Anti-HMGCR Specificity of HALIP: A Confirmatory Study
Por:
Baucells, A, Martinez, MA, Alvarado-Cardenas, M, Mariscal, A, Martinez-Martinez, L, Juarez, C, Selva-O'Callaghan, A
Publicada:
16 jul 2020
Resumen:
A distinctive new indirect immunofluorescence pattern in liver tissue has been associated with anti-HMGCR autoantibodies. It is known as HALIP (HMGCR Associated Liver Immunofluorescence Pattern). In this study, we furthered the original studies to demonstrate the association of anti-HMGCR antibodies with the HALIP. Human anti-HMGCR antibodies from patients' sera were purified and incubated with rat triple tissue (kidney/stomach/liver). A characteristic HALIP was observed. Additionally, a colocalization assay of human anti-HMGCR antibodies with rabbit polyclonal anti-HMGCR antibodies showed colocalization of both immunofluorescence patterns. This study confirms that the HALIP is due to human anti-HMGCR antibodies.
Filiaciones:
Baucells, A:
Hosp Santa Creu & Sant Pau, Immunol Dept, Barcelona 08041, Spain
Martinez, MA:
Hosp Santa Creu & Sant Pau, Immunol Dept, Barcelona 08041, Spain
Alvarado-Cardenas, M:
Univ Autonoma Barcelona, Hosp Vall dHebron, Med Dept, Syst Autoimmune Dis Unit, Barcelona, Spain
Mariscal, A:
Hosp Santa Creu & Sant Pau, Immunol Dept, Barcelona 08041, Spain
Martinez-Martinez, L:
Hosp Santa Creu & Sant Pau, Immunol Dept, Barcelona 08041, Spain
Juarez, C:
Hosp Santa Creu & Sant Pau, Immunol Dept, Barcelona 08041, Spain
Selva-O'Callaghan, A:
Univ Autonoma Barcelona, Hosp Vall dHebron, Med Dept, Syst Autoimmune Dis Unit, Barcelona, Spain
Gold, Green Published
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