Extraintestinal Manifestations in Patients with Inflammatory Bowel Disease: Study Based on the ENEIDA Registry
Por:
Algaba, A, Guerra, I, Ricart, E, Iglesias, E, Manosa, M, Gisbert, JP, Guardiola, J, Minguez, M, Castro, B, de Francisco, R, Nos, P, Bertoletti, F, Mesonero, F, Barrio, J, Martin-Arranz, MD, Calvet, X, Garcia-Lopez, S, Sicilia, B, Alcain, G, Esteve, M, Marquez, L, Piqueras, M, Jimenez, L, Perez-Calle, JL, Bujanda, L, Garcia-Sepulcre, M, Fernandez, A, Moraleja, I, Lorente, RH, Garcia-Bosch, O, Lamban, A, Blazquez, I, Rodriguez, E, Huguet, JM, Lucendo, AJ, Almela, P, Busquets, D, de la Piscina, PR, Perez, M, Domenech, E, Bermejo, F
Publicada:
1 jun 2021
Ahead of Print:
1 jul 2020
Resumen:
Background Patients with inflammatory bowel disease (IBD) may present extraintestinal manifestations (EIMs) that affect the joints, skin, eyes, and hepatobiliary area, among others. Aims Our aim was to analyse the prevalence and characteristics of EIMs in patients with IBD and to identify the possible risk factors associated with the development of EIMs in the largest series published to date. Methods Observational, cross-sectional study including patients from the Spanish ENEIDA registry promoted by GETECCU. We retrospectively identified all cases of EIMs in the ENEIDA registry until January 2018. Results The study included 31,077 patients, 5779 of whom had at least one EIM (global prevalence 19%; 95% CI 18.2-19.0). Among the different types of EIMs, rheumatic manifestations had a prevalence of 13% (95% CI 12.9-13.7; 63% of EIMs), with a prevalence of 5% (95% CI 4.7-5.2) for mucocutaneous manifestations, 2.1% (95% CI 1.9-2.2) for ocular manifestations, and 0.7% (95% CI 0.6-0.8) for hepatobiliary manifestations. The multivariable analysis showed that the type of IBD (Crohn's disease,p < 0.001), gender (female,p < 0.001), the need for an immunomodulator (p < 0.001) or biologic drugs (p < 0.001), a previous family history of IBD (p < 0.001), and an extensive location of IBD (p < 0.001) were risk factors for the presence of EIMs. Conclusions One-fifth of patients with IBD may have associated EIMs, with rheumatic manifestations as the most frequent (> 60% of EIMs). Female patients with severe Crohn's disease represent the group with the highest risk of developing EIMs. These patients should therefore be specially monitored and referred to the corresponding specialist when suggestive symptoms appear.
Filiaciones:
Algaba, A:
Hosp Univ Fuenlabrada, Dept Gastroenterol, Madrid, Spain
Inst Invest Sanitaria Hosp La Paz IdiPaz, Madrid, Spain
Guerra, I:
Hosp Univ Fuenlabrada, Dept Gastroenterol, Madrid, Spain
Inst Invest Sanitaria Hosp La Paz IdiPaz, Madrid, Spain
Ricart, E:
Hosp Clin Barcelona, Dept Gastroenterol, Barcelona, Spain
Inst Invest Biomed August Pi I Sunyer IDIBAPS, Barcelona, Spain
Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid, Spain
Iglesias, E:
Hosp Univ Reina Sofia, Dept Gastroenterol, Cordoba, Spain
Inst Maimonides Invest Biomed Cordoba IMIBIC, Cordoba, Spain
Manosa, M:
Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid, Spain
Hosp Badalona Germans Trias & Pujol, Dept Gastroenterol, Barcelona, Spain
Gisbert, JP:
Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid, Spain
Hosp Univ La Princesa, Dept Gastroenterol, Madrid, Spain
Inst Invest Sanitaria Princesa IIS IP, Madrid, Spain
Univ Autonoma Madrid, Madrid, Spain
Guardiola, J:
Hosp Univ Bellvitge, Dept Gastroenterol, Barcelona, Spain
Inst Invest Biomed Bellvitge IDIBELL, Barcelona, Spain
Minguez, M:
Hosp Clin Valencia, Dept Gastroenterol, Valencia, Spain
Univ Valencia, Valencia, Spain
Castro, B:
Hosp Univ Marques de Valdecilla, Dept Gastroenterol, Santander, Spain
Inst Invest Marques de Valdecilla, Santander, Spain
de Francisco, R:
Hosp Univ Cent Asturias, Dept Gastroenterol, Asturias, Spain
Inst Invest Sanitaria Principado Asturias ISPA, Oviedo, Spain
Nos, P:
Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid, Spain
Hosp Univ & Politecn La Fe, Gastroenterol Dept, Valencia, Spain
Bertoletti, F:
Hosp Santa Creu & Sant Pau, Dept Gastroenterol, Barcelona, Spain
Mesonero, F:
Hosp Univ Ramon & Cajal, Dept Gastroenterol, Madrid, Spain
Barrio, J:
Hosp Univ Rio Hortega, Dept Gastroenterol, Valladolid, Spain
Martin-Arranz, MD:
La Paz Hosp, Dept Gastroenterol, Madrid, Spain
La Paz Hosp, IdiPAZ Inst Hlth Res, Innate Immun Grp, Madrid, Spain
Calvet, X:
Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid, Spain
Corp Sanitaria Univ Parc Tauli, Dept Gastroenterol, Sabadell, Spain
Univ Autonoma Barcelona, Barcelona, Spain
Garcia-Lopez, S:
Hosp Univ Miguel Servet, Dept Gastroenterol, Zaragoza, Spain
Sicilia, B:
Hosp Univ Burgos, Dept Gastroenterol, Burgos, Spain
Alcain, G:
Hosp Clin Malaga, Dept Gastroenterol, Malaga, Spain
Esteve, M:
Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid, Spain
Hosp Univ Mutua Terrassa, Dept Gastroenterol, Barcelona, Spain
Marquez, L:
Hosp Mar, Gastroenterol Dept, Barcelona, Spain
IMIM Hosp Mar Med Res Inst, Barcelona, Spain
Piqueras, M:
Consorci Sanitari Terrassa, Dept Gastroenterol, Barcelona, Spain
Jimenez, L:
Hosp Univ Fuenlabrada, Dept Gastroenterol, Madrid, Spain
Inst Invest Sanitaria Hosp La Paz IdiPaz, Madrid, Spain
Perez-Calle, JL:
Hosp Univ Fdn Alcorcon, Dept Gastroenterol, Madrid, Spain
Bujanda, L:
Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid, Spain
Hosp Donostia, Dept Gastroenterol, Inst Biodonostia, San Sebastian, Guipuzcoa, Spain
Univ Basque Country, UPV EHU, San Sebastian, Guipuzcoa, Spain
Garcia-Sepulcre, M:
Hosp Gen Univ Elche, Dept Gastroenterol, Alicante, Spain
Fernandez, A:
Hosp Univ Salamanca, Dept Gastroenterol, Salamanca, Spain
Moraleja, I:
Hosp Galdakao, Dept Gastroenterol, Vizcaya, Spain
Lorente, RH:
Hosp Gen Univ Ciudad Real, Gastroenterol Dept, Ciudad Real, Spain
Garcia-Bosch, O:
Hosp St Joan Despi Moises Brog, Dept Gastroenterol, Barcelona, Spain
Lamban, A:
Hosp Gen San Jorge, Dept Gastroenterol, Huesca, Spain
Blazquez, I:
Hosp Torrejon, Dept Gastroenterol, Madrid, Spain
Rodriguez, E:
Hosp Univ Nuestra Senora Candelaria, Dept Gastroenterol, Santa Cruz De Tenerife, Spain
Huguet, JM:
Hosp Gen Univ Valencia, Dept Gastroenterol, Valencia, Spain
Lucendo, AJ:
Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid, Spain
Hosp Gen Tomelloso, Dept Gastroenterol, Ciudad Real, Spain
Almela, P:
Hosp Gen Univ Castello, Dept Gastroenterol, Castellon de La Plana, Spain
Busquets, D:
Hosp Dr Josep Trueta, Dept Gastroenterol, Girona, Spain
de la Piscina, PR:
Hosp Univ Araba, Dept Gastroenterol, Vitoria, Alava, Spain
Perez, M:
Hosp St Jaume de Calella, Dept Gastroenterol, Barcelona, Spain
Domenech, E:
Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid, Spain
Hosp Badalona Germans Trias & Pujol, Dept Gastroenterol, Barcelona, Spain
Bermejo, F:
Hosp Univ Fuenlabrada, Dept Gastroenterol, Madrid, Spain
Inst Invest Sanitaria Hosp La Paz IdiPaz, Madrid, Spain
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