High-frequency oscillations >250 Hz in people with Down syndrome and associated Alzheimer's disease dementia
Por:
Lisgaras, CP, Giménez, S, Carmona-Iragui, M, Maure-Blesa, L, Blessing, E, Fortea, J, Osorio, RS
Publicada:
1 jul 2025
Resumen:
INTRODUCTION: Alzheimer's disease (AD) dementia has near full penetrance in adults with Down syndrome (DS) and is strongly linked to late-onset myoclonic epilepsy in Down syndrome (LOMEDS). However, promising biomarkers of epileptogenicity, such as high-frequency oscillations (HFOs >250 Hz), have not been studied. This study is the first to use wideband polysomnography in DS to investigate if HFOs occurred and preceded AD dementia and LOMEDS. METHODS: Wideband (0.1 to 500 Hz, 2048 Hz) polysomnography was performed using the international 10-20 system. HFOs were automatically detected during slow-wave sleep, followed by manual review. RESULTS: Fourteen individuals with DS and five age-matched euploid controls were studied, with all DS cases showing HFOs. HFOs emerged before AD dementia and LOMEDS and showed hemispheric lateralization in asymptomatic but not symptomatic AD dementia cases. A trend toward increasing HFO rates with age in DS warrants further confirmation. DISCUSSION: HFOs are promising biomarkers that may predict symptomatic AD dementia in adults with DS.
Filiaciones:
Lisgaras, CP:
NYU, Grossman Sch Med, Dept Psychiat, One Pk Ave,8th FL, New York, NY 10016 USA
Nathan S Kline Inst Psychiat Res, New York State Off Mental Hlth, New York, NY USA
Giménez, S:
Hosp Santa Creu & Sant Pau, Biomed Res Inst St Pau, Resp Dept, Multidisciplinary Sleep Unit, Barcelona, Spain
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau, Dept Neurol,St Pau Memory Unit, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Madrid, Spain
Carmona-Iragui, M:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau, Dept Neurol,St Pau Memory Unit, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Madrid, Spain
Fundacio Catalana Sindrome, Barcelona Med Ctr, Barcelona, Spain
Maure-Blesa, L:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau, Dept Neurol,St Pau Memory Unit, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Madrid, Spain
Blessing, E:
NYU, Grossman Sch Med, Dept Psychiat, One Pk Ave,8th FL, New York, NY 10016 USA
Nathan S Kline Inst Psychiat Res, New York State Off Mental Hlth, New York, NY USA
Fortea, J:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau, Dept Neurol,St Pau Memory Unit, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Madrid, Spain
Fundacio Catalana Sindrome, Barcelona Med Ctr, Barcelona, Spain
Osorio, RS:
NYU, Grossman Sch Med, Dept Psychiat, One Pk Ave,8th FL, New York, NY 10016 USA
Nathan S Kline Inst Psychiat Res, New York State Off Mental Hlth, New York, NY USA
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