Negative symptoms and sex differences in first episode schizophrenia: What's their role in the functional outcome? A longitudinal study
Por:
Amoretti, S, Mezquida, G, Verdolini, N, Bioque, M, Sánchez-Torres, AM, Pina-Camacho, L, Zorrilla, I, Trabsa, A, Rodriguez-Jimenez, R, Corripio, I, Sarró, S, Ibañez, A, Usall, J, Segarra, R, Vieta, E, Roberto, N, Ramos-Quiroga, JA, Tortorella, A, Menculini, G, Cuesta, MJ, Parellada, M, González-Pinto, A, Berrocoso, E, Bernardo, M
Publicada:
1 jun 2025
Ahead of Print:
1 jun 2025
Resumen:
Introduction: Negative symptoms (NS) include asociality, avolition, anhedonia, alogia, and blunted affect and are linked to poor prognosis. It has been suggested that they reflect two different factors: diminished expression (EXP) (blunted affect and alogia) and amotivation/pleasure (MAP) (anhedonia, avolition, asociality). The aim of this article was to examine potential sex differences among first-episode schizophrenia (FES) patients and analyze sex-related predictors of two NS symptoms factors (EXP and MAP) and functional outcome. Material and methods: Two hundred and twenty-three FES (71 females and 152 males) were included and evaluated at baseline, six-months and one-year. Repeated measures ANOVA was used to examine the effects of time and sex on NS and a multiple linear regression backward elimination was performed to predict NS factors (MAP-EXP) and functioning. Results: Females showed fewer NS (p = 0.031; Cohen's d=-0.312), especially those related to EXP (p = 0.024; Cohen's d=-0.326) rather than MAP (p = 0.086), than males. In both male and female group, worse premorbid adjustment and higher depressive symptoms made a significant contribution to the presence of higher deficits in EXP at one-year follow-up, while positive and depressive symptoms predicted alterations in MAP. Finally, in females, lower deficits in MAP and better premorbid adjustment predicted better functioning at one-year follow-up (R-2 = 0.494; p < 0.001), while only higher deficits in MAP predicted worse functioning in males (R-2 =0.088; p = 0.012). Conclusions: Slightly sex differences have been found in this study. Our results lead us to consider that early interventions of NS, especially those focusing on motivation and pleasure symptoms, could improve functional outcomes. (c) 2023 The Authors. Published by Elsevier Espana, S.L.U. on behalf of Sociedad Espanola de Psiquiatr & imath;a y Salud Mental (SEPSM). This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/).
Filiaciones:
Amoretti, S:
Vall dHebron Res Inst VHIR, Vall Hebron Res Inst VHIR, Psychiat Genet Unit, Grp Psychiat Mental Hlth & Addict, Barcelona, Catalonia, Spain
Univ Barcelona UB, Hosp Clin, Inst Neurociencies UBNeuro, Dept Med,Inst Invest Biomed August Pi i Sunyer IDI, Barcelona, Spain
Hosp Clin Barcelona, Bipolar & Depress Disorders Unit, Barcelona, Spain
Univ Barcelona UB, Fac Med Ciencies Salut, Dept Med, Barcelona, Spain
Inst Neurosci UBNeuro, Inst Invest Biomed August Pi i Sunyer IDIBAPS, Barcelona, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Univ Perugia, Dept Psychiat, Perugia, Italy
Mezquida, G:
Univ Barcelona UB, Hosp Clin, Inst Neurociencies UBNeuro, Dept Med,Inst Invest Biomed August Pi i Sunyer IDI, Barcelona, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Univ Barcelona, Dept Basic Clin Practice, Barcelona, Spain
Verdolini, N:
Hosp Clin Barcelona, Bipolar & Depress Disorders Unit, Barcelona, Spain
Univ Barcelona UB, Fac Med Ciencies Salut, Dept Med, Barcelona, Spain
Inst Neurosci UBNeuro, Inst Invest Biomed August Pi i Sunyer IDIBAPS, Barcelona, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Bioque, M:
Univ Barcelona UB, Hosp Clin, Inst Neurociencies UBNeuro, Dept Med,Inst Invest Biomed August Pi i Sunyer IDI, Barcelona, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Sánchez-Torres, AM:
Complejo Hosp Navarra, Dept Psychiat, Pamplona, Spain
Navarra Inst Hlth Res, IdiSNA, Pamplona, Spain
Pina-Camacho, L:
Inst Salud Carlos III, Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Univ Complutense, Univ Gregorio Maranon, Hosp Gen, IiSGM,Sch Med,Dept Child & Adolescent Psychiat,Ins, Madrid, Spain
Zorrilla, I:
Inst Salud Carlos III, Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Univ Pai Vasco Euskal Herriko Unibertsitatea, Leioa, Spain
Araba Univ Hosp, Bioaraba Res Inst, Dept Psychiat, Vitoria, Spain
Trabsa, A:
Hosp Mar Med Res Inst, Barcelona, Spain
Rodriguez-Jimenez, R:
Inst Salud Carlos III, Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Inst Invest Sanitaria Hosp 12 Octubre Imas12, Madrid, Spain
Univ Complutense Madrid UCM, CogPsy Grp, Madrid, Spain
Corripio, I:
Inst Salud Carlos III, Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Univ Autonoma Barcelona UAB, Hosp Santa Creu & Sant Pau, Inst Invest Biomed Sant Pau IIB SANT PAU, Dept Psychiat, Barcelona, Spain
Sarró, S:
Inst Salud Carlos III, Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
FIDMAG Germanes Hospitalaries Res Fdn, Barcelona, Spain
Ibañez, A:
Inst Salud Carlos III, Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Univ Alcala, Hosp Univ Ramon & Cajal, IRYCIS, Dept Psychiat, Madrid, Spain
Usall, J:
Inst Recerca Sant Joan Deu, Teaching Res & Innovat Unit, Parc Sanit Sant Joan Deu, Esplugas de Llobregat, Spain
Segarra, R:
Inst Salud Carlos III, Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Univ Basque Country UPV EHU, Cruces Univ Hosp, BioCruces Hlth Res Inst, Leioa, Vizcaya, Spain
Vieta, E:
Hosp Clin Barcelona, Bipolar & Depress Disorders Unit, Barcelona, Spain
Univ Barcelona UB, Fac Med Ciencies Salut, Dept Med, Barcelona, Spain
Inst Neurosci UBNeuro, Inst Invest Biomed August Pi i Sunyer IDIBAPS, Barcelona, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Roberto, N:
Hosp Clin Barcelona, Bipolar & Depress Disorders Unit, Barcelona, Spain
Univ Barcelona UB, Fac Med Ciencies Salut, Dept Med, Barcelona, Spain
Inst Neurosci UBNeuro, Inst Invest Biomed August Pi i Sunyer IDIBAPS, Barcelona, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Ramos-Quiroga, JA:
Vall dHebron Res Inst VHIR, Vall Hebron Res Inst VHIR, Psychiat Genet Unit, Grp Psychiat Mental Hlth & Addict, Barcelona, Catalonia, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Univ Autonoma Barcelona, Dept Psychiat & Legal Med, Barcelona, Catalonia, Spain
Tortorella, A:
Hosp Univ Vall dHebron, Dept Psychiat, , Catalonia, Barcelona, Spain
Menculini, G:
Hosp Univ Vall dHebron, Dept Psychiat, , Catalonia, Barcelona, Spain
Cuesta, MJ:
Complejo Hosp Navarra, Dept Psychiat, Pamplona, Spain
Navarra Inst Hlth Res, IdiSNA, Pamplona, Spain
Parellada, M:
Inst Salud Carlos III, Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Univ Complutense, Univ Gregorio Maranon, Hosp Gen, IiSGM,Sch Med,Dept Child & Adolescent Psychiat,Ins, Madrid, Spain
González-Pinto, A:
Inst Salud Carlos III, Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Univ Pai Vasco Euskal Herriko Unibertsitatea, Leioa, Spain
Araba Univ Hosp, Bioaraba Res Inst, Dept Psychiat, Vitoria, Spain
Berrocoso, E:
Inst Salud Carlos III, Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Univ Cadiz, Dept Psychol, Neuropsychopharmacol & Psychobiol Res Grp, Cadiz, Spain
Hosp Univ Puerta Mar, Inst Invest Innovac Biomed Cadiz, INiBICA, Cadiz, Spain
Bernardo, M:
Univ Barcelona UB, Hosp Clin, Inst Neurociencies UBNeuro, Dept Med,Inst Invest Biomed August Pi i Sunyer IDI, Barcelona, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Green Submitted, Bronze
|