The history of Down syndrome-associated Alzheimer's disease; past, present, and future
Por:
Maure-Blesa, L, Carmona-Iragui, M, Lott, I, Head, E, Wisniewski, T, Rafii, MS, Espinosa, J, Flórez, J, Mobley, WC, Holland, A, Strydom, A, Zaman, S, Fortea, J
Publicada:
1 jun 2025
Resumen:
The landscape of Down syndrome-associated Alzheimer's disease (DSAD) research reflects decades of scientific endeavor and collaborative effort, charting a remarkable journey from initial observations to the elucidation of complex genetic and molecular mechanisms. This perspective article chronicles key milestones and breakthroughs, paying homage to the pioneering scientists and advancements that have shaped the field. A thorough review of historical and contemporary literature offers a comprehensive narrative, highlighting the evolution of knowledge surrounding DSAD, from early recognition to the characterization of clinical presentation and natural history. The unique challenges and ethical considerations associated with DSAD populations are also examined, underscoring the importance of tailoring research and clinical approaches. By reflecting on the field's trajectory, this work celebrates past achievements while emphasizing the critical need for sustained research efforts. As part of a special issue, this article provides a foundation for appreciating the challenges and opportunities that lie ahead in advancing DSAD understanding and care.
Filiaciones:
Maure-Blesa, L:
Univ Autonoma Barcelona, Hosp Santa Creu & Santa Pau, Biomed Res Inst St Pau, Dept Neurol,St Pau Memory Unit,Dept Med, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Alzheimers Dis & Other Neurodegenerat Dementias, Madrid, Spain
Carmona-Iragui, M:
Univ Autonoma Barcelona, Hosp Santa Creu & Santa Pau, Biomed Res Inst St Pau, Dept Neurol,St Pau Memory Unit,Dept Med, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Alzheimers Dis & Other Neurodegenerat Dementias, Madrid, Spain
Barcelona Med Ctr, Fdn Catalana Sindrome, Barcelona, Spain
Lott, I:
Univ Calif Irvine, Inst Memory Impairments & Neurol Disorders MIND, Irvine, CA USA
Univ Calif Irvine, Irvine Sch Med, Dept Pediat, Orange, CA USA
Head, E:
Univ Calif Irvine, Dept Pathol & Lab Med, Irvine, CA USA
Wisniewski, T:
NYU Grossman Sch Med, Ctr Cognit Neurol, Dept Neurol, New York, NY USA
NYU Grossman Sch Med, Dept Pathol, New York, NY USA
NYU Grossman Sch Med, Dept Psychiat, New York, NY USA
Rafii, MS:
Univ Southern Calif, Alzheimers Therapeut Res Inst, Keck Sch Med, San Diego, CA USA
Espinosa, J:
Univ Colorado, Linda Crnic Inst Syndrome, Anschutz Med Campus, Aurora, CO USA
Univ Colorado, Dept Pharmacol, Anschutz Med Campus, Aurora, CO USA
Flórez, J:
Univ Cantabria, Dept Physiol & Pharmacol, Santander, Spain
Mobley, WC:
Univ Calif San Diego, Dept Neurosci, La Jolla, CA USA
Holland, A:
Univ Cambridge, Dept Psychiat, Cambridge Intellectual & Dev Disabil Res Grp, Cambridge, England
Strydom, A:
Kings Coll London, Dept Forens & Neurodev Sci, Inst Psychiat Psychol & Neurosci, London, England
Zaman, S:
Univ Cambridge, Dept Psychiat, Cambridge Intellectual & Dev Disabil Res Grp, Cambridge, England
Fortea, J:
Univ Autonoma Barcelona, Hosp Santa Creu & Santa Pau, Biomed Res Inst St Pau, Dept Neurol,St Pau Memory Unit,Dept Med, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Alzheimers Dis & Other Neurodegenerat Dementias, Madrid, Spain
Barcelona Med Ctr, Fdn Catalana Sindrome, Barcelona, Spain
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