GRADE concept paper 9: rationale and process for creating a GRADE Ontology
Por:
Whaley, P, Alper, B, Dehnbostel, J, Alva-Diaz, C, Antoniou, S, Bognanni, A, Bracchiglione, J, Dalsbo, TK, Grant, S, Hunter, J, Iorio, A, Lagisz, M, Lehmann, H, Li, SY, Meerpohl, J, Mokrane, S, Monaco, C, Neumann, I, Pottie, K, Sayfi, S, Sekercioglu, N, Singh, J, Sousa-Pinto, B, Tufte, J, Vasanthan, LT, Wang, L, Xia, J, Yao, XM, Schünemann, H
Publicada:
1 nov 2025
Ahead of Print:
1 sep 2025
Resumen:
Context: As the rate of research production accelerates, the ability to efficiently and unambiguously communicate judgments relating to the synthesis, evaluation, and use of scientific information becomes paramount. Perspective: Scientific information can be viewed as a "layered infrastructure" of data, evidence, knowledge, and use. The GRADE approach serves as a de facto data standard for this infrastructure, supporting movement between layers by reducing ambiguity in claims to knowledge (in the form of judgements of certainty in the evidence when answering research questions) and level of commitment to possible solutions to problems (in the form of strength of recommendations for interventions). Purpose: This GRADE concept paper outlines the structure, purpose, and potential benefits of the GRADE Ontology for (a) the creators of, educators in, and users of systematic reviews, health guidelines, and health technology assessments, and (b) the development of tools that help with conducting, finding, and summarising the same. This paper also presents the processes for the development and maintenance of the GRADE Ontology, a formalised terminology standard within GRADE that will support the efficiency, rigour, consistency, and interoperability of GRADE's use. (c) 2025 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Filiaciones:
Whaley, P:
Univ Lancaster, Lancaster Environm Ctr, Lancaster LA1 4YQ, England
Johns Hopkins Bloomberg Sch Publ Hlth, Evidence Based Toxicol Collaborat, Baltimore, MD USA
Alper, B:
Computable Publishing LLC, 41 Labor in Vain Rd, Franklin, NC 01938 USA
Sci Knowledge Accelerator Fdn, Franklin, NC USA
Dehnbostel, J:
Computable Publishing LLC, 41 Labor in Vain Rd, Franklin, NC 01938 USA
Sci Knowledge Accelerator Fdn, Franklin, NC USA
Univ Arizona, Mel & Enid Zuckerman Coll Publ Hlth, Tucson, AZ USA
Alva-Diaz, C:
Univ Cient Sur, Grp Invest NEMECS Neurociencias Metab Efect Clin, Lima, Peru
Hosp Daniel Alcides Carrion, Serv Neurol, Dept Med & Oficina Apoyo Docencia Invest OADI, Callao, Peru
Antoniou, S:
Papageorgiou Gen Hosp, Dept Gen Surg, Thessaloniki, Greece
Papageorgiou GRADE Ctr, Thessaloniki, Greece
Bognanni, A:
McMaster Univ, Dept Hlth Res Methods Evidence & Impact, Hamilton, ON, Canada
Bracchiglione, J:
Inst Recerca St Pau IR St Pau, Iberoamer Cochrane Ctr, CIBERESP, Barcelona, Spain
Univ Autonoma Barcelona, Barcelona, Spain
Univ Valparaiso, Interdisciplinary Ctr Hlth Studies CIESAL, Vina Del Mar, Chile
Dalsbo, TK:
Natl Inst Occupat Hlth, Oslo, Norway
Grant, S:
Univ Oregon, Coll Educ, Eugene, OR USA
Hunter, J:
Hlth Res Grp Pty Ltd, Sydney, Australia
Univ Sydney, Fac Med & Hlth, Sydney, Australia
Iorio, A:
McMaster Univ, Dept Hlth Res Methods Evidence & Impact, Hamilton, ON, Canada
Lagisz, M:
Univ New South Wales, Sch Biol Earth & Environm Sci, Evolut & Ecol Res Ctr, Kensington Campus, Sydney, NSW 2052, Australia
Univ Alberta, Dept Biol Sci, Edmonton, AB T6G 2E9, Canada
Lehmann, H:
Johns Hopkins Univ, Dept Med, Baltimore, MD USA
Li, SY:
Sichuan Univ, West China Hosp, Dept Endocrinol & Metab, MAGIC China Ctr, Chengdu 610041, Sichuan, Peoples R China
Meerpohl, J:
Univ Freiburg, Inst Evidence Med, Med Ctr, Freiburg, Germany
Univ Freiburg, Fac Med, Freiburg, Germany
Cochrane Germany Fdn, Cochrane Germany, Freiburg, Germany
Mokrane, S:
Univ Libre Bruxelles, Fac Med, Dept Med Gen, Brussels, Belgium
Monaco, C:
Ctr Univ Sao Camilo, Sch Med, Sao Paulo, Brazil
Neumann, I:
Univ San Sebastian, Sch Med, Santiago, Chile
Pottie, K:
Bruyere Hlth Res Inst, CT Lamont Ctr Primary Care, Ottawa, ON, Canada
Western Univ, Dept Family Med, London, ON, Canada
Sayfi, S:
McMaster Univ, Dept Hlth Res Methods Evidence & Impact, Hamilton, ON, Canada
Sekercioglu, N:
McMaster Univ, Dept Hlth Res Methods Evidence & Impact, Hamilton, ON, Canada
Hlth Sci Univ, Dept Internal Med, Div Nephrol, Istanbul, Turkiye
Singh, J:
Baylor Coll Med, One Baylor Plaza, Houston, TX 77030 USA
Michael E DeBakey VA Med Ctr, 2002 Holcombe Blvd, Houston, TX 77030 USA
Sousa-Pinto, B:
Univ Porto, Fac Med, Porto, Portugal
Tufte, J:
Hassanah Consulting, Seattle, WA 98122 USA
Vasanthan, LT:
Christian Med Coll Vellore, Ida Scudder Rd, Vellore 632004, Tamil Nadu, India
Wang, L:
McMaster Univ, Dept Anesthesia, Hamilton, ON, Canada
Xia, J:
Univ Nottingham Ningbo China, Sch Econ, 199 Taikang East Rd, Ningbo 315100, Peoples R China
Yao, XM:
McMaster Univ, Dept Hlth Res Methods Evidence & Impact, Hamilton, ON, Canada
Schünemann, H:
Humanitas Univ, Clin Epidemiol & Res Ctr CERC, Milan, Italy
Humanitas Res Hosp, Milan, Italy
Fraunhofer Inst Translat Med & Pharmacol ITMP, Allergol & Immunol, Berlin, Germany
Humanitas Univ, Clin & Epidemiol & Res Ctr CERC, Dept Biomed Sci, Via Rita Levi Montalcini 4, I-20072 Pieve Emanuele, MI, Italy
IRCCS Humanitas Res Hosp, Via Rita Levi Montalcini 4, I-20072 Pieve Emanuele, MI, Italy
Green Submitted, hybrid
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