Clinical use and reporting of neurofilament quantification in neurological disorders: A global overview
Por:
Delaby, C, Ladang, A, Martinez-Yriarte, J, Zecca, C, Logroscino, G, Koertvelyessy, P, Tumani, H, Parchi, P, Quadrio, I, Hart, M, Olsen, DA, Alcolea, D, Blennow, K, Fortea, J, Lleo, A, Algeciras-Schimnich, A, Ayrignac, X, Bedel, A, Santos, GAA, Borelli, W, Bouaziz-Amar, E, Baldeiras, I, Bigot-Corbel, E, Bjerke, M, Perez, MC, Casoli, T, Chabrashvili, T, Chapman, MD, Cusato, J, Dursun, E, Fourier, A, Galimberti, D, Gezen-Ak, D, Gordon, BA, Gouju, J, Florez, SD, Sanchez, JH, Herwerth, M, Imperiale, D, Kaczorowski, F, Kasuga, K, Keshavan, A, Khalil, M, Kuhle, J, Leithner, C, Lewczuk, P, Letournel, F, Tsolaki, M, Giuffre, GM, Blanc, MC, Mroczko, B, Rodriguez, JEM, Musso, G, Kulczynska-Przybik, A, Nogueira, L, Paquet, C, Baiardi, S, Gaetani, L, Parnetti, L, Garay, RP, Poesen, K, Quillard-Muraine, M, Borja, ER, Schraen, S, Terracciano, D, Bachhuber, F, Halbgebauer, S, Tzartos, S, Tzartos, J, Unterwalder, N, Vermunt, L, Wellington, CL, Zetterberg, H, Teunissen, C, Lehmann, S
Publicada:
1 jun 2025
Resumen:
INTRODUCTIONNeurofilament light chain (NfL) quantification aids in diagnosing and predicting neurological disorders, but clinical and laboratory practices vary across centers. Differences in result interpretation and reporting further challenge test commutability. This study aimed to review the global analytical and post-analytical methods used for NfL measurement in routine clinical practice across different contexts.METHODSWe established an international working group (WG) and distributed a survey to its members to gather information on context of use (COU), (pre) analytical methods, cutoff usage, as well as the interpretation and reporting of NfL measurements.RESULTSAmong the centers, 63% measured NfL in cerebrospinal fluid (CSF), 87% in blood, and 53% in both. COU was widespread, with 50% defining pathological cutoffs based on publications and 42% considering age. Reporting was primarily done through numeric results (95%).DISCUSSIONHarmonizing cutoffs, reporting, and interpretation across various clinical contexts will facilitate the incorporation of this biomarker into routine clinical practice.Highlights Unique international overview of current analytical and post-analytical methods for neurofilament light chain (NfL) measurement in routine clinical practice. Tailored sheets for each neurological application. Strategies to harmonize cutoffs, reporting, and interpretation of NfL's measurement.
Filiaciones:
Delaby, C:
Univ Montpellier, LBPC PPC, CHU Montpellier, INSERM, Montpellier, France
Univ Autonoma Barcelona, Hosp Santa Creu iSant Pau, Biomed Res Inst St Pau, Dept Unitat Memoria, Barcelona, Spain
Ladang, A:
CHU Liege, Clin Chem Dept, Liege, Belgium
Martinez-Yriarte, J:
Hosp Meixoeiro, Clin Anal Serv, Area Sanitaria Vigo, Vigo, Spain
Zecca, C:
Univ Bari Aldo Moro, Pia Fdn Cardinale G Pan, Ctr Neurodegenerat Dis & Aging Brain, Dept Clin Res Neurol,Pia Fdn Cardinale G Panico, Tricase, Lecce, Italy
Logroscino, G:
Univ Bari Aldo Moro, Pia Fdn Cardinale G Pan, Ctr Neurodegenerat Dis & Aging Brain, Dept Clin Res Neurol,Pia Fdn Cardinale G Panico, Tricase, Lecce, Italy
Koertvelyessy, P:
Charite Univ Med Berlin, Dept Neurol, Berlin, Germany
German Ctr Neurodegenerat Dis DZNE, Dept Neurol, Magdeburg, Germany
Lab Berlin, Div Innovat, Berlin, Germany
Tumani, H:
Univ Ulm, CSF Lab, Ulm, Germany
Parchi, P:
Univ Bologna, Dept Biomed & Neuromotor Sci DIBINEM, Bologna, Italy
IRCCS Ist Sci Neurol Bologna, Dept Clin Neurobiol, Bologna, Italy
Quadrio, I:
Lyon Neurosci Res Ctr, BIORAN Team, Biochem & Mol Biol Dept, INSERM,U1028,CNRS,UMR 5292,Neurodegenerat Pathol L, Lyon, France
Hart, M:
UCL Queen Sq Inst Neurol, Dept Neuroinflammat, London, England
Olsen, DA:
Univ Hosp southern Denmark, Dept Biochem & Immunol, Univ Hosp Southern Denmark, Lillebaelt Hosp, , Southern Denmark, Odense, Denmark
Alcolea, D:
Univ Autonoma Barcelona, Hosp Santa Creu iSant Pau, Biomed Res Inst St Pau, Dept Unitat Memoria, Barcelona, Spain
CIBERNED, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Dept Neurol, Barcelona, Spain
Blennow, K:
Univ Gothenburg, Dept Clin Neurochem, Gothenburg, Sweden
Fortea, J:
Univ Autonoma Barcelona, Hosp Santa Creu iSant Pau, Biomed Res Inst St Pau, Dept Unitat Memoria, Barcelona, Spain
CIBERNED, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Dept Neurol, Barcelona, Spain
Lleo, A:
Univ Autonoma Barcelona, Hosp Santa Creu iSant Pau, Biomed Res Inst St Pau, Dept Unitat Memoria, Barcelona, Spain
CIBERNED, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Dept Neurol, Barcelona, Spain
Algeciras-Schimnich, A:
Mayo Clin, Dept Lab Med & Pathol, Rochester, MN USA
Ayrignac, X:
Univ Montpellier, Dept Neurol, CHU Montpellier, INSERM, Montpellier, France
Bedel, A:
Univ Bordeaux, Dept Biochim, CHU Bordeaux, INSERM,BRIC,U1312, Bordeaux, France
Santos, GAA:
Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Surg & Anat, Sao Paulo, Brazil
Sao Leopoldo MAND Sch Med, Dept Neurol, Araras, Brazil
Univ Estadual Campinas, Fac Food Engn, Dept Food & Nutr, Sao Paulo, Brazil
Borelli, W:
Univ Fed Rio Grande do Sul, Dept Biochem, Porto Alegre, Brazil
Bouaziz-Amar, E:
Univ Paris Cite Paris, Hop Lariboisiere Fernand Widal AP HP, Dept Biochem, UMR 8638,C TAC,COMETE, Paris, France
Baldeiras, I:
Univ Coimbra, Fac Med, Coimbra, Portugal
Univ Coimbra, Ctr Innovat Biomed & Biotechnol, Coimbra, Portugal
Bigot-Corbel, E:
CHU Nantes, Dept Biochim, Nantes, France
Bjerke, M:
Vrije Univ Brussel VUB, Univ Ziekenhuis Brussel UZ Brussel, Ctr Neurosci, Lab Clin Neurochem,Dept Clin Biol, Brussels, Belgium
Perez, MC:
Dept Neurol, , Tenerife, Santa Cruz De Tenerife, Tenerife, Spain
Casoli, T:
IRCCS INRCA, Dept Neurobiol Ageing, Ancona, Italy
Chabrashvili, T:
SUNY Upstate Med Univ, Dept Neurol, Syracuse, NY USA
Chapman, MD:
Natl Hosp Neurol & Neurosurg, Neuroimmunol & CSF Lab, London, England
Cusato, J:
UNITO, Dept Med Sci, Turin, Italy
Dursun, E:
Istanbul Univ Cerrahpasa, Inst Neurol Sci, Dept Neurosci, Istanbul, Turkiye
Fourier, A:
Lyon Neurosci Res Ctr, BIORAN Team, Biochem & Mol Biol Dept, INSERM,U1028,CNRS,UMR 5292,Neurodegenerat Pathol L, Lyon, France
Galimberti, D:
Univ Milan, Dept Biomed Surg & Dent Sci, Milan, Italy
IRCCS Fdn IRCCS CaGranda, Osped Maggiore Policlin, Milan, Italy
Gezen-Ak, D:
Istanbul Univ Cerrahpasa, Inst Neurol Sci, Dept Neurosci, Istanbul, Turkiye
Gordon, BA:
Washington Univ, Sch Med, Dept Radiol, St Louis, MO USA
Gouju, J:
Univ Angers, MINT, INSERM, CNRS 6021,SFR-ICAT,U1066, F-49333 Angers, France
Florez, SD:
Hosp Univ Nuestra Senora Candelaria Santa Cruz De, Dept Neurol, Santa Cruz de La Palma, Spain
Sanchez, JH:
Lab Referencia Catalunya, Dept Neurol, Unitat Neuroquim, Barcelona, Spain
Herwerth, M:
Univ Hosp Zurich, Neurol Dept, Zurich, Switzerland
Imperiale, D:
UNITO, Dept Med Sci, Turin, Italy
Kaczorowski, F:
Lyon Neurosci Res Ctr, BIORAN Team, Biochem & Mol Biol Dept, INSERM,U1028,CNRS,UMR 5292,Neurodegenerat Pathol L, Lyon, France
Kasuga, K:
Niigata Univ, Brain Res Inst, Dept Mol Genet, Niigata, Japan
Keshavan, A:
UCL Queen Sq Inst Neurol, Dementia Res Ctr, London, England
Khalil, M:
Med Univ Graz, Dept Neurol, Graz, Austria
Kuhle, J:
Univ Hosp Basel, Dept Neurol, Basel, Switzerland
Leithner, C:
Charite Univ Med Berlin, Dept Neurol, Berlin, Germany
Lewczuk, P:
Univ Klinikum Erlagen, Dept Psychiat & Psychotherapy, Erlangen, Germany
Med Univ Bialystok, Dept Neurodegenerat Diagnost, Bialystok, Poland
Letournel, F:
Univ Angers, MINT, INSERM, CNRS 6021,SFR-ICAT,U1066, F-49333 Angers, France
Tsolaki, M:
AHEPA Univ Hosp, Dept Neurol, Thessaloniki, Greece
Giuffre, GM:
Univ Cattolica Sacro Cuore, Dept Neurosci, Rome, Italy
Blanc, MC:
Cochin Hosp, Biochem Dept, AP HP, Paris, France
Mroczko, B:
Med Univ Bialystok, Dept Neurol, Bialystok, Poland
Rodriguez, JEM:
Hosp Mar, Serv Neurol, Neuroimmunol Grp, IMIM, Barcelona, Spain
Musso, G:
Univ Padua, Dept Med, Padua, Italy
Kulczynska-Przybik, A:
Med Univ Bialystok, Dept Neurol, Bialystok, Poland
Nogueira, L:
CHU PURPAN, UMR 5165, CNRS, Toulouse, France
Paquet, C:
Univ Paris Cite, Dept Neurol Cognit, Paris, France
Baiardi, S:
Univ Bologna, Dept Biomed & Neuromotor Sci DIBINEM, Bologna, Italy
IRCCS Ist Sci Neurol Bologna, Dept Clin Neurobiol, Bologna, Italy
Gaetani, L:
Univ Perugia, Dept Neurol, Perugia, Italy
Parnetti, L:
Univ Perugia, Dept Neurol, Perugia, Italy
Garay, RP:
Cruces Univ Hosp, Dept Clin Anal Serv, OSAKIDETZA, Immunopathol Res Grp,Biobizkaia Hlth Res Inst, Baracaldo, Spain
Poesen, K:
Katholieke Univ Leuven, Leuven Brain Inst, Alzheimer Res Ctr, Leuven, Belgium
Quillard-Muraine, M:
Rouen Univ Hosp, Clin Biol Ctr, INSERM, CIC1404, Rouen, France
Borja, ER:
Hosp Clin Univ Valencia, Lab Bioquim Clin & Patol Mol, Valencia, Spain
Schraen, S:
CHU Lille, Dept Biochem, Lille, France
Terracciano, D:
Univ Federico II, Dept Translat Med Sci, Naples, Italy
Bachhuber, F:
Univ Federico II, Dept Translat Med Sci, Naples, Italy
Halbgebauer, S:
Univ Ulm, CSF Lab, Ulm, Germany
Tzartos, S:
Tzartos NeuroDiagnost, Athens, Greece
Tzartos, J:
Natl & Kapodistrian Univ Athens, Dept Neurol, Dept Neurol 2, Athens, Greece
Unterwalder, N:
LaborBerlin, Dept Neurol, Berlin, Germany
Vermunt, L:
Vrije Univ Amsterdam, Amsterdam UMC, Amsterdam Neurosci, Alzheimer Ctr Amsterdam,Dept Neurol, Amsterdam, Netherlands
Wellington, CL:
Univ British Columbia, Dept Pathol & Lab Med, Vancouver, BC, Canada
Zetterberg, H:
Univ Gothenburg, Dept Clin Neurochem, Gothenburg, Sweden
Teunissen, C:
Vrije Univ Amsterdam, Amsterdam UMC, Amsterdam Neurosci, Alzheimer Ctr Amsterdam,Dept Neurol, Amsterdam, Netherlands
Lehmann, S:
Univ Montpellier, LBPC PPC, CHU Montpellier, INSERM, Montpellier, France
Green Submitted, Green Accepted, hybrid
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