Modes of death in heart failure according to age, sex and left ventricular ejection fraction
Por:
Salamanca-Bautista, P, Alvarez-Garcia, J, Aramburu-Bodas, O, Ferrero-Gregori, A, Arias-Jimenez, JL, Delgado, JF, Formiga, F, Vazquez, R, Manzano, L, Puig, T, Llacer, P, Vives-Borras, M, Cinca, J, Montero-Perez-Barquero, M
Publicada:
1 abr 2021
Ahead of Print:
1 ago 2020
Resumen:
Modes of death in patients with heart failure (HF) have been well characterized in randomized studies, but data from real-life are scarce, especially in the elderly, women and in HF with mid-range or preserved left ventricular ejection fraction (LVEF). Our purpose was to examine modes of death in HF patients according to age, sex and LVEF. We analysed the mode of death of HF patients from two prospective multicentre contemporary Spanish registries conducted by cardiologists (REDINSCOR,n = 2150) and by internists (RICA,n = 1396). Mode of death was pre-specified. Out of 3546 patients, 485 (13.7%) died during the 9-month follow-up. Cardiovascular (CV) causes were the most frequent, regardless of the age, sex and LVEF. More than half of patients died due to worsening HF in both groups of patients, followed by other non-CV causes in those attended by internists, and sudden cardiac death in those cared by cardiologists. Stroke was more common among elderly patients, women and HF with preserved LVEF. Non-CV causes, particularly infectious diseases, accounted for a remarkable proportion of deaths, especially in the elderly and in HF patients with preserved LVEF. Functional class, age and anaemia had a strong influence on both CV and non-CV death. CV death due to refractory HF was the most prevalent among our population, irrespective of age, sex or LVEF. However, a significant proportion of HF patients died from non-CV causes, particularly elderly with mid-range and preserved LVEF. These patients could benefit significantly from a multidisciplinary follow-up.
Filiaciones:
Salamanca-Bautista, P:
Univ Seville, Hosp Univ Virgen Macarena, Internal Med Dept, Av Dr Fedriani S-N, Seville 41009, Spain
Alvarez-Garcia, J:
Univ Autonoma Barcelona, Cardiol Dept, IIb St Pau CIBERCV, Hosp Santa Creu & St Pau, Barcelona, Spain
Aramburu-Bodas, O:
Univ Seville, Hosp Univ Virgen Macarena, Internal Med Dept, Av Dr Fedriani S-N, Seville 41009, Spain
Ferrero-Gregori, A:
Univ Autonoma Barcelona, Cardiol Dept, IIb St Pau CIBERCV, Hosp Santa Creu & St Pau, Barcelona, Spain
Arias-Jimenez, JL:
Univ Seville, Hosp Univ Virgen Macarena, Internal Med Dept, Av Dr Fedriani S-N, Seville 41009, Spain
Delgado, JF:
Fac Med UCM, Hosp Univ Doce Octubre, Cardiol Dept, CIBERCV,Fdn Invest I 12, Madrid, Spain
Formiga, F:
Hosp Univ Bellvitge, Internal Med Dept, Barcelona, Spain
Vazquez, R:
Hosp Univ Puerta Mar, Cardiol Dept, Cadiz, Spain
Manzano, L:
Univ Alcala De Henares, Hosp Univ Ramon Y Cajal, Internal Med Dept, IRYCIS, Madrid, Spain
Puig, T:
Univ Autonoma Barcelona, Epidemiol & Publ Hlth Dept, 2 B SantPau, Hosp Santa Creu & St Pau, Barcelona, Spain
Llacer, P:
Hosp Manises, Internal Med Dept, Valencia, Spain
Vives-Borras, M:
Univ Autonoma Barcelona, Cardiol Dept, IIb St Pau CIBERCV, Hosp Santa Creu & St Pau, Barcelona, Spain
Cinca, J:
Univ Autonoma Barcelona, Cardiol Dept, IIb St Pau CIBERCV, Hosp Santa Creu & St Pau, Barcelona, Spain
Montero-Perez-Barquero, M:
Univ Cordoba, Hosp Univ Reina Sofia, Internal Med Dept, IMIBIC, Cordoba, Spain
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