A Spanish-Portuguese GWAS of progressive supranuclear palsy reveals a novel risk locus in NFASC
Por:
García-González, P, Lara, HR, Compta, Y, Fernandez, M, van der Lee, SJ, de Rojas, I, Saiz, L, Painous, C, Camara, A, Muñoz, E, Marti, MJ, Valldeoriola, F, Puerta, R, Illán-Gala, I, Pagonabarraga, J, Dols-Icardo, O, Kulisevsky, J, Fortea, J, Lleó, A, Olivé, C, de Boer, SCM, Hulsman, M, Pijnenburg, YAL, Belloso, RD, Muñoz-Delgado, L, Rueda, DB, Gómez-Garre, P, Aldecoa, I, Aragonés, G, Vara, JH, Mendioroz, M, Pérez-Tur, J, Visser, PJ, den Braber, A, Papma, JM, Montes, AM, Rodriguez-Rodriguez, E, Blázquez-Folch, J, Miguel, A, García-Gutiérrez, F, Cano, A, Valero, S, Marquié, M, Capdevila-Bayo, M, Rosende-Roca, M, Quintela, I, Carracedo, A, Tàrraga, L, Real, LM, Royo, JL, Erro, ME, Guerrero, C, Torres, DC, Blázquez-Estrada, M, San Millán, B, Teijeira, S, Rolan, DV, Hernández, I, Sánchez-Soblechero, A, de la Casa-Fages, B, López, SS, Baviera-Muñoz, R, Lavín, A, Taipa, R, Amer, G, Martinez-Saez, E, Fernández-Matarrubia, M, Lage-Martínez, C, Alvarez, V, Molina-Porcel, L, Holstege, H, Mir, P, Belbin, O, Boada, M, Fernández, V, Bullido, MJ, Rábano, A, Sánchez-Juan, P, Ruiz, A
Publicada:
1 jul 2025
Ahead of Print:
1 may 2025
Resumen:
Progressive supranuclear palsy (PSP) is a rare 4-repeat tauopathy that causes behavioural, movement and cognitive abnormalities. We genotyped all available clinical and histopathological PSP cases in Spain and Portugal (N = 522), and conducted the largest PSP GWAS of the Iberian population to date. Genetic burden analysis revealed reduced diagnostic specificity in clinically diagnosed atypical PSP cases-when applying the 2017 MDS criteria-compared to Richardson's syndrome cases. We independently replicated eight PSP risk variants in seven known loci (MAPT, MOBP, EIF2AK3, STX6, SLCO1A2, DUSP10 and APOE), and identified a novel locus in NFASC/CNTN2 (rs12744678 C: OR[95%CI] = 0.83[0.78-0.89]; p = 4.1510-08) after meta-analysis with a newly available Dutch cohort and publicly available summary statistics (3,099 PSP; 11,482 controls). Enrichment analysis and protein expression profiling highlighted oligodendrocyte function and myelination as likely contributors to PSP pathogenesis. Our findings broaden the genetic landscape of PSP and suggest potential therapeutic avenues focused on modulating neuron-oligodendrocyte interactions.
Filiaciones:
García-González, P:
Univ Int Catalunya, Ace Alzheimer Ctr Barcelona, Barcelona, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Univ Barcelona, Fac Pharm & Food Sci, Biotecnol, Barcelona, Spain
Lara, HR:
Hosp Clin Univ Virgen Arrixaca, Banco Cerebros Reg Murcia, El Palmar, Spain
Compta, Y:
Univ Barcelona, Hosp Clin Univ Barcelona 1, Neurol Serv, Parkinsons Dis & Movement Disorders Unit, Barcelona, Catalonia, Spain
Univ Barcelona, Inst Clin Neurociencies, Maria Maeztu Excellence Ctr, IDIBAPS,CIBERNED CB06 05 0018 ISCIII,ERN RND, Barcelona, Catalonia, Spain
Univ Barcelona, Hosp Clin Barcelona, Inst Invest Biomed August Pi & Sunyer IDIBAPS, Inst Neurociencies,Lab Parkinson Dis & Other Neuro, Barcelona, Catalonia, Spain
Univ Barcelona, Hosp Clin Barcelona, Inst Invest Biomed August Pi & Sunyer IDIBAPS, Inst Neurociencies,Dept Neurol, Barcelona, Catalonia, Spain
Fernandez, M:
Univ Barcelona, Hosp Clin Univ Barcelona 1, Neurol Serv, Parkinsons Dis & Movement Disorders Unit, Barcelona, Catalonia, Spain
Univ Barcelona, Inst Clin Neurociencies, Maria Maeztu Excellence Ctr, IDIBAPS,CIBERNED CB06 05 0018 ISCIII,ERN RND, Barcelona, Catalonia, Spain
Univ Barcelona, Hosp Clin Barcelona, Inst Invest Biomed August Pi & Sunyer IDIBAPS, Inst Neurociencies,Lab Parkinson Dis & Other Neuro, Barcelona, Catalonia, Spain
Univ Barcelona, Hosp Clin Barcelona, Inst Invest Biomed August Pi & Sunyer IDIBAPS, Inst Neurociencies,Dept Neurol, Barcelona, Catalonia, Spain
van der Lee, SJ:
Vrije Univ Amsterdam, Genom Neurodegenerat Dis & Aging, Human Genet, Amsterdam UMC Locat VUmc, Amsterdam, Netherlands
Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Neurol, Amsterdam UMC Locat VUmc, Amsterdam, Netherlands
Amsterdam Neurosci, Neurodegenerat, Amsterdam, Netherlands
de Rojas, I:
Univ Int Catalunya, Ace Alzheimer Ctr Barcelona, Barcelona, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Saiz, L:
Queen Sofia Fdn, CIEN Fdn, Alzheimer Ctr, Alzheimers Dis Res Unit, Madrid, Spain
Painous, C:
Univ Barcelona, Hosp Clin Univ Barcelona 1, Neurol Serv, Parkinsons Dis & Movement Disorders Unit, Barcelona, Catalonia, Spain
Univ Barcelona, Inst Clin Neurociencies, Maria Maeztu Excellence Ctr, IDIBAPS,CIBERNED CB06 05 0018 ISCIII,ERN RND, Barcelona, Catalonia, Spain
Univ Barcelona, Hosp Clin Barcelona, Inst Invest Biomed August Pi & Sunyer IDIBAPS, Inst Neurociencies,Lab Parkinson Dis & Other Neuro, Barcelona, Catalonia, Spain
Univ Barcelona, Hosp Clin Barcelona, Inst Invest Biomed August Pi & Sunyer IDIBAPS, Inst Neurociencies,Dept Neurol, Barcelona, Catalonia, Spain
Camara, A:
Univ Barcelona, Hosp Clin Univ Barcelona 1, Neurol Serv, Parkinsons Dis & Movement Disorders Unit, Barcelona, Catalonia, Spain
Univ Barcelona, Inst Clin Neurociencies, Maria Maeztu Excellence Ctr, IDIBAPS,CIBERNED CB06 05 0018 ISCIII,ERN RND, Barcelona, Catalonia, Spain
Univ Barcelona, Hosp Clin Barcelona, Inst Invest Biomed August Pi & Sunyer IDIBAPS, Inst Neurociencies,Lab Parkinson Dis & Other Neuro, Barcelona, Catalonia, Spain
Univ Barcelona, Hosp Clin Barcelona, Inst Invest Biomed August Pi & Sunyer IDIBAPS, Inst Neurociencies,Dept Neurol, Barcelona, Catalonia, Spain
Muñoz, E:
Univ Barcelona, Hosp Clin Univ Barcelona 1, Neurol Serv, Parkinsons Dis & Movement Disorders Unit, Barcelona, Catalonia, Spain
Univ Barcelona, Inst Clin Neurociencies, Maria Maeztu Excellence Ctr, IDIBAPS,CIBERNED CB06 05 0018 ISCIII,ERN RND, Barcelona, Catalonia, Spain
Univ Barcelona, Hosp Clin Barcelona, Inst Invest Biomed August Pi & Sunyer IDIBAPS, Inst Neurociencies,Lab Parkinson Dis & Other Neuro, Barcelona, Catalonia, Spain
Univ Barcelona, Hosp Clin Barcelona, Inst Invest Biomed August Pi & Sunyer IDIBAPS, Inst Neurociencies,Dept Neurol, Barcelona, Catalonia, Spain
Marti, MJ:
Univ Barcelona, Hosp Clin Univ Barcelona 1, Neurol Serv, Parkinsons Dis & Movement Disorders Unit, Barcelona, Catalonia, Spain
Univ Barcelona, Inst Clin Neurociencies, Maria Maeztu Excellence Ctr, IDIBAPS,CIBERNED CB06 05 0018 ISCIII,ERN RND, Barcelona, Catalonia, Spain
Univ Barcelona, Hosp Clin Barcelona, Inst Invest Biomed August Pi & Sunyer IDIBAPS, Inst Neurociencies,Lab Parkinson Dis & Other Neuro, Barcelona, Catalonia, Spain
Univ Barcelona, Hosp Clin Barcelona, Inst Invest Biomed August Pi & Sunyer IDIBAPS, Inst Neurociencies,Dept Neurol, Barcelona, Catalonia, Spain
Valldeoriola, F:
Univ Barcelona, Hosp Clin Univ Barcelona 1, Neurol Serv, Parkinsons Dis & Movement Disorders Unit, Barcelona, Catalonia, Spain
Univ Barcelona, Inst Clin Neurociencies, Maria Maeztu Excellence Ctr, IDIBAPS,CIBERNED CB06 05 0018 ISCIII,ERN RND, Barcelona, Catalonia, Spain
Univ Barcelona, Hosp Clin Barcelona, Inst Invest Biomed August Pi & Sunyer IDIBAPS, Inst Neurociencies,Lab Parkinson Dis & Other Neuro, Barcelona, Catalonia, Spain
Univ Barcelona, Hosp Clin Barcelona, Inst Invest Biomed August Pi & Sunyer IDIBAPS, Inst Neurociencies,Dept Neurol, Barcelona, Catalonia, Spain
Puerta, R:
Univ Int Catalunya, Ace Alzheimer Ctr Barcelona, Barcelona, Spain
Univ Barcelona, Fac Pharm & Food Sci, Biotecnol, Barcelona, Spain
Illán-Gala, I:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Inst Recerca St Pau, Dept Neurol, St Pau Memory Unit, Barcelona, Spain
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Pagonabarraga, J:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Inst Recerca St Pau, Dept Neurol, Movement Disorders Unit, Barcelona, Spain
Dols-Icardo, O:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Inst Recerca St Pau, Dept Neurol, St Pau Memory Unit, Barcelona, Spain
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Kulisevsky, J:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Inst Recerca St Pau, Dept Neurol, Movement Disorders Unit, Barcelona, Spain
Fortea, J:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Inst Recerca St Pau, Dept Neurol, St Pau Memory Unit, Barcelona, Spain
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Lleó, A:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Inst Recerca St Pau, Dept Neurol, St Pau Memory Unit, Barcelona, Spain
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Olivé, C:
Univ Int Catalunya, Ace Alzheimer Ctr Barcelona, Barcelona, Spain
de Boer, SCM:
Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Neurol, Amsterdam UMC Locat VUmc, Amsterdam, Netherlands
Amsterdam Neurosci, Neurodegenerat, Amsterdam, Netherlands
Univ Sydney, Sch Psychol, Sydney, Australia
Univ Sydney, Brain & Mind Ctr, Sydney, Australia
Hulsman, M:
Vrije Univ Amsterdam, Genom Neurodegenerat Dis & Aging, Human Genet, Amsterdam UMC Locat VUmc, Amsterdam, Netherlands
Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Neurol, Amsterdam UMC Locat VUmc, Amsterdam, Netherlands
Amsterdam Neurosci, Neurodegenerat, Amsterdam, Netherlands
Pijnenburg, YAL:
Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Neurol, Amsterdam UMC Locat VUmc, Amsterdam, Netherlands
Amsterdam Neurosci, Neurodegenerat, Amsterdam, Netherlands
Belloso, RD:
Univ Seville, Unidad Trastornos Movimiento, Inst Biomed Sevilla IBiS, Hosp Univ Virgen Rocio,CSIC,Serv Neurol & Neurofis, Seville, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Muñoz-Delgado, L:
Univ Seville, Unidad Trastornos Movimiento, Inst Biomed Sevilla IBiS, Hosp Univ Virgen Rocio,CSIC,Serv Neurol & Neurofis, Seville, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Rueda, DB:
Univ Seville, Unidad Trastornos Movimiento, Inst Biomed Sevilla IBiS, Hosp Univ Virgen Rocio,CSIC,Serv Neurol & Neurofis, Seville, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Gómez-Garre, P:
Univ Seville, Unidad Trastornos Movimiento, Inst Biomed Sevilla IBiS, Hosp Univ Virgen Rocio,CSIC,Serv Neurol & Neurofis, Seville, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Aldecoa, I:
Biobanc Hosp Clin FRCB IDIBAPS, Neurol Tissue Bank, Barcelona, Spain
Univ Barcelona, Hosp Clin Barcelona, Pathol Dept, Barcelona, Spain
Aragonés, G:
Biobanc Hosp Clin FRCB IDIBAPS, Neurol Tissue Bank, Barcelona, Spain
Vara, JH:
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Vall dHebron Inst Recerca VHIR, Serv Neurol, Barcelona, Spain
Vall dHebron Inst Recerca VHIR, Grp Enfermedades Neurodegenerat, Barcelona, Spain
Mendioroz, M:
Navarrabiomed, Pamplona, Spain
Hosp Univ Navarra, Dept Neurol, Pamplona, Spain
Inst Invest Sanitaria Navarra IdiSNA, Pamplona, Spain
Pérez-Tur, J:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
CSIC, Unitat Genet Mol, Inst Biomed Valencia, Valencia, Spain
Visser, PJ:
Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Neurol, Amsterdam UMC Locat VUmc, Amsterdam, Netherlands
Amsterdam Neurosci, Neurodegenerat, Amsterdam, Netherlands
Maastricht Univ, Alzheimer Ctr Limburg, Sch Mental Hlth & Neurosci, Maastricht, Netherlands
Karolinska Inst, Div Neurogeriatr, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden
den Braber, A:
Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Neurol, Amsterdam UMC Locat VUmc, Amsterdam, Netherlands
Amsterdam Neurosci, Neurodegenerat, Amsterdam, Netherlands
Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, Gothenburg, Sweden
Papma, JM:
Univ Med Ctr, Dept Neurol, Erasmus MC, Rotterdam, Netherlands
Univ Med Ctr, Alzheimer Ctr, Erasmus MC, Rotterdam, Netherlands
Univ Med Ctr, Dept Internal Med, Erasmus MC, Rotterdam, Netherlands
Montes, AM:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Hosp La Paz, Inst Hlth Res, IdiPAZ, Madrid, Spain
La Paz Univ Hosp, Dept Neurol, Madrid, Spain
Rodriguez-Rodriguez, E:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Univ Cantabria, Marques Valdecilla Univ Hosp, Neurol Serv, Santander, Spain
IDIVAL, Santander, Spain
Blázquez-Folch, J:
Univ Int Catalunya, Ace Alzheimer Ctr Barcelona, Barcelona, Spain
Miguel, A:
Univ Int Catalunya, Ace Alzheimer Ctr Barcelona, Barcelona, Spain
García-Gutiérrez, F:
Univ Int Catalunya, Ace Alzheimer Ctr Barcelona, Barcelona, Spain
Cano, A:
Univ Int Catalunya, Ace Alzheimer Ctr Barcelona, Barcelona, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Valero, S:
Univ Int Catalunya, Ace Alzheimer Ctr Barcelona, Barcelona, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Marquié, M:
Univ Int Catalunya, Ace Alzheimer Ctr Barcelona, Barcelona, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Capdevila-Bayo, M:
Univ Int Catalunya, Ace Alzheimer Ctr Barcelona, Barcelona, Spain
Univ Barcelona, Fac Pharm & Food Sci, Dept Pharmacol Toxicol & Therapeut Chem, Barcelona, Spain
Rosende-Roca, M:
Univ Int Catalunya, Ace Alzheimer Ctr Barcelona, Barcelona, Spain
Quintela, I:
Fdn Publ Galega Med Xen, Grp Med Xen, Santiago De Compostela, Spain
Carracedo, A:
Univ Santiago de Compostela, Grp Med Xen CIBERER, Santiago De Compostela, Spain
Tàrraga, L:
Univ Int Catalunya, Ace Alzheimer Ctr Barcelona, Barcelona, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Real, LM:
Univ Seville, Hosp Univ Virgen Valme, Dept Bioqim Med Biol Mol & Inmunol, Inst Biomed Sevilla IBiS,CSIC, Seville, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Infect Dis, CIBERINFEC, Madrid, Spain
Royo, JL:
Univ Malaga, Fac Med, Dept Especialidades Quirurg Bioquim & Inmunol, Malaga, Spain
Erro, ME:
Hosp Univ Navarra, Serv Neurol, Pamplona, Spain
Navarrabiomed, Grp Invest Neuroepigenet, Pamplona, Spain
Guerrero, C:
Hosp Univ Fdn Alcorcon, Banco Cerebros Biobanco, Alcorcon, Spain
Torres, DC:
Inst Invest Sanitaria Principado Asturias ISPA, Biobank Principado Asturias, Oviedo, Spain
Blázquez-Estrada, M:
Hosp Univ Cent Asturias, Serv Neurol, Oviedo, Spain
Inst Invest Sanitaria Principado Asturias ISPA, Oviedo, Spain
San Millán, B:
SERGAS UVIGO, Hosp Alvaro Cunqueiro, Galicia Sur Hlth Res Inst IIS Galicia Sur, Rare Dis & Pediat Med Res Grp, Vigo, Spain
SERGAS UVIGO, Alvaro Cunqueiro Hosp, Galicia Sur Hlth Res Inst IIS Galicia Sur, Pathol Dept, Vigo, Spain
Teijeira, S:
SERGAS UVIGO, Hosp Alvaro Cunqueiro, Galicia Sur Hlth Res Inst IIS Galicia Sur, Rare Dis & Pediat Med Res Grp, Vigo, Spain
SERGAS UVIGO, Hosp Alvaro Cunqueiro, Biobank Galicia Sur Hlth Res Inst Biobank IIS Gali, Vigo, Spain
Rolan, DV:
Hosp Badalona Germans Trias & Pujol, Neurol Serv, Movement Disorders Unit, Badalona, Barcelona, Spain
Hernández, I:
Univ Int Catalunya, Ace Alzheimer Ctr Barcelona, Barcelona, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Sánchez-Soblechero, A:
Hosp Gen Univ Gregorio Maranon, Dept Neurol, Inst Invest Sanitaria Gregorio Maranon, Madrid, Spain
de la Casa-Fages, B:
Hosp Gen Univ Gregorio Maranon, Neurol Dept, Movement Disorders Unit, Inst Invest Sanitaria Gregorio Maranon, Madrid, Spain
López, SS:
Hosp La Paz, Inst Hlth Res, IdiPAZ, Madrid, Spain
La Paz Univ Hosp, Dept Neurol, Madrid, Spain
Baviera-Muñoz, R:
Inst Invest Sanitaria La Fe, Mol Cellular & Genom Biomed Res Grp, Valencia, Spain
Lavín, A:
Univ Publ Navarra UPNA, Navarrabiomed, Hosp Univ Navarra HUN, IdiSNA, Pamplona, Spain
Taipa, R:
Ctr Hosp Univ Santo Antonio, Dept Neuropathol, Porto, Portugal
Univ Porto, UMIB Unit Multidisciplinary Res Biomed, ICBAS Sch Med & Biomed Sci, Porto, Portugal
Amer, G:
Son Espases Univ Hosp, Cognit Neurol Unit, Palma De Mallorca, Spain
Martinez-Saez, E:
Vall dHebron Univ Hosp, Pathol Dept, Neuropathol, Barcelona, Spain
Vall dHebron Univ Hosp, Vall dHebron Hosp Res Inst, Biobank, Barcelona, Spain
Fernández-Matarrubia, M:
Clin Univ Navarra, Dept Neurol, Pamplona, Spain
Navarra Inst Hlth Res, IdiSNA, Pamplona, Spain
Lage-Martínez, C:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Marques Valdecilla Univ Hosp IDIVAL, Neurol Serv, Santander, Spain
Univ Calif San Francisco, Global Brain Hlth Inst, Equ Brain Hlth, San Francisco, CA USA
Alvarez, V:
Inst Invest Sanitaria Principado Asturias ISPA, Oviedo, Spain
Hosp Univ Cent Asturias, Lab Genet, Oviedo, Spain
Molina-Porcel, L:
Biobanc Hosp Clin FRCB IDIBAPS, Neurol Tissue Bank, Barcelona, Spain
Univ Barcelona, Neurol Serv, Fundacio Recerca Clin Barcelona IDIBAPS, Alzheimers Dis & Other Cognit Disorders Unit,Hosp, Barcelona, Spain
Holstege, H:
Vrije Univ Amsterdam, Genom Neurodegenerat Dis & Aging, Human Genet, Amsterdam UMC Locat VUmc, Amsterdam, Netherlands
Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Neurol, Amsterdam UMC Locat VUmc, Amsterdam, Netherlands
Amsterdam Neurosci, Neurodegenerat, Amsterdam, Netherlands
Mir, P:
Univ Seville, Unidad Trastornos Movimiento, Inst Biomed Sevilla IBiS, Hosp Univ Virgen Rocio,CSIC,Serv Neurol & Neurofis, Seville, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Univ Seville, Fac Med, Dept Med, Seville, Spain
Belbin, O:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Dept Neurol, IIB St Pau, Barcelona, Spain
Boada, M:
Univ Int Catalunya, Ace Alzheimer Ctr Barcelona, Barcelona, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Fernández, V:
Univ Int Catalunya, Ace Alzheimer Ctr Barcelona, Barcelona, Spain
Bullido, MJ:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Hosp La Paz, Inst Hlth Res, IdiPAZ, Madrid, Spain
UAM, Ctr Biol Mol Severo Ochoa, CSIC, Madrid, Spain
Univ Autonoma Madrid, Madrid, Spain
Rábano, A:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
CIEN Fdn, Alzheimers Ctr Reina Sofia, ISCIII, Madrid, Spain
Sánchez-Juan, P:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
CIEN Fdn, Alzheimers Ctr Reina Sofia, ISCIII, Madrid, Spain
Ruiz, A:
Univ Int Catalunya, Ace Alzheimer Ctr Barcelona, Barcelona, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Univ Texas Hlth Sci Ctr San Antonio, Glenn Biggs Inst Alzheimers & Neurodegenerat Dis, San Antonio, TX USA
Univ Texas Hlth Sci Ctr, Long Sch Med, Dept Microbiol Immunol & Mol Genet, San Antonio, TX USA
Green Submitted, Green Published
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