Quality of life and psychological status in people with acromegaly in relation to disease-related facial changes
Por:
Martínez-Momblán, MA, Alonso-Fernández, S, Marques-Pamies, M, Salinas, I, Vázquez, F, Soldevila, B, Asensio-Wandosell, D, Ciriza, R, Santos, A, Valassi, E, Webb, SM, Puig-Domingo, M
Publicada:
1 may 2025
Resumen:
The diagnosis of acromegaly is often delayed, leading to facial disfigurements that persist despite endocrine cure. We aimed to study the relationship between facial modifications, quality of life (QoL) and psychological status in patients with acromegaly.MethodsSixty-five patients in remission or with hormonal disease control participated (29 women and 36 men; mean age 57.4 +/- 13.5 years). The following variables were assessed: i) sex; ii) QoL by AcroQoL; iii) anxiety level with the STAI questionnaire; iv) self-esteem by the Rosenberg scale; and v) facial acromegaly phenotypical changes evaluated from face photographs by eight experienced endocrinologists using a Likert scale.ResultsThe global AcroQoL score for the whole cohort showed mid-range values, with higher median values for men (72.3 vs 56.6, P = 0.022) mostly dependent on the physical domain, which was higher for men (59.0 vs 34.9, P = 0.006), rather than the psychological domain (65.7 vs 54.5, P = 0.069). Anxiety scores were also higher for women (7.3 vs 5.9, P = 0.009). Self-esteem state was high (2.7 +/- 0.6 for a maximal value of 3) for the whole cohort without sex differences. A higher difference in the global phenotypic facial acromegaly features score from baseline and post-diagnosis was associated with a lower value on QoL mostly in women (-14.38 95% CI -5.25 to -23.52; P-value = 0.005), with less effect in men (-6.31 95% CI 0.61 to -13.22; P-value = 0.070).ConclusionIn controlled acromegaly, QoL is relatively preserved in both genders, although men have higher general and physical domain scores and lower anxiety status. Facial changes intensity negatively impacted QoL mostly in women.
Filiaciones:
Martínez-Momblán, MA:
Univ Barcelona UB, Nursing Fac, Fundamental & Clin Nursing Dept, Barcelona, Spain
ISCIII, CIBERER Unit 747, Madrid, Spain
Univ Autonoma Barcelona, Dept Med, Barcelona, Spain
Alonso-Fernández, S:
Univ Barcelona UB, Nursing Fac, Fundamental & Clin Nursing Dept, Barcelona, Spain
IDIBELL, Bellvitge Biomed Res Inst, GRIN Res Grp, Barcelona, Spain
Marques-Pamies, M:
Germans Trias & Pujol Hosp & Res Inst, Endocrinol & Nutr Serv, Barcelona, Spain
Autonomous Univ Barcelona UAB, Dept Med, Barcelona, Spain
Hosp Gen Granollers, Endocrinol & Nutr Serv, Barcelona, Spain
Salinas, I:
Germans Trias & Pujol Hosp & Res Inst, Endocrinol & Nutr Serv, Barcelona, Spain
Autonomous Univ Barcelona UAB, Dept Med, Barcelona, Spain
Vázquez, F:
Germans Trias & Pujol Hosp & Res Inst, Endocrinol & Nutr Serv, Barcelona, Spain
Autonomous Univ Barcelona UAB, Dept Med, Barcelona, Spain
Soldevila, B:
Germans Trias & Pujol Hosp & Res Inst, Endocrinol & Nutr Serv, Barcelona, Spain
Autonomous Univ Barcelona UAB, Dept Med, Barcelona, Spain
Asensio-Wandosell, D:
Germans Trias & Pujol Hosp & Res Inst, Endocrinol & Nutr Serv, Barcelona, Spain
Autonomous Univ Barcelona UAB, Dept Med, Barcelona, Spain
Ciriza, R:
Spanish Assoc Acromegaly People, Barcelona, Spain
Santos, A:
ISCIII, CIBERER Unit 747, Madrid, Spain
Hosp S Pau, Dept Endocrinol, Barcelona, Spain
Inst Recerca St Pau IIB St Pau, Res Ctr Pituitary Dis, Barcelona, Spain
Valassi, E:
ISCIII, CIBERER Unit 747, Madrid, Spain
Germans Trias & Pujol Hosp & Res Inst, Endocrinol & Nutr Serv, Barcelona, Spain
Autonomous Univ Barcelona UAB, Dept Med, Barcelona, Spain
Univ Int Catalunya, Barcelona, Spain
Webb, SM:
ISCIII, CIBERER Unit 747, Madrid, Spain
Univ Autonoma Barcelona, Dept Med, Barcelona, Spain
Hosp S Pau, Dept Endocrinol, Barcelona, Spain
Inst Recerca St Pau IIB St Pau, Res Ctr Pituitary Dis, Barcelona, Spain
Puig-Domingo, M:
ISCIII, CIBERER Unit 747, Madrid, Spain
Univ Autonoma Barcelona, Dept Med, Barcelona, Spain
Germans Trias & Pujol Hosp & Res Inst, Endocrinol & Nutr Serv, Barcelona, Spain
Autonomous Univ Barcelona UAB, Dept Med, Barcelona, Spain
Green Submitted, gold
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