Digital biomechanical assessment of gait in patients with peripheral neuropathies
Por:
Tejada-Illa, C, Pegueroles, J, Claramunt-Molet, M, Pi-Cervera, A, Heras-Delgado, A, Gascón-Fontal, J, Idelsohn-Zielonka, S, Rico, M, Vidal, N, Martin-Aguilar, L, Caballero-Avila, M, Lleixà, C, Collet-Vidiella, R, Llansó, L, Carbayo, A, Vesperinas, A, Querol, L, Pascual-Goñi, E
Publicada:
13 jul 2025
Resumen:
BackgroundThe clinical status and treatment response of patients with peripheral neuropathies (PNs) rely on subjective and inaccurate clinical scales. Wearable sensors have been evaluated successfully in other neurological conditions to study gait and balance. Our aim was to explore the ability of biomechanical analysis using wearable technology to monitor disease activity in PN.MethodsWe conducted a single-center, longitudinal study to analyze gait parameters in PN patients and healthy controls using wearable biomechanical sensors. We used a novel technology that registers and integrates data from multiple wearable inertial sensors placed at different locations and plantar insoles. This system allows measuring kinematics, spatio-temporal parameters and plantar pressure. Patients wore the wearable system while performing the 2-min walking test (2MWT).ResultsWe included 37 chronic inflammatory demyelinating polyneuropathy (CIDP) patients, 3 chronic ataxic neuropathy, ophthalmoplegia, immunoglobulin M [IgM] paraprotein (CANOMAD) patients, 21 monoclonal gammopathy patients of undetermined significance associated with IgM (IgM-MGUS) patients, 7 patients with autoimmune nodopathies, 11 patients with hereditary neuropathies, and 50 healthy controls. First, we analyzed the sensor's ability to detect changes in ataxia and steppage gait severity and found significant differences in spatiotemporal and angular variables of the gait cycle. Second, we found correlations between biomechanical features and clinical scales and with the specific gait phenotype they associated with. Finally, we demonstrated that this technology is able to capture clinically significant changes in gait features over time.ConclusionsOur study provides proof-of-concept that wearable technology effectively detects and grades gait impairment, captures clinically relevant changes, and could enhance gait assessment in routine care and clinical research for patients with PN.
Filiaciones:
Tejada-Illa, C:
Inst Recerca Sant Pau IR SANt PAU, Barcelona, Spain
Univ Autonoma Barcelona, Hosp Santa Creu i Sant Pau, Dept Neurol, Neuromuscular Dis Unit, Sant Quinti 77 2nd Floor, Barcelona 08041, Spain
Pegueroles, J:
Ephion Hlth, Barcelona, Spain
Claramunt-Molet, M:
Ephion Hlth, Barcelona, Spain
Pi-Cervera, A:
Ephion Hlth, Barcelona, Spain
Heras-Delgado, A:
Ephion Hlth, Barcelona, Spain
Gascón-Fontal, J:
Ephion Hlth, Barcelona, Spain
Idelsohn-Zielonka, S:
Ephion Hlth, Barcelona, Spain
Eurecat Ctr Tecnol Catalunya, Unit Digital Hlth, Barcelona, Spain
Rico, M:
Ephion Hlth, Barcelona, Spain
Vidal, N:
Univ Autonoma Barcelona, Hosp Santa Creu i Sant Pau, Dept Neurol, Neuromuscular Dis Unit, Sant Quinti 77 2nd Floor, Barcelona 08041, Spain
Martin-Aguilar, L:
Univ Autonoma Barcelona, Hosp Santa Creu i Sant Pau, Dept Neurol, Neuromuscular Dis Unit, Sant Quinti 77 2nd Floor, Barcelona 08041, Spain
Caballero-Avila, M:
Inst Recerca Sant Pau IR SANt PAU, Barcelona, Spain
Univ Autonoma Barcelona, Hosp Santa Creu i Sant Pau, Dept Neurol, Neuromuscular Dis Unit, Sant Quinti 77 2nd Floor, Barcelona 08041, Spain
Lleixà, C:
Inst Recerca Sant Pau IR SANt PAU, Barcelona, Spain
Univ Autonoma Barcelona, Hosp Santa Creu i Sant Pau, Dept Neurol, Neuromuscular Dis Unit, Sant Quinti 77 2nd Floor, Barcelona 08041, Spain
Ctr Invest Biomed Red Enfermedades Raras CIBERER, Madrid, Spain
Collet-Vidiella, R:
Inst Recerca Sant Pau IR SANt PAU, Barcelona, Spain
Univ Autonoma Barcelona, Hosp Santa Creu i Sant Pau, Dept Neurol, Neuromuscular Dis Unit, Sant Quinti 77 2nd Floor, Barcelona 08041, Spain
Llansó, L:
Univ Autonoma Barcelona, Hosp Santa Creu i Sant Pau, Dept Neurol, Neuromuscular Dis Unit, Sant Quinti 77 2nd Floor, Barcelona 08041, Spain
Carbayo, A:
Univ Autonoma Barcelona, Hosp Santa Creu i Sant Pau, Dept Neurol, Neuromuscular Dis Unit, Sant Quinti 77 2nd Floor, Barcelona 08041, Spain
Vesperinas, A:
Univ Autonoma Barcelona, Hosp Santa Creu i Sant Pau, Dept Neurol, Neuromuscular Dis Unit, Sant Quinti 77 2nd Floor, Barcelona 08041, Spain
Querol, L:
Inst Recerca Sant Pau IR SANt PAU, Barcelona, Spain
Univ Autonoma Barcelona, Hosp Santa Creu i Sant Pau, Dept Neurol, Neuromuscular Dis Unit, Sant Quinti 77 2nd Floor, Barcelona 08041, Spain
Ctr Invest Biomed Red Enfermedades Raras CIBERER, Madrid, Spain
Pascual-Goñi, E:
Inst Recerca Sant Pau IR SANt PAU, Barcelona, Spain
Univ Autonoma Barcelona, Hosp Santa Creu i Sant Pau, Dept Neurol, Neuromuscular Dis Unit, Sant Quinti 77 2nd Floor, Barcelona 08041, Spain
Ctr Invest Biomed Red Enfermedades Raras CIBERER, Madrid, Spain
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