguez-Baz, I, Bejanin, A, Arriola-Infante, JE, Bueno, A, Fernandez, S, Ribas, L, Zsadanyi, SE, Morcillo-Nieto, AO, Alcolea, D, Lisgaras, CP, Blessing, E, Osorio, RS, Lleo, A, Fortea, J
Publicada:
1 jul 2025
Resumen:
INTRODUCTIONDown syndrome (DS) is a genetic form of Alzheimer's disease (AD), with a high prevalence of sleep disorders, but data in adults with DS and dementia are lacking. We aim to assess sleep in adults with DS across the AD continuum.METHODSWe studied 78 healthy controls and 229 adults with DS (154 asymptomatic, 25 with prodromal AD, and 75 with AD) with subjective sleep measures and objective nocturnal polysomnography.RESULTSAdults with DS presented worse sleep quality and higher prevalence of unnoticed obstructive sleep apnea (OSA) than controls. Sleep disruption and OSA severity increased across the AD continuum. Age-related decreases in slow-wave sleep and rapid eye movement sleep were more pronounced in the DS group. Subjective sleep measures did not capture sleep disorders.CONCLUSIONSIn DS, AD is linked to worse sleep disturbances and altered architecture. However, longitudinal studies are needed to clarify directionality and disease progression.Highlights Down syndrome (DS) is associated with increased slow-wave sleep (SWS) and reduced rapid eye movement (REM) sleep. Obstructive sleep apnea prevalence increases along the Alzheimer's disease continuum in DS. Age-related decreases in SWS and REM sleep are accelerated in DS. Subjective sleep measures do not detect sleep disturbances in adults with DS.
Filiaciones:
Giménez, S:
Hosp Santa Creu & Sant Pau, Biomed Res Inst St Pau IIB SANT PAU, Resp Dept, Multidisciplinary Sleep Unit, Barcelona, Spain
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau IIB SANT PAU, Dept Neurol,St Pau Memory Unit, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Madrid, Spain
Vaqué-Alcázar, L:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau IIB SANT PAU, Dept Neurol,St Pau Memory Unit, Barcelona, Spain
Univ Barcelona, Inst Neurosci, Inst Invest Biomed August Pi & Sunyer IDIBAPS, Dept Med,Fac Med & Hlth Sci, Barcelona, Spain
Zhu, NL:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau IIB SANT PAU, Dept Neurol,St Pau Memory Unit, Barcelona, Spain
Benejam, B:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau IIB SANT PAU, Dept Neurol,St Pau Memory Unit, Barcelona, Spain
Fundacio Catalana Sindrome De Down, Barcelona Down Med Ctr, Barcelona, Spain
Arranz, J:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau IIB SANT PAU, Dept Neurol,St Pau Memory Unit, Barcelona, Spain
Maure-Blesa, L:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau IIB SANT PAU, Dept Neurol,St Pau Memory Unit, Barcelona, Spain
Videla, L:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau IIB SANT PAU, Dept Neurol,St Pau Memory Unit, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Madrid, Spain
Fundacio Catalana Sindrome De Down, Barcelona Down Med Ctr, Barcelona, Spain
Carmona-Iragui, M:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau IIB SANT PAU, Dept Neurol,St Pau Memory Unit, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Madrid, Spain
Fundacio Catalana Sindrome De Down, Barcelona Down Med Ctr, Barcelona, Spain
Barroeta, I:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau IIB SANT PAU, Dept Neurol,St Pau Memory Unit, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Madrid, Spain
Rebillat, AS:
Inst Jerome Lejeune, Paris, France
Rodriguez-Baz, I:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau IIB SANT PAU, Dept Neurol,St Pau Memory Unit, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Madrid, Spain
Bejanin, A:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau IIB SANT PAU, Dept Neurol,St Pau Memory Unit, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Madrid, Spain
Arriola-Infante, JE:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau IIB SANT PAU, Dept Neurol,St Pau Memory Unit, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Madrid, Spain
Bueno, A:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau IIB SANT PAU, Dept Neurol,St Pau Memory Unit, Barcelona, Spain
Fernandez, S:
Fundacio Catalana Sindrome De Down, Barcelona Down Med Ctr, Barcelona, Spain
Ribas, L:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau IIB SANT PAU, Dept Neurol,St Pau Memory Unit, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Madrid, Spain
Zsadanyi, SE:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau IIB SANT PAU, Dept Neurol,St Pau Memory Unit, Barcelona, Spain
Morcillo-Nieto, AO:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau IIB SANT PAU, Dept Neurol,St Pau Memory Unit, Barcelona, Spain
Alcolea, D:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau IIB SANT PAU, Dept Neurol,St Pau Memory Unit, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Madrid, Spain
Lisgaras, CP:
New York Univ Langone Hlth, Dept Psychiat, New York, NY 10017 USA
Nathan S Kline Inst Psychiat Res, New York State Off Mental Hlth, Albany, NY USA
Blessing, E:
New York Univ Langone Hlth, Dept Psychiat, New York, NY 10017 USA
Nathan S Kline Inst Psychiat Res, New York State Off Mental Hlth, Albany, NY USA
Osorio, RS:
New York Univ Langone Hlth, Dept Psychiat, New York, NY 10017 USA
Nathan S Kline Inst Psychiat Res, New York State Off Mental Hlth, Albany, NY USA
Lleo, A:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau IIB SANT PAU, Dept Neurol,St Pau Memory Unit, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Madrid, Spain
Fortea, J:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau IIB SANT PAU, Dept Neurol,St Pau Memory Unit, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Madrid, Spain
Fundacio Catalana Sindrome De Down, Barcelona Down Med Ctr, Barcelona, Spain
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