Transferability of European-derived Alzheimer's disease polygenic risk scores across multiancestry populations

Por: Nicolas, A, Sherva, R, Grenier-Boley, B, Kim, Y, Kikuchi, M, Timsina, J, de Rojas, I, Dalmasso, MC, Zhou, XP, Le Guen, Y, Arboleda-Bustos, CE, Bicalho, MAC, Guerchet, M, van der Lee, S, Goss, M, Castillo, A, Bellenguez, C, Küçükali, F, Satizabal, CL, Fongang, B, Yang, Q, Peters, O, Schneider, A, Dichgans, M, Rujescu, D, Scherbaum, N, Deckert, J, Riedel-Heller, S, Hausner, L, Molina-Porcel, L, Duezel, E, Grimmer, T, Wiltfang, J, Heilmann-Heimbach, S, Moebus, S, Tegos, T, Scarmeas, N, Dols-Icardo, O, Moreno, F, Pérez-Tur, J, Bullido, MJ, Pastor, P, Sánchez-Valle, R, Alvarez, V, Cao, H, Ip, NY, Fu, AKY, Ip, FCF, Olivar, N, Muchnik, C, Cuesta, C, Campanelli, L, Solis, P, Politis, DG, Kochen, S, Brusco, LI, Boada, M, García-González, P, Puerta, R, Mir, P, Real, LM, Pinol-Ripoll, G, García-Alberca, JM, Royo, JL, Rodriguez-Rodriguez, E, Soininen, H, Heikkinen, S, de Mendonça, A, Mehrabian, S, Traykov, L, Hort, J, Vyhnalek, M, Rasmussen, KL, Thomassen, JQ, Pijnenburg, YAL, Holstege, H, van Swieten, JC, Seelaar, H, Claassen, JAHR, Jansen, WJ, Ramakers, I, Verhey, F, van der Lugt, A, Scheltens, P, Ortega-Rojas, J, Mera, AGC, Mahecha, MF, Pardo, R, Arboleda, G, Bahrami, S, Fominykh, V, Selbaek, G, Graff, C, Papenberg, G, Giedraitis, V, Boland, A, Deleuze, JF, de Marco, LA, de Moraes, EN, Viana, BD, Cintra, MTG, Juarez-Cedillo, T, Griswold, AJ, Forund, T, Haines, J, Farrer, L, Destefano, A, Wijsman, E, Mayeux, R, Pericak-Vance, M, Kunkle, B, Goate, A, Schellenberg, GD, Vardarajan, B, Wang, LS, Leung, YY, Dalgard, CL, Nicolas, G, Wallon, D, Dufouil, C, Pasquier, F, Hanon, O, Debette, S, Gruenblatt, E, Popp, J, Angel, B, Gloger, S, Chacon, MV, Aranguiz, R, Orellana, P, Slachevsky, A, Gonzalez-Billault, C, Albala, C, Fuentes, P, Sachdev, P, Mather, KA, Hauger, RL, Merritt, V, Panizzon, M, Zhang, R, Gaziano, JM, Ghidoni, R, Galimberti, D, Arosio, B, Mecocci, P, Solfrizzi, V, Parnetti, L, Squassina, A, Tremolizzo, L, Borroni, B, Nacmias, B, Caffarra, P, Seripa, D, Rainero, I, Daniele, A, Piras, F, Leonard, HL, Yokoyama, JS, Nalls, MA, Miyashita, A, Hara, N, Ozaki, K, Niida, S, Williams, J, Masullo, C, Amouyel, P, Preux, PM, Mbelesso, P, Bandzouzi, B, Saykin, A, Jessen, F, Kehoe, PG, Van Duijn, C, Ben Salem, N, Frikke-Schmidt, R, Cherni, L, Greicius, MD, Tsolaki, M, Sánchez-Juan, P, Silva, MAR, Porter, T, Laws, SM, Sleegers, K, Ingelsson, M, Dartigues, JF, Seshadri, S, Rossi, G, Morelli, L, Hiltunen, M, Sims, R, van der Flier, W, Andreassen, OA, Arboleda, H, Cruchaga, C, Escott-Price, V, Ruiz, A, Lee, KH, Ikeuchi, T, Ramirez, A, Gim, J, Logue, M, Lambert, JC

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Publicada: 1 jul 2025 Ahead of Print: 1 jun 2025

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Filiaciones:
Nicolas, A:
 Univ Lille, RID AGE Facteurs Risque & Determinants Mol Maladi, Inst Pasteur Lille, Inserm,CHU Lille, Lille, France

 Sorbonne Univ, Hop Pitie La Salpetriere, AP HP, Inst Cerveau,Paris Brain Inst,ICM,CNRS,Inserm, Paris, France

Sherva, R:
 VA Boston Healthcare Syst, Behav Sci Div, Natl Ctr PTSD, Boston, MA USA

 Boston Univ, Dept Med Biomed Genet, Boston, MA USA

Grenier-Boley, B:
 Univ Lille, RID AGE Facteurs Risque & Determinants Mol Maladi, Inst Pasteur Lille, Inserm,CHU Lille, Lille, France

Kim, Y:
 Chosun Univ, BK FOUR Dept Integrat Biol Sci, Gwangju, South Korea

Kikuchi, M:
 Univ Tokyo, Grad Sch Frontier Sci, Tokyo, Japan

Timsina, J:
 Washington Univ, Dept Psychiat, Sch Med, St Louis, MO USA

 Washington Univ, NeuroGenom & Informat Ctr, Sch Med, St Louis, MO USA

de Rojas, I:
 Univ Int Catalunya, Ace Alzheimer Ctr Barcelona, Barcelona, Spain

 Natl Inst Hlth Carlos III, CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain

Dalmasso, MC:
 Univ Cologne, Fac Med, Dept Psychiat & Psychotherapy, Cologne, Germany

 Univ Cologne, Univ Hosp Cologne, Div Neurogenet & Mol Psychiat, Cologne, Germany

 UNAJ, Neurosci & Complex Syst Unit ENyS, CONICET, HEC, Santiago, Chile

Zhou, XP:
 Hong Kong Univ Sci & Technol, Div Life Sci, State Key Lab Mol Neurosci, Mol Neurosci Ctr,Kowloon, Hong Kong, Peoples R China

 Hong Kong Ctr Neurodegenerat Dis, Hong Kong, Peoples R China

 Shenzhen Hong Kong Inst Brain Sci, HKUST Shenzhen Res Inst, Guangdong Prov Key Lab Brain Sci Dis & Drug Dev, Shenzhen, Peoples R China

Le Guen, Y:
 Stanford Univ, Dept Neurol & Neurol Sci, Sch Med, Stanford, CA USA

 Paris Brain Inst ICM, Inst Cerveau, Paris, France

Arboleda-Bustos, CE:
 Univ Nacl Colombia, Sch Med, Neurosci Grp, Bogota, Colombia

 Univ Nacl Colombia, Sch Med, Cell Death Res Grp, Bogota, Colombia

 Univ Nacl Colombia, Genet Inst, Neurosci Grp, Bogota, Colombia

 Univ Nacl Colombia, Genet Inst, Cell Death Res Grp, Bogota, Colombia

Bicalho, MAC:
 Fed Univ Minas Gerais UFMG, Dept Clin Med, Belo Horizonte, MG, Brazil

 Fed Univ Minas Geraes, Natl Inst Sci & Technol INCT Neurotec R, Belo Horizonte, MG, Brazil

 Univ Fed Minas Gerais, Geriatr Serv, Univ Hosp, Belo Horizonte, MG, Brazil

Guerchet, M:
 Univ Limoges, EpiMaCT Epidemiol Chron Dis Trop Zone, Inst Epidemiol & Trop Neurol, Inserm,U1094,IRD,UMR270,CHU Limoges,OmegaHlth, Limoges, France

van der Lee, S:
 Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Dept Neurol, Amsterdam Neurosci,Amsterdam UMC, Amsterdam, Netherlands

 Vrije Univ, Dept Complex Trait Genet, Ctr Neurogen & Cognit Res, Amsterdam Neurosci, Amsterdam, Netherlands

Goss, M:
 Glenn Biggs Inst Alzheimers & Neurodegenerat Dis, San Antonio, TX USA

Castillo, A:
 Cardiff Univ, Sch Med, Div Psychol Med & Clin Neurosci, Cardiff, Wales

Bellenguez, C:
 Univ Lille, RID AGE Facteurs Risque & Determinants Mol Maladi, Inst Pasteur Lille, Inserm,CHU Lille, Lille, France

Küçükali, F:
 VIB, VIB Ctr Mol Neurol, Complex Genet Alzheimers Dis Grp, Antwerp, Belgium

 Univ Antwerp, Dept Biomed Sci, Antwerp, Belgium

Satizabal, CL:
 Glenn Biggs Inst Alzheimers & Neurodegenerat Dis, San Antonio, TX USA

 Boston Univ, Boston, MA USA

 NHLBIs Framingham Heart Study, Boston, MA USA

 Boston Univ, Dept Neurol, Sch Med, Boston, MA USA

Fongang, B:
 Glenn Biggs Inst Alzheimers & Neurodegenerat Dis, San Antonio, TX USA

 Univ Texas Hlth Sci Ctr San Antonio, Dept Biochem & Struct Biol, San Antonio, TX USA

 Univ Texas Hlth Sci Ctr San Antonio, Dept Populat Hlth Sci, San Antonio, TX USA

Yang, Q:
 Boston Univ, Boston, MA USA

 NHLBIs Framingham Heart Study, Boston, MA USA

 Boston Univ, Dept Neurol, Sch Med, Boston, MA USA

Peters, O:
 German Ctr Neurodegenerat Dis DZNE, Berlin, Germany

 Charite Univ Med Berlin, Inst Psychiat & Psychotherapy, Berlin, Germany

 Free Univ Berlin, Berlin, Germany

 Humboldt Univ, Berlin, Germany

 Berlin Inst Hlth, Berlin, Germany

Schneider, A:
 German Ctr Neurodegenerat Dis DZNE, Bonn, Germany

 Univ Hosp Bonn, Dept Neurodegenerat Dis & Geriatr Psychiat, Bonn, Germany

Dichgans, M:
 Ludwig Maximilians Univ Munchen, Univ Hosp, Inst Stroke & Dementia Res ISD, Munich, Germany

 German Ctr Neurodegenerat Dis DZNE, Munich, Germany

 Munich Cluster Syst Neurol SyNergy, Munich, Germany

Rujescu, D:
 Med Univ Vienna, Dept Psychiat, Vienna, Austria

 Med Univ Vienna, Comprehens Ctr Neurosci & Mental Hlth, Vienna, Austria

Scherbaum, N:
 Univ Duisburg Essen, Fac Med, LVR Univ Hosp Essen, Dept Psychiat & Psychotherapy, Essen, Germany

Deckert, J:
 Univ Hosp Wurzburg, Ctr Mental Hlth, Dept Psychiat Psychosomat & Psychotherapy, Wurzburg, Germany

Riedel-Heller, S:
 Univ Leipzig, Inst Social Med Occupat Hlth & Publ Hlth, Leipzig, Germany

Hausner, L:
 Heidelberg Univ, Fac Mannheim, Cent Inst Mental Hlth Mannheim, Dept Geriatr Psychiat, Heidelberg, Germany

Molina-Porcel, L:
 Hosp Clin Barcelona, Neurol Tissue Bank Biobanc, FRCB, IDIBAPS, Barcelona, Spain

 Hosp Clin Barcelona, Dept Neurol, Alzheimers Dis & Other Cognit Disorders Unit, Barcelona, Spain

Duezel, E:
 German Ctr Neurodegenerat Dis DZNE, Magdeburg, Germany

 Otto Von Guericke Univ, Inst Cognit Neurol & Dementia Res IKND, Magdeburg, Germany

Grimmer, T:
 Tech Univ Munich, Sch Med, Ctr Cognit Disorders, Dept Psychiat & Psychotherapy, Munich, Germany

Wiltfang, J:
 Univ Med Ctr Goettingen, Dept Psychiat & Psychotherapy, Gottingen, Germany

 German Ctr Neurodegenerat Dis DZNE, Gottingen, Germany

 iBiMED, Med Sci Dept, Aveiro, Portugal

Heilmann-Heimbach, S:
 Univ Bonn, Sch Med, Inst Human Genet, Bonn, Germany

 Univ Hosp Bonn, Bonn, Germany

Moebus, S:
 Univ Duisburg Essen, Univ Hosp Essen, Inst Urban Publ Hlth, Essen, Germany

Tegos, T:
 Aristotle Univ Thessaloniki, Sch Med, Dept Neurol 1, Thessaloniki, Greece

Scarmeas, N:
 Natl & Kapodistrian Univ Athens, Sch Med, Aiginit Hosp, Dept Neurol 1, Athens, Greece

 Columbia Univ, Dept Neurol, New York, NY USA

Dols-Icardo, O:
 Natl Inst Hlth Carlos III, CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain

 IIB St Pau, Genet Neurodegenerat Dis Unit, Barcelona, Spain

Moreno, F:
 Natl Inst Hlth Carlos III, CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain

 Hosp Univ Donostia, Dept Neurol, San Sebastian, Spain

 Inst Biogipuzkoa, Neurosci Area, San Sebastian, Spain

Pérez-Tur, J:
 Natl Inst Hlth Carlos III, CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain

 Inst Biomed Valencia, CSIC, Unitat Genet Mol, Valencia, Spain

Bullido, MJ:
 Natl Inst Hlth Carlos III, CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain

 UAM, CSIC, Ctr Biol Mol Severo Ochoa, Madrid, Spain

 Hosp la Paz IdIPaz, Inst Invest Sanitaria, Madrid, Spain

 Univ Autonoma Madrid, Madrid, Spain

Pastor, P:
 Univ Hosp Germans Trias & Pujol, Unit Neurodegenerat Dis, Dept Neurol, Badalona, Spain

 Germans Trias & Pujol Res Inst IGTP, Badalona, Spain

Sánchez-Valle, R:
 Univ Barcelona, Alzheimers Dis & Other Cognit Disorders Unit, Inst Invest Biomed August Pi & Sunyer, Serv Neurol,Hosp Clin Barcelona, Barcelona, Spain

Alvarez, V:
 Hosp Univ Cent Asturias, Lab Genet, Oviedo, Spain

 Inst Invest Sanitaria Principado Asturias ISPA, Oviedo, Spain

Cao, H:
 Hong Kong Univ Sci & Technol, Div Life Sci, State Key Lab Mol Neurosci, Mol Neurosci Ctr,Kowloon, Hong Kong, Peoples R China

Ip, NY:
 Hong Kong Univ Sci & Technol, Div Life Sci, State Key Lab Mol Neurosci, Mol Neurosci Ctr,Kowloon, Hong Kong, Peoples R China

 Hong Kong Ctr Neurodegenerat Dis, Hong Kong, Peoples R China

 Shenzhen Hong Kong Inst Brain Sci, HKUST Shenzhen Res Inst, Guangdong Prov Key Lab Brain Sci Dis & Drug Dev, Shenzhen, Peoples R China

Fu, AKY:
 Hong Kong Univ Sci & Technol, Div Life Sci, State Key Lab Mol Neurosci, Mol Neurosci Ctr,Kowloon, Hong Kong, Peoples R China

 Hong Kong Ctr Neurodegenerat Dis, Hong Kong, Peoples R China

 Shenzhen Hong Kong Inst Brain Sci, HKUST Shenzhen Res Inst, Guangdong Prov Key Lab Brain Sci Dis & Drug Dev, Shenzhen, Peoples R China

Ip, FCF:
 Hong Kong Ctr Neurodegenerat Dis, Hong Kong, Peoples R China

 Shenzhen Hong Kong Inst Brain Sci, HKUST Shenzhen Res Inst, Guangdong Prov Key Lab Brain Sci Dis & Drug Dev, Shenzhen, Peoples R China

Olivar, N:
 Univ Buenos Aires, Sch Med, Ctr Neuropsychiat & Behav Neurol, Buenos Aires, DF, Argentina

Muchnik, C:
 Univ Buenos Aires, Sch Med, Ctr Neuropsychiat & Behav Neurol, Buenos Aires, DF, Argentina

Cuesta, C:
 Hosp Interzonal Gen Agudos Eva Peron, Buenos Aires, DF, Argentina

Campanelli, L:
 Fdn Inst Leloir IIBBA, Lab Brain Aging & Neurodegenerat, Buenos Aires, DF, Argentina

Solis, P:
 UNAJ, Studies Neurosci & Complex Syst Unit, CONICET, HEC, Buenos Aires, DF, Argentina

Politis, DG:
 Hosp Interzonal Gen Agudos Eva Peron, Buenos Aires, DF, Argentina

Kochen, S:
 UNAJ, Studies Neurosci & Complex Syst Unit, CONICET, HEC, Buenos Aires, DF, Argentina

Brusco, LI:
 Univ Buenos Aires, Sch Med, Ctr Neuropsychiat & Behav Neurol, Buenos Aires, DF, Argentina

Boada, M:
 Univ Int Catalunya, Ace Alzheimer Ctr Barcelona, Barcelona, Spain

 Natl Inst Hlth Carlos III, CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain

García-González, P:
 Univ Int Catalunya, Ace Alzheimer Ctr Barcelona, Barcelona, Spain

Puerta, R:
 Univ Int Catalunya, Ace Alzheimer Ctr Barcelona, Barcelona, Spain

Mir, P:
 Natl Inst Hlth Carlos III, CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain

 Univ Seville, Inst Biomed Sevilla IBiS, Unidad Trastornos Movimiento,CSIC, Serv Neurol & Neurofisiol,Hosp Univ Virgen del Ro, Seville, Spain

Real, LM:
 Natl Inst Hlth Carlos III, CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain

 Hosp Univ Virgen de Valme, IBiS, Inst Biomed Sevilla, Seville, Spain

 Univ Seville, Fac Med, Dept Bioquim Med Biol Mol & Inmunol, Seville, Spain

Pinol-Ripoll, G:
 Hosp Univ Santa Maria Lleida, Unitat Trastorns Cognitius, Lleida, Spain

 Inst Recerca Biomed Lleida IRBLLeida, Lleida, Spain

García-Alberca, JM:
 Natl Inst Hlth Carlos III, CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain

 Andalusian Inst Neurosci, Alzheimer Res Ctr, Malaga, Spain

 Andalusian Inst Neurosci, Memory Clin, Malaga, Spain

Royo, JL:
 Univ Malaga, Fac Med, Dept Especialidades Quirurg Bioquim & Inmunol, Malaga, Spain

Rodriguez-Rodriguez, E:
 Natl Inst Hlth Carlos III, CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain

 Univ Cantabria, Marques de Valdecilla Univ Hosp, Neurol Serv, Santander, Spain

 IDIVAL, Santander, Spain

Soininen, H:
 Univ Eastern Finland, Inst Clin Med Neurol, Kuopio, Finland

Heikkinen, S:
 Univ Eastern Finland, Inst Biomed, Kuopio, Finland

de Mendonça, A:
 Univ Lisbon, Fac Med, Lisbon, Portugal

Mehrabian, S:
 Med Univ, Clin Neurol, UH Alexandrovska, Sofia, Bulgaria

Traykov, L:
 Med Univ, Dept Neurol, UH Alexandrovska, Sofia, Bulgaria

Hort, J:
 Charles Univ Prague, Fac Med 2, Memory Clin, Dept Neurol, Brno, Czech Republic

 Motol Univ Hosp, Brno, Czech Republic

 St Annes Univ Hosp Brno, Int Clin Res Ctr, Brno, Czech Republic

Vyhnalek, M:
 Charles Univ Prague, Fac Med 2, Memory Clin, Dept Neurol, Brno, Czech Republic

 Motol Univ Hosp, Brno, Czech Republic

 St Annes Univ Hosp Brno, Int Clin Res Ctr, Brno, Czech Republic

Rasmussen, KL:
 Copenhagen Univ Hosp, Rigshosp, Dept Clin Biochem, Copenhagen, Denmark

 Univ Copenhagen, Dept Clin Med, Copenhagen, Denmark

Thomassen, JQ:
 Copenhagen Univ Hosp, Rigshosp, Dept Clin Biochem, Copenhagen, Denmark

Pijnenburg, YAL:
 Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Dept Neurol, Amsterdam Neurosci,Amsterdam UMC, Amsterdam, Netherlands

Holstege, H:
 Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Dept Neurol, Amsterdam Neurosci,Amsterdam UMC, Amsterdam, Netherlands

 Vrije Univ Amsterdam Med Ctr, Dept Clin Genet, Amsterdam, Netherlands

van Swieten, JC:
 Erasmus MR, Dept Neurol, Alzheimer Ctr, Rotterdam, Netherlands

Seelaar, H:
 Erasmus MR, Dept Neurol, Alzheimer Ctr, Rotterdam, Netherlands

Claassen, JAHR:
 Radboud Univ Nijmegen Med Ctr, Res Inst Med Innovat, Dept Geriatr, Rotterdam, Netherlands

 Univ Leicester, Dept Cardiovasc Sci, Leicester, Leics, England

Jansen, WJ:
 Maastricht Univ, Alzheimer Ctr Limburg, Dept Psychiat & Neuropsychol, Maastricht, Netherlands

Ramakers, I:
 Maastricht Univ, Alzheimer Ctr Limburg, Dept Psychiat & Neuropsychol, Maastricht, Netherlands

Verhey, F:
 Maastricht Univ, Alzheimer Ctr Limburg, Dept Psychiat & Neuropsychol, Maastricht, Netherlands

van der Lugt, A:
 ErasmusMC, Dept Radiol, Rotterdam, Netherlands

Scheltens, P:
 Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Dept Neurol, Amsterdam Neurosci,Amsterdam UMC, Amsterdam, Netherlands

Ortega-Rojas, J:
 Univ Nacl Colombia, Sch Med, Neurosci Grp, Bogota, Colombia

 Univ Nacl Colombia, Sch Med, Cell Death Res Grp, Bogota, Colombia

 Univ Nacl Colombia, Genet Inst, Neurosci Grp, Bogota, Colombia

 Univ Nacl Colombia, Genet Inst, Cell Death Res Grp, Bogota, Colombia

Mera, AGC:
 Univ Nacl Colombia, Sch Med, Neurosci Grp, Bogota, Colombia

 Univ Nacl Colombia, Sch Med, Cell Death Res Grp, Bogota, Colombia

 Univ Nacl Colombia, Genet Inst, Neurosci Grp, Bogota, Colombia

 Univ Nacl Colombia, Genet Inst, Cell Death Res Grp, Bogota, Colombia

Mahecha, MF:
 Univ Nacl Colombia, Sch Med, Neurosci Grp, Bogota, Colombia

 Univ Nacl Colombia, Sch Med, Cell Death Res Grp, Bogota, Colombia

 Univ Nacl Colombia, Genet Inst, Neurosci Grp, Bogota, Colombia

 Univ Nacl Colombia, Genet Inst, Cell Death Res Grp, Bogota, Colombia

Pardo, R:
 Univ Nacl Colombia, Sch Med, Neurosci Grp, Bogota, Colombia

 Univ Nacl Colombia, Sch Med, Cell Death Res Grp, Bogota, Colombia

 Univ Nacl Colombia, Genet Inst, Neurosci Grp, Bogota, Colombia

 Univ Nacl Colombia, Genet Inst, Cell Death Res Grp, Bogota, Colombia

Arboleda, G:
 Univ Nacl Colombia, Sch Med, Neurosci Grp, Bogota, Colombia

 Univ Nacl Colombia, Sch Med, Cell Death Res Grp, Bogota, Colombia

 Univ Nacl Colombia, Genet Inst, Neurosci Grp, Bogota, Colombia

 Univ Nacl Colombia, Genet Inst, Cell Death Res Grp, Bogota, Colombia

Bahrami, S:
 Oslo Univ Hosp, NORMENT Ctr, Div Mental Hlth & Addict, Oslo, Norway

 Univ Oslo, Inst Clin Med, Oslo, Norway

Fominykh, V:
 Oslo Univ Hosp, NORMENT Ctr, Div Mental Hlth & Addict, Oslo, Norway

 Univ Oslo, Inst Clin Med, Oslo, Norway

Selbaek, G:
 Vestfold Hosp Trust, Norwegian Ctr Ageing & Hlth, Tonsberg, Norway

 Univ Oslo, Fac Med, Oslo, Norway

 Oslo Univ Hosp, Dept Geriatr Med, Oslo, Norway

 Univ Tunis El Manar, Fac Sci Tunis, Lab Genet Immunol & Human Pathol, Tunis, Tunisia

Graff, C:
 Karolinska Univ Hosp Solna, Unit Hereditary Dementias, Theme Aging, Stockholm, Sweden

Papenberg, G:
 Karolinska Inst, Aging Res Ctr, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden

 Stockholm Univ, Stockholm, Sweden

Giedraitis, V:
 Uppsala Univ, Dept Publ Hlth & Carins Sci Geriatr, Uppsala, Sweden

Boland, A:
 Univ Paris Saclay, Ctr Natl Rech Genom Humaine CNRGH, CEA, Evry, France

Deleuze, JF:
 Univ Paris Saclay, Ctr Natl Rech Genom Humaine CNRGH, CEA, Evry, France

de Marco, LA:
 Fed Univ Minas Geraes, Natl Inst Sci & Technol INCT Neurotec R, Belo Horizonte, MG, Brazil

 Fed Univ Minas Gerais UFMG, Dept Surg, Belo Horizonte, MG, Brazil

de Moraes, EN:
 Fed Univ Minas Gerais UFMG, Dept Clin Med, Belo Horizonte, MG, Brazil

 Univ Fed Minas Gerais, Geriatr Serv, Univ Hosp, Belo Horizonte, MG, Brazil

Viana, BD:
 Fed Univ Minas Geraes, Natl Inst Sci & Technol INCT Neurotec R, Belo Horizonte, MG, Brazil

 Fed Univ Minas Gerais UFMG, Dept Psychiat, Belo Horizonte, MG, Brazil

 Univ Fed Minas Gerais, Univ Hosp, Psychiat Serv, Belo Horizonte, MG, Brazil

Cintra, MTG:
 Fed Univ Minas Gerais UFMG, Dept Clin Med, Belo Horizonte, MG, Brazil

 Univ Fed Minas Gerais, Geriatr Serv, Univ Hosp, Belo Horizonte, MG, Brazil

Juarez-Cedillo, T:
 Inst Mexicano Seguro Social, Ctr Med Nacl Siglo XXI, Area Envejecimiento, Unidad Invest Epidemiol & Serv Salud, Mexico City, DF, Mexico

Griswold, AJ:
 Univ Miami, John P Hussman Inst Human Genom, Miami, FL USA

Forund, T:
 Indiana Univ, Dept Med & Mol Genet, Indianapolis, IN USA

Haines, J:
 Case Western Reserve Univ, Dept Epidemiol & Biostat, Cleveland, OH USA

Farrer, L:
 Boston Univ, Dept Med Biomed Genet, Boston, MA USA

 Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA

 Boston Univ, Dept Epidemiol, Boston, MA USA

 Boston Univ, Dept Neurol, Boston, MA USA

 Boston Univ, Dept Ophthalmol, Boston, MA USA

Destefano, A:
 Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA

Wijsman, E:
 Univ Washington, Dept Med Med Genet, Seattle, WA USA

 Univ Washington, Dept Biostat, Seattle, WA USA

 Univ Washington, Dept Genome Sci, Seattle, WA USA

Mayeux, R:
 Columbia Univ, Taub Inst Alzheimers Dis & Aging Brain, Dept Neurol, New York, NY USA

 Columbia Univ, Gertrude H Sergievsky Ctr, New York, NY USA

Pericak-Vance, M:
 Univ Miami, John P Hussman Inst Human Genom, Miami, FL USA

 Univ Miami, Dept Human Genet, Dr John T Macdonald Fdn, Miami, FL USA

Kunkle, B:
 Univ Miami, John P Hussman Inst Human Genom, Miami, FL USA

Goate, A:
 Mt Sinai Sch Med, Dept Neurosci, New York, NY USA

Schellenberg, GD:
 Univ Penn, Dept Pathol & Lab Med, Penn Neurodegenerat Genom Ctr, Perelman Sch Med, Philadelphia, PA USA

Vardarajan, B:
 Columbia Univ, Dept Neurol, New York, NY USA

 Columbia Univ, Taub Inst Alzheimers Dis & Aging Brain, Dept Neurol, New York, NY USA

 Columbia Univ, Gertrude H Sergievsky Ctr, New York, NY USA

Wang, LS:
 Univ Penn, Dept Pathol & Lab Med, Penn Neurodegenerat Genom Ctr, Perelman Sch Med, Philadelphia, PA USA

Leung, YY:
 Univ Penn, Dept Pathol & Lab Med, Penn Neurodegenerat Genom Ctr, Perelman Sch Med, Philadelphia, PA USA

Dalgard, CL:
 Uniformed Serv Univ Hlth Sci, Dept Anat Physiol & Genet, Bethesda, MD USA

 Uniformed Serv Univ Hlth Sci, Amer Genome Ctr, Ctr Mil Precis Hlth, Bethesda, MD USA

Nicolas, G:
 Normandie Univ, Univ Rouen Normandie, Inserm, Dept Genet,U1245, Rouen, France

 Normandie Univ, Univ Rouen Normandie, Inserm, CNR MAJ,U1245, Rouen, France

 CHU Rouen, Rouen, France

Wallon, D:
 Normandie Univ, Univ Rouen Normandie, Inserm, Dept Genet,U1245, Rouen, France

 Normandie Univ, Univ Rouen Normandie, Inserm, CNR MAJ,U1245, Rouen, France

 CHU Rouen, Rouen, France

Dufouil, C:
 Univ Bordeaux, Bordeaux Populat Hlth Res Ctr, Univ Bordeaux, Inserm,UMR 1219,ISPED,CIC 1401,EC, Bordeaux, France

 CHU Bordeaux, Pole Sante Publ, Bordeaux, France

Pasquier, F:
 Univ Lille, CHU Clin & Res Memory Res Ctr CMRR Distalz Lille, Inserm 1171, Paris, France

Hanon, O:
 Univ Paris, Hop Broca, AP HP, EA 4468, Paris, France

Debette, S:
 Univ Bordeaux, Bordeaux Populat Hlth Res Ctr, INSERM, Bordeaux, France

 Bordeaux Univ Hosp, Dept Neurol, Bordeaux, France

Gruenblatt, E:
 Univ Zurich, Univ Hosp Psychiat Zurich, Dept Child & Adolescent Psychiat & Psychotherapy, Zurich, Switzerland

 Univ Zurich, Neurosci Ctr Zurich, Zurich, Switzerland

 Swiss Fed Inst Technol, Zurich, Switzerland

 Univ Zurich, Zurich Ctr Integrat Human Physiol, Zurich, Switzerland

Popp, J:
 Lausanne Univ Hosp, Old Age Psychiat, Dept Psychiat, Lausanne, Switzerland

 Univ Hosp Psychiat Zurich, Dept Geriatr Psychiat, Zurich, Switzerland

 Univ Zurich, Inst Regenerat Med, Zurich, Switzerland

Angel, B:
 Univ Chile, Inst Nutr & Food Technol, Publ Hlth Nutr Unit, Santiago, Chile

 Interuniv Ctr Hlth Aging RED21993, Santiago, Chile

Gloger, S:
 Ctr Estudios Clin, Biomed Res Grp, Santiago, Chile

 Univ Chile, Fac Med, Dept Psiquiatria & Salud Mental, Campus Oriente, Santiago, Chile

Chacon, MV:
 Ctr Estudios Clin, Biomed Res Grp, Santiago, Chile

Aranguiz, R:
 Ctr Estudios Clin, Biomed Res Grp, Santiago, Chile

 Inst Nacl Geriatria, Santiago, Chile

 Clin Alemana, Dept Neurol & Psychiat, Santiago, Chile

Orellana, P:
 Gerosci Ctr Brain Hlth & Metab, Santiago, Chile

 Univ Adolfo Ibanez, Latin Amer Inst Brain Hlth BrainLat, Santiago, Chile

Slachevsky, A:
 Gerosci Ctr Brain Hlth & Metab, Santiago, Chile

 Univ Chile, Hosp Salvador, Dept Neurol, Memory & Neuropsychiat Ctr CMYN, Santiago, Chile

 Univ Chile, Fac Med, Santiago, Chile

Gonzalez-Billault, C:
 Univ Chile, Inst Nutr & Food Technol, Publ Hlth Nutr Unit, Santiago, Chile

 Gerosci Ctr Brain Hlth & Metab, Santiago, Chile

Albala, C:
 Univ Chile, Inst Nutr & Food Technol, Publ Hlth Nutr Unit, Santiago, Chile

 Interuniv Ctr Hlth Aging RED21993, Santiago, Chile

Fuentes, P:
 Univ Chile, Geriatr Sect, Clin Hosp, Santiago, Chile

 Hosp Salvador, Neurol Serv, Santiago, Chile

Sachdev, P:
 Univ New South Wales, Sch Psychiat, Fac Med, Ctr Hlth Brain Ageing, Sydney, NSW, Australia

Mather, KA:
 Univ New South Wales, Sch Psychiat, Fac Med, Ctr Hlth Brain Ageing, Sydney, NSW, Australia

Hauger, RL:
 VA San Diego Healthcare Syst, Ctr Excellence Stress & Mental Hlth CESAMH, San Diego, CA USA

 Univ Calif San Diego, Ctr Behav Genet Aging, La Jolla, CA USA

Merritt, V:
 VA San Diego Healthcare Syst, San Diego, CA USA

 Univ Calif San Diego, Dept Psychiat, La Jolla, CA USA

 VA San Diego Healthcare Syst, Ctr Excellence Stress & Mental Hlth, San Diego, CA USA

Panizzon, M:
 Univ Calif San Diego, Ctr Behav Genet Aging, La Jolla, CA USA

 Univ Calif San Diego, Dept Psychiat, La Jolla, CA USA

 VA San Diego Healthcare Syst, Ctr Excellence Stress & Mental Hlth, San Diego, CA USA

Zhang, R:
 VA Boston Healthcare Syst, Behav Sci Div, Natl Ctr PTSD, Boston, MA USA

Gaziano, JM:
 VA Boston Healthcare Syst, Massachusetts Vet Epidemiol Res & Informat Ctr MA, Boston, MA USA

 Harvard Med Sch, Brigham & Womens Hosp, Div Aging, Boston, MA USA

Ghidoni, R:
 IRCCS Ist Ctr San Giovanni Dio Fatebenefratell, Mol Markers Lab, Brescia, Italy

Galimberti, D:
 Fdn IRCCS Ca Granda, Osped Policlin, Neurodegenerat Dis Unit, Milan, Italy

 Univ Milan, Dept Biomed Surg & Dent Sci, Milan, Italy

Arosio, B:
 Univ Milan, Dept Clin Sci & Community Hlth, Milan, Italy

Mecocci, P:
 Univ Perugia, Dept Med & Surg, Inst Gerontol & Geriatr, Perugia, Italy

 Karolinska Inst, Div Clin Geriatr, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden

Solfrizzi, V:
 Univ Bari A Moro, Geriatr Med & Memory Unit, Interdisciplinary Dept Med, Bari, Italy

Parnetti, L:
 Univ Perugia, Neurol Sect, Lab Clin Neurochemistry, Ctr Memory Disturbances, Perugia, Italy

Squassina, A:
 Univ Cagliari, Dept Biomed Sci, Cagliari, Italy

Tremolizzo, L:
 Monza & Univ Milano Bicocca, IRCCS San Gerardo Tintori, Neurol, Milan, Italy

Borroni, B:
 Univ Brescia Italy, Dept Clin & Expt Sci, Brescia, Italy

 ASST Spedali Civili Brescia, Dept Continu Care & Frailty, Brescia, Italy

Nacmias, B:
 Univ Florence, Dept Neurosci Psychol Drug Res & Child Hlth, Florence, Italy

 IRCCS Fdn Don Carlo Gnocchi, Florence, Italy

Caffarra, P:
 Univ Parma, Dementia Unit, Parma, Italy

Seripa, D:
 Vito Fazzi Hosp, Dept Hematol & Stem Cell Transplant, Lecce, Italy

Rainero, I:
 Univ Torino, Dept Neurosci Rita Levi Montalcini, Turin, Italy

Daniele, A:
 Univ Cattolica Sacro Cuore, Dept Neurosci, Rome, Italy

 IRCCS Fdn Policlin Univ A Gemelli, Neurol Unit, Rome, Italy

Piras, F:
 IRCCS Santa Lucia Fdn, Lab Neuropsychiat, Rome, Italy

Leonard, HL:
 NIH, Ctr Alzheimers & Related Dementias, Bethesda, MD USA

 DataTecn LLC, Washington, DC USA

Yokoyama, JS:
 DataTecn LLC, Washington, DC USA

 Univ Calif San Francisco, Weill Inst Neurosci, Memory & Aging Ctr, Dept Neurol, San Francisco, CA USA

 Univ Calif San Francisco, Pharmaceut Sci & Pharmacogen Grad Program, San Francisco, CA USA

 Univ Calif San Francisco, Dept Radiol & Biomed Imaging, San Francisco, CA USA

Nalls, MA:
 NIH, Ctr Alzheimers & Related Dementias, Bethesda, MD USA

 DataTecn LLC, Washington, DC USA

 NIH, Lab Neurogenet, Bethesda, MD USA

Miyashita, A:
 Niigata Univ, Brain Res Inst, Niigata, Japan

Hara, N:
 Niigata Univ, Brain Res Inst, Niigata, Japan

Ozaki, K:
 Natl Ctr Geriatr & Gerontol, Res Ctr, Obu, Japan

Niida, S:
 Natl Ctr Geriatr & Gerontol, Res Ctr, Obu, Japan

Williams, J:
 Cardiff Univ, Sch Med, Div Psychol Med & Clin Neurosci, Cardiff, Wales

 Cardiff Univ, UK Dementia Res Inst, Cardiff, Wales

Masullo, C:
 Univ Cattolica Sacro Cuore, Inst Neurol, Rome, Italy

Amouyel, P:
 Univ Lille, RID AGE Facteurs Risque & Determinants Mol Maladi, Inst Pasteur Lille, Inserm,CHU Lille, Lille, France

Preux, PM:
 Univ Limoges, EpiMaCT Epidemiol Chron Dis Trop Zone, Inst Epidemiol & Trop Neurol, Inserm,U1094,IRD,UMR270,CHU Limoges,OmegaHlth, Limoges, France

Mbelesso, P:
 Univ Limoges, EpiMaCT Epidemiol Chron Dis Trop Zone, Inst Epidemiol & Trop Neurol, Inserm,U1094,IRD,UMR270,CHU Limoges,OmegaHlth, Limoges, France

 Amitie Hosp, Dept Neurol, Bangui, Cent Afr Republ

Bandzouzi, B:
 Brazzaville Univ Hosp, Dept Neurol, Brazzaville, Rep Congo

Saykin, A:
 Indiana Univ, Dept Med & Mol Genet, Indianapolis, IN USA

 Indiana Univ, Dept Radiol, Indianapolis, IN USA

Jessen, F:
 Univ Cologne, Fac Med, Dept Psychiat & Psychotherapy, Cologne, Germany

 German Ctr Neurodegenerat Dis DZNE, Bonn, Germany

 Univ Cologne, Univ Hosp Cologne, Cologne, Germany

 Univ Cologne, Cluster Excellence Cellular Stress Responses Agin, Cologne, Germany

Kehoe, PG:
 Univ Bristol, Bristol Med Sch, Translat Hlth Sci, Bristol, Avon, England

Van Duijn, C:
 ErasmusMC, Dept Epidemiol, Rotterdam, Netherlands

 Univ Oxford, Nuffield Dept Populat Hlth, Oxford, England

Ben Salem, N:
 Univ Monastir, High Inst Biotechnol, Monastir, Tunisia

Frikke-Schmidt, R:
 Copenhagen Univ Hosp, Rigshosp, Dept Clin Biochem, Copenhagen, Denmark

 Univ Copenhagen, Dept Clin Med, Copenhagen, Denmark

Cherni, L:
 Univ Monastir, High Inst Biotechnol, Monastir, Tunisia

Greicius, MD:
 Stanford Univ, Dept Neurol & Neurol Sci, Sch Med, Stanford, CA USA

Tsolaki, M:
 Aristotle Univ Thessaloniki, Sch Med, Dept Neurol 1, Thessaloniki, Greece

Sánchez-Juan, P:
 Natl Inst Hlth Carlos III, CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain

 ISCIII, CIEN Fdn, Alzheimers Ctr Reina Sofia, Madrid, Spain

Silva, MAR:
 Fed Univ Minas Geraes, Natl Inst Sci & Technol INCT Neurotec R, Belo Horizonte, MG, Brazil

 Fed Univ Minas Gerais UFMG, Dept Psychiat, Belo Horizonte, MG, Brazil

Porter, T:
 Edith Cowan Univ, Ctr Precis Hlth, Perth, WA, Australia

 Edith Cowan Univ, Sch Med & Hlth Sci, Collaborat Genom & Translat Grp, Perth, WA, Australia

 Curtin Univ, Curtin Hlth Innovat Res Inst, Perth, WA, Australia

Laws, SM:
 Edith Cowan Univ, Ctr Precis Hlth, Perth, WA, Australia

 Edith Cowan Univ, Sch Med & Hlth Sci, Collaborat Genom & Translat Grp, Perth, WA, Australia

 Curtin Univ, Curtin Hlth Innovat Res Inst, Perth, WA, Australia

Sleegers, K:
 VIB, VIB Ctr Mol Neurol, Complex Genet Alzheimers Dis Grp, Antwerp, Belgium

 Univ Antwerp, Dept Biomed Sci, Antwerp, Belgium

Ingelsson, M:
 Uppsala Univ, Dept Publ Hlth & Caring Sci Geriatr, Uppsala, Sweden

 Univ Hlth Network, Krembil Brain Inst, Toronto, ON, Canada

 Univ Toronto, Tanz Ctr Res Neurodegenerat Dis, Dept Med, Toronto, ON, Canada

Dartigues, JF:
 INSERM, Bordeaux Populat Hlth Res Ctr, Bordeaux UMR 1219, Bordeaux, France

Seshadri, S:
 Glenn Biggs Inst Alzheimers & Neurodegenerat Dis, San Antonio, TX USA

 Boston Univ, Boston, MA USA

 NHLBIs Framingham Heart Study, Boston, MA USA

 Boston Univ, Dept Neurol, Sch Med, Boston, MA USA

Rossi, G:
 Fdn IRCCS Ist Neurol Carlo Besta, Milan, Italy

Morelli, L:
 Fdn Inst Leloir IIBBA, Lab Brain Aging & Neurodegenerat, Buenos Aires, DF, Argentina

Hiltunen, M:
 Univ Eastern Finland, Inst Biomed, Kuopio, Finland

Sims, R:
 Cardiff Univ, Sch Med, Div Psychol Med & Clin Neurosci, Cardiff, Wales

van der Flier, W:
 Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Dept Neurol, Amsterdam Neurosci,Amsterdam UMC, Amsterdam, Netherlands

Andreassen, OA:
 Oslo Univ Hosp, NORMENT Ctr, Div Mental Hlth & Addict, Oslo, Norway

 Univ Oslo, Inst Clin Med, Oslo, Norway

Arboleda, H:
 Univ Nacl Colombia, Sch Med, Neurosci Grp, Bogota, Colombia

 Univ Nacl Colombia, Sch Med, Cell Death Res Grp, Bogota, Colombia

 Univ Nacl Colombia, Genet Inst, Neurosci Grp, Bogota, Colombia

 Univ Nacl Colombia, Genet Inst, Cell Death Res Grp, Bogota, Colombia

Cruchaga, C:
 Washington Univ, Dept Psychiat, Sch Med, St Louis, MO USA

 Washington Univ, NeuroGenom & Informat Ctr, Sch Med, St Louis, MO USA

Escott-Price, V:
 Cardiff Univ, UK Dementia Res Inst, Cardiff, Wales

 Cardiff Univ, Sch Med, Ctr Neuropsychiat Genet & Genom, Cardiff, Wales

Ruiz, A:
 Univ Int Catalunya, Ace Alzheimer Ctr Barcelona, Barcelona, Spain

 Natl Inst Hlth Carlos III, CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Madrid, Spain

 Univ Texas Hlth Sci Ctr San Antonio, Glenn Biggs Inst Alzheimers & Neurodegenerat Dis, San Antonio, TX USA

Lee, KH:
 Chosun Univ, BK FOUR Dept Integrat Biol Sci, Gwangju, South Korea

 Chosun Univ, Dept Biomed Sci, Gwangju, South Korea

 Chosun Univ, Gwangju Alzheimers & Related Dementia GARD Cohort, Gwangju, South Korea

Ikeuchi, T:
 Niigata Univ, Brain Res Inst, Niigata, Japan

Ramirez, A:
 Univ Texas Hlth Sci Ctr San Antonio, Glenn Biggs Inst Alzheimers & Neurodegenerat Dis, San Antonio, TX USA

 Univ Cologne, Fac Med, Dept Psychiat & Psychotherapy, Div Neurogenet & Mol Psychiat, Cologne, Germany

 German Ctr Neurodegenerat Dis DZNE Bonn, Bonn, Germany

 Univ Hosp Bonn, Univ Bonn, Dept Old Age Psychiat & Cognit Disorders, Bonn, Germany

 Univ Cologne, Cologne Excellence Cluster Cellular Stress Respon, Cologne, Germany

Gim, J:
 Chosun Univ, BK FOUR Dept Integrat Biol Sci, Gwangju, South Korea

 Chosun Univ, Dept Biomed Sci, Gwangju, South Korea

 Chosun Univ, Gwangju Alzheimers & Related Dementia GARD Cohort, Gwangju, South Korea

Logue, M:
 VA Boston Healthcare Syst, Behav Sci Div, Natl Ctr PTSD, Boston, MA USA

 Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA

 Boston Univ, Dept Psychiat, Chobanian & Avedisian Sch Med, Boston, MA USA

 Boston Univ, Chobanian & Avedisian Sch Med, Dept Med, Biomed Genet, Boston, MA USA

Lambert, JC:
 Univ Lille, RID AGE Facteurs Risque & Determinants Mol Maladi, Inst Pasteur Lille, Inserm,CHU Lille, Lille, France