Influence of Familial Inflammatory Bowel Disease History on the Use of Immunosuppressants, Biological Agents and Surgery in Patients with Pediatric-Onset of the Disease in the Era of Biological Therapies. Results from the ENEIDA Registry
Por:
González-Muñoza, C, Giordano, A, Ricart, E, Nos, P, Iglesias, E, Gisbert, JP, García-López, S, Mesonero, F, Pascual, I, Tardillo, C, Rivero, M, Riestra, S, Mañosa, M, Zabana, Y, Gomollón, F, Calvet, X, García-Sepulcre, MF, Gutiérrez, A, Pérez-Calle, JL, Sierra-Ausín, M, Bermejo, F, Arias, L, Barreiro-de Acosta, M, Barrio, J, Lorente, R, Guardiola, J, Varela, P, Ponferrada-Díaz, A, Marín-Jiménez, I, Pascual, CM, Garcia-Planella, E, Domènech, E
Publicada:
12 may 2025
Resumen:
Background: Pediatric-onset familial inflammatory bowel disease (IBD) may differ from sporadic pediatric-onset IBD in its genetic and environmental background and may have distinct clinical and therapeutic implications. Objective: To evaluate the influence of a positive family history of IBD on the use of medical therapies and surgical interventions in adult patients with pediatric-onset IBD. Methods: Retrospective case-control study using the Spanish ENEIDA registry, including adults diagnosed with pediatric-onset IBD since 2006. Familial forms (FFs) (defined by a first-degree relative with IBD) and sporadic forms (SF) (with no relatives of any grade with IBD) were matched 1:4 by type of IBD, sex, age at IBD diagnosis, disease location, disease pattern, development of perianal disease and smoking status at diagnosis. The study outcomes were the use of immunomodulators, biological therapies, intestinal surgery, and perianal surgery during follow-up. Results: Six-hundred and fifty-five Crohn's disease (CD) (131 FF) and 440 ulcerative colitis (UC) (88 FF) patients were included. Immunomodulators, biological therapy, and intestinal surgery were used evenly among FF and SF patients for both UC and CD. However, a higher requirement for perianal surgery among FF-CD patients (18.3% vs. 10.5%, p = 0.014), together with a shorter time to perianal surgery (11 vs. 20 months, log-rank p = 0.004), was observed. Conclusions: Patients with FF of pediatric-onset IBD do not exhibit an increased use of immunomodulators, biological agents, or intestinal surgery, but do exhibit a higher need for perianal surgery, as compared to patients with SF pediatric-onset IBD.
Filiaciones:
González-Muñoza, C:
Hosp Santa Creu & Sant Pau, Gastroenterol Dept, Barcelona 08025, Spain
Univ Autonoma Barcelona, Dept Med, Cerdanyola Del Valles 08193, Spain
Giordano, A:
Hosp Santa Creu & Sant Pau, Gastroenterol Dept, Barcelona 08025, Spain
Univ Autonoma Barcelona, Dept Med, Cerdanyola Del Valles 08193, Spain
Ricart, E:
Hosp Clin Barcelona, Gastroenterol Dept, Barcelona 08036, Spain
Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona 08036, Spain
Ctr Invest Biomed RED CIBEREHD, Madrid 28029, Spain
Nos, P:
Hosp Univ & Politecn La Fe, Gastroenterol Dept, Valencia 46026, Spain
II S La Fe, Valencia 46026, Spain
Iglesias, E:
Hosp Reina Sofia, Gastroenterol Dept, Cordoba 14004, Spain
IMIBIC, Cordoba 14004, Spain
Gisbert, JP:
Ctr Invest Biomed RED CIBEREHD, Madrid 28029, Spain
Hosp Univ La Princesa, Gastroenterol Dept, Madrid 28006, Spain
Inst Invest Sanitaria Princesa IIS Princesa, Madrid 28006, Spain
Univ Autonoma Madrid UAM, Madrid 28049, Spain
García-López, S:
Hosp Univ Miguel Servet, Gastroenterol Dept, Zaragoza 50009, Spain
Inst Invest Sanitaria Aragon IIS, Zaragoza 50009, Spain
Mesonero, F:
Hosp Univ Ramon y Cajal, Gastroenterol Dept, Madrid 28034, Spain
Pascual, I:
Hosp Clin Valencia, Gastroenterol Dept, Valencia 46010, Spain
Tardillo, C:
Hosp Univ Nuestra Sra Candelaria, Gastroenterol Dept, Santa Cruz De Tenerife 38010, Spain
Rivero, M:
Inst Invest Valdecilla IDIVAL, Grp Invest Clin & Traslac Enfermedades Digest, Santander 39011, Spain
Hosp Univ Marques de Valdecilla, Santander 39008, Spain
Riestra, S:
Hosp Univ Cent Asturias, Gastroenterol Dept, Oviedo 33011, Spain
Inst Invest Sanitaria Principado Asturias ISPA, Oviedo 33011, Spain
Mañosa, M:
Ctr Invest Biomed RED CIBEREHD, Madrid 28029, Spain
Hosp Badalona Germans Trias & Pujol, Gastroenterol Dept, Badalona 08916, Spain
Zabana, Y:
Ctr Invest Biomed RED CIBEREHD, Madrid 28029, Spain
Hosp Univ Mutua Terrassa, Gastroenterol Dept, Terrassa 08221, Spain
Univ Barcelona, Barcelona 08007, Spain
Gomollón, F:
Ctr Invest Biomed RED CIBEREHD, Madrid 28029, Spain
Inst Invest Sanitaria Aragon IIS, Zaragoza 50009, Spain
Hosp Clin Lozano Blesa, Gastroenterol Dept, Zaragoza 50009, Spain
Calvet, X:
Univ Autonoma Barcelona, Dept Med, Cerdanyola Del Valles 08193, Spain
Ctr Invest Biomed RED CIBEREHD, Madrid 28029, Spain
Hosp Univ, Gastroenterol Dept, Parc Tauli, Sabadell 08208, Spain
Inst Invest & Innovacio Parc Tauli, Sabadell 08208, Spain
García-Sepulcre, MF:
Hosp Gen Univ Elche, Gastroenterol Dept, Elche 03203, Spain
Gutiérrez, A:
Ctr Invest Biomed RED CIBEREHD, Madrid 28029, Spain
Hosp Gen Univ Dr Balmis, Gastroenterol Dept, ISABIAL, Alicante 03010, Spain
Pérez-Calle, JL:
Hosp Univ Fdn Alcorcon, Gastroenterol Dept, Alcorcon 28922, Spain
Sierra-Ausín, M:
Complejo Asistencial Univ Leon, Gastroenterol Dept, Leon 24008, Spain
Bermejo, F:
Hosp Fuenlabrada, Gastroenterol Dept, Fuenlabrada 28942, Spain
Arias, L:
Hosp Univ Burgos, Gastroenterol Dept, Burgos 09006, Spain
Barreiro-de Acosta, M:
Hosp Clin Univ Santiago de Compostela, Gastroenterol Dept, Santiago De Compostela 15706, Spain
Barrio, J:
Hosp Rio Hortega, Gastroenterol Dept, Valladolid 47012, Spain
Lorente, R:
Hosp Gen Univ Ciudad Real, Gastroenterol Dept, Ciudad Real 13005, Spain
Guardiola, J:
Hosp Univ Bellvitge, Gastroenterol Dept, Lhospitalet De Llobregat 08907, Spain
Varela, P:
Hosp Univ Cabuenes, Gastroenterol Dept, Gijon 33394, Spain
Ponferrada-Díaz, A:
Hosp Univ Infanta Leonor, Gastroenterol Dept, Madrid 28031, Spain
Marín-Jiménez, I:
IiSGM, Madrid 28009, Spain
Hosp Gregorio Maranon, Gastroenterol Dept, Madrid 28007, Spain
Univ Complutense Madrid, Med Fac, Madrid 28040, Spain
Pascual, CM:
Hosp Clin Univ Virgen de la Arrixaca, Gastroenterol Dept, El Palmar 30120, Spain
Garcia-Planella, E:
Hosp Santa Creu & Sant Pau, Gastroenterol Dept, Barcelona 08025, Spain
Univ Autonoma Barcelona, Dept Med, Cerdanyola Del Valles 08193, Spain
Domènech, E:
Univ Autonoma Barcelona, Dept Med, Cerdanyola Del Valles 08193, Spain
Ctr Invest Biomed RED CIBEREHD, Madrid 28029, Spain
Hosp Badalona Germans Trias & Pujol, Gastroenterol Dept, Badalona 08916, Spain
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